acetoacetic acid has been researched along with Autoimmune Diabetes in 34 studies
acetoacetic acid : A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "People with type 1 diabetes frequently encounter elevated levels of the ketone bodies acetoacetate (AA), beta-hydroxybutyrate (BHB), and acetone (ACE)." | 2.69 | Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients. ( Jain, SK; McVie, R, 1999) |
| "In diabetes, mainly type-1, ketoacidosis is the pathological response to glucose malabsorption." | 2.66 | Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States. ( Balcerczyk, A; Dąbek, A; Pirola, L; Wojtala, M, 2020) |
| "Hyperketonemia is a condition with elevated blood levels of acetoacetate, 3-β-hydroxybutyrate, and acetone." | 2.53 | Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes. ( Jain, SK; Kanikarla-Marie, P, 2016) |
| "Diabetic ketoacidosis is a life-threatening complication of Type 1 diabetes." | 2.49 | Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review. ( Craig, ME; Klocker, AA; Phelan, H; Twigg, SM, 2013) |
| "Outcomes examined were prevention of diabetic ketoacidosis, time to recovery from diabetic ketoacidosis, healthcare costs and patient or caregiver satisfaction." | 2.49 | Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review. ( Craig, ME; Klocker, AA; Phelan, H; Twigg, SM, 2013) |
| "No study assessed prevention of diabetic ketoacidosis." | 2.49 | Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review. ( Craig, ME; Klocker, AA; Phelan, H; Twigg, SM, 2013) |
| "Type 1 diabetes is associated with elevated levels of blood PAI-1 and cardiovascular disease (CVD) incidence." | 1.37 | Effects of high glucose and ketosis (acetoacetate, ss-hydroxybutyrate) on PAI-1 secretion in human umbilical vascular endothelial cells. ( Jain, SK; Velusamy, T, 2011) |
| "Net uptake of ketones was seen in IDDM subjects before but not after insulin." | 1.28 | Cerebral blood flow and substrate utilization in insulin-treated diabetic subjects. ( Björkman, O; Blomqvist, G; Grill, V; Gutniak, M; Lindqvist, M; Reichard, P; Seitz, RJ; Stone-Elander, S; Widén, L, 1990) |
| "In the IDDM subjects, the mean reductions in glucose concentration were 99 mg% and 84 mg% during continuous and intermittent exercise, respectively." | 1.27 | Responses to continuous and intermittent exercise in healthy and insulin-dependent diabetic children. ( Cerny, FJ; Sills, IN, 1983) |
| "Another six IDDM patients and six normal subjects were given saline, lactic acid, and saline infusions at the same rates of infusion after an overnight fast during euglycemic insulin-glucose clamp." | 1.27 | Metabolic control of kidney hemodynamics in normal and insulin-dependent diabetic subjects. Effects of acetoacetic, lactic, and acetic acids. ( Avogaro, A; Doria, A; Duner, E; Fioretto, P; Iori, E; Merkel, C; Nosadini, R; Trevisan, R; Valerio, A; Velussi, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (29.41) | 18.7374 |
| 1990's | 13 (38.24) | 18.2507 |
| 2000's | 6 (17.65) | 29.6817 |
| 2010's | 4 (11.76) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Dąbek, A | 1 |
| Wojtala, M | 1 |
| Pirola, L | 1 |
| Balcerczyk, A | 1 |
| Kanikarla-Marie, P | 1 |
| Jain, SK | 8 |
| Velusamy, T | 1 |
| Kurepa, D | 1 |
| Pramanik, AK | 1 |
| Kakkilaya, V | 1 |
| Caldito, G | 1 |
| Groome, LJ | 1 |
| Bocchini, JA | 3 |
| Klocker, AA | 1 |
| Phelan, H | 1 |
| Twigg, SM | 1 |
| Craig, ME | 1 |
| Yamanouchi, K | 1 |
| Abe, R | 1 |
| Takeda, A | 1 |
| Atsumi, Y | 1 |
| Shichiri, M | 1 |
| Sato, Y | 1 |
| Harano, Y | 2 |
| Kannan, K | 2 |
| Lim, G | 3 |
| Matthews-Greer, J | 1 |
| McVie, R | 5 |
| Corey, HE | 1 |
| Prisco, F | 1 |
| Picardi, A | 1 |
| Iafusco, D | 1 |
| Lorini, R | 1 |
| Minicucci, L | 1 |
| Martinucci, ME | 1 |
| Toni, S | 1 |
| Cerutti, F | 1 |
| Rabbone, I | 1 |
| Buzzetti, R | 1 |
| Crino, A | 1 |
| Pozzilli, P | 1 |
| Sills, IN | 1 |
| Cerny, FJ | 1 |
| Kosugi, K | 1 |
| Hyosu, T | 1 |
| Suzuki, M | 1 |
| Hidaka, H | 1 |
| Kashiwagi, A | 1 |
| Uno, S | 1 |
| Shigeta, Y | 1 |
| Hall, SE | 1 |
| Wastney, ME | 1 |
| Bolton, TM | 1 |
| Braaten, JT | 1 |
| Berman, M | 1 |
| Nicholson, JK | 1 |
| O'Flynn, MP | 1 |
| Sadler, PJ | 1 |
| Macleod, AF | 1 |
| Juul, SM | 1 |
| Sönksen, PH | 1 |
| Edge, JA | 1 |
| Harris, DA | 2 |
| Phillips, PE | 1 |
| Pal, BR | 1 |
| Matthews, DR | 1 |
| Dunger, DB | 2 |
| Avogaro, A | 7 |
| Crepaldi, C | 1 |
| Piarulli, F | 1 |
| Milan, D | 1 |
| Valerio, A | 4 |
| Pavan, P | 1 |
| Sacerdoti, D | 1 |
| Calabrò, A | 1 |
| Macdonald, I | 1 |
| Crepaldi, G | 2 |
| Scognamiglio, R | 1 |
| Tiengo, A | 3 |
| Jaramillo, JJ | 1 |
| Chen, Y | 1 |
| Pounder, DJ | 1 |
| Stevenson, RJ | 1 |
| Taylor, KK | 1 |
| Acerini, CL | 1 |
| Matyka, KA | 1 |
| Watts, AP | 1 |
| Umpleby, AM | 1 |
| Russell-Jones, DL | 1 |
| Jackson, R | 1 |
| Levine, SN | 1 |
| McGarry, JD | 1 |
| Gnudi, L | 1 |
| Maran, A | 1 |
| Miola, M | 1 |
| Duner, E | 4 |
| Marescotti, C | 2 |
| Iori, E | 3 |
| Nosadini, R | 7 |
| Watanabe, T | 1 |
| Sugiyama, H | 1 |
| Uchimura, I | 1 |
| Maezawa, H | 1 |
| Grill, V | 1 |
| Gutniak, M | 1 |
| Björkman, O | 1 |
| Lindqvist, M | 1 |
| Stone-Elander, S | 1 |
| Seitz, RJ | 1 |
| Blomqvist, G | 1 |
| Reichard, P | 1 |
| Widén, L | 1 |
| Møller, N | 1 |
| Jørgensen, JO | 1 |
| Møller, J | 1 |
| Orskov, L | 1 |
| Pørksen, N | 1 |
| Alberti, KG | 1 |
| Schmitz, O | 1 |
| Doria, A | 4 |
| Tremolada, C | 1 |
| Baccaglini, U | 1 |
| Ambrosio, F | 1 |
| Merkel, C | 2 |
| Nosadini, A | 1 |
| Trevisan, R | 6 |
| Fioretto, P | 4 |
| Semplicini, A | 1 |
| Angeli, P | 1 |
| Rigon, E | 1 |
| Sama, B | 1 |
| Jori, E | 1 |
| Velussi, M | 1 |
| Féry, F | 1 |
| Balasse, EO | 1 |
| Cobelli, C | 2 |
| Toffolo, G | 2 |
| Saccà, L | 1 |
| Vigorito, C | 1 |
| de Kreutzenberg, S | 1 |
| Tessari, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Modulating Physiologic Effects Of Phospholipid Metabolism In Obesity And Diabetes; AIM 4: Composition and Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome[NCT02122666] | 100 participants (Anticipated) | Observational | 2014-03-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for acetoacetic acid and Autoimmune Diabetes
| Article | Year |
|---|---|
Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Diabetes Mellitus, Type 1; Diet, Ketogenic; Epigenesi | 2020 |
Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes.
Topics: Acetoacetates; Diabetes Mellitus, Type 1; Energy Metabolism; Glucose; Humans; Ketone Bodies; Ketones | 2016 |
Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Critical Care; Crown-Rump Length; Diabetes Mellitus, Type 1; D | 2013 |
[Blood level of ketone bodies and its clinical significance].
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Biomarkers; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type | 2002 |
3 trials available for acetoacetic acid and Autoimmune Diabetes
| Article | Year |
|---|---|
The hemodynamic abnormalities in short-term insulin deficiency: the role of prostaglandin inhibition.
Topics: 3-Hydroxybutyric Acid; 6-Ketoprostaglandin F1 alpha; Acetoacetates; Adult; Blood Glucose; Diabetes M | 1996 |
Effects of low-dose recombinant human insulin-like growth factor-I on insulin sensitivity, growth hormone and glucagon levels in young adults with insulin-dependent diabetes mellitus.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; D | 1998 |
Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Child; Diabetes Mellitus, Type 1; Erythrocytes; Gluta | 1999 |
27 other studies available for acetoacetic acid and Autoimmune Diabetes
| Article | Year |
|---|---|
Effects of high glucose and ketosis (acetoacetate, ss-hydroxybutyrate) on PAI-1 secretion in human umbilical vascular endothelial cells.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetic Ketoacido | 2011 |
Elevated acetoacetate and monocyte chemotactic protein-1 levels in cord blood of infants of diabetic mothers.
Topics: Acetoacetates; Adult; Case-Control Studies; Chemokine CCL2; Diabetes Mellitus, Type 1; Diabetes, Ges | 2012 |
The effect of walking before and after breakfast on blood glucose levels in patients with type 1 diabetes treated with intensive insulin therapy.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type | 2002 |
Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes.
Topics: Acetoacetates; Adolescent; Age of Onset; Cells, Cultured; Child; Diabetes Mellitus, Type 1; Diabetic | 2003 |
The anion gap (AG): studies in the nephrotic syndrome and diabetic ketoacidosis (DKA).
Topics: Acetoacetates; Acid-Base Equilibrium; Adolescent; Adult; Anions; Child; Child, Preschool; Diabetes M | 2006 |
Blood ketone bodies in patients with recent-onset type 1 diabetes (a multicenter study).
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Blood Glucose; Child; Child, Preschool; Diabetes M | 2006 |
Responses to continuous and intermittent exercise in healthy and insulin-dependent diabetic children.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Blood Glucose; Butyrates; Child; Diabetes Mellitus | 1983 |
Ketone bodies as markers for type 1 (insulin-dependent) diabetes and their value in the monitoring of diabetic control.
Topics: Acetoacetates; Adolescent; Adult; Aged; Blood Glucose; Child; Circadian Rhythm; Diabetes Mellitus, T | 1984 |
Ketone body kinetics in humans: the effects of insulin-dependent diabetes, obesity, and starvation.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Adult; Diabetes Mellitus, Type 1; Diabetic Ketoaci | 1984 |
Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Amino Acids; Diabetes Mellitus, Type 1; Diabet | 1984 |
Evidence for a role for insulin and growth hormone in overnight regulation of 3-hydroxybutyrate in normal and diabetic adolescents.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Adult; Age Factors; C-Peptide; Child; Circadian Rh | 1993 |
Hyperketonemia (acetoacetate) increases the oxidizability of LDL + VLDL in Type-I diabetic patients.
Topics: Acetoacetates; Adolescent; Case-Control Studies; Child; Diabetes Mellitus, Type 1; Female; Humans; K | 1998 |
Alcoholic ketoacidosis at autopsy.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholis | 1998 |
Effect of hyperketonemia on plasma lipid peroxidation levels in diabetic patients.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Child; Diabetes Mellitus; Diabetes Mellitus, Type 1; Di | 1999 |
Hyperketonemia increases tumor necrosis factor-alpha secretion in cultured U937 monocytes and Type 1 diabetic patients and is apparently mediated by oxidative stress and cAMP deficiency.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetylcysteine; Antioxidants; Cyclic AMP; Diabetes Mellitus, T | 2002 |
What if Minkowski had been ageusic? An alternative angle on diabetes.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adipose Tissue; Blood Glucose; Diabetes Mellitus, Type 1; Diab | 1992 |
The effects of different plasma insulin concentrations on lipolytic and ketogenic responses to epinephrine in normal and type 1 (insulin-dependent) diabetic humans.
Topics: Acetoacetates; Adult; Blood Glucose; Blood Pressure; C-Peptide; Diabetes Mellitus, Type 1; Epinephri | 1992 |
Serum ketone response to glucagon as a marker of insulin dependency in diabetics.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Biomarkers; Blood Glucose; C-Peptide; Diabetes Mellitus | 1991 |
Cerebral blood flow and substrate utilization in insulin-treated diabetic subjects.
Topics: Acetoacetates; Adult; Blood Glucose; Brain; Carbon Dioxide; Cerebrovascular Circulation; Diabetes Me | 1990 |
Lack of effects of hyperglycemia on the disposal of 3-hydroxybutyrate in insulin-dependent diabetic patients.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Fatty Acids, | 1990 |
Substrate availability other than glucose in the brain during euglycemia and insulin-induced hypoglycemia in dogs.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental | 1990 |
Tubular Na+ handling in type I insulin-dependent diabetics during saline and ketone body infusion.
Topics: Acetoacetates; Adult; Blood Pressure; Diabetes Mellitus, Type 1; Glomerular Filtration Rate; Glucose | 1989 |
Ketone bodies increase glomerular filtration rate in normal man and in patients with type 1 (insulin-dependent) diabetes mellitus.
Topics: Acetoacetates; Bicarbonates; Diabetes Mellitus, Type 1; Female; Glomerular Filtration Rate; Hemodyna | 1987 |
Metabolic control of kidney hemodynamics in normal and insulin-dependent diabetic subjects. Effects of acetoacetic, lactic, and acetic acids.
Topics: Acetates; Acetic Acid; Acetoacetates; Adolescent; Adult; Aged; Blood Glucose; Child; Diabetes Mellit | 1987 |
Ketone body production and disposal in diabetic ketosis. A comparison with fasting ketosis.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Adolescent; Adult; Diabetes Mellitus, Type 1; Diabet | 1985 |
Acetoacetate and 3-hydroxybutyrate kinetics in obese and insulin-dependent diabetic humans.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetic | 1985 |
Ketone body metabolism in normal and diabetic human skeletal muscle.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Carbon Radioisotopes; Diabetes Mellitus; Diabetes Melli | 1985 |