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acetoacetic acid and Acidosis, Diabetic

acetoacetic acid has been researched along with Acidosis, Diabetic in 28 studies

acetoacetic acid : A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.

Research Excerpts

ExcerptRelevanceReference
"A complication of diabetes is diabetic ketoacidosis (DKA), which if left untreated is a life threatening condition."2.53Evaluation of the Accuracy of Capillary Hydroxybutyrate Measurement Compared with Other Measurements in the Diagnosis of Diabetic Ketoacidosis: A Systematic Review. ( Brooke, J; Ojo, O; Stiell, M, 2016)
"Diabetic ketoacidosis is a life-threatening complication of Type 1 diabetes."2.49Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review. ( Craig, ME; Klocker, AA; Phelan, H; Twigg, SM, 2013)
"Outcomes examined were prevention of diabetic ketoacidosis, time to recovery from diabetic ketoacidosis, healthcare costs and patient or caregiver satisfaction."2.49Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review. ( Craig, ME; Klocker, AA; Phelan, H; Twigg, SM, 2013)
"No study assessed prevention of diabetic ketoacidosis."2.49Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review. ( Craig, ME; Klocker, AA; Phelan, H; Twigg, SM, 2013)
"Severe hypertriglyceridemia was considered to have been a consequence of impaired insulin action and his apolipoprotein E4/2 phenotype."1.51Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. ( Aiba, S; Imai, J; Katagiri, H; Kikuchi, K; Kohata, M; Kurosawa, S; Nakajima, T; Satake, C; Sawada, S; Takahashi, K; Takeda, K; Tsuchiya, S, 2019)
"Soft-drink diabetic ketosis, characterized by acute onset ketosis induced by excessive ingestion of sugar-containing drinks, is often seen in obese, young patients, even with undiagnosed type 2 diabetes."1.51Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. ( Aiba, S; Imai, J; Katagiri, H; Kikuchi, K; Kohata, M; Kurosawa, S; Nakajima, T; Satake, C; Sawada, S; Takahashi, K; Takeda, K; Tsuchiya, S, 2019)
"The eruptive xanthoma lesions gradually diminished in size and number and eventually disappeared by 12 months."1.51Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. ( Aiba, S; Imai, J; Katagiri, H; Kikuchi, K; Kohata, M; Kurosawa, S; Nakajima, T; Satake, C; Sawada, S; Takahashi, K; Takeda, K; Tsuchiya, S, 2019)
"Diabetes and alcohol abuse may cause severe metabolic disturbances that can be fatal."1.39Assessment of Traub formula and ketone bodies in cause of death investigations. ( Keltanen, T; Lindroos, K; Palo, JU; Partanen, T; Sajantila, A; Valonen, T, 2013)
"Type 1 diabetes is associated with elevated levels of blood PAI-1 and cardiovascular disease (CVD) incidence."1.37Effects of high glucose and ketosis (acetoacetate, ss-hydroxybutyrate) on PAI-1 secretion in human umbilical vascular endothelial cells. ( Jain, SK; Velusamy, T, 2011)
"During diabetic ketoacidosis (DKA), serum ketone concentrations markedly increase; however, little is known about whether ketone bodies accumulate in cerebral tissues during DKA."1.33Detection of cerebral {beta}-hydroxy butyrate, acetoacetate, and lactate on proton MR spectroscopy in children with diabetic ketoacidosis. ( Barnes, PD; Buonocore, MH; Dicarlo, J; Glaser, N; Kuppermann, N; Marcin, J; Neely, EK; Wootton-Gorges, SL, 2005)
"An emaciated patient suffering from Duchenne Muscular Dystrophy and volume depletion presented with acidosis of unknown origin."1.33Unexplained acidosis of malnutrition: a study by ion-exchange chromatography/mass spectrometry. ( Forni, LG; Hilton, PJ; Lord, GA; McKinnon, W; Peron, JM, 2006)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19906 (21.43)18.7374
1990's3 (10.71)18.2507
2000's11 (39.29)29.6817
2010's8 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Heimer, J1
Gascho, D1
Chatzaraki, V1
Knaute, DF1
Sterzik, V1
Martinez, RM1
Thali, MJ1
Zoelch, N1
Polidori, D1
Iijima, H1
Goda, M1
Maruyama, N1
Inagaki, N1
Crawford, PA1
Tsuchiya, S1
Sawada, S1
Takeda, K1
Takahashi, K1
Nakajima, T1
Kohata, M1
Kurosawa, S1
Satake, C1
Imai, J1
Kikuchi, K1
Aiba, S1
Katagiri, H1
Keltanen, T1
Sajantila, A1
Palo, JU1
Partanen, T1
Valonen, T1
Lindroos, K1
Akram, M1
Brooke, J1
Stiell, M1
Ojo, O1
Velusamy, T1
Jain, SK3
Klocker, AA1
Phelan, H1
Twigg, SM1
Craig, ME1
Harano, Y1
Hoffman, WH1
Cheng, C1
Passmore, GG1
Carroll, JE1
Hess, D1
Kannan, K1
Lim, G2
Matthews-Greer, J1
McVie, R2
Bocchini, JA1
Khan, AS1
Talbot, JA1
Tieszen, KL1
Gardener, EA1
Gibson, JM1
New, JP1
Taboulet, P1
Haas, L1
Porcher, R1
Manamani, J1
Fontaine, JP1
Feugeas, JP1
Gautier, JF1
Royer, LO1
Knudsen, FS1
de Oliveira, MA1
Tavares, MF1
Bechara, EJ1
Wootton-Gorges, SL1
Buonocore, MH1
Kuppermann, N1
Marcin, J1
Dicarlo, J1
Neely, EK1
Barnes, PD1
Glaser, N1
Ramakrishnan, R1
Sheeladevi, R1
Suthanthirarajan, N1
Namasivayam, A1
Corey, HE1
Prisco, F1
Picardi, A1
Iafusco, D1
Lorini, R1
Minicucci, L1
Martinucci, ME1
Toni, S1
Cerutti, F1
Rabbone, I1
Buzzetti, R1
Crino, A1
Pozzilli, P1
Hilton, PJ1
McKinnon, W1
Lord, GA1
Peron, JM1
Forni, LG1
Hall, SE1
Wastney, ME1
Bolton, TM1
Braaten, JT1
Berman, M1
Ohgaku, S2
Brady, PS2
Schumann, WC2
Bartsch, GE2
Margolis, JM2
Kumaran, K2
Landau, SB1
Landau, BR2
Scofield, RF1
Horvat, A1
Mann, S1
Quin, JD1
Smith, K1
Beastall, GH1
Miell, JP1
MacCuish, AC1
Avogaro, A2
Crepaldi, C1
Piarulli, F1
Milan, D1
Valerio, A1
Pavan, P1
Sacerdoti, D1
Calabrò, A1
Macdonald, I1
Crepaldi, G1
Scognamiglio, R1
Tiengo, A1
Jackson, R1
Levine, SN1
Nuwayhid, NF1
Johnson, GF1
Feld, RD1
Féry, F1
Balasse, EO1
Nosadini, R1
Trevisan, R1
Duner, E1
Marescotti, C1
Iori, E1
Cobelli, C1
Toffolo, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Development of Ketoacidosis During the Perioperative Period: an Observational Study 'The DKAP Study'[NCT05225467]58 participants (Actual)Observational [Patient Registry]2022-03-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for acetoacetic acid and Acidosis, Diabetic

ArticleYear
A focused review of the role of ketone bodies in health and disease.
    Journal of medicinal food, 2013, Volume: 16, Issue:11

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Alzheimer Disease; Blood Glucose; Diabetic Ketoacidos

2013
Evaluation of the Accuracy of Capillary Hydroxybutyrate Measurement Compared with Other Measurements in the Diagnosis of Diabetic Ketoacidosis: A Systematic Review.
    International journal of environmental research and public health, 2016, 08-23, Volume: 13, Issue:9

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dia

2016
Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review.
    Diabetic medicine : a journal of the British Diabetic Association, 2013, Volume: 30, Issue:7

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Critical Care; Crown-Rump Length; Diabetes Mellitus, Type 1; D

2013
[Blood level of ketone bodies and its clinical significance].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 8

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Biomarkers; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type

2002

Trials

2 trials available for acetoacetic acid and Acidosis, Diabetic

ArticleYear
Intra- and inter-subject variability for increases in serum ketone bodies in patients with type 2 diabetes treated with the sodium glucose co-transporter 2 inhibitor canagliflozin.
    Diabetes, obesity & metabolism, 2018, Volume: 20, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Biological Variation, Population; Blood Glucose; Canagliflozin

2018
The hemodynamic abnormalities in short-term insulin deficiency: the role of prostaglandin inhibition.
    Diabetes, 1996, Volume: 45, Issue:5

    Topics: 3-Hydroxybutyric Acid; 6-Ketoprostaglandin F1 alpha; Acetoacetates; Adult; Blood Glucose; Diabetes M

1996

Other Studies

22 other studies available for acetoacetic acid and Acidosis, Diabetic

ArticleYear
Postmortem
    International journal of legal medicine, 2018, Volume: 132, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Diabetic Ketoacidosis; Glucose; Humans; Ketone

2018
Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2.
    Endocrine journal, 2019, Jan-28, Volume: 66, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Apolipoprotein E2; Apolipoprotein E4; Carbonated B

2019
Assessment of Traub formula and ketone bodies in cause of death investigations.
    International journal of legal medicine, 2013, Volume: 127, Issue:6

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Alcoholism; Algorithms; Autopsy; Biomarkers; Blood Gl

2013
Effects of high glucose and ketosis (acetoacetate, ss-hydroxybutyrate) on PAI-1 secretion in human umbilical vascular endothelial cells.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2011, Volume: 17, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetic Ketoacido

2011
Acetoacetate increases expression of intercellular adhesion molecule-1 (ICAM-1) in human brain microvascular endothelial cells.
    Neuroscience letters, 2002, Dec-13, Volume: 334, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Brain; Cells, Cultured; Diabetic Ketoacidosis; Dose-Response R

2002
Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes.
    Diabetes care, 2003, Volume: 26, Issue:7

    Topics: Acetoacetates; Adolescent; Age of Onset; Cells, Cultured; Child; Diabetes Mellitus, Type 1; Diabetic

2003
Evaluation of a bedside blood ketone sensor: the effects of acidosis, hyperglycaemia and acetoacetate on sensor performance.
    Diabetic medicine : a journal of the British Diabetic Association, 2004, Volume: 21, Issue:7

    Topics: Acetoacetates; Acidosis; Biosensing Techniques; Blood Glucose; Blood Glucose Self-Monitoring; Diabet

2004
Urinary acetoacetate or capillary beta-hydroxybutyrate for the diagnosis of ketoacidosis in the Emergency Department setting.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2004, Volume: 11, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Biomarkers; Capillaries; Critical Illness; Diabetic Ketoacidos

2004
Peroxynitrite-initiated oxidation of acetoacetate and 2-methylacetoacetate esters by oxygen: potential sources of reactive intermediates in keto acidoses.
    Chemical research in toxicology, 2004, Volume: 17, Issue:12

    Topics: Acetoacetates; Diabetic Ketoacidosis; Electron Spin Resonance Spectroscopy; Free Radicals; Hydrogen-

2004
Detection of cerebral {beta}-hydroxy butyrate, acetoacetate, and lactate on proton MR spectroscopy in children with diabetic ketoacidosis.
    AJNR. American journal of neuroradiology, 2005, Volume: 26, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Child; Diabetic Ketoacidosis; Female; Humans; Lactic Acid; Mag

2005
An acute hyperglycemia or acidosis-induced changes of indolamines level correlates with PKC-alpha expression in rat brain.
    Brain research bulletin, 2005, Sep-30, Volume: 67, Issue:1-2

    Topics: Acetoacetates; Ammonium Chloride; Animals; Brain; Brain Chemistry; Diabetes Complications; Diabetic

2005
The anion gap (AG): studies in the nephrotic syndrome and diabetic ketoacidosis (DKA).
    The Journal of laboratory and clinical medicine, 2006, Volume: 147, Issue:3

    Topics: Acetoacetates; Acid-Base Equilibrium; Adolescent; Adult; Anions; Child; Child, Preschool; Diabetes M

2006
Blood ketone bodies in patients with recent-onset type 1 diabetes (a multicenter study).
    Pediatric diabetes, 2006, Volume: 7, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Blood Glucose; Child; Child, Preschool; Diabetes M

2006
Unexplained acidosis of malnutrition: a study by ion-exchange chromatography/mass spectrometry.
    Biomedical chromatography : BMC, 2006, Volume: 20, Issue:12

    Topics: Acetoacetates; Acidosis; Adolescent; Chromatography, High Pressure Liquid; Chromatography, Ion Excha

2006
Ketone body kinetics in humans: the effects of insulin-dependent diabetes, obesity, and starvation.
    Journal of lipid research, 1984, Volume: 25, Issue:11

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Adult; Diabetes Mellitus, Type 1; Diabetic Ketoaci

1984
A method for quantitating the contributions of the pathways of acetoacetate formation and its application to diabetic ketosis in vivo.
    The Journal of biological chemistry, 1982, Aug-25, Volume: 257, Issue:16

    Topics: Acetoacetates; Acetyl Coenzyme A; Acyl Coenzyme A; Animals; Chemical Phenomena; Chemistry; Diabetes

1982
Pathways of acetoacetate's formation in liver and kidney.
    The Journal of biological chemistry, 1982, Aug-25, Volume: 257, Issue:16

    Topics: Acetoacetates; Acetyl Coenzyme A; Acyl Coenzyme A; Animals; Chemical Phenomena; Chemistry; Diabetes

1982
The effect of recombinant insulin-like growth factor I on ketone body, lipid and apolipoprotein concentrations and its use to treat ketoacidosis in severe insulin resistance.
    Diabetic medicine : a journal of the British Diabetic Association, 1994, Volume: 11, Issue:6

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Apolipoproteins; Diabetic Ketoacidosis; Humans; Hy

1994
Effect of hyperketonemia on plasma lipid peroxidation levels in diabetic patients.
    Diabetes care, 1999, Volume: 22, Issue:7

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Child; Diabetes Mellitus; Diabetes Mellitus, Type 1; Di

1999
Kinetic measurement of the combined concentrations of acetoacetate and beta-hydroxybutyrate in serum.
    Clinical chemistry, 1988, Volume: 34, Issue:9

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Catalysis; Diabetic Ketoacidosis; Female; Humans; Hydro

1988
Ketone body production and disposal in diabetic ketosis. A comparison with fasting ketosis.
    Diabetes, 1985, Volume: 34, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Adolescent; Adult; Diabetes Mellitus, Type 1; Diabet

1985
Acetoacetate and 3-hydroxybutyrate kinetics in obese and insulin-dependent diabetic humans.
    The American journal of physiology, 1985, Volume: 248, Issue:5 Pt 2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetic

1985