acetic acid has been researched along with Canavan Disease in 2 studies
Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
acetic acid : A simple monocarboxylic acid containing two carbons.
Canavan Disease: A rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. Aspartoacylase deficiency leads to an accumulation of N-acetylaspartate in astrocytes. Inheritance may be autosomal recessive or the illness may occur sporadically. This illness occurs more frequently in individuals of Ashkenazic Jewish descent. The neonatal form features the onset of hypotonia and lethargy at birth, rapidly progressing to coma and death. The infantile form features developmental delay, DYSKINESIAS, hypotonia, spasticity, blindness, and megalencephaly. The juvenile form is characterized by ATAXIA; OPTIC ATROPHY; and DEMENTIA. (From Adams et al., Principles of Neurology, 6th ed, p944; Am J Med Genet 1988 Feb;29(2):463-71)
Excerpt | Relevance | Reference |
---|---|---|
"Canavan disease is a devastating neurodegenerative childhood disease caused by mutations in aspartoacylase, an enzyme that deacetylates N-acetylaspartate to generate free acetate in the brain." | 1.31 | Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease. ( Jacobowitz, DM; Kallarakal, AT; Kirmani, BF; Namboodiri, MA, 2002) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Kirmani, BF | 1 |
Jacobowitz, DM | 1 |
Kallarakal, AT | 1 |
Namboodiri, MA | 2 |
Madhavarao, CN | 1 |
Arun, P | 1 |
Moffett, JR | 1 |
Szucs, S | 1 |
Surendran, S | 1 |
Matalon, R | 1 |
Garbern, J | 1 |
Hristova, D | 1 |
Johnson, A | 1 |
Jiang, W | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Phase 1 Treatment With GTA in Two Infant With Canavan Disease[NCT00278707] | Phase 1 | 5 participants | Interventional | 2006-01-31 | Active, not recruiting | ||
Evaluation of the Tolerance and Efficiency of a Combined Oral Therapy With Lithium and GTA in Patients With Canavan Disease[NCT00657748] | Phase 2 | 0 participants (Actual) | Interventional | 2009-09-30 | Withdrawn | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
2 other studies available for acetic acid and Canavan Disease
Article | Year |
---|---|
Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease.
Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Central Nervous System; Cytop | 2002 |
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.
Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Brain; Canavan Disease; DNA; Hu | 2005 |
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.
Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Brain; Canavan Disease; DNA; Hu | 2005 |
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.
Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Brain; Canavan Disease; DNA; Hu | 2005 |
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.
Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Brain; Canavan Disease; DNA; Hu | 2005 |