Page last updated: 2024-10-16

acetic acid and Canavan Disease

acetic acid has been researched along with Canavan Disease in 2 studies

Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
acetic acid : A simple monocarboxylic acid containing two carbons.

Canavan Disease: A rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. Aspartoacylase deficiency leads to an accumulation of N-acetylaspartate in astrocytes. Inheritance may be autosomal recessive or the illness may occur sporadically. This illness occurs more frequently in individuals of Ashkenazic Jewish descent. The neonatal form features the onset of hypotonia and lethargy at birth, rapidly progressing to coma and death. The infantile form features developmental delay, DYSKINESIAS, hypotonia, spasticity, blindness, and megalencephaly. The juvenile form is characterized by ATAXIA; OPTIC ATROPHY; and DEMENTIA. (From Adams et al., Principles of Neurology, 6th ed, p944; Am J Med Genet 1988 Feb;29(2):463-71)

Research Excerpts

ExcerptRelevanceReference
"Canavan disease is a devastating neurodegenerative childhood disease caused by mutations in aspartoacylase, an enzyme that deacetylates N-acetylaspartate to generate free acetate in the brain."1.31Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease. ( Jacobowitz, DM; Kallarakal, AT; Kirmani, BF; Namboodiri, MA, 2002)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kirmani, BF1
Jacobowitz, DM1
Kallarakal, AT1
Namboodiri, MA2
Madhavarao, CN1
Arun, P1
Moffett, JR1
Szucs, S1
Surendran, S1
Matalon, R1
Garbern, J1
Hristova, D1
Johnson, A1
Jiang, W1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase 1 Treatment With GTA in Two Infant With Canavan Disease[NCT00278707]Phase 15 participants Interventional2006-01-31Active, not recruiting
Evaluation of the Tolerance and Efficiency of a Combined Oral Therapy With Lithium and GTA in Patients With Canavan Disease[NCT00657748]Phase 20 participants (Actual)Interventional2009-09-30Withdrawn
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

2 other studies available for acetic acid and Canavan Disease

ArticleYear
Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease.
    Brain research. Molecular brain research, 2002, Nov-15, Volume: 107, Issue:2

    Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Central Nervous System; Cytop

2002
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Apr-05, Volume: 102, Issue:14

    Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Brain; Canavan Disease; DNA; Hu

2005
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Apr-05, Volume: 102, Issue:14

    Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Brain; Canavan Disease; DNA; Hu

2005
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Apr-05, Volume: 102, Issue:14

    Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Brain; Canavan Disease; DNA; Hu

2005
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Apr-05, Volume: 102, Issue:14

    Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Brain; Canavan Disease; DNA; Hu

2005