acetic acid has been researched along with Ache in 767 studies
Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
acetic acid : A simple monocarboxylic acid containing two carbons.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To evaluate the analgesic effects of AC, 4 different pain models including hot plate assay, acetic acid writhing assay, formalin and CFA induced pain models were adopted in this study." | 8.02 | Comparison of analgesic activities of aconitine in different mice pain models. ( Chen, J; Deng, J; Feng, Q; Han, J; Huang, Q; Leung, EL; Liu, Z; Lu, L; Qi, X; Wang, D; Wang, Y; Zhang, Y, 2021) |
| "Here, we found that intratesticular bradykinin evokes pain behavior via stimulation of bradykinin B2 receptors and that intratesticular acetic acid injection induces intratesticular bradykinin synthesis, consequently leading to pain behavior." | 7.88 | Intratesticular Bradykinin Involvement in Rat Testicular Pain Models. ( Fujimoto, K; Masuda, N; Takeda, M; Yoshino, T; Yoshioka, K; Yuyama, H, 2018) |
| "To clarify the role of bradykinin in urogenital pain, we investigated bradykinin involvement in rat models of testicular pain." | 7.88 | Intratesticular Bradykinin Involvement in Rat Testicular Pain Models. ( Fujimoto, K; Masuda, N; Takeda, M; Yoshino, T; Yoshioka, K; Yuyama, H, 2018) |
| "An injection of bradykinin into the testes of conscious rats induced pain behaviors that were dose-proportionally reduced by prior administration of FK3657." | 7.88 | Intratesticular Bradykinin Involvement in Rat Testicular Pain Models. ( Fujimoto, K; Masuda, N; Takeda, M; Yoshino, T; Yoshioka, K; Yuyama, H, 2018) |
| "Overt pain-like behaviors were determined by the number of abdominal writhings induced by phenyl-p-benzoquinone and acetic acid." | 7.85 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| "Probucol reduced overt pain-like behavior, and carrageenan-induced mechanical and thermal hyperalgesia." | 7.85 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| "This study aimed to investigate the involvement of opioid receptors in the systemic and peripheral antinociceptive activities of montelukast in different animal models of pain." | 7.83 | Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of montelukast in the animal models of pain. ( Alboghobeish, S; Ghorbanzadeh, B; Mansouri, MT; Sahraei, H, 2016) |
| "In this study, we examined the interaction between EA and venlafaxine (VLF) on pain induced by intraperitoneal acetic acid in mice using isobolographic analysis." | 7.81 | Ellagic acid enhances the antinociceptive action of venlafaxine in mouse acetic acid-induced pain: An isobolographic analysis. ( Ghorbanzadeh, B; Mansouri, MT; Naghizadeh, B, 2015) |
| " Compound 1 inhibited carrageenan-induced paw edema and acetic acid-induced abdominal writhing, which are its only known anti-inflammatory activities." | 7.80 | Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. ( Ambrosio, SR; Arakawa, NS; Carvalho, TT; Casagrande, R; de Souza, AR; Ferraz, CR; Hayashida, TH; Hohmann, MS; Mizokami, SS; Possebon, MI; Staurengo-Ferrari, L; Verri, WA; Zarpelon, AC, 2014) |
| "In the present study, we have investigated the anti-nociceptive and anti-allodynic activity of the renin inhibitor, aliskiren, in various pain models." | 7.79 | Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models. ( Deshpande, SS; Jain, MR; Patel, RB; Pawar, VD; Prajapati, KD; Shah, GB; Sonara, BM, 2013) |
| " Opioid coadministration had a synergistic effect in the acute tonic pain (acetic acid writhing test), acute phasic pain (tail flick test) and inflammatory pain (orofacial formalin test)." | 7.79 | Systemic synergism between codeine and morphine in three pain models in mice. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Zepeda, RJ, 2013) |
| "This study was carried out to investigate the effect of amentoflavone isolated from methanolic root extract of CF on lipopolysaccharide (LPS)-induced neuroinflammatory cascade of events associated to the oxidative and nitrative stress, and TNF-α production in rat astrocytoma cell line (C6) and human monocytic leukemia cell line (THP-1), respectively." | 7.79 | Evaluation of amentoflavone isolated from Cnestis ferruginea Vahl ex DC (Connaraceae) on production of inflammatory mediators in LPS stimulated rat astrocytoma cell line (C6) and THP-1 cells. ( Adeyemi, OO; Chaturvedi, JP; Ishola, IO; Narender, T; Rai, S; Rajasekar, N; Shukla, R, 2013) |
| "Rat astrocytoma cells (C6) were stimulated with LPS (10μg/ml) alone and in the presence of different concentrations of amentoflavone (0." | 7.79 | Evaluation of amentoflavone isolated from Cnestis ferruginea Vahl ex DC (Connaraceae) on production of inflammatory mediators in LPS stimulated rat astrocytoma cell line (C6) and THP-1 cells. ( Adeyemi, OO; Chaturvedi, JP; Ishola, IO; Narender, T; Rai, S; Rajasekar, N; Shukla, R, 2013) |
| " Here we use the writhing assay, a model of visceral pain, to investigate the analgesic effects of NT69L (binds NTS1 and NTS2 equally), NT79 (NTS2-selective), NT72 (NTS1 selective) and levocabastine (NTS2-selective) in WT, NTS1 knock-out, and NTS2 knock-out mice." | 7.78 | NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain. ( Boules, M; Richelson, E; Smith, KE; Williams, K, 2012) |
| "The synergistic interaction between paracetamol and oxcarbazepine provides new information about combination pain treatment and should be explored further in patients, especially with somatic and/or visceral pain." | 7.76 | Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents. ( Bosković, B; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2010) |
| "This study compared effects of the mu opioid receptor agonist morphine (an acknowledged analgesic), the dopamine receptor antagonist haloperidol (a non-analgesic sedative), the adenosine receptor antagonist caffeine (a non-analgesic stimulant) and the neurokinin-1 receptor antagonist CJ 11,974-01 (a candidate analgesic) on acetic acid-induced writhing (a traditional pain-stimulated behavior) and acetic acid-induced suppression of locomotor activity (a pain-depressed behavior) in male ICR mice." | 7.75 | Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice. ( Adams, C; Bilsky, EJ; Cormier, J; Dunbar, C; Mercer, H; Negus, SS; Stevenson, GW, 2009) |
| ", synergistic) in preclinical models of visceral and inflammatory pain, specifically acetic acid-induced writhing in mice and carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats." | 7.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| " Isobolographic analysis of the effects of duloxetine in combination with ibuprofen revealed a significant synergistic (greater than additive) interaction between duloxetine and ibuprofen both for reducing acetic acid-induced writhing and carrageenan-induced thermal hyperalgesia, but were additive for reversing mechanical allodynia." | 7.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| "Our data indicate that duloxetine and ibuprofen have synergistic efficacy in a visceral and an inflammatory pain model in rodents, and suggest that duloxetine and ibuprofen in combination may provide a useful approach to the clinical treatment of persistent pain, particularly inflammation-related pain." | 7.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| "These data demonstrated the comparable efficacy of gabapentin with morphine in visceral pain." | 7.74 | Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. ( Meymandi, MS; Sepehri, G, 2008) |
| " Here, the antinociceptive effects of MOR agonists, the 6beta-glycine derivative of 14-O-methyloxymorphone (HS-731), DAMGO and morphine were evaluated in a mouse model of visceral pain." | 7.74 | DAMGO and 6beta-glycine substituted 14-O-methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens. ( Al-Khrasani, M; Friedmann, T; Furst, S; Király, K; Riba, P; Schmidhammer, H; Spetea, M, 2007) |
| " pacari extract in carrageenan-induced paw oedema, acetic acid writhing and LPS-induced fever, respectively." | 7.73 | Anti-inflammatory, analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid. ( Albuquerque, DA; Ambrosio, SR; da Costa, FB; de Souza, GE; Faccioli, LH; Fontanari, C; França, SC; Melo, MC; Pereira, PS; Rogerio, AP, 2006) |
| "The antihyperalgesic effect of pentoxifylline was investigated in three experimental pain models." | 7.72 | Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. ( Benevides, VM; Brito, GA; Cunha, FQ; da Rocha, FA; Ferreira, SH; Poole, S; Ribeiro, RA; Sachs, D; Vale, ML, 2004) |
| "In a model of visceral pain consisting of intraperitoneal injection of acetic acid (writhing test), simultaneous administration of subanalgesic doses of metamizol (150 mg/kg) and morphine (0." | 7.70 | Metamizol potentiates morphine effects on visceral pain and evoked c-Fos immunoreactivity in spinal cord. ( Fernaud, I; Mellström, B; Naranjo, JR; Taylor, J, 1998) |
| "This study investigates the antinociceptive and the oedema inhibition properties of the novel non-peptide bradykinin (BK) B2 receptor antagonist, NPC 18884." | 7.70 | Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. ( Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ, 1999) |
| "treatment with oxyntomodulin during the second, but not the first phase." | 5.48 | Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models. ( Hong, JW; Jang, SP; Lee, HJ; Lee, JR; Park, SH; Suh, HW, 2018) |
| "Mechanical and thermal hyperalgesia induced by carrageenan were determined using an electronic anesthesiometer and hot plate apparatus, respectively." | 5.46 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| "Stigmasterol is a common sterol found in plants, but the anti-nociceptive effect of this compound and its mechanism of action are not fully explored." | 5.46 | Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain. ( da Silva Brum, E; Ferreira, J; Oliveira, SM; Rossato, MF; Tonello, R; Trevisan, G; Walker, CIB, 2017) |
| "Furthermore, it markedly attenuated the mechanical allodynia caused by surgical incision (after acute treatment with stigmasterol, preventive and curative effects were observed) and partial sciatic nerve ligation (after acute treatment with stigmasterol) and complete Freund's adjuvant (after acute or repeated treatment with stigmasterol)." | 5.46 | Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain. ( da Silva Brum, E; Ferreira, J; Oliveira, SM; Rossato, MF; Tonello, R; Trevisan, G; Walker, CIB, 2017) |
| " In vivo experiments confirmed that TSY extract not only reduced the number of voluntary activities in the mouse model but also exhibited a synergistic effect on sodium pentobarbital-induced sleep, reduced the number of mice exhibiting writhing responses to acetic acid, and increased the hot plate pain threshold of mice." | 5.41 | The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data. ( Huang, XZ; Ji, XY; Li, HR; Sun, QR; Tang, Y; Wang, QQ; Wang, XQ; Zhang, B; Zhang, K, 2023) |
| "Visceral pain is one of the most common forms of pain and for which new drugs would be welcome." | 5.35 | Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. ( Meymandi, MS; Sepehri, G, 2008) |
| "Since pain is the main syndrome of dysmenorrhea, the present investigation was carried out to evaluate the analgesic activity of LIG in vivo." | 5.34 | Ligustilide attenuates pain behavior induced by acetic acid or formalin. ( Du, J; Ke, Y; Qian, ZM; Wang, C; Yu, Y; Zhu, L, 2007) |
| "Gastric ulcer is a source of visceral pain." | 5.33 | Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats. ( Bogdanov, A; Filaretova, L; Yarushkina, N, 2006) |
| "Gastric ulcers were induced by luminal application of 60% acetic acid under surgical conditions." | 5.33 | Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats. ( Bogdanov, A; Filaretova, L; Yarushkina, N, 2006) |
| "Pentoxifylline did not inhibit the nociceptive response in the hot plate test in mice." | 5.32 | Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. ( Benevides, VM; Brito, GA; Cunha, FQ; da Rocha, FA; Ferreira, SH; Poole, S; Ribeiro, RA; Sachs, D; Vale, ML, 2004) |
| "Pretreatment with flavone (50 mg/kg, sc) always exhibited a tendency to reverse the hyperglycemia, if any, but enhanced the antinociceptive response either after swim stress or after dextrose." | 5.31 | Modulation by insulin rather than blood glucose of the pain threshold in acute physiological and flavone induced antinociception in mice. ( Parvathavarthini, S; Rajendran, NN; Ramaswamy, S; Thirugnanasambandam, P; Viswanathan, S, 2001) |
| "prevented BK and carrageenan-induced hyperalgesia (mean ID50 values of 6 nmol/kg and 13 nmol/kg), without affecting the hyperalgesia induced by des-Arg9-bradykinin (DABK) or by prostaglandin E2 (PGE2)." | 5.30 | Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. ( Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ, 1999) |
| "To evaluate the effect of SHO on experimental hemorrhoids in rats induced by croton oil and glacial acetic acid." | 4.84 | The beneficial effect of Sanhuang ointment and its active constituents on experimental hemorrhoids in rats. ( Li, G; Li, W; Piao, S; Yan, M; Yu, Q; Zhang, H; Zhang, X; Zhao, Y, 2024) |
| " Hemorrhoids were induced by 6% balsam and glacial acetic acid respectively in the anorectal region of rats." | 4.84 | The beneficial effect of Sanhuang ointment and its active constituents on experimental hemorrhoids in rats. ( Li, G; Li, W; Piao, S; Yan, M; Yu, Q; Zhang, H; Zhang, X; Zhao, Y, 2024) |
| " In Hemorrhoids like rats, acetic acid induced inflammation was inhibited in a dose-dependent manner during SHO treatment." | 4.84 | The beneficial effect of Sanhuang ointment and its active constituents on experimental hemorrhoids in rats. ( Li, G; Li, W; Piao, S; Yan, M; Yu, Q; Zhang, H; Zhang, X; Zhao, Y, 2024) |
| " Losartan (Los) is known to reduce pain; however, its function in IBS is unclear." | 4.31 | Losartan attenuates acetic acid enema-induced visceral hypersensitivity by inhibiting the ACE1/Ang II/AT1 receptor axis in enteric glial cells. ( Chen, Y; Dai, F; Li, J; Li, L; Liu, X; Mei, L; Meng, R; Quan, X; Shi, H; Sun, Y; Wang, J; Wang, L; Wang, T; Zhang, Y, 2023) |
| " Here, we investigated gene modulation in the trigeminal ganglion and intraoral pain-related behavior in a rat model of acetic acid-induced oral ulcerative mucositis." | 4.31 | Hepcidin expression in the trigeminal ganglion and the oral mucosa in an oral ulcerative mucositis rat model. ( Hitomi, S; Kokabu, S; Nakatomi, C; Nodai, T; Omiya, Y; Ono, K; Sago-Ito, M; Shikayama, T; Shinoda, M; Terawaki, K, 2023) |
| " Anti-inflammatory activity was determined by the carrageenan-induced and histamine-induce Rat paw edema in rats, analgesic activity was determined by acetic acid-Induced writhing test, formalin-induced hind paw licking in mice and Tail immersion test." | 4.12 | Evaluation of anti-inflammatory and analgesic effects of Hertia intermedia (Boiss.) Kuntze extract. ( Arslan, M; Iqbal, J; Jabbar, A; Jan, SU; Khan, Z; Mehjabeen, -; Muhammad, S; Qadir, A; Shah, PA; Soomer Khan, N; Younis, M, 2022) |
| " AiME showed significant dose-dependent analgesic activity against acetic acid-induced writhing, formalin-induced paw licking, and hot plate pain model." | 4.02 | Pharmacological investigation of analgesic and antipyretic activities of methanol extract of the whole part of Aeginetia indica. ( Abeer, M; Ahmed, J; Barek, MA; Haque, ME; Jafrin, S; Jashimuddin, M; Naznin, NE; Reza, MS; Ud Daula, AFMS, 2021) |
| " To evaluate the analgesic effects of AC, 4 different pain models including hot plate assay, acetic acid writhing assay, formalin and CFA induced pain models were adopted in this study." | 4.02 | Comparison of analgesic activities of aconitine in different mice pain models. ( Chen, J; Deng, J; Feng, Q; Han, J; Huang, Q; Leung, EL; Liu, Z; Lu, L; Qi, X; Wang, D; Wang, Y; Zhang, Y, 2021) |
| " The acetylcholinesterase inhibitor (ACHEI); neostigmine, is known clinically for its analgesic effect in the perioperative phases proving high efficacy; besides possessing anti-inflammatory properties controlling immune cells and cytokine level." | 4.02 | The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation. ( Abdel-Bary, A; El-Tahan, RA; Gowayed, MA, 2021) |
| " AMWD was subjected to activity testing, using chemical-induced (acetic acid and formalin test) and heat-induced (hot plate) pain models." | 4.02 | Allium macrostemon Bunge. exerts analgesic activity by inhibiting NaV1.7 channel. ( Dai, Y; Fu, W; Han, C; Ji, Z; Xu, Y; Yang, X; Zhang, X, 2021) |
| " The compound was tested on acute models of pain such as acetic acid-induced abdominal writhing, formalin-induced nociception and carrageenan-induced mechanical hyperalgesia." | 3.96 | Investigation of anti-inflammatory potential of 5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione compound. ( Almeida, DS; Costa, EA; da Silva, DPB; Florentino, IF; Ghedini, PC; Lião, LM; Menegatti, R; Moreira, LKDS; Sanz, G; Vaz, BG, 2020) |
| " Acetic acid-induced abdominal writhing and CFA-induced mechanical hyperalgesia were performed to evaluate the antinociceptive activity, and the anti-oedematogenic activity was studied by CFA-induced paw oedema and croton oil-induced ear oedema." | 3.96 | Anti-inflammatory and antinociceptive activity profile of a new lead compound - LQFM219. ( Cardoso, CS; Costa, EA; da Silva, ACG; da Silva, DPB; de S Gil, E; Florentino, IF; Galvão, GM; Leite, JA; Lião, LM; Menegatti, R; Sabino, JR; Sanz, G; Silva, ALP; Valadares, MC; Vaz, BG, 2020) |
| " The plant extract at doses of 50, 100 and 150 mg/kg was tested for anti-inflammatory activity against carrageenan and egg albumin induced paw edema in mice and analgesic activity was appraised against acetic acid induced writhing and formalin induced paw licking in mice models." | 3.96 | Evaluation of anti-inflammatory and analgesic activities of aqueous methanolic extract of Ranunculus muricatus in albino mice. ( Alamgeer, -; Asif, H; Hasan, UH; Irfan, HM; Nasreen, P; Sharif, A; Uttra, AM; Younis, W, 2020) |
| " Enhanced analgesic and anti-inflammatory activity was observed with S-SMEDD formulations in acetic acid-induced writhings and carrageenan-induced paw edema models, respectively." | 3.91 | Mefenamic acid-loaded solid SMEDDS: an innovative aspect for dose reduction and improved pharmacodynamic profile. ( Bedi, N; Kumar, M; Singh, D, 2019) |
| " The anti-inflammatory and analgesic activities of the three crystalline forms were evaluated by acetic acid induced writhing in mice, the hot plate method, carrageenan induced mouse paw edema models, Xylene-induced mouse ear edema models and cotton pellet-induced mouse granuloma models." | 3.91 | Anti-inflammatory and analgesic activity based on polymorphism of cedrol in mice. ( Chen, SS; Ding, M; Guan, J; Li, W; Su, GY; Wang, JW; Zhang, YM; Zhao, YQ, 2019) |
| "It is aimed to investigate the possible contribution of cannabinoid system that supresses the nociceptive process by the activation of CB1 and CB2 receptors in central and peripheral levels of pain pathways, to the analgesic activity of protocatechuic acid." | 3.91 | Cannabinoid system involves in the analgesic effect of protocatechuic acid. ( Arslan, R; Bektas, N; Dikmen, DY; Okcay, Y, 2019) |
| " Additionally, Western blotting was performed to investigate intracellular signaling pathways, and the anti-nociceptive activity of three doses of DH (100, 200, and 300mg/kg) against acetic acid-induced writhing responses and its inhibitory effects on xylene-induced ear edema were researched in mice through oral administration." | 3.88 | Inhibitory effects of Dianthi Herba ethanolic extract on inflammatory and nociceptive responses in murine macrophages and mouse models of abdominal writhing and ear edema. ( Cho, WK; Hwang, YH; Jeong, YH; Ma, JY; Oh, YC, 2018) |
| " To assess the usefulness of this model for testing potential analgesics, three known synthetic pain medications were assessed (ibuprofen, acetaminophen and tramadol) along with three naturally occurring products (honokiol, tetrahydrocannabinol and cannabidiol)." | 3.88 | Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception. ( Achenbach, JC; Berrue, F; Ellis, LD; Hill, J; McDougall, JJ; Morash, M, 2018) |
| " Interestingly, the acid-induced trigeminal pain behaviour was inhibited by amiloride, an antagonist of acid-sensing ion channels (ASICs), but not by AMG-9810, an inhibitor of transient receptor potential cation channel V1(TRPV1)." | 3.88 | Increased Asics Expression via the Camkii-CREB Pathway in a Novel Mouse Model of Trigeminal Pain. ( Fu, X; Huang, L; Lu, Z; Wang, X; Wang, Y; Xiao, Z; Zhu, F, 2018) |
| " Antinociceptive activity was detected in acetic acid-induced writhing, tail-immersion, and formalin tests, indicating interference with both non-inflammatory and inflammatory pain." | 3.88 | Saline extract of Pilosocereus gounellei stem has antinociceptive effect in mice without showing acute toxicity and altering motor coordination. ( da Silva, WAV; de Luna Freire, MO; de Medeiros, PL; de Melo Carvalho, B; de Oliveira, AM; Ferreira, MRA; Napoleão, TH; Paiva, PMG; Soares, LAL, 2018) |
| "Here, we found that intratesticular bradykinin evokes pain behavior via stimulation of bradykinin B2 receptors and that intratesticular acetic acid injection induces intratesticular bradykinin synthesis, consequently leading to pain behavior." | 3.88 | Intratesticular Bradykinin Involvement in Rat Testicular Pain Models. ( Fujimoto, K; Masuda, N; Takeda, M; Yoshino, T; Yoshioka, K; Yuyama, H, 2018) |
| "To clarify the role of bradykinin in urogenital pain, we investigated bradykinin involvement in rat models of testicular pain." | 3.88 | Intratesticular Bradykinin Involvement in Rat Testicular Pain Models. ( Fujimoto, K; Masuda, N; Takeda, M; Yoshino, T; Yoshioka, K; Yuyama, H, 2018) |
| "An injection of bradykinin into the testes of conscious rats induced pain behaviors that were dose-proportionally reduced by prior administration of FK3657." | 3.88 | Intratesticular Bradykinin Involvement in Rat Testicular Pain Models. ( Fujimoto, K; Masuda, N; Takeda, M; Yoshino, T; Yoshioka, K; Yuyama, H, 2018) |
| "Overt pain-like behaviors were determined by the number of abdominal writhings induced by phenyl-p-benzoquinone and acetic acid." | 3.85 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| "Probucol reduced overt pain-like behavior, and carrageenan-induced mechanical and thermal hyperalgesia." | 3.85 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| "The extract was assessed for antinociceptive activity using chemical and heat induced pain models such as hot plate, tail immersion, acetic acid-induced writhing, formalin, glutamate, and cinnamaldehyde test models in mice at the doses of 100, 200, and 400 mg/kg (p." | 3.85 | Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice. ( Khan, MF; Khatun, A; Mannan, MA, 2017) |
| "The probable mechanisms of action of kolaviron were assessed by using naloxone, prazosin, and atropine to investigate the involvement of adrenergic, opioidergic, and cholinergic systems, respectively, using tail flick, the acetic acid-induced writhing, formalin-induced paw licking, and carrageenan-induced paw edema models." | 3.83 | Antinociceptive and anti-inflammatory potentials of kolaviron: mechanisms of action. ( Onasanwo, SA; Rotu, RA, 2016) |
| "Kolaviron possesses antinociceptive and anti-inflammatory activity, both centrally and peripherally, which justifies its folkloric use to relieve pain and inflammation." | 3.83 | Antinociceptive and anti-inflammatory potentials of kolaviron: mechanisms of action. ( Onasanwo, SA; Rotu, RA, 2016) |
| "The analgesic effects on pain-related behaviors following the topical application of hangeshashinto were evaluated in an oral ulcer rat model treated with acetic acid using recently developed methods." | 3.83 | The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model. ( Hattori, T; Hitomi, S; Imai, R; Inenaga, K; Kase, Y; Kubota, K; Omiya, Y; Ono, K; Terawaki, K; Yamaguchi, K, 2016) |
| " The analgesic, anti-inflammatory and anti-platelet activities were assessed using acetic acid and formalin-induced nociception in mice, carrageenan-induced rat paw edema and arachidonic acid-induced platelets aggregation tests." | 3.83 | Analgesic, anti-inflammatory and anti-platelet activities of Buddleja crispa. ( Bukhari, IA; Gilani, AH; Meo, SA; Saeed, A, 2016) |
| " In addition to inhibiting paw edema and leukocyte recruitment (particularly of polymorphonuclear cells) into the peritoneal cavity of mice, MECu reduced the number of abdominal writhings induced by acetic acid and the duration of formalin-induced paw licking." | 3.83 | Anti-inflammatory and antinociceptive activities of Croton urucurana Baillon bark. ( Cordeiro, KW; de Cássia Freitas, K; de Oliveira Figueiredo, P; do Prado, PR; Felipe, JL; Garcez, FR; Garcez, WS; Malange, KF; Toffoli-Kadri, MC, 2016) |
| "This study aimed to investigate the involvement of opioid receptors in the systemic and peripheral antinociceptive activities of montelukast in different animal models of pain." | 3.83 | Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of montelukast in the animal models of pain. ( Alboghobeish, S; Ghorbanzadeh, B; Mansouri, MT; Sahraei, H, 2016) |
| "The EMN and allantoin antinociceptive activity were evaluated in mice using both chemical and heat-induced pain models such as acetic acid-induced writhing, formalin and tail-flick tests." | 3.83 | Antinociceptive and anti-inflammatory effects of Memora nodosa and allantoin in mice. ( Costa, EA; de Paula, JR; Florentino, IF; Galdino, PM; Lino, RC; Martins, JLR; Silva, DM; Silva, DPB; Tresvenzol, LMF, 2016) |
| "The combination of pomegranate seed oil and ketoprofen in nanoemulsions aiming to improve the antinociceptive effect was evaluated according to the writhing test and Complete Freud's Adjuvant induced paw inflammation in mice." | 3.83 | Pomegranate seed oil nanoemulsions improve the photostability and in vivo antinociceptive effect of a non-steroidal anti-inflammatory drug. ( Barbieri, AV; Beck, RCR; Cervi, VF; Cruz, L; Ferreira, LM; Gehrcke, M; Nogueira, CW; Sari, MHM; Zborowski, VA, 2016) |
| " AEPM and MEPM antinociceptive effects were evaluated at the doses of 35, 75, 150 and 300mg/kg given orally, against pain induced by acetic acid, formalin, hot plate, capsaicin and glutamate." | 3.83 | Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice. ( Awouafack, MD; Kamanyi, A; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD; Wandji, BA, 2016) |
| " Oral administration of both extracts significantly reduced pain symptoms induced by acetic acid, formalin, capsaicin, glutamate and hot plate." | 3.83 | Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice. ( Awouafack, MD; Kamanyi, A; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD; Wandji, BA, 2016) |
| " In vivo animal models of phorbol 12-myristate 13-acetate (TPA)-induced ear edema and acetic acid-induced writhing response tests were used to analyze the in vivo anti-inflammatory effects and anti-nociceptive effects of DP extract, respectively." | 3.83 | Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of Dendropanax morbifera Mediated by the Nrf2/HO-1 Pathway. ( Akram, M; Bae, ON; Kim, CY; Kim, ES; Kim, KA; Lee, JS; Syed, AS, 2016) |
| "76% and 84% pain relief in acetic acid induced writhing test at 100 mg/kg i." | 3.83 | Antinociceptive, antioxidant and phytochemical studies of Pakistani medicinal plants. ( Khan, H; Rauf, A; Siddiqui, BS; Uddin, G; Ullah, R, 2016) |
| " The hot plate test and acetic acid-induced writhing assay in Kunming mice were adopted to evaluate the pain-relieving effects of BLG." | 3.83 | Anti-inflammatory and analgesic effects of Bi-yuan-ling granules. ( Chen, XB; Dai, K; He, F; Liu, HX; Ren, YS; Su, HW; Xiang, MX; Yin, X, 2016) |
| " At same doses, SP-Ul was tested on Wistar rats on paw edema elicited by different irritants (carrageenan, dextran, bradykinin, histamine or serotonin)." | 3.83 | Analgesic and anti-inflammatory actions on bradykinin route of a polysulfated fraction from alga Ulva lactuca. ( Benevides, NM; Bezerra, MM; Chaves, HV; de Araújo, IW; de Sousa Oliveira Vanderlei, E; Maciel, GF; Pereira, KM; Quinderé, AL; Ribeiro, KA; Ribeiro, NA; Rodrigues, JA; Silva, JF, 2016) |
| " Materials and methods Analgesic and anti-inflammatory activities of ISA were evaluated using writhing, hot plate, xylene-induced ear oedema, carrageenan-induced paw oedema and cotton pellets-induced granuloma test, meanwhile the prostaglandin E2 (PGE2) and malondialdehyde (MDA) levels were assessed in the oedema paw tissue." | 3.83 | Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid. ( Dong, K; Sun, JY; Xing, JF; You, CY; You, HS, 2016) |
| " Analgesic activity using acetic acid induced writhing and formalin test in mice, anti-inflammatory activity using carrageenan induced paw oedema and acetic acid-induced vascular permeability in mice, and antipyretic activity using Brewer's yeast induced pyrexia in rats were evaluated at 100mg/kg, 200mg/kg, and 400mg/kg doses of the extract." | 3.83 | Anti-oxidant, anti-inflammatory, analgesic and antipyretic activities of grapevine leaf extract (Vitis vinifera) in mice and identification of its active constituents by LC-MS/MS analyses. ( Aouey, B; Bouaziz, M; Fetoui, H; Samet, AM; Simmonds, MSJ, 2016) |
| "6% acetic acid, indicating that fraction has an antinociceptive effect on the visceral inflammatory pain model." | 3.81 | Structure of an arabinogalactan from the edible tropical fruit tamarillo (Solanum betaceum) and its antinociceptive activity. ( Baggio, CH; Cordeiro, LM; Corso, CR; do Nascimento, GE; Iacomini, M; Werner, MF, 2015) |
| "The antinociceptive activity of EEHC was evaluated in mice using both chemical- and heat-induced pain models such as acetic acid-induced writhing, hot plate, tail immersion, formalin, and glutamate tests at 50, 100, and 200mg/kg doses." | 3.81 | Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice. ( Ferdous, A; Irin, S; Moniruzzaman, M, 2015) |
| " Then, the pharmacological activities of FJHQT extract with respect to clinical use was investigated with acetic acid-induced writhing response, formalin-induced licking response and carrageenan-induced paw edema." | 3.81 | Anti-nociceptive, anti-inflammatory and toxicological evaluation of Fang-Ji-Huang-Qi-Tang in rodents. ( Chang, CW; Lin, YC; Wu, CR, 2015) |
| " The antinociceptive activity of BHE was assessed in mice using chemically and heat-induced pain models, such as the acetic acid-induced writhing, hot plate, tail-flick and glutamate tests." | 3.81 | Phytochemical composition and antinociceptive activity of Bauhinia glauca subsp. hupehana in rats. ( Wei, L; Xu, J; Xu, R; Yang, Y; Yu, N; Zhao, Q; Zhao, Y, 2015) |
| " analgesic and anti-inflammatory activities were assessed in mice using acetic acid induced writhing, formalin induced paw edema, xylene induced ear edema assays." | 3.81 | Exploring new pharmacology and toxicological screening and safety evaluation of one widely used formulation of Nidrakar Bati from South Asia region. ( Akter, J; Akter, L; Al Mamun, A; Alam, ME; Habib, MA; Jalil, MA; Khan, MS; Syeed, SH; Zaman, A, 2015) |
| "01) of the acetic acid-induced writhing in mice and suppressed xylene induced ear edema and formalin-induced licking response of animals in both phases of the test." | 3.81 | Exploring new pharmacology and toxicological screening and safety evaluation of one widely used formulation of Nidrakar Bati from South Asia region. ( Akter, J; Akter, L; Al Mamun, A; Alam, ME; Habib, MA; Jalil, MA; Khan, MS; Syeed, SH; Zaman, A, 2015) |
| "This study showed that TS has anti-visceral pain properties comparable with those of rofecoxib (a cyclooxygenase-2 inhibitor) and diclofenac, which suggests promise for the treatment of intractable visceral pain in humans." | 3.81 | Toona sinensis leaf extract has antinociceptive effect comparable with non-steroidal anti-inflammatory agents in mouse writhing test. ( Chan, TF; Hsu, HK; Hwang, SL; Lee, KS; Lieu, AS; Lin, CL; Su, YF; Yang, YC, 2015) |
| "Yeast induced pyrexia, Paw edema, acetic acid-induced writhing and hot plate test were carried out in vivo." | 3.81 | Antipyretic, anti-inflammatory and analgesic activity of Acacia hydaspica R. Parker and its phytochemical analysis. ( Afsar, T; Khan, MR; Mirza, B; Razak, S; Ullah, S, 2015) |
| "In this study, we examined the interaction between EA and venlafaxine (VLF) on pain induced by intraperitoneal acetic acid in mice using isobolographic analysis." | 3.81 | Ellagic acid enhances the antinociceptive action of venlafaxine in mouse acetic acid-induced pain: An isobolographic analysis. ( Ghorbanzadeh, B; Mansouri, MT; Naghizadeh, B, 2015) |
| "Antinociceptive and anti-inflammatory activities were investigated by hot plate test, acetic acid-induced abdominal writhing test and formalin test, xylene-induced ear edema test." | 3.81 | Antinociceptive and anti-inflammatory activities of Schefflera octophylla extracts. ( Chen, Y; Shen, Z; Tao, S; Xie, L; Zeng, F, 2015) |
| " And its five different polar fractions especially the CHCl3 fraction significantly inhibited the abdominal writhing induced by acetic acid and ear edema induced by xylene, also increased pain threshold in hot plate test in 120 min and reduced ticking times in formalin test." | 3.81 | Antinociceptive and anti-inflammatory activities of Schefflera octophylla extracts. ( Chen, Y; Shen, Z; Tao, S; Xie, L; Zeng, F, 2015) |
| " We found that EMP reduced xylene-induced ear edema and relieved both acetic acid-induced pain and pain in the hot plate test." | 3.81 | Antiinflammatory and Analgesic Activities of Ethanol Extract and Isolated Compounds from Millettia pulchra. ( Cao, L; Gao, L; Guo, Y; Huo, X; Li, L; Si, J; Zhang, L, 2015) |
| " The biological activities of the HERP (3, 10, and 30mg/kg) and formononetin (10mg/kg) were evaluated using the antinociceptive (acetic acid, formalin, and glutamate injections) and anti-inflammatory (carrageenan-induced hindpaw oedema and peritonitis) models in mice after oral administration." | 3.81 | Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents. ( Belo Neto, R; Berretta E Silva, AA; Cordeiro Cardoso, J; de Souza Santos, J; Divino de Araujo, E; Lima Cavendish, R; Maria Thomazzi, S; Oliveira Paixão, A; Valéria Oliveira, J; Zanardo Gomes, M, 2015) |
| " The intragastric administration of MECb (100-300 mg/kg) significantly inhibited the nociception caused by acetic acid (48 ± 2%), inflammatory phase (49 ± 3%) and paw edema (32 ± 6) caused by formalin, and MECb (100mg/kg, i." | 3.81 | Pharmacological evidence favouring the traditional use of the root bark of Condalia buxifolia Reissek in the relief of pain and inflammation in mice. ( Coelho, IS; Junqueira, SC; Maldaner, G; Morel, AF; Pizzolatti, MG; Ruani, AP; Santos, AR; Simões, RR; Venzke, D; Zanchet, EM, 2015) |
| " Intraperitoneal injection with EOCO (5 or 10mg/kg), aspirin (positive control, 300mg/kg), or DMSO (negative control) was performed 1h before the nociception tests: acetic acid-induced writhing response, formalin test, and hot plate test in mice, and acidic saline-induced allodynia in rats." | 3.81 | Antinociceptive and anti-inflammatory effects of essential oil extracted from Chamaecyparis obtusa in mice. ( Cho, CS; Jung, SM; Kim, WU; Park, BJ; Park, Y; Woo, JM; Yoo, SA; Yoon, CH, 2015) |
| " In the PGIS KO mice, lipopolysaccharide-primed pain nociception (as assessed by the acetic acid-induced writhing reaction) was also reduced." | 3.81 | Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1. ( Akatsu, M; Hara, S; Ishii, T; Ishikawa, Y; Kamiyama, A; Kamiyama, S; Kuwata, H; Matsumoto, K; Nakatani, Y; Sasaki, Y; Yokoyama, C, 2015) |
| " On the other hand, unlike mPGES-1 deficiency (which suppressed azoxymethane-induced colon carcinogenesis), PGIS deficiency up-regulated both aberrant crypt foci formation at the early stage of carcinogenesis and polyp formation at the late stage." | 3.81 | Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1. ( Akatsu, M; Hara, S; Ishii, T; Ishikawa, Y; Kamiyama, A; Kamiyama, S; Kuwata, H; Matsumoto, K; Nakatani, Y; Sasaki, Y; Yokoyama, C, 2015) |
| " Oral treatment of HE, K-3-R and K-3-G at all doses significantly reduced both the nociceptive response and cinnamaldehyde-induced paw edema, effect that was superior to aspirin." | 3.80 | Antinociceptive and anti-inflammatory activities of extract and two isolated flavonoids of Carthamus tinctorius L. ( Chen, P; Li, Y; Tang, C; Wang, Y; Zhang, H, 2014) |
| " & Naudin (Ss-EtOH) in the experimental models of edema induced by carrageenan, dextran, or histamin and nociception induced by chemical stimuli, such as acetic acid, formalin, capsaicin, or glutamate." | 3.80 | Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents. ( Almeida, FR; Amaral, MP; Chaves, MH; Costa, DA; Figueiredo, KA; Júnior, FB; Oliveira, FA; Oliveira, IS; Oliveira, RC; Silva, FV, 2014) |
| " Acetic acid-induced writhing, paw licking induced by formalin, hot plate, and carrageenan-induced paw edema tests were used to investigate the anti-inflammatory and antinociceptive activities of the xanthone compound." | 3.80 | Analgesic and anti-inflammatory activities of the 2,8-dihydroxy-1,6-dimethoxyxanthone from Haploclathra paniculata (Mart) Benth (Guttiferae). ( Dias Silva, MJ; Dias, DF; Doriguetto, AC; dos Santos, MH; Giusti-Paiva, A; Gontijo, VS; Moreira, ME; Nagem, TJ; Pereira, RG; Veloso, MP, 2014) |
| " The bioactivity of this compound was assessed using carrageenan-induced paw oedema in rats and carrageenan-induced pulmonary oedema in mice for the anti-inflammatory activity, while acetic acid-induced writhing test in mice and zymosan-induced fever in rats were used for analgesic test." | 3.80 | Studies on the anti-inflammatory, analgesic and antipyrexic activities of betulinic acid derived from Tetracera potatoria. ( Oridupa, OA; Oyebanji, BO; Saba, AB, 2014) |
| "The antinociceptive activity of the extract (at the doses of 50, 100, and 200 mg/kg) was evaluated by using chemical- and heat-induced pain models such as acetic acid-induced writhing, hot plate, tail immersion, formalin, and glutamate test." | 3.80 | Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica. ( Imam, MZ; Moniruzzaman, M, 2014) |
| " Analgesic (non-narcotic) activity was determined by observed decreases in abdominal writhings in intraperitoneally administered acetic acid-induced pain model in mice." | 3.80 | A preliminary evaluation of antihyperglycemic and analgesic activity of Alternanthera sessilis aerial parts. ( Faisal, M; Hossain, AI; Jahan, R; Rahman, S; Rahmatullah, M, 2014) |
| " In the writhing test, pain responses were scored every 5 min during a 30-min period after intraperitoneal injection of diluted acetic acid." | 3.80 | Synergic effects of pregabalin-acetaminophen combination in somatic and visceral nociceptive reactivity. ( Lupusoru, CE; Lupusoru, RV; Mititelu Tartau, L; Ochiuz, L; Popa, EG; Stoleriu, I, 2014) |
| " Compound 1 inhibited carrageenan-induced paw edema and acetic acid-induced abdominal writhing, which are its only known anti-inflammatory activities." | 3.80 | Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. ( Ambrosio, SR; Arakawa, NS; Carvalho, TT; Casagrande, R; de Souza, AR; Ferraz, CR; Hayashida, TH; Hohmann, MS; Mizokami, SS; Possebon, MI; Staurengo-Ferrari, L; Verri, WA; Zarpelon, AC, 2014) |
| "Intra-gastric administration of AGB (75, 150, and 300 mg/kg) showed a dose-dependent antinociceptive effect in intraperitoneal acetic acid (writhing), thermal nociception in CD1 mice, and subplantar formalin models, as well as anti-inflammatory effect in carrageenan- induced paw edema in Wistar rats." | 3.80 | Antinociceptive and anti-inflammatory activities of Geranium bellum and its isolated compounds. ( Altamirano-Báez, DA; Ángeles, LJ; Bautista-Ávila, M; Cariño-Cortés, R; De la O Arciniega, M; Gayosso de Lucio, JA; Ortiz, MI; Velázquez-González, C, 2014) |
| " bellum (AGB) extract and the isolated compounds were assessed using experimental pain models, including thermal nociception like hot plate test, and chemical nociception induced by intraperitoneal acetic acid or subplantar formalin injection in vivo." | 3.80 | Antinociceptive and anti-inflammatory activities of Geranium bellum and its isolated compounds. ( Altamirano-Báez, DA; Ángeles, LJ; Bautista-Ávila, M; Cariño-Cortés, R; De la O Arciniega, M; Gayosso de Lucio, JA; Ortiz, MI; Velázquez-González, C, 2014) |
| " Further, an acetic acid-induced writhing test and tail immersion test were employed to screen for analgesic effects, yeast-induced pyrexia was used to test for antipyretic effects, and gastric ulceration was used to evaluate ulcerogenic effects." | 3.79 | Dietary component p-coumaric acid suppresses monosodium urate crystal-induced inflammation in rats. ( Pragasam, SJ; Rasool, M, 2013) |
| "In the present study, we have investigated the anti-nociceptive and anti-allodynic activity of the renin inhibitor, aliskiren, in various pain models." | 3.79 | Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models. ( Deshpande, SS; Jain, MR; Patel, RB; Pawar, VD; Prajapati, KD; Shah, GB; Sonara, BM, 2013) |
| " Opioid coadministration had a synergistic effect in the acute tonic pain (acetic acid writhing test), acute phasic pain (tail flick test) and inflammatory pain (orofacial formalin test)." | 3.79 | Systemic synergism between codeine and morphine in three pain models in mice. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Zepeda, RJ, 2013) |
| "001), given orally, produced dose dependent inhibition of acetic acid-induced visceral pain." | 3.79 | Evaluation of mechanisms involved in the antinociception of the ethanol extract from the inner bark of Caesalpinia pyramidalis in mice. ( Santana, DG; Santos, CA; Santos, DS; Thomazzi, SM, 2013) |
| "Collectively, the present results suggest that the ethanol extract of Caesalpinia pyramidalis produced dose-related antinociception in several models of pain through mechanisms that involved both glutamatergic system and/or the l-arginine-nitric oxide pathway, supporting the folkloric usage of the plant to treat various painful processes." | 3.79 | Evaluation of mechanisms involved in the antinociception of the ethanol extract from the inner bark of Caesalpinia pyramidalis in mice. ( Santana, DG; Santos, CA; Santos, DS; Thomazzi, SM, 2013) |
| " The antinociceptive study of DV was performed using models of acetic acid-induced writhing and formalin-induced pain in mice." | 3.79 | Bioassay-guided evaluation of Dioscorea villosa - an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach. ( Araújo, AA; Barreto, RS; de Albuquerque, RL; de Almeida, EB; Lima, AK; Lima, CM; Melo, MG; Moraes, VR; Nogueira, PC; Oliveira, DL; Oliveira, ER; Quintans-Júnior, LJ; Serafini, MR, 2013) |
| " The anti-inflammatory and anti-nociceptive activities of 40% ethanolic extracts of the three plants were compared using the models of xylene-induced ear edema, formalin-induced inflammation, carrageenan-induced air pouch inflammation, acetic acid-induced writhing and formalin-induced nociception." | 3.79 | Comparison of active constituents, acute toxicity, anti-nociceptive and anti-inflammatory activities of Porana sinensis Hemsl., Erycibe obtusifolia Benth. and Erycibe schmidtii Craib. ( Chen, Z; Liao, L; Wang, Z; Wu, L; Zhang, Z, 2013) |
| "Three mice experimental models: acetic acid-induced writhing response test, hot-plate latent pain response test and pentobarbital-induced sleep model were used to evaluate DCXFEE activity." | 3.79 | Analgesic activity of DaChuanXiongFang after intranasal administration and its potential active components in vivo. ( Duan, JA; Guo, J; Pan, W; Qian, D; Shang, E; Tang, Y, 2013) |
| " The analgesic and anticonvulsant effects of piperine were studied in mice using acetic acid-induced writhing, tail flick assay, pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures models." | 3.79 | The analgesic and anticonvulsant effects of piperine in mice. ( Alhumayyd, MS; Bukhari, IA; Gilani, AH; Mahesar, AL; Pivac, N, 2013) |
| "This study was carried out to investigate the effect of amentoflavone isolated from methanolic root extract of CF on lipopolysaccharide (LPS)-induced neuroinflammatory cascade of events associated to the oxidative and nitrative stress, and TNF-α production in rat astrocytoma cell line (C6) and human monocytic leukemia cell line (THP-1), respectively." | 3.79 | Evaluation of amentoflavone isolated from Cnestis ferruginea Vahl ex DC (Connaraceae) on production of inflammatory mediators in LPS stimulated rat astrocytoma cell line (C6) and THP-1 cells. ( Adeyemi, OO; Chaturvedi, JP; Ishola, IO; Narender, T; Rai, S; Rajasekar, N; Shukla, R, 2013) |
| "Rat astrocytoma cells (C6) were stimulated with LPS (10μg/ml) alone and in the presence of different concentrations of amentoflavone (0." | 3.79 | Evaluation of amentoflavone isolated from Cnestis ferruginea Vahl ex DC (Connaraceae) on production of inflammatory mediators in LPS stimulated rat astrocytoma cell line (C6) and THP-1 cells. ( Adeyemi, OO; Chaturvedi, JP; Ishola, IO; Narender, T; Rai, S; Rajasekar, N; Shukla, R, 2013) |
| " The anti-inflammatory activity was investigated using carragenin, egg-albumin induced oedema models, while acetic acid, formalin-induced paw licking and thermal-induced pain models were used to evaluate the antinociceptive property." | 3.78 | Anti-inflammatory and analgesic activities of Melanthera scandens. ( Amazu, LU; Frank, SG; Okokon, JE; Udoh, AE, 2012) |
| " In carrageenan-induced rat paw oedema test, compound 2c and 2f exhibited good anti-inflammatory effect at 3rd h, whereas compounds 2c, 2e, 2d, 2g and 2h showed activity in croton oil induced ear oedema assay in mice." | 3.78 | Fluorine bearing sydnones with styryl ketone group: synthesis and their possible analgesic and anti-inflammatory activities. ( Deshpande, SR; Pai, KV, 2012) |
| " All the compounds were assessed for analgesic and antiinflammatory activities using an acetic acid-induced writhing model, a hot-plate test, a carrageenan-induced paw oedema model, a cotton-pellet oedema model and in vitro lipoxygenase inhibitory assay." | 3.78 | Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc. ( Adhikari, A; Gul, F; Kaleem, WA; Khan, A; Khan, I; Khan, IA; Khan, N; Nisar, M; Qayum, M; Shah, MR; Zia-Ul-Haq, M, 2012) |
| "Anti-inflammatory activity was determined by using carrageenan induced-edema of mice paw and croton oil-induced edema of mice ear; analgesic effect was evaluated using acetic acid-induced writhing." | 3.78 | Pharmacological properties and related constituents of stem bark of Pterocarpus erinaceus Poir. (Fabaceae). ( André, T; Christine, B; Emmanuelle, HA; Jean, K; Marie-Geneviève, D; Marius, L; Noufou, O; Pierre, GI; Wamtinga, SR, 2012) |
| "Both methanol and dichloromethane extracts, friedelin, lupeol and epicatechin showed a significant anti-inflammatory effect using croton oil induced-ear edema." | 3.78 | Pharmacological properties and related constituents of stem bark of Pterocarpus erinaceus Poir. (Fabaceae). ( André, T; Christine, B; Emmanuelle, HA; Jean, K; Marie-Geneviève, D; Marius, L; Noufou, O; Pierre, GI; Wamtinga, SR, 2012) |
| " CETD was evaluated for anti-inflammatory activity in experimental acute (carrageenan-, histamine- and serotonin-induced paw oedema) and chronic models (cotton pellet-induced granuloma) in Wistar albino rats." | 3.78 | Protective role of the triterpenoid-enriched extract of Trichosanthes dioica root against experimentally induced pain and inflammation in rodents. ( Bhattacharya, S; Haldar, PK, 2012) |
| "The anti-oedemogenic activity of the hydroalcoholic extract of the roots of Byttneria herbacea (HBH) was evaluated against carrageenan and histamine induced rat paw oedema, acetic acid induced writhing and histamine induced vascular permeability in mice." | 3.78 | A report on anti-oedemogenic activity of Byttneria herbacea roots--possible involvement of histamine receptor (type I). ( Bhuvaneswari, N; Fukui, H; Islam, MN; Karmakar, S; Mizuguchi, H; Samanta, SK; Sarkar, L; Sen, T, 2012) |
| "05) against carrageenan and histamine induced rat paw oedema." | 3.78 | A report on anti-oedemogenic activity of Byttneria herbacea roots--possible involvement of histamine receptor (type I). ( Bhuvaneswari, N; Fukui, H; Islam, MN; Karmakar, S; Mizuguchi, H; Samanta, SK; Sarkar, L; Sen, T, 2012) |
| "The results suggest that the methanolic extract of Cyathula prostrata possesses anti-inflammatory and analgesic activities and this authenticates the use of the plant in the traditional treatment of ailments associated with inflammation and pain." | 3.78 | Antiinflammatory, analgesic and antioxidant activities of Cyathula prostrata (Linn.) Blume (Amaranthaceae). ( Ibrahim, B; Sowemimo, A; Van de Venter, M; van Rooyen, A, 2012) |
| " Carrageenan induced paw edema model was used for anti-inflammatory and acetic acid induced model used for analgesic activity." | 3.78 | Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum. ( Afzal, M; Afzal, O; Alam, J; Anwar, F; Gupta, G; Gupta, R; Hakeem, KR; Kazmi, I; Pravez, M; Rahman, M, 2012) |
| " Here we use the writhing assay, a model of visceral pain, to investigate the analgesic effects of NT69L (binds NTS1 and NTS2 equally), NT79 (NTS2-selective), NT72 (NTS1 selective) and levocabastine (NTS2-selective) in WT, NTS1 knock-out, and NTS2 knock-out mice." | 3.78 | NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain. ( Boules, M; Richelson, E; Smith, KE; Williams, K, 2012) |
| " Nevertheless, the anti-inflammatory activity was tested in carrageenan induced paw edema and histamine induced inflammatory tests." | 3.78 | Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. ( Khan, H; Muhammad, N; Saeed, M, 2012) |
| " Similarly carrageenan and histamine induces inflammation was significantly antagonized by VBME, 66." | 3.78 | Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. ( Khan, H; Muhammad, N; Saeed, M, 2012) |
| " Analgesic activity was evaluated using the acetic acid-induced writhing and hot plate tests in mice while carrageenan induced paw oedema test was used to investigate the anti-inflammatory actions of the fractions obtained." | 3.78 | Bioactivity guided isolation of analgesic and anti-inflammatory constituents of Cnestis ferruginea Vahl ex DC (Connaraceae) root. ( Adeyemi, OO; Agbaje, OE; Ishola, IO; Narender, T; Shukla, R, 2012) |
| "05) dose dependent inhibition of pain response elicited by acetic acid and increased nociceptive reaction latency in hot plate test." | 3.78 | Bioactivity guided isolation of analgesic and anti-inflammatory constituents of Cnestis ferruginea Vahl ex DC (Connaraceae) root. ( Adeyemi, OO; Agbaje, OE; Ishola, IO; Narender, T; Shukla, R, 2012) |
| "The extract was evaluated for antinociceptive activity using chemical- and heat-induced pain models such as acetic acid-induced writhing, hot plate, tail immersion and formalin test." | 3.78 | Antinociceptive activity of methanol extract of flowers of Impatiens balsamina. ( Akter, S; Imam, MZ; Nahar, N; Rana, MS, 2012) |
| " EO(MeOH) was evaluated for its analgesic activity in acetic acid-induced writhing response and formalin test, and anti-inflammatory effect was examined by λ-carrageenan-induced paw edema assay." | 3.78 | Analgesic and anti-inflammatory activities of the methanol extract of Elaeagnus oldhamii Maxim. in mice. ( Chang, YS; Ho, YL; Lai, SC; Liao, CR; Peng, WH, 2012) |
| "Sixteen recipes induced SD rats sweating, remitted spasm of guinea pig trachea smooth muscle, and relieved ICR mouse pain due to acetic acid in comparison with animal model group or normal control groups." | 3.78 | Quantitatively analyze composition principle of Ma Huang Tang by structural equation modeling. ( Gai, Y; He, Y; Wan, H; Wu, X, 2012) |
| "In northeastern Brazil, Dinoponera (Ponerinae) ants macerate are used to treat ear ache and its sting, rheumatism, and back pain." | 3.78 | Venom's antinociceptive property in the primitive ant Dinoponera quadriceps. ( Assreuy, AM; do Vale, JF; Pereira, MG; Ponte, EL; Quinet, Y; Sousa, PL; Torres, AF, 2012) |
| " The anti-nociceptive activities of MPP were measured using various experimental pain models including thermal nociception methods such as the tail immersion test and the hot plate test as well as chemical nociception methods like acetic acid-induced writhing test and formalin test." | 3.78 | Anti-inflammatory and anti-nociceptive properties of Prunus padus. ( Cha, DS; Choi, JH; Jeon, H, 2012) |
| "The results showed that the ethanolic extract of the Bougainvillea xbuttiana has significant anti-inflammatory and antinociceptive activities, by inhibition of nociception induced by acetic acid and paw oedema." | 3.78 | Anti-inflammatory and antinociceptive activities of the ethanolic extract of Bougainvillea xbuttiana. ( Alvarez Perez Gil, AL; Barbosa Navarro, L; Patipo Vera, M; Petricevich, VL, 2012) |
| " We have investigated the behavioural effects of carvacrol in animal models of pain, such as acetic acid-induced abdominal constriction, formalin and hot-plate tests in mice." | 3.78 | Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice. ( Cavalcante Melo, FH; Citó, Mdo C; de Sousa, DP; de Sousa, FC; de Vasconcelos, SM; Fernandes, ML; Rios, ER; Rocha, NF, 2012) |
| "The antinociceptive and antiinflammatory activities of MEA were evaluated using the writhing, formalin, and tail-flick tests, carrageenan-induced paw edema and arachidonic acid-induced ear edema." | 3.77 | Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: evidence for a role of IL-1β inhibition. ( Barros, TA; Lucchese, AM; Nogueira, TM; Nonato, FR; Oliveira, CE; Santos, RR; Soares, MB; Villarreal, CF, 2011) |
| " In addition, MEA (100 and 200mg/kg/IP) inhibited important events related to the inflammatory response induced by carrageenan or arachidonic acid, namely local edema and increase in tissue interleukin-1β levels." | 3.77 | Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: evidence for a role of IL-1β inhibition. ( Barros, TA; Lucchese, AM; Nogueira, TM; Nonato, FR; Oliveira, CE; Santos, RR; Soares, MB; Villarreal, CF, 2011) |
| " Firstly, the anti-inflammatory and analgesic effects of the FEO were studied by xylene-induced ear edema, adjuvant-induced joint inflammation law in rats, acetic acid-induced writhing and hot-plate tests in mice." | 3.77 | The studies of anti-inflammatory and analgesic activities and pharmacokinetics of Oxytropis falcate Bunge extraction after transdermal administration in rats. ( Cai, BC; Chen, HX; Chen, J; Chen, ZP; Liu, D; Lu, TL; Qu, MM; Xiao, YY, 2011) |
| " While the analgesic activity was examined against thermally and chemically induced nociceptive pain in mice, using the acetic acid and hot-plate test methods." | 3.77 | Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha. ( Duan, JA; Hua, YQ; Qian, DW; Su, S; Tang, YP; Wang, T; Yu, L; Zhou, W, 2011) |
| " The antinociceptive effects of LEJ were assessed using experimental models of pain, including thermal nociception methods, such as the tail immersion test and the hotplate test, and chemical nociception induced by intraperitoneal acetic acid and subplantar formalin in mice." | 3.77 | Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica. ( Cha, DS; Eun, JS; Jeon, H, 2011) |
| " Moreover, LEJ also demonstrated strong and dose-dependent antinociceptive activity compared to tramadol and indomethacin in various experimental pain models." | 3.77 | Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica. ( Cha, DS; Eun, JS; Jeon, H, 2011) |
| "To evaluate the antinociceptive effect of Emilia sonchifolia hydroethanolic extract (EsHE) administered by oral route, peripheral (acetic acid-induced abdominal writhing and formalin), spinal (tail flick) and supra-spinal (hot plate) behavioral models of acute pain were used." | 3.77 | Antinociceptive effect of extract of Emilia sonchifolia in mice. ( Couto, VM; Dias, DF; Dos Santos, MH; Giusti-Paiva, A; Nascimento, CG; Soncini, R; Vilela, FC, 2011) |
| " Antinociceptive activity was determined using a model of acetic acid-induced gastric pain in mice and anti-hyperglycemic activity through glucose tolerance test using glucose loaded mice." | 3.77 | Antinociceptive and anti-hyperglycemic activity of methanol leaf extract of Cyperus scariosus. ( Alam, MA; Das, AK; Jahan, R; Rahman, S; Rahmatullah, M, 2011) |
| " (PEtExt) stem bark and its fractions using various animal models such as acetic acid-induced abdominal writhing, formalin-induced pain and croton oil-induced ear edema tests." | 3.77 | Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid. ( Costa, EA; de Paula, JR; Florentino, IF; Galdino, PM; Nascimento, MV; Sampaio, BL; Vanderlinde, FA, 2011) |
| " Several animal models of persistent inflammatory and neuropathic pain (tail-flick test, hot plate test, acetic acid-induced writhing test, formalin-induced paw licking, carrageenan-induced paw edema) were used to test analgesic functions of recombinant anntoxin (r-anntoxin)." | 3.77 | Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin. ( Dong, L; Lai, R; Liu, H; Liu, R; Wei, L; Yang, H; You, D; Zhao, T, 2011) |
| " This study was undertaken to determine the nature of the interaction between codeine and celecoxib or etoricoxib in peritoneal irritation-induced visceral pain in mice." | 3.77 | Codeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice. ( Janovsky, M; Krsiak, M, 2011) |
| "This study investigated the analgesic effects of taraxeren-3-one, which is an ingredient from Diospyros maritima (DM), using the models of acetic acid-induced writhing response and the formalin test, and its anti-inflammatory effects using the model of λ-carrageenan (Carr)-induced paw edema." | 3.77 | Analgesic effects and mechanisms of anti-inflammation of taraxeren-3-one from Diospyros maritima in mice. ( Chang, CI; Chang, TN; Chang, YS; Deng, JS; Huang, GJ; Huang, SS; Kuo, YH; Yang, HL, 2011) |
| " At the doses of 25-100 mg/kg, Ipomoea involucrata exhibited dose-dependent and significant increase in pain threshold in acetic acid -induced writhing test of mice (P<0." | 3.77 | Antinociceptive and anti-inflammatory activities of crude extracts of Ipomoea involucrata leaves in mice and rats. ( Aderonke, SO; Augustina, MA; Ifeyinwa, CN; Ijeoma, UF; Ogbonna, O, 2011) |
| " At 200 mg/kg dose, the inhibition ratio of the extract on carrageenan-induced rat hind paw oedema, dextran-induced rat paw oedema, cotton pellet granuloma in rats, carrageenan-induced peritonitis and acetic acid-induced vascular permeability were 59." | 3.77 | Anti-inflammatory and anti-nociceptive activities of Sipunculus nudus L. extract. ( Cai, QX; Dai, ZR; Zhang, CX, 2011) |
| " Treatment of male ICR mice with ETL significantly inhibited the numbers of acetic acid-induced writhing response and the formalin-induced pain in the late phase." | 3.77 | Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola. ( Chi, CS; Deng, JS; Huang, GJ; Huang, SS; Lin, TH; Shie, PH, 2011) |
| "The antinociceptive effect of MCO was evaluated using several experimental pain models, including thermal nociception methods, such as the tail immersion and the hotplate tests, as well as chemical nociception induced by intraperitoneal acetic acid and subplantar formalin administration in mice." | 3.77 | Antinociceptive and hypnotic properties of Celastrus orbiculatus. ( Cha, DS; Jeon, H; Park, HJ, 2011) |
| "MCO demonstrated strong and dose-dependent antinociceptive activity compared to tramadol and indomethacin in various experimental pain models." | 3.77 | Antinociceptive and hypnotic properties of Celastrus orbiculatus. ( Cha, DS; Jeon, H; Park, HJ, 2011) |
| "Salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their complexes [Zn(LASSBio-466)H(2)O](2) (1) and [Zn(HLASSBio-1064)Cl](2) (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation." | 3.77 | Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their zinc(II) complexes. ( Alexandre-Moreira, MS; Alves, MA; Barreiro, EJ; Beraldo, H; Castellano, EE; Júnior, WB; Lima, LM; Parrilha, GL; Perez-Rebolledo, A; Piro, OE, 2011) |
| "TF-P was evaluated in mice for analgesic activity using acetic acid-induced abdominal contractions test and for anti-inflammatory activity using xylene-induced ear oedema model." | 3.77 | The analgesic and anti-rheumatic effects of Thladiantha dubia fruit crude polysaccharide fraction in mice and rats. ( Di, L; Lin, X; Liu, Y; Wang, L; Xu, T; Yang, B; Yang, X; Zhao, D; Zhou, X, 2011) |
| " The analgesic effect was studied using acetic acid-induced abdominal constriction and hot plate test in mice, while the anti-inflammatory effect was investigated using carrageenan induced paw oedema in rats." | 3.77 | Evaluation of analgesic and anti-inflammatory effects of ethanol extract of Ficus iteophylla leaves in rodents. ( Abdulkadir, MF; Abdullahi, MI; Abdulmalik, IA; Musa, AM; Sule, MI; Yaro, AH; Yusuf, H, 2011) |
| " The anti- oedema effect was compared with indomethacin." | 3.76 | Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum. ( Antonisamy, P; Ignacimuthu, S, 2010) |
| " Immunomodulatory effect was investigated by using ovalbumin- induced active paw anaphylaxis and sheep red blood cells (SRBC)-induced DTH tests." | 3.76 | Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum. ( Antonisamy, P; Ignacimuthu, S, 2010) |
| " Our results showed that the iridoid glycosides extract could decrease acetic-acid-induced writhings times and formalin-induced lickings times, inhibit carrageenan-induced hind paw edema and xylene-induced ear swelling, and suppress peritoneal capillary permeability and leukocyte infiltration also induced by acetic acid in mice." | 3.76 | Antinociceptive and anti-inflammatory activities of iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo. ( Fan, P; Jia, Z; Li, M; Shang, X; Wei, L; Ying, Q; Zhang, R, 2010) |
| "This study examined the analgesic and anti-inflammatory actions of cis-mulberroside A isolated from Ramulus mori in several models of inflammatory pain in mice." | 3.76 | Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori. ( Shi, L; Zhang, Z, 2010) |
| "Oxymatrine-carbenoxolone sodium inclusion compound (OCSIC) has been reported as a novel painkiller, but its effectiveness and mechanism remain unknown." | 3.76 | Oxymatrine-carbenoxolone sodium inclusion compound induces antinociception and increases the expression of GABA(A)alpha1 receptors in mice. ( Jiang, Y; Jin, S; Tao, L; Yang, G; Yu, J; Zhou, J, 2010) |
| "Injection of acetic acid (1% and 3%) induced pain behaviors and bladder overactivity proportional to the concentration." | 3.76 | Behavioral and urological evaluation of a testicular pain model. ( Tanahashi, M; Uchida, W; Yoshioka, K, 2010) |
| "Injection of dilute acetic acid into the testes produces a reproducible testicular pain model involving testicular inflammation and activation of primary afferent C fibers and suggests a neural pathway for interaction between testicular pain and bladder overactivity." | 3.76 | Behavioral and urological evaluation of a testicular pain model. ( Tanahashi, M; Uchida, W; Yoshioka, K, 2010) |
| " Experiments were conducted on Swiss mice using the acetic acid-induced writhing test, the hot plate test, the formalin-induced pain test and zymosan A-induced peritonitis test." | 3.76 | The antinociceptive and anti-inflammatory activities of Piptadenia stipulacea Benth. (Fabaceae). ( Agra, Mde F; Alexandre-Moreira, MS; da Matta, CB; da Silva, DJ; de Aquino, AB; de Araújo-Júnior, JX; de Lira, DP; de Queiroz, AC; de Souza, ET; Dias, Tde L; Filho, JM; Mella, EA; Santos, BV; Silva, LH, 2010) |
| " For the anti-inflammatory activity, the carrageenan-induced hind paw edema and acetic acid-induced increased capillary permeability models were used, whereas for the antinociceptive activity, the p-benzoquinone-induced writhing and hot plate tests in mice were used." | 3.76 | Assessment of anti-inflammatory and antinociceptive activities of Olea europaea L. ( Akkol, EK; Baykal, T; Süntar, IP, 2010) |
| " The newly synthesized compounds were screened for analgesic and anti-inflammatory activities on acetic acid induced writhing in mice and carrageenan induced paw oedema in rats." | 3.76 | In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives. ( Achar, KC; Hosamani, KM; Seetharamareddy, HR, 2010) |
| "The synergistic interaction between paracetamol and oxcarbazepine provides new information about combination pain treatment and should be explored further in patients, especially with somatic and/or visceral pain." | 3.76 | Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents. ( Bosković, B; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2010) |
| " The blueberry extract produced a significant decrease in constrictions induced by acetic acid and caused graded inhibition of the second phase of formalin-induced pain." | 3.76 | Preliminary studies on the antinociceptive activity of Vaccinium ashei berry in experimental animal models. ( Barros, DM; de Castro, MR; de Souza, MM; Dickel, OE; Guterres, L; Henriques, AT; Ramirez, MR, 2010) |
| " Antipyretic (Baker's yeast-induced fever test), analgesic (acetic acid-induced writhing, tail immersion assays), anti-inflammatory (carrageenan-induced paw edema) and in vitro antioxidant (DPPH radical, superoxide radical scavenging) activities of evodione and leptonol were tested." | 3.76 | Antipyretic, analgesic, anti-inflammatory and antioxidant activities of two major chromenes from Melicope lunu-ankenda. ( Baby, S; Chandrasekhar, A; Chandrika, SP; Johnson, AJ; Kumar R, A; Rasheed, SA; Subramoniam, A, 2010) |
| " Using the animal pain models by applying Acetic Acid Writhing Test and Formalin Test, the combination of SF and OMT showed significant analgesic effect in dose-dependent manner." | 3.76 | The analgesic effect and mechanism of the combination of sodium ferulate and oxymatrine. ( Chen, F; Gao, Y; Liu, H; Liu, Z; Sun, Y; Xu, M, 2010) |
| " Synthesized compounds shown significant anti-inflammatory activity comparable to that of Diclofenac sodium in the carrageenan-induced rat paw edema test and all of the compounds were found to be equipotent to Diclofenac sodium in the acetic acid induced writhing analgesic model." | 3.76 | Synthesis and pharmacological evaluation of novel 1-(2-(benzoyl-substituted-2-phenyl-1H-indol-5-carbony) hydrazinyloxy) vinyl nitrate derivatives as potent non-ulcerogenic, analgesic and anti-inflammatory agents. ( Bhandari, SV; Bothara, KG; Burange, PJ; Dhoot, NS; Mokale, VJ; Naik, JB; Raut, MK, 2010) |
| " Intra-peritoneal administration of this GM induced a marked and dose-dependent inhibition of acetic acid-induced visceral pain with an ID(50) of 0." | 3.76 | Chemical structure and selected biological properties of a glucomannan from the lichenized fungus Heterodermia obscurata. ( Baggio, CH; Carbonero, ER; Eliasaro, S; Freitas, CS; Gorin, PA; Iacomini, M; Marcon, R; Pereira, MI; Ruthes, AC; Santos, AR; Sassaki, GL, 2010) |
| "001) dose-dependent analgesic effect in the tail flick, hot plate, and tail clip (central) as well as in acetic acid-induced writhing (peripheral) nociceptive tests in mice, suggesting the involvement of both central and peripheral mechanisms in alleviating the pain response." | 3.76 | Analgesic and antipyretic activities of ethanol extract of Stereospermum suaveolens. ( Kumar, CT; Mpharm, TB, 2010) |
| "Many traditional Indian medicinal plants which contain large quantity of a secoiridoid, swertiamarin are being used to relieve pain." | 3.75 | Antinociceptive activity of swertiamarin isolated from Enicostemma axillare. ( Badami, S; Jaishree, V; Rupesh Kumar, M; Tamizhmani, T, 2009) |
| ") 1 h prior to testing, produced dose-dependent inhibition of acetic acid-induced visceral pain, with ID50 value of 241." | 3.75 | Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice. ( Calixto, JB; Chaves, J; Ferreira, VM; Guginski, G; Luiz, AP; Martins, DF; Massaro, M; Mattos, RW; Santos, AR; Silva, MD; Silveira, D, 2009) |
| " The anti-inflammatory activity was assessed through croton oil-induced mouse ear oedema and carrageenan-induced peritonitis." | 3.75 | Antinociceptive and anti-inflammatory kaempferol glycosides from Sedum dendroideum. ( Costa, EA; Costa, SS; de Matos, LG; De Melo, GO; Kaiser, CR; Malvar, Ddo C; Pires, PA; Rocha, FF; Vanderlinde, FA, 2009) |
| "3%, respectively, the croton oil-induced oedema (dexamethasone: 5." | 3.75 | Antinociceptive and anti-inflammatory kaempferol glycosides from Sedum dendroideum. ( Costa, EA; Costa, SS; de Matos, LG; De Melo, GO; Kaiser, CR; Malvar, Ddo C; Pires, PA; Rocha, FF; Vanderlinde, FA, 2009) |
| "Our findings show that the major kaempferol glycosides may account for the renowned medicinal use of Sedum dendroideum against pain and inflammatory troubles." | 3.75 | Antinociceptive and anti-inflammatory kaempferol glycosides from Sedum dendroideum. ( Costa, EA; Costa, SS; de Matos, LG; De Melo, GO; Kaiser, CR; Malvar, Ddo C; Pires, PA; Rocha, FF; Vanderlinde, FA, 2009) |
| "The HE was evaluated in acetic acid and glutamate models of pain or by biting behavior following intrathecal (i." | 3.75 | Involvement of glutamate and cytokine pathways on antinociceptive effect of Pfaffia glomerata in mice. ( Baggio, CH; dos Santos, AC; dos Santos, AR; dos Santos, CA; Freitas, CS; Luiz, AP; Marques, MC; Mayer, B; Twardowschy, A, 2009) |
| "Oral administration of HE produced dose-dependent inhibition of acetic acid-induced visceral pain and glutamate-induced pain, with ID(50) of 64." | 3.75 | Involvement of glutamate and cytokine pathways on antinociceptive effect of Pfaffia glomerata in mice. ( Baggio, CH; dos Santos, AC; dos Santos, AR; dos Santos, CA; Freitas, CS; Luiz, AP; Marques, MC; Mayer, B; Twardowschy, A, 2009) |
| "6% of 10 ml) induced pain and the effects were also compared to aspirin, morphine and naloxone while formalin induced pain (0." | 3.75 | Antinociceptive activity of Amaranthus spinosus in experimental animals. ( Amresh, G; Rao, CV; Singh, S; Zeashan, H, 2009) |
| "It has been shown that the ethanol and aqueous extracts significantly increased the hot-plate pain threshold and reduced acetic acid-induced writhing response in mice." | 3.75 | Anti-inflammatory and analgesic effects of ethanol and aqueous extracts of Pterocephalus hookeri (C.B. Clarke) Höeck. ( Du, GH; Fang, WS; Hu, JJ; Lin, JW; Zhang, L, 2009) |
| " The effects on the pain threshold index in hot-plate test and the writhing times in acetic acid-induced writhing test were observed." | 3.75 | Intracerebroventricular or intrathecal injection of glycine produces analgesia in thermal nociception and chemical nociception via glycine receptors. ( Chen, HS; Cheng, MY; Cheng, W; Feng, T; Liu, GJ; Wang, S; Yin, Q; Zeng, YM, 2009) |
| "Although decursinol, which is one of the coumarins purified from the dried roots of Angelica gigas Nakai, was previously demonstrated to have antinociceptive effects on various mouse pain models such as tail-flick, hot-plate, formalin, writhing, and several cytokine-induced pain tests, the possible involvement of its analgesic effects and non-steroidal anti-inflammatory drugs (NSAIDs) has not been clearly elucidated yet." | 3.75 | The analgesic effect of decursinol. ( Choi, SM; Huh, GH; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Sim, YB; Suh, HW, 2009) |
| "The present study examined the antinociceptive effects of (O-methyl) N-benzoyl-tyramine (riparin I, ripI) isolated from the unripe fruit of Aniba riparia in chemical and thermal behavioral models of pain, such as acetic acid-induced abdominal writhing, formalin, and hot-plate tests in mice." | 3.75 | Antinociceptive effects of (O-methyl)-N-benzoyl tyramine (riparin I) from Aniba riparia (Nees) Mez (Lauraceae) in mice. ( Amaral, JF; Araújo, FL; Barbosa-Filho, JM; de Sousa, FC; Gutierrez, SJ; Leite, CP; Melo, CT; Moura, BA; Rocha, NF; Vasconcelos, SM; Viana, GS, 2009) |
| "This study compared effects of the mu opioid receptor agonist morphine (an acknowledged analgesic), the dopamine receptor antagonist haloperidol (a non-analgesic sedative), the adenosine receptor antagonist caffeine (a non-analgesic stimulant) and the neurokinin-1 receptor antagonist CJ 11,974-01 (a candidate analgesic) on acetic acid-induced writhing (a traditional pain-stimulated behavior) and acetic acid-induced suppression of locomotor activity (a pain-depressed behavior) in male ICR mice." | 3.75 | Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice. ( Adams, C; Bilsky, EJ; Cormier, J; Dunbar, C; Mercer, H; Negus, SS; Stevenson, GW, 2009) |
| "Antinociceptive activity of coniine was tested dose in Hotplate test (thermal pain model) and in Writhing test (chemical pain model) in different nociception models." | 3.75 | Antinociceptive activity of coniine in mice. ( Arihan, O; Boz, M; Ilhan, M; Iskit, AB, 2009) |
| " Pretreatment with a single dose of sophocarpine also produced significant dose-dependent anti-inflammatory effects on carrageenan-induced rat hind paw edema (15 and 30 mg/kg), xylene-induced mouse ear edema (20 and 40 mg/kg) and acetic acid-induced mouse vascular permeation (20 and 40 mg/kg)." | 3.75 | Anti-nociceptive and anti-inflammatory activity of sophocarpine. ( Fu, C; Gao, Y; Li, B; Li, C; Li, G; Li, M; Zhu, X, 2009) |
| "Pretreatment with a single dose of sophocarpine (20 and 40 mg/kg) produced dose-dependent anti-nociceptive effects in thermally and chemically induced mouse pain models." | 3.75 | Anti-nociceptive and anti-inflammatory activity of sophocarpine. ( Fu, C; Gao, Y; Li, B; Li, C; Li, G; Li, M; Zhu, X, 2009) |
| " Acetic acid-induced writhing response and formalin-induced pain were examined the analgesics effects of WET." | 3.75 | Analgesic and anti-inflammatory activities of a water extract of Trachelospermum jasminoides (Apocynaceae). ( Chen, JS; Cheng, HC; Chien, YC; Chou, PY; Huang, GJ; Huang, MH; Sheu, MJ; Wang, BS; Wu, CH, 2009) |
| " WET significantly inhibited the numbers of acetic acid-induced writhing responses and the formalin-induced pain in the late phase." | 3.75 | Analgesic and anti-inflammatory activities of a water extract of Trachelospermum jasminoides (Apocynaceae). ( Chen, JS; Cheng, HC; Chien, YC; Chou, PY; Huang, GJ; Huang, MH; Sheu, MJ; Wang, BS; Wu, CH, 2009) |
| "A model of visceral pain consisting of intraperitoneal injection of acetic acid (writhing test) was used." | 3.75 | Guaifenesin enhances the analgesic potency of ibuprofen, nimesulide and celecoxib in mice. ( Dolezal, T; Krsiak, M; Sliva, J; Sykora, D; Vosmanska, M, 2009) |
| "01), acetic acid-induced peritoneal capillary permeability test, and the cotton pellet granuloma test in mice or rats (P < ." | 3.75 | Anti-inflammatory and analgesic activities of Chaenomeles speciosa fractions in laboratory animals. ( Chen, WS; Li, X; Sun, LN; Yang, Q; Yang, YB, 2009) |
| ") dose-dependently inhibited nociceptive behavior in the acetic acid-induced pain test." | 3.74 | Quercetin: further investigation of its antinociceptive properties and mechanisms of action. ( de Souza, MM; Filho, AW; Filho, VC; Olinger, L, 2008) |
| " The glucan was tested for its effects on the acetic acid-induced writhing reaction in mice, a typical model for quantifying inflammatory pain." | 3.74 | Anti-inflammatory and analgesic properties in a rodent model of a (1-->3),(1-->6)-linked beta-glucan isolated from Pleurotus pulmonarius. ( Baggio, CH; Carbonero, ER; Freitas, CS; Gorin, PA; Iacomini, M; Marcon, R; Olsen, LM; Santos, AR; Smiderle, FR, 2008) |
| ", synergistic) in preclinical models of visceral and inflammatory pain, specifically acetic acid-induced writhing in mice and carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats." | 3.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| " Isobolographic analysis of the effects of duloxetine in combination with ibuprofen revealed a significant synergistic (greater than additive) interaction between duloxetine and ibuprofen both for reducing acetic acid-induced writhing and carrageenan-induced thermal hyperalgesia, but were additive for reversing mechanical allodynia." | 3.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| "Our data indicate that duloxetine and ibuprofen have synergistic efficacy in a visceral and an inflammatory pain model in rodents, and suggest that duloxetine and ibuprofen in combination may provide a useful approach to the clinical treatment of persistent pain, particularly inflammation-related pain." | 3.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| " For evaluation of inflammation carrageenan-, histamine- and serotonin-induced paw edema served as acute models and formaldehyde-induced arthritis served as a chronic model in rats." | 3.74 | Antinociceptive and anti-inflammatory effects of Thespesia populnea bark extract. ( Gunnam, KK; Parle, M; Vasudevan, M, 2007) |
| "Using a conditioned place paradigm, we examined the involvement of the bed nucleus of the stria terminalis (BST) in the negative affective component of visceral and somatic pain induced by intraperitoneal acetic acid and intraplantar formalin injections, respectively, in rats." | 3.74 | Involvement of the bed nucleus of the stria terminalis in the negative affective component of visceral and somatic pain in rats. ( Deyama, S; Kaneko, S; Minami, M; Nakagawa, T; Uehara, T, 2007) |
| " The anti-inflammatory effects were investigated using arachidonic acid, 12-O-tetradecanoylphorbol 13-acetate or carrageenan-induced oedema assays." | 3.74 | In-vitro and in-vivo anti-inflammatory action of the ethanol extract of Trachelospermi caulis. ( Choi, WS; Ha, CG; Her, E; Jun, SH; Kim, BK; Kim, NW; Kim, YM; Ko, NY; Lee, JH; Lee, JM; Lee, MH; Lee, SH; Mun, SH; Park, SH, 2007) |
| ") route produced dose-related antinociception when evaluated against acetic acid-induced visceral pain in mice." | 3.74 | Antinociceptive action of myricitrin: involvement of the K+ and Ca2+ channels. ( Fachinetto, R; Maffi, LC; Meotti, FC; Missau, FC; Pizzolatti, MG; Rocha, JB; Santos, AR, 2007) |
| "In the present study, we have investigated the analgesic effect of the aqueous extract of the root of Glycine tomentella (AGT) using models of acetic acid-induced writhing response and formalin test, the anti-inflammatory effect of AGT using model of lambda-carrageenan-induced paw edema." | 3.74 | Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice. ( Huang, HW; Hung, YC; Ko, YZ; Lin, YC; Lu, TC; Peng, WH, 2007) |
| "o) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma produced significant analgesic activity in acetic acid-induced writhing and tail immersion tests, anti-inflammatory effect against carrageenin induced inflammation and adjuvant induced polyarthritis and antipyretic activity against yeast-induced pyrexia." | 3.74 | Analgesic, anti-inflammatory and antipyretic activities of the ethanolic extract and its fractions of Cleome rutidosperma. ( Bose, A; Dash, GK; Ghosh, T; Gupta, JK; Mondal, S; Si, S, 2007) |
| "These data demonstrated the comparable efficacy of gabapentin with morphine in visceral pain." | 3.74 | Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. ( Meymandi, MS; Sepehri, G, 2008) |
| " Here, the antinociceptive effects of MOR agonists, the 6beta-glycine derivative of 14-O-methyloxymorphone (HS-731), DAMGO and morphine were evaluated in a mouse model of visceral pain." | 3.74 | DAMGO and 6beta-glycine substituted 14-O-methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens. ( Al-Khrasani, M; Friedmann, T; Furst, S; Király, K; Riba, P; Schmidhammer, H; Spetea, M, 2007) |
| " After having established the mouse model of analgesia by intraperitoneal or subcutaneous injections of appropriate doses of emulsified enflurane, isoflurane or sevoflurane, we injected different doses of AMPA intrathecally and observed effects on the pain threshold using the hot-plate and acetic acid-induced writhing tests." | 3.74 | Spinal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors may mediate the analgesic effects of emulsified halogenated anaesthetics. ( Dai, TJ; Hang, LH; Shao, DH; Yang, YH; Zeng, YM, 2007) |
| " indica dry extract (100, 200 and 400 mg kg-1) exhibited dose dependent and significant anti-inflammatory activity in acute (carrageenean and histamine induced hind paw oedema, p < 0." | 3.74 | Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals. ( Gupta, PK; Rao, CV; Verma, AR; Vijayakumar, M, 2007) |
| " Based on a clinical observation of synergism between nefopam, a centrally acting non-opioid that inhibits monoamines reuptake, and ketoprofen, a non-steroidal anti-inflammatory drug, the objective of this study was to further explore this antinociceptive synergy in four distinct animal models of pain (both drugs were administered subcutaneously)." | 3.74 | Nefopam and ketoprofen synergy in rodent models of antinociception. ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008) |
| " In the present study, the oral analgesic activity of ZC88 in animal models of acute and neuropathic pain, and functional interactions between ZC88 and morphine in terms of analgesia, tolerance and dependence were investigated." | 3.74 | Analgesic activity of ZC88, a novel N-type voltage-dependent calcium channel blocker, and its modulation of morphine analgesia, tolerance and dependence. ( Li, J; Liu, Y; Lu, XQ; Meng, G; Su, RB; Wu, N; Yun, LH; Zhang, C; Zheng, JQ, 2008) |
| " In the present study, we examined the antinociceptive effect of nicotine administered supra-spinally on acetic acid-induced visceral pain induction (writhing test), and found that the antinociceptive effect of nicotine was abolished by mu-, delta-, and kappa-opioid receptor antagonist administered i." | 3.74 | The effect of formalin pretreatment on nicotine-induced antinociceptive effect: the role of mu-opioid receptor in the hippocampus. ( Choi, SM; Jung, JS; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Suh, HW, 2008) |
| "There is evidence supporting the antinociceptive effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in various models of neuropathic pain as well as inflammatory somatic pain." | 3.74 | The antinociceptive effects of anticonvulsants in a mouse visceral pain model. ( Boskovic, B; Milovanovic, S; Paranos, S; Prostran, MS; Stepanovic-Petrovic, RM; Tomic, MA; Ugresic, ND; Vuckovic, SM, 2008) |
| " The acetic acid-induced writhing test, tail flick test and the tetradecanoylphorbol acetate (TPA)-induced ear inflammation model in mice were used to determine these effects." | 3.73 | Analgesic and topical anti-inflammatory activity of Hypericum canariense L. and Hypericum glandulosum Ait. ( Bonkanka, CX; Hernández-Pérez, M; Rabanal, RM; Sánchez-Mateo, CC, 2005) |
| " This analgesic property was confirmed in rats using two different models of bradykinin-induced hyperalgesia; there was 75% inhibition of pain in the modified Hargreaves assay, and 100% inhibition in the classical Hargreaves assay." | 3.73 | Antinociceptive effect of Nidularium procerum: a Bromeliaceae from the Brazilian coastal rain forest. ( Amendoeira, FC; Bozza, PT; Castro-Faria-Neto, HC; Chedier, LM; Figueiredo, MR; Frutuoso, VS; Kaplan, MA; Pearman, AT; Prescott, SM, 2005) |
| " Two different animal models, the carrageenin-induced edema, in the rat, and acetic acid-induced writhing test in mice, were adopted." | 3.73 | Anti-inflammatory, anti-nociceptive and antioxidant activities of Balanites aegyptiaca (L.) Delile. ( Cervellati, R; Costa, S; Dall' Acqua, S; Govoni, P; Guerra, MC; Innocenti, G; Speroni, E, 2005) |
| " The extract at given doses significantly and dose dependently reduced the frequency of acetic acid induced writhing in mice, prolonged the tail flicking latency in mice, reduced Carrageenan-induced paw edema volume in rat, delayed the onset as well as reduced the frequency of castor oil induced diarrhoeal episodes in mice, decreased gastrointestinal motility as assessed by the charcoal motility test in mice and prolonged pentobarbitone induced sleeping time in mice." | 3.73 | Preliminary pharmacological studies on Piper chaba stem bark. ( Ahmed, M; Faiz Hossain, C; Shilpi, JA; Taufiq-Ur-Rahman, M, 2005) |
| " The oral administration of aspartame (2-16mg/kg, po) significantly increased the pain threshold against acetic acid-induced writhes in mice." | 3.73 | Possible analgesic and anti-inflammatory interactions of aspartame with opioids and NSAIDs. ( Jain, NK; Kulkarni, SK; Sharma, S, 2005) |
| " SAG inhibited dose-dependently edematic response of arachidonic acid (AA)- and 12-O-tetradecanoyl 13-acetate (TPA)-induced ear edema in mice, which is an animal model of acute inflammation." | 3.73 | New anti-inflammatory formulation containing Synurus deltoides extract. ( Bae, K; Chang, HW; Choi, YH; Kang, SS; Kim, HP; Son, KH, 2005) |
| " It also inhibited carrageenan-induced acute edema and acetic acid-induced writhing response." | 3.73 | Prevention of arthritic inflammation using an oriental herbal combination BDX-1 isolated from Achyranthes bidentata and Atractylodes japonica. ( Han, SB; Kang, JS; Kim, HM; Lee, CW; Lee, JH; Lee, K; Lee, KH; Park, SK; Yoon, WK; Yoon, YD, 2005) |
| "001) delayed the onset of, and antagonized, pentylenetetrazole (PTZ)-induced seizures." | 3.73 | Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice. ( Ojewole, JA, 2005) |
| " sativa seed polyphenols were prepared, and analgesic and anti-inflammatory effects were studied in mice and rats using the acetic acid-induced writhing, formalin, light tail flick, carrageenan-induced paw edema, and croton oil-induced ear edema tests." | 3.73 | An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols. ( Ghannadi, A; Hajhashemi, V; Jafarabadi, H, 2005) |
| ", popularly known in China as "jin gang ten", was tested for its anti-inflammatory activities in rats by egg-albumin-induced edema and anti-nociceptive effects in mice using hot-plate test and acetic acid-induced abdominal constriction test, respectively." | 3.73 | Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract. ( Gao, ZH; Shu, XS; Yang, XL, 2006) |
| "5% formalin injection into the hind paw, acetic acid administration intraperitoneally or neuropathic pain testing consisting of mechanical allodynia (von Frey filament) and thermal hyperalgesia (Plantar test)." | 3.73 | Antinociceptive effects of tetrodotoxin (TTX) in rodents. ( Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS, 2006) |
| "Systemic injections of TTX diminished pain behaviour in a dose-dependent manner in models of inflammatory, visceral and neuropathic pain without causing adverse events, whereas morphine analgesia was associated with heavy sedation." | 3.73 | Antinociceptive effects of tetrodotoxin (TTX) in rodents. ( Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS, 2006) |
| " The methanolic extract and total alkaloids of Glaucium paucilobum caused graded inhibition of both phases of formalin-induced pain." | 3.73 | Analgesic activity of the methanolic extract and total alkaloids of Glaucium paucilobum. ( Heidar, MR; Mahmoudi, M; Morteza-Semnani, K, 2006) |
| " The analgesic effect of the drug was studied with pain model of mice induced by acetic acid and hot plate, The severity of oedema in inflamed animal was observed to study the anti-inflammatory effects of Bailian Caogen granule." | 3.73 | [Experimental study of Bailian Caogen granule on pharmacodynamics]. ( Chen, KM; Hao, W; Li, DM; Zhao, LN; Zhao, RY; Zhou, YX, 2006) |
| " The number of writhing induced by acetic acid was reduced and the pain threshold of mice was increased by Bailian Caogen granule." | 3.73 | [Experimental study of Bailian Caogen granule on pharmacodynamics]. ( Chen, KM; Hao, W; Li, DM; Zhao, LN; Zhao, RY; Zhou, YX, 2006) |
| " pacari extract in carrageenan-induced paw oedema, acetic acid writhing and LPS-induced fever, respectively." | 3.73 | Anti-inflammatory, analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid. ( Albuquerque, DA; Ambrosio, SR; da Costa, FB; de Souza, GE; Faccioli, LH; Fontanari, C; França, SC; Melo, MC; Pereira, PS; Rogerio, AP, 2006) |
| " The antiinflammatory property of the aqueous leaf extract was investigated in rats, using fresh egg albumin-induced pedal (paw) edema, while the analgesic effect of the plant extract was evaluated by the "hot-plate" and "acetic acid" test models of pain in mice." | 3.73 | Antiinflammatory and analgesic effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rats and mice. ( Ojewole, JA, 2006) |
| " To investigate the anti-inflammatory and anti-oxidant activity of these compounds, their effects on carrageenan-induced paw edema, arachidonic acid (AA)-induced ear edema and analgesic activity in acetic acid (HAc)-induced writhing response were carried out in vivo; cyclooxygenase (COX) activity, reactive oxygen species (ROS) generation in rat basophilic leukemia (RBL 2H3) cells and 1,1-diphenyl-2-picryl-hydroazyl (DPPH) scavenging activity were determined in vitro." | 3.73 | Anti-inflammatory action of phenolic compounds from Gastrodia elata root. ( Jang, YW; Kang, HS; Kim, CJ; Lee, JY; Moon, H; Sim, SS, 2006) |
| "Carrageenin-induced paw edema, tail-flick, formalin, acetic acid-induced abdominal writhing and capsaicin models of pain were carried out." | 3.72 | Anti-inflammatory and antinociceptive activity of diphenyl diselenide. ( Jung, EA; Nogueira, CW; Quinhones, EB; Rocha, JB; Zeni, G, 2003) |
| " The effect on acute inflammation was studied using vascular permeability increased by acetic acid and xylene-induced ear oedema in mice." | 3.72 | Antinociceptive, antiinflammatory and acute toxicity effects of Salvia leriifolia Benth seed extract in mice and rats. ( Arash, AR; Haddadkhodaparast, MH; Hosseinzadeh, H, 2003) |
| "Clitoria ternatea roots methanol extract when given by oral route to rats was found to inhibit both the rat paw oedema caused by carrageenin and vascular permeability induced by acetic acid in rats." | 3.72 | Anti-inflammatory, analgesic and antipyretic properties of Clitoria ternatea root. ( Boominathan, R; Devi, BP; Mandal, SC, 2003) |
| "Dried leaves extract from Bouchea fluminensis was assessed in anti-inflammatory (mouse paw edema) and analgesic models (acetic acid-induced writhings and hot plate)." | 3.72 | Anti-inflammatory and analgesic activity of Bouchea fluminensis. ( Costa, VB; Coube, CS; Fernandes, PD; Leitão, SG; Marinho, BG; Matheus, ME, 2003) |
| "The croton oil-induced mouse ear oedema test, acetic acid-induced abdominal writhing, and carrageenan-induced peritonitis were used to study the anti-inflammatory effects of the crude ethanol extract and its alkaloid fraction from Solanum lycocarpum fruits." | 3.72 | Anti-inflammatory effect of Solanum lycocarpum fruits. ( Costa, EA; Ferreira, EC; Ferreira, HD; Ferreira, PM; Ferri, PH; Matos, LG; Rodovalho, W; Vieira, G, 2003) |
| " The antinociceptive effect of 1 was evaluated on chemical (acetic acid, formalin and capsaicin) and thermal (hot plate and tail flick) pain models in mice, using classical standard drugs." | 3.72 | Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla. ( Alexandre-Moreira, MS; Barreiro, EJ; Bolzani, Vda S; Palhares de Miranda, AL; Viegas, C, 2003) |
| "Colitis was induced by intracolonic instillation of 4% acetic acid in male Sprague-Dawley rats." | 3.72 | Visceral hypersensitivity and altered colonic motility after subsidence of inflammation in a rat model of colitis. ( Kang, JW; Kim, HJ; Kim, TW; La, JH; Sung, TS; Yang, IS, 2003) |
| ") had no effect in two acute pain models, namely, the acetic acid-induced writhing (visceral pain) and the formalin test (tonic pain)." | 3.72 | Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. ( Jain, NK; Kulkarni, SK; Padi, SS; Singh, S, 2004) |
| " Antiinflammatory activity was evaluated using carrageenan-induced paw oedema in rats and croton oil-induced ear oedema in mice." | 3.72 | Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. ( Ghannadi, A; Hajhashemi, V; Jafarabadi, H, 2004) |
| ") HBK (Piperaceae) was tested for anti-inflammatory (paw edema induced by carrageenin and arachidonic acid) and analgesic activity (abdominal writhes and hot plate) in rats and mice, respectively." | 3.72 | Anti-inflammatory and analgesic activity of Peperomia pellucida (L.) HBK (Piperaceae). ( Andrade, MR; Antoniolli, AR; de Fátima Arrigoni-Blank, M; Dmitrieva, EG; Franzotti, EM; Marchioro, M, 2004) |
| " It was found that all extracts possessed strong inhibitory effects on the acute phase of inflammation as seen in ethyl phenylpropiolate (EPP)- and arachidonic acid (AA)-induced ear edema as well as in carrageenin-induced paw edema in rats." | 3.72 | Anti-inflammatory activity of methanolic extracts from Ventilago harmandiana Pierre. ( Kanjanapothi, D; Panthong, A; Panthong, K; Phankummoon, A; Reutrakul, V; Taesotikul, T, 2004) |
| " The analgesic investigations were carried out against two types of noxious stimuli, chemical (formalin-induced pain and acetic acid-induced writhing) and thermal (hotplate and tail immersion tests)." | 3.72 | Analgesic and antiinflammatory activities of Erigeron floribundus. ( Asongalem, EA; Dimo, T; Folefoc, GN; Foyet, HS; Kamtchouing, P; Ngogang, J, 2004) |
| " Thus, we used acetic acid (AA) which produces a delayed inflammatory response and episodes of abdominal writhing, a marker of pain, when injected intraperitoneally (i." | 3.72 | Effects of a chromogranin-derived peptide (CgA 47-66) in the writhing nociceptive response induced by acetic acid in rats. ( Angel, F; Aunis, D; Crenner, F; Ghia, JE; Metz-Boutigue, MH, 2004) |
| " Pain nociception, as assessed by the acetic acid writhing response, was reduced significantly in KO mice relative to WT mice." | 3.72 | Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1. ( Akira, S; Azuma, Y; Hirasawa, N; Ishii, T; Ishikawa, Y; Kamei, D; Kawaguchi, H; Kudo, I; Mikami-Nakanishi, M; Murakami, M; Nakatani, Y; Oh-Ishi, S; Ohuchi, K; Takegoshi, Y; Uematsu, S; Yamakawa, K; Yasui, H, 2004) |
| "The aqueous and ethanol extracts of the dry leaves of Kalanchoe crenata (300 and 600 mg/kg) were evaluated for their analgesic properties on the pain induced by acetic acid, formalin and heat in mice and by pressure on rats." | 3.72 | Analgesic properties of the aqueous and ethanol extracts of the leaves of Kalanchoe crenata (Crassulaceae). ( Dimo, T; Fotio, AL; Kamanyi, A; Nguelefack, TB; Wansi, SL; Watcho, P, 2004) |
| " Results indicated that the extracts assayed showed anti-nociceptive activities because they were able to reduce the nociceptive response to chemical pain stimuli, such as in the acetic acid-induced writhing test." | 3.72 | Studies on the analgesic and anti-inflammatory effects of Sideritis candicans Ait. var. eriocephala Webb aerial part. ( Hernández-Pérez, M; Montalbetti-Moreno, Y; Rabanal, RM; Sánchez-Mateo, CC, 2004) |
| " Concerning the gastric effects, lavender oil, linalool and linalyl acetate oral administration protected against acute ethanol-induced gastric ulcers but did not prevent indomethacin-induced lesions indicating no interference with arachidonic acid metabolic cascade." | 3.72 | Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil. ( Ballabeni, V; Barocelli, E; Bianchi, A; Bruni, R; Calcina, F; Chiavarini, M; Impicciatore, M, 2004) |
| "The antihyperalgesic effect of pentoxifylline was investigated in three experimental pain models." | 3.72 | Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. ( Benevides, VM; Brito, GA; Cunha, FQ; da Rocha, FA; Ferreira, SH; Poole, S; Ribeiro, RA; Sachs, D; Vale, ML, 2004) |
| ") decreased thermal hyperalgesia observed in carrageenan-induced inflammatory hypersensitivity without affecting paw edema, abolished acetic acid-induced writhing activity in mice, and was shown to reduce mechanical allodynia and thermal hyperalgesia observed in a model of post-operative hypersensitivity and formalin-induced spontaneous pain." | 3.72 | Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities. ( Decker, MW; Gauvin, DM; Honore, P; Lynch, JJ; Mikusa, JP; Wade, CL; Wilson, SG; Wismer, CT; Zhu, CZ, 2004) |
| " Against the acute inflammatory animal model of mouse croton oil-induced ear oedema assay, the extract did not show significant inhibition at 100-800 mg/kg by oral administration." | 3.72 | Antiinflammatory activity of Synurus deltoides. ( Bae, K; Chang, HW; Kang, SS; Kim, HP; Kim, SW; Park, JH; Son, KH, 2004) |
| "Acetic acid-induced abdominal writhing, the tail flick test and carrageenan-induced peritonitis were used to study the analgesic and anti-inflammatory activity of the crude ethanolic extract from Spiranthera odoratissima roots." | 3.72 | Analgesic and anti-inflammatory activity of the ethanolic extract from Spiranthera odoratissima A. St. Hillaire (Manacá) roots. ( Costa, EA; Matos, LG; Paula, JR; Pontes, IS; Tresvenzol, LM, 2004) |
| "5, 5 and 10 mg kg (-1)) was investigated and compared with diclofenac sodium (5 mg kg (-1)) using the formalin-, histamine-, and carrageenan-induced paw oedema and cotton pellet granuloma tests." | 3.71 | Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice. ( Büyükokuroğlu, ME, 2002) |
| " In vitro and in vivo approaches were used to assess whether cizolirtine could affect the spinal release of two pain-related neuropeptides, substance P (SP) and calcitonin gene-related peptide (CGRP), in rats." | 3.71 | The novel analgesic, cizolirtine, inhibits the spinal release of substance P and CGRP in rats. ( Aubel, B; Ballet, S; Bourgoin, AS; Cesselin, F; Farré, A; Hamon, M; Mauborgne, A; Poliénor, H, 2001) |
| " These acid-induced writhing reactions were significantly attenuated by capsazepine, a VR1 receptor-specific antagonist, but the phenylbenzoquinone-induced one was not, suggesting that the acids but not phenylbenzoquinone activate the VR1 receptor, which is involved in polymodal pain perception." | 3.71 | Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice. ( Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A, 2001) |
| " The effect of the extracts against acute inflammation was studied by acetic acid increased vascular permeability and xylene-induced ear edema in mice." | 3.71 | Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats. ( Fadishei, M; Hosseinzadeh, H; Mahmoudi, M; Ramezani, M, 2002) |
| "The tachykinin neuropeptides, substance P and substance K, are produced in nociceptive primary sensory neurons and in many brain regions involved in pain signaling." | 3.70 | Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene. ( Baffi, J; König, M; Mezey, E; Palkovits, M; Reynolds, K; Usdin, T; Zimmer, A; Zimmer, AM, 1998) |
| " That is, it exhibited in vivo anti-inflammatory activity in several tested inflammatory reactions including 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema, carrageenan-induced rat paw edema, and acetic acid-induced mouse writhing." | 3.70 | Suppression of inflammatory responses by surfactin, a selective inhibitor of platelet cytosolic phospholipase A2. ( Jung, JK; Jung, SY; Kim, DK; Kim, K; Lee, CH; Lee, DK; Park, JK, 1998) |
| "In a model of visceral pain consisting of intraperitoneal injection of acetic acid (writhing test), simultaneous administration of subanalgesic doses of metamizol (150 mg/kg) and morphine (0." | 3.70 | Metamizol potentiates morphine effects on visceral pain and evoked c-Fos immunoreactivity in spinal cord. ( Fernaud, I; Mellström, B; Naranjo, JR; Taylor, J, 1998) |
| "The present study shows that meloxicam dose-dependently exhibited systemic antinociceptive action when assessed against neurogenic and inflammatory pain caused by acetic acid, formalin and capsaicin models." | 3.70 | Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice. ( De Freitas, GA; Santos, AR; Vedana, EM, 1998) |
| " Furthermore bukittinggine could significantly reduce fever in yeast-induced hyperthermic rats and possessed analgesic activity comparable to that of acetylsalicylic acid when tested in acetic acid-induced writhing response in mice." | 3.70 | Anti-inflammatory activity of the alkaloid bukittinggine from Sapium baccatum. ( Arbain, D; Kanjanapothi, D; Panthong, A; Taesotikul, T; Thitiponpunt, Y, 1998) |
| "This study investigates the antinociceptive and the oedema inhibition properties of the novel non-peptide bradykinin (BK) B2 receptor antagonist, NPC 18884." | 3.70 | Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. ( Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ, 1999) |
| " (Bignoniaceae) ('huarumo') were analysed to determine their anti-inflammatory activity (carrageenan-induced edema test), antinociceptive activity (acetic acid writhing test) and 'in vitro' toxicity in Chinese hamster ovary cells, human hepatome cells and human larynx epidermal carcinoma cells." | 3.70 | Tecoma sambucifolia: anti-inflammatory and antinociceptive activities, and 'in vitro' toxicity of extracts of the 'huarumo' of peruvian incas. ( Alguacil, LF; Galán de Mera, A; Gómez, J; Llinares, F; Morales, L; Muñoz-Mingarro, MD; Pozuelo, JM; Vicente Orellana, JA, 2000) |
| " Acetic acid induced writhing in mice and egg albumin induced rat paw edema procedures were used to evaluate analgesic and anti-inflammatory activities of the compounds respectively." | 3.70 | Anti-sickling, analgesic and anti-inflammatory properties of 3,5-dimethoxy-4-hydroxy benzoic acid and 2,3,4-trihydroxyacetophenone. ( Gamaniel, K; Kapu, DS; Okogun, JI; Samson, A; Samuel, BB; Wagner, H; Wambebe, C, 2000) |
| " Tests of other neurogenic inflammatory stimuli in NK1 -/- mice revealed impaired behavioural responses to cyclophosphamide cystitis and no acute reflex responses or primary hyperalgesia to intracolonic acetic acid." | 3.70 | Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene. ( Cervero, F; De Felipe, C; Hunt, SP; Laird, JM; Olivar, T; Roza, C, 2000) |
| ") caused an inhibition of increase in vascular permeability in both cyclophosphamide-induced haemorrhagic cystitis and acetic acid-induced vascular permeability in rats and mice, respectively." | 3.70 | Studies on the anti-inflammatory and related pharmacological properties of the aqueous extract of Bridelia ferruginea stem bark. ( Awe, SO; Makinde, JM; Okpako, DT; Olajide, OA, 2000) |
| " The HE of the Phyllanthus species elicited significant inhibition of the capsaicin-induced neurogenic pain, with mean ID(50) values of 8." | 3.70 | Antinociceptive properties of extracts of new species of plants of the genus Phyllanthus (Euphorbiaceae). ( Calixto, JB; De Campos, RO; Filho, VC; Miguel, OG; Santos, AR; Siani, AC; Yunes, RA, 2000) |
| "Analgesic and antiinflammatory activity of proanthocyanidin isolated from Polypodium feei roots has been tested using acetic acid-induced writhing and carrageenan-induced paw edema methods, respectively." | 3.70 | Analgesic and anti-inflammatory activity of the proanthocyanidin shellegueain A from Polypodium feei METT. ( Subarnas, A; Wagner, H, 2000) |
| " Rolipram, a selective PDE IV inhibitor and theophylline a nonspecific PDE inhibitor exerted dose dependent analgesic and anti-inflammatory effect against acetic acid-induced writhing in mice and carrageenan-induced paw edema in rats, respectively." | 3.70 | Analgesic and anti-inflammatory effects of phosphodiesterase inhibitors. ( Jain, NK; Kulkarni, SK; Kumar, A, 2000) |
| "The aim of the present study was to investigate the role of phosphodiesterase (PDE) enzyme inhibitors namely rolipram and theophylline in pain and inflammation in experimental animals." | 3.70 | Analgesic and anti-inflammatory effects of phosphodiesterase inhibitors. ( Jain, NK; Kulkarni, SK; Kumar, A, 2000) |
| " Eto inhibited carrageenin-induced edema in rats, adjuvant-induced arthritis in rats, acetic acid-induced writhing in mice and brewer's yeast-induced hyperalgesia and fever in rats." | 3.69 | Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs. ( Fujisawa, H; Inoue, K; Inoue, Y; Kimura, K; Kyoi, T; Motonaga, A; Ueda, F, 1994) |
| " Eleven compounds in series I plus one in series II and six in series I plus seven in series II were active in the carrageenan-induced edema and acetic acid-induced writhing assays, respectively." | 3.69 | Synthesis and antiinflammatory, analgesic, and antipyretic testing of 4-[1-oxo-(3-substituted aryl)-2-propenyl]-3-phenylsydnones and of 3-[4-[3-(substituted aryl)-1-oxo-2-propenyl]phenyl]sydnones. ( Rao, MN; Satyanarayana, K, 1995) |
| " administration of acetic acid produces abdominal contractions reflecting visceral pain, and gastrointestinal ileus characterized by inhibition of gastric emptying and small intestine transit." | 3.69 | Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats. ( Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ, 1997) |
| "We have examined whether or not the presence of pain can block the development of tolerance to morphine antinociception in mice." | 3.68 | Development of tolerance to morphine antinociception in mice treated with nociceptive stimulants. ( Kaneto, H; Rahman, AF; Takahashi, M, 1993) |
| " It also compared the inhibition of pain behavior and Fos expression by a mu-selective opioid agonist, morphine, and a kappa-selective opioid agonist, U-50,488." | 3.68 | Morphine or U-50,488 suppresses Fos protein-like immunoreactivity in the spinal cord and nucleus tractus solitarii evoked by a noxious visceral stimulus in the rat. ( Basbaum, AI; Gogas, KR; Hammond, DL; Presley, R, 1992) |
| "The pharmacological properties of the five samples of glycyrrhizic acid, paeoniflorin, the extracts of Glycyrrhizae Radix, the extracts of Paeoniae Radix and a preparation of Chinese drug Shakuyakukanzo-To were compared by investigating their actions in the carrageenan-induced paw edema, the cotton pellet granuloma formation and acetic acid-induced writhing syndrome tests, using ddY-strain mice." | 3.67 | Studies on the combination of Glycyrrhizae Radix in Shakuyakukanzo-To. ( Amagaya, S; Ogihara, Y; Sugishita, E, 1984) |
| " acetic acid) has been investigated during the development of arthritis experimentally induced in rats by s." | 3.67 | [Reduction of the behavioral response to a viscero-peritoneal nociceptive stimulation during the development of experimental polyarthritis in the rat]. ( Calvino, B; Le Bars, D, 1986) |
| "A significant number of rats (31-68%) subjected to pain stimulation (intraperitoneal injection of 1% or 5% acetic acid, 5 ml/kg), immobilization stress (6 hrs in a supine position) or cold stress (3 hrs at 4-6 degrees C) exhibited postural asymmetry of hind limbs after spinal cord transection at T7 level." | 3.66 | Postural asymmetry in rats induced by stress and pain stimuli. ( Krivosheev, OG; Stolyarov, GK, 1982) |
| "Pain was measured at 0, 2, 4, 6, 8, 10, 15, and 20 minutes using a 10-cm visual analog scale (VAS)." | 2.70 | A randomized paired comparison trial of cutaneous treatments for acute jellyfish (Carybdea alata) stings. ( Ahern, RM; Kuwaye, TT; Nomura, JT; Sato, RL; Snow, JL; Yamamoto, LG, 2002) |
| "Hemorrhoids were induced by 6% balsam and glacial acetic acid respectively in the anorectal region of rats." | 2.44 | The beneficial effect of Sanhuang ointment and its active constituents on experimental hemorrhoids in rats. ( Li, G; Li, W; Piao, S; Yan, M; Yu, Q; Zhang, H; Zhang, X; Zhao, Y, 2024) |
| " Patients were followed up at 6 weeks for any complication and reassessed by VIA and colposcopy at 12 months for any persistent or recurrent lesion and for any adverse event." | 1.72 | Evaluation of effectiveness, acceptability and safety of thermal ablation in the treatment of cervical neoplasia in Burundi. ( Barango, P; Bazikamwe, S; Harerimana, S; Lucas, E; Ndayikengurukiye, A; Sauvaget, C, 2022) |
| "Sulfasalazine and JLC were administrated orally and initialized 6 h after TNBS enema, once a day for seven consecutive days." | 1.62 | Jiaolong capsule protects SD rats against 2,4,6-trinitrobenzene sulfonic acid induced colitis. ( Chen, G; Diao, F; Dong, M; Li, Y; Lin, W; Liu, T; Liu, Y; Mei, Q; Ruan, Y; Sun, Y; Tang, T; Zhou, H, 2021) |
| "The acetylcholinesterase inhibitor (ACHEI); neostigmine, is known clinically for its analgesic effect in the perioperative phases proving high efficacy; besides possessing anti-inflammatory properties controlling immune cells and cytokine level." | 1.62 | The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation. ( Abdel-Bary, A; El-Tahan, RA; Gowayed, MA, 2021) |
| "Moreover, opioid-induced hyperalgesia was observed after repeated administration of morphine, but not BN-9." | 1.56 | Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia. ( Chen, D; Fang, Q; Li, N; Niu, J; Xiao, J; Xu, B; Xu, K; Zhang, M; Zhang, Q; Zhang, R; Zhao, G; Zhu, H, 2020) |
| "Rubimaillin (Rub) is a naphthoquinone compound extracted from Chinese herbal medicine, and it has various biological activities." | 1.56 | Analgesic action of Rubimaillin in vitro and in vivo. ( Fan, F; Jiang, Z; Yan, W, 2020) |
| "Morphine was administered intramuscularly immediately prior to algogen administration." | 1.51 | Nociceptive-like behavior and analgesia in silver catfish (Rhamdia quelen). ( Baldisserotto, B; Barbosa, LB; Bianchini, AE; Ferrari, FT; Heinzmann, BM; Rodrigues, P, 2019) |
| "Although the magnitude of the hyperalgesia is dependent on the intensity of the conditioning stimulus, we find that the direction of effect is dependent on the effective test stimulus intensity, with lower-intensity stimuli leading to hyperalgesia and higher-intensity stimuli leading to hypoalgesia." | 1.51 | Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity. ( Austin, JS; Coderre, TJ; Diamond, L; George, N; Macintyre, LC; Martin, LJ; Meluban, L; Mogil, JS; Sotocinal, SG; Tansley, SN, 2019) |
| "The current investigation is focused on solid self-microemulsifying drug-delivery systems (S-SMEDDS) of mefenamic acid (MFA) for improving pharmacodynamic activity." | 1.51 | Mefenamic acid-loaded solid SMEDDS: an innovative aspect for dose reduction and improved pharmacodynamic profile. ( Bedi, N; Kumar, M; Singh, D, 2019) |
| " The optimized liquid SMEDD formulation was spray dried to solid dosage form and observed with enhanced amorphization or molecular dispersion of MFA in S-SMEDDS, as evident from x-ray diffractometry and differential scanning calorimetry studies." | 1.51 | Mefenamic acid-loaded solid SMEDDS: an innovative aspect for dose reduction and improved pharmacodynamic profile. ( Bedi, N; Kumar, M; Singh, D, 2019) |
| " These include stability, dissolution rate, bioavailability and solubility, which can affect pharmacokinetics and pharmacodynamics." | 1.51 | Anti-inflammatory and analgesic activity based on polymorphism of cedrol in mice. ( Chen, SS; Ding, M; Guan, J; Li, W; Su, GY; Wang, JW; Zhang, YM; Zhao, YQ, 2019) |
| "miliacea in the treatment of fever with possible anti-nociceptive effects." | 1.51 | Antipyretic and anti-nociceptive effects of methanol extract of leaves of Fimbristylis miliacea in mice model. ( Akter, A; Barek, MA; Basher, MA; Liya, IJ; Roy, R; Sultana, S; Ud Daula, AFMS, 2019) |
| "Protocatechuic acid is an antioxidant which is shown to have analgesic activity in limited studies." | 1.51 | Cannabinoid system involves in the analgesic effect of protocatechuic acid. ( Arslan, R; Bektas, N; Dikmen, DY; Okcay, Y, 2019) |
| " Both aqueous and alcoholic extracts were found safe at dose of 5000mg/kg." | 1.48 | Acute toxicity study and anti-nociceptive activity of Bauhinia acuminata Linn. leaf extracts in experimental animal models. ( Kulkarni, YA; Londhe, VY; Padgaonkar, AV; Suryavanshi, SV, 2018) |
| "treatment with oxyntomodulin during the second, but not the first phase." | 1.48 | Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models. ( Hong, JW; Jang, SP; Lee, HJ; Lee, JR; Park, SH; Suh, HW, 2018) |
| "Mechanical and thermal hyperalgesia induced by carrageenan were determined using an electronic anesthesiometer and hot plate apparatus, respectively." | 1.46 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| "Stigmasterol is a common sterol found in plants, but the anti-nociceptive effect of this compound and its mechanism of action are not fully explored." | 1.46 | Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain. ( da Silva Brum, E; Ferreira, J; Oliveira, SM; Rossato, MF; Tonello, R; Trevisan, G; Walker, CIB, 2017) |
| "Furthermore, it markedly attenuated the mechanical allodynia caused by surgical incision (after acute treatment with stigmasterol, preventive and curative effects were observed) and partial sciatic nerve ligation (after acute treatment with stigmasterol) and complete Freund's adjuvant (after acute or repeated treatment with stigmasterol)." | 1.46 | Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain. ( da Silva Brum, E; Ferreira, J; Oliveira, SM; Rossato, MF; Tonello, R; Trevisan, G; Walker, CIB, 2017) |
| "Visceral pain has a greater emotional component than somatic pain." | 1.46 | Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States. ( Baeyens, JM; Cervero, F; Cobos, EJ; Coderre, TJ; Gonzalez-Cano, R; Lehmann, M; Pitcher, MH; Vincent, K, 2017) |
| "Chronic pain affects the lives of millions yearly, but few new treatments are available." | 1.46 | A novel zebrafish-based model of nociception. ( DeBerry, JJ; Dewberry, LS; Sorge, RE; Taylor, JC; Totsch, SK; Watts, SA; Yessick, LR, 2017) |
| "Pretreatment with naloxone and bicuculline significantly attenuated the reduction of abdominal constrictions produced by all the tested trimethoxy flavones indicating a definite role of opioid and GABAergic mechanisms in the anti-nociceptive effect of trimethoxy flavones." | 1.43 | Anti-nociceptive activity of a few structurally related trimethoxy flavones and possible mechanisms involved. ( Cheriyan, BV; Kadhirvelu, P; Nadipelly, J; Sayeli, V; Shanmugasundaram, J; Subramanian, V, 2016) |
| " In the acute toxicity test, the LD50 estimated for CPE was>5000 mg/kg p." | 1.43 | Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae). ( Alonso-Castro, AJ; Carranza-Álvarez, C; González-Chávez, MM; Hernández-Benavides, DM; Hernández-Morales, A; Zapata-Morales, JR, 2016) |
| "Pain is sensed, transmitted, and modified by a variety of mediators and receptors." | 1.43 | Analgesic Effects of 1st Generation Anti-histamines in Mice. ( Endo, Y; Fujita, T; Fukumoto, S; Hagiwara, Y; Mizoguchi, H; Sakurada, S; Shima, K; Sugawara, S; Tadano, T; Takahashi, M; Tsuchiya, M; Watanabe, M, 2016) |
| "The treatment with allantoin (40, 60 and 80mg/kg p." | 1.43 | Antinociceptive and anti-inflammatory effects of Memora nodosa and allantoin in mice. ( Costa, EA; de Paula, JR; Florentino, IF; Galdino, PM; Lino, RC; Martins, JLR; Silva, DM; Silva, DPB; Tresvenzol, LMF, 2016) |
| "Allantoin has peripheral antinociceptive activity that involves the opioid receptor and ATP-sensitive K(+)channels." | 1.43 | Antinociceptive and anti-inflammatory effects of Memora nodosa and allantoin in mice. ( Costa, EA; de Paula, JR; Florentino, IF; Galdino, PM; Lino, RC; Martins, JLR; Silva, DM; Silva, DPB; Tresvenzol, LMF, 2016) |
| " Furthermore, time- and dose-response curves were obtained to determine the antinociceptive effect of the formulations." | 1.43 | Pomegranate seed oil nanoemulsions improve the photostability and in vivo antinociceptive effect of a non-steroidal anti-inflammatory drug. ( Barbieri, AV; Beck, RCR; Cervi, VF; Cruz, L; Ferreira, LM; Gehrcke, M; Nogueira, CW; Sari, MHM; Zborowski, VA, 2016) |
| " tragacantha exhibited anti-inflammatory and analgesic properties and they are also safe for medicinal use." | 1.43 | Phytochemical screening, safety evaluation, anti-inflammatory and analgesic studies of the leaf extracts of Sterculia tragacantha. ( Abatan, MO; Adedapo, AA; Mogbojuri, OM, 2016) |
| " EVV produced significant dose-response anti-inflammatory activity against carrageenan-induced paw edema." | 1.43 | Anti-oxidant, anti-inflammatory, analgesic and antipyretic activities of grapevine leaf extract (Vitis vinifera) in mice and identification of its active constituents by LC-MS/MS analyses. ( Aouey, B; Bouaziz, M; Fetoui, H; Samet, AM; Simmonds, MSJ, 2016) |
| "Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, antinociceptive, and antipyretic activities." | 1.42 | Evaluation of antinociceptive activity of nanoliposome-encapsulated and free-form diclofenac in rats and mice. ( Chiong, HS; Goh, JZ; Hakim, MN; Tang, SN; Yong, YK; Zuraini, A, 2015) |
| "Fever was inhibited by BA most significantly by 3hours post-injection of zymosan (1." | 1.40 | Studies on the anti-inflammatory, analgesic and antipyrexic activities of betulinic acid derived from Tetracera potatoria. ( Oridupa, OA; Oyebanji, BO; Saba, AB, 2014) |
| "AE and OE were not toxic to mice since the LD50 was higher than 5000 mg/kg." | 1.40 | Chemical composition, potential toxicity, and quality control procedures of the crude drug of Cyrtopodium macrobulbon. ( Laguna-Hernández, G; Mata, R; Morales-Sánchez, V; Rivero-Cruz, I; Salazar-Chávez, G, 2014) |
| "When acacetin was injected, it produced marked effect with maximum activity of 33." | 1.40 | Antipyretic and antinociceptive potential of extract/fractions of Potentilla evestita and its isolated compound, acacetin. ( Khan, H; Khan, R; Pervez, S; Rauf, A; Ullah, B, 2014) |
| "It is drunk against stomachache, dysenteries, and diarrheas." | 1.39 | Evaluation of mechanisms involved in the antinociception of the ethanol extract from the inner bark of Caesalpinia pyramidalis in mice. ( Santana, DG; Santos, CA; Santos, DS; Thomazzi, SM, 2013) |
| "pretreatment with naloxone (5 µg) reversed the decreased acetic acid-induced writhing response." | 1.39 | Antinociceptive profiles and mechanisms of orally administered coumarin in mice. ( Kang, YJ; Kim, CH; Kim, SJ; Kim, SS; Lim, SM; Park, SH; Sim, YB; Suh, HW, 2013) |
| " In this regard, we carried out to evaluated both antinociceptive and anti-inflammatory activities in experimental models and assess the toxic effects of the acute (single dose) and subchronic (30 days) oral administration of dry extract of Dioscorea villosa in rodents." | 1.39 | Bioassay-guided evaluation of Dioscorea villosa - an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach. ( Araújo, AA; Barreto, RS; de Albuquerque, RL; de Almeida, EB; Lima, AK; Lima, CM; Melo, MG; Moraes, VR; Nogueira, PC; Oliveira, DL; Oliveira, ER; Quintans-Júnior, LJ; Serafini, MR, 2013) |
| "ELPCS exhibited significant peripheral analgesic activity at doses of 60, 80, 100, 200 and 400mg/kg in mice, but it did not display central analgesic activity and not was toxic to LLC-MK2 cell (LD50>400 µg/mL)." | 1.39 | In vivo analgesic activity, toxicity and phytochemical screening of the hydroalcoholic extract from the leaves of Psidium cattleianum Sabine. ( Alvarenga, FQ; Borges, A; e Silva, ML; Esperandim, V; Fonseca, JM; Laurentiz, RS; Leite, MN; Mota, BC; Oliveira, DA; Royo, Vde A, 2013) |
| " Brucine in MTAF was absorbed more completely than it alone at the same dosage of brucine after transdermal administration." | 1.38 | Analgesic and anti-inflammatory activity and pharmacokinetics of alkaloids from seeds of Strychnos nux-vomica after transdermal administration: effect of changes in alkaloid composition. ( Cai, BC; Cai, H; Chen, J; Chen, ZP; Liu, X; Lu, TL; Qu, YG; Wang, X; Xu, F, 2012) |
| "To validate its folk use in the treatment of pain, wood was extracted successively with petroleum ether, chloroform, ethyl acetate, ethanol, and water to produce respective extracts." | 1.38 | Antinociceptive activity of Sesbania sesban (Linn) wood extracts, a preliminary study. ( Bairagi, JH; Mandal, SC; Nirmal, SA; Pal, SC; Patil, AN; Upasani, CD, 2012) |
| "Morphine sulfate was used as reference analgesic agent." | 1.38 | Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents. ( Bum, EN; Dawe, A; De Waard, M; Dimo, T; Dzeufiet, PD; Nguimbou, RM; Sidiki, N; Taïwe, GS; Talla, E, 2012) |
| "In addition, TFC reduced CFA-induced tactile hyperalgesia in a dose-dependent manner and the LD50 of TFC was determined to be 400 mg/kg." | 1.38 | Isolation and biological activity of triglycerides of the fermented mushroom of Coprinus Comatus. ( Guo, JY; Han, CC; Liu, ZQ; Ren, J; Shi, JL, 2012) |
| "Amentoflavone (CF-2) was isolated from the aqueous/n-butanol fraction." | 1.38 | Bioactivity guided isolation of analgesic and anti-inflammatory constituents of Cnestis ferruginea Vahl ex DC (Connaraceae) root. ( Adeyemi, OO; Agbaje, OE; Ishola, IO; Narender, T; Shukla, R, 2012) |
| "crassifolius for the treatment of pain and inflammation." | 1.38 | Anti-nociceptive and anti-inflammatory effects of Croton crassifolius ethanol extract. ( Fang, F; Wang, G; Yang, L; Yu, L; Zhao, J, 2012) |
| "URB937 is a peripherally restricted inhibitor of the anandamide-deactivating enzyme fatty-acid amide hydrolase (FAAH)." | 1.38 | Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier. ( Bertorelli, R; Guijarro, A; Moreno-Sanz, G; Oluyemi, O; Piomelli, D; Reggiani, A; Sasso, O, 2012) |
| "Vitexin, which was isolated from the ethyl acetate extract did not show any activity in all models tested when used alone at the same concentration as it appears in the extract." | 1.38 | Anti-nociceptive activity of Pereskia bleo Kunth. (Cactaceae) leaves extracts. ( Abdul-Wahab, IR; Boylan, F; Fernandes, PD; Guilhon, CC, 2012) |
| "Carvacrol was administered orally, at single doses of 50 and 100 mg/kg while indometacin (5 mg/kg), morphine (7." | 1.38 | Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice. ( Cavalcante Melo, FH; Citó, Mdo C; de Sousa, DP; de Sousa, FC; de Vasconcelos, SM; Fernandes, ML; Rios, ER; Rocha, NF, 2012) |
| "armatum in the treatment of inflammation and pain is warranted." | 1.37 | Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice. ( Cai, CC; Deng, YX; Guo, T; Pan, SL; Wang, YL; Xie, H; Yao, CY, 2011) |
| " Secondly, we developed a sensitive and specific HPLC method to analyze 2', 4'-dihydroxychalcone (TFC, the mainly ingredient of FEO) in rat plasma to study the pharmacokinetic of TEC." | 1.37 | The studies of anti-inflammatory and analgesic activities and pharmacokinetics of Oxytropis falcate Bunge extraction after transdermal administration in rats. ( Cai, BC; Chen, HX; Chen, J; Chen, ZP; Liu, D; Lu, TL; Qu, MM; Xiao, YY, 2011) |
| " The pharmacokinetics and absolute bioavailability of FEO in rat, furthermore, was studied." | 1.37 | The studies of anti-inflammatory and analgesic activities and pharmacokinetics of Oxytropis falcate Bunge extraction after transdermal administration in rats. ( Cai, BC; Chen, HX; Chen, J; Chen, ZP; Liu, D; Lu, TL; Qu, MM; Xiao, YY, 2011) |
| " The inhibition of oedema formation increased with increasing dosage from 25 to 100mg/kg." | 1.37 | Analgesic effects and anti-inflammatory properties of the crude methanolic extract of Schwenckia americana Linn (Solanaceae). ( Abdullahi, N; Adebisi, I; Chika, A; Jimoh, AO; Umar, MT, 2011) |
| " The analgesic activity of the ethanolic extract and its fractions has been carried out by tail-flick method and writhing test at a dosage of 300 mg/kg po." | 1.37 | Anti-inflammatory and anti-nociceptive activities of ethanolic extract and its various fractions from Adiantum capillus veneris Linn. ( Alam, MM; Alam, MS; Gupta, A; Haider, S; Hamid, H; Nazreen, S, 2011) |
| "27%) at 300 mg/kg po dosage when compared to the standard drug Indomethacin (63." | 1.37 | Anti-inflammatory and anti-nociceptive activities of ethanolic extract and its various fractions from Adiantum capillus veneris Linn. ( Alam, MM; Alam, MS; Gupta, A; Haider, S; Hamid, H; Nazreen, S, 2011) |
| " The stretching times of mice induced by acetic acid were significantly reduced by EOC at dosage of 0." | 1.37 | [GC-MS analysis and analgesic activity of essential oil from fresh rhizoma of Cyperus rotundus]. ( Chen, Y; Huang, LQ; Liu, JT; Peng, CS; Wang, XY; Zhao, YY, 2011) |
| "Caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of Annona squamosa and studied for its analgesic and anti-inflammatory activity." | 1.36 | Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark. ( Chavan, MJ; Shinde, DB; Wakte, PS, 2010) |
| "Treatment with violacein showed a significant (p<0." | 1.36 | Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum. ( Antonisamy, P; Ignacimuthu, S, 2010) |
| "Violacein was isolated from Chromobacterium violaceum, a soil Gram negative bacterium collected from the forest water body soil sample of Kolli Hills; Tamil Nadu, India." | 1.36 | Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum. ( Antonisamy, P; Ignacimuthu, S, 2010) |
| "Morin was shown to contain an in vivo anti-inflammatory activity using a carrageenan-induced air pouch model in mice." | 1.36 | Evaluation of the antiangiogenic, anti-inflammatory, and antinociceptive activities of morin. ( Jung, HJ; Kim, SJ; Lim, CJ; Park, EH; Song, YS, 2010) |
| " SO-3 co-administered with morphine left-shift the dose-response curve of morphine in mice acetic acid writhing test and significantly potentiated morphine analgesia in rat formalin test." | 1.36 | Spinal antinociception of synthetic omega-conotoxin SO-3, a selective N-type neuronal voltage-sensitive calcium channel blocker, and its effects on morphine analgesia in chemical stimulus tests in rodent. ( Dong, HJ; Gong, ZH; Huang, PT; Liu, YL; Su, RB; Yan, LD; Zhang, L; Zhou, PL, 2010) |
| "Pain is an unpleasant sensory and emotional experience." | 1.35 | Role of enhanced noradrenergic transmission within the ventral bed nucleus of the stria terminalis in visceral pain-induced aversion in rats. ( Deyama, S; Kaneko, S; Katayama, T; Kondoh, N; Minami, M; Nakagawa, T; Yamaguchi, T; Yoshioka, M, 2009) |
| "Cryptolepine has been shown to inhibit nitric oxide production, and DNA binding of Nuclear Factor-kappa B following inflammatory stimuli in vitro." | 1.35 | Anti-inflammatory properties of cryptolepine. ( Ajayi, AM; Olajide, OA; Wright, CW, 2009) |
| "treatment with naloxone (1 mg/kg) or D-arginine (40 mg/kg)." | 1.35 | Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice. ( Calixto, JB; Chaves, J; Ferreira, VM; Guginski, G; Luiz, AP; Martins, DF; Massaro, M; Mattos, RW; Santos, AR; Silva, MD; Silveira, D, 2009) |
| "Myricetin was also not able to increase the sleeping time induced by pentobarbital, which further indicated that the analgesic effect of myricetin was unrelated to sedation." | 1.35 | Analgesic activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves. ( Cao, YL; Tong, Y; Wang, SJ; Yang, Y; Zhou, XM, 2009) |
| "Pain was severe (65%), with rapid onset (<30 minutes in 79%)." | 1.35 | Irukandji syndrome case series from Australia's Tropical Northern Territory. ( Currie, BJ; Jacups, SP; Nickson, CP; Waugh, EB, 2009) |
| "Activities associated with stings included snorkeling or scuba diving (35%) and swimming (29%)." | 1.35 | Irukandji syndrome case series from Australia's Tropical Northern Territory. ( Currie, BJ; Jacups, SP; Nickson, CP; Waugh, EB, 2009) |
| "Glycine was injected intracerebroventricularly or intrathecally and strychnine, a glycine receptor antagonist, was injected intracerebroventricularly or intrathecally before glycine injection." | 1.35 | Intracerebroventricular or intrathecal injection of glycine produces analgesia in thermal nociception and chemical nociception via glycine receptors. ( Chen, HS; Cheng, MY; Cheng, W; Feng, T; Liu, GJ; Wang, S; Yin, Q; Zeng, YM, 2009) |
| "Coniine has antinociceptive effect via the nicotinic receptors." | 1.35 | Antinociceptive activity of coniine in mice. ( Arihan, O; Boz, M; Ilhan, M; Iskit, AB, 2009) |
| "Guaifenesin alone did not produce any antinociceptive effect." | 1.35 | Guaifenesin enhances the analgesic potency of ibuprofen, nimesulide and celecoxib in mice. ( Dolezal, T; Krsiak, M; Sliva, J; Sykora, D; Vosmanska, M, 2009) |
| "speciosa for treating pain and inflammation." | 1.35 | Anti-inflammatory and analgesic activities of Chaenomeles speciosa fractions in laboratory animals. ( Chen, WS; Li, X; Sun, LN; Yang, Q; Yang, YB, 2009) |
| "Visceral pain is one of the most common forms of pain and for which new drugs would be welcome." | 1.35 | Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. ( Meymandi, MS; Sepehri, G, 2008) |
| "In rat carrageenan-induced tactile allodynia, single administration of nefopam or ketoprofen only partially reduced allodynia." | 1.35 | Nefopam and ketoprofen synergy in rodent models of antinociception. ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008) |
| "Since pain is the main syndrome of dysmenorrhea, the present investigation was carried out to evaluate the analgesic activity of LIG in vivo." | 1.34 | Ligustilide attenuates pain behavior induced by acetic acid or formalin. ( Du, J; Ke, Y; Qian, ZM; Wang, C; Yu, Y; Zhu, L, 2007) |
| "Casticin has potent analgesic and anti-hyperprolactinaemia properties, is likely to be one of the active components of Fructus Viticis, and may have a role in treating PMS (premenstrual syndrom)." | 1.34 | Anti-nociceptive and anti-hyperprolactinemia activities of Fructus Viticis and its effective fractions and chemical constituents. ( Hu, Y; Qin, LP; Rahman, K; Xin, HL; Zhang, QY; Zheng, HC, 2007) |
| "Ketorolac is a non-steroidal anti-inflammatory drug." | 1.34 | Ketorolac-dextran conjugates: synthesis, in vitro and in vivo evaluation. ( Chaturvedi, SC; Trivedi, P; Vyas, S, 2007) |
| "Ketorolac contents were evaluated by UV-spectrophotometric analysis." | 1.34 | Ketorolac-dextran conjugates: synthesis, in vitro and in vivo evaluation. ( Chaturvedi, SC; Trivedi, P; Vyas, S, 2007) |
| "Pain is commonly associated with inflammation." | 1.33 | Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats. ( Kulkarni, SK; Patil, CS; Singh, VP, 2005) |
| "The effect on carrageenan-induced mechanical hyperalgesia, and acetic acid-induced vascular permeability was also determined." | 1.33 | Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats. ( Kulkarni, SK; Patil, CS; Singh, VP, 2005) |
| "Pre-treatment with naloxone (10 mg/kg), a general opioid receptor antagonist, for 5 min, followed by COAE, was found to completely block its peripheral, but not central, antinociceptive activity." | 1.33 | The influences of temperature and naloxone on the antinociceptive activity of Corchorus olitorius L. in mice. ( Fatimah, CA; Mat Jais, AM; Safarul, M; Somchit, MN; Sulaiman, MR; Valsala, R; Zakaria, ZA, 2005) |
| "Remifentanil is a relatively new opioid analgesic related to the fentanyl family of mu opioid receptor agonists and is used clinically for its unique property of having an ultra-short duration of action." | 1.33 | Systemic and spinal administration of the mu opioid, remifentanil, produces antinociception in amphibians. ( Mohan, S; Stevens, CW, 2006) |
| " Systemic and spinal administration of remifentanil produced log dose-response curves which yielded ED50 values of 7." | 1.33 | Systemic and spinal administration of the mu opioid, remifentanil, produces antinociception in amphibians. ( Mohan, S; Stevens, CW, 2006) |
| "Gastric ulcer is a source of visceral pain." | 1.33 | Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats. ( Bogdanov, A; Filaretova, L; Yarushkina, N, 2006) |
| "Gastric ulcers were induced by luminal application of 60% acetic acid under surgical conditions." | 1.33 | Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats. ( Bogdanov, A; Filaretova, L; Yarushkina, N, 2006) |
| "Morphine was also effective in relieving pain in all three tests but with signs of considerable sedation." | 1.33 | Antinociceptive effects of tetrodotoxin (TTX) in rodents. ( Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS, 2006) |
| "Tetrodotoxin (TTX) is a powerful sodium channel blocker extracted from the puffer fish." | 1.33 | Antinociceptive effects of tetrodotoxin (TTX) in rodents. ( Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS, 2006) |
| "It also diminished mechanical allodynia and thermal hyperalgesia with an ED(50) of 1." | 1.33 | Antinociceptive effects of tetrodotoxin (TTX) in rodents. ( Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS, 2006) |
| "Pain is a multidimensional conscious experience including sensory and negative affective components." | 1.32 | Differential contributions of the basolateral and central nuclei of the amygdala in the negative affective component of chemical somatic and visceral pains in rats. ( Minami, M; Nakagawa, T; Satoh, M; Tanimoto, S; Yamauchi, Y, 2003) |
| "Pain was caused by an intraperitoneal injection of 2% acetic acid (0." | 1.32 | [Suppression of visceral pain by action of the low intensity polarized light on acupuncture antinociceptive points]. ( Huliar, SO; Lymans'kyĭ, IuP; Tamarova, ZA, 2003) |
| "Colitis was induced by intracolonic instillation of 4% acetic acid in male Sprague-Dawley rats." | 1.32 | Visceral hypersensitivity and altered colonic motility after subsidence of inflammation in a rat model of colitis. ( Kang, JW; Kim, HJ; Kim, TW; La, JH; Sung, TS; Yang, IS, 2003) |
| " Thus, the direct-compression properties and antiulcerogenic activity, combined with the demonstrated solubilizing power and analgesic effect enhancer ability towards the drug, make chitosan particularly suitable for developing a reduced-dose fast-release solid oral dosage form of naproxen." | 1.32 | Comparison of the effect of chitosan and polyvinylpyrrolidone on dissolution properties and analgesic effect of naproxen. ( Chemtob, C; Maestrelli, F; Mennini, N; Mura, P; Zerrouk, N, 2004) |
| " The compound (2) was the most effective anti-inflammatory one in the carrageenin-induced paw edema in rats and was the only one which showed dose-response correlation for this assay with r = 0." | 1.32 | Analgesic and anti-inflammatory activities evaluation of (-)-O-acetyl, (-)-O-methyl, (-)-O-dimethylethylamine cubebin and their preparation from (-)-cubebin. ( Bastos, JK; Carvalho, JC; da Silva Filho, AA; da Silva, R; de Souza, VA; Donate, PM; e Silva, ML; Pereira, AC; Royo, Vde A; Souza, GH, 2004) |
| " At a dosage of 100mg/kg mouse, the triterpene mixture exhibited 51% analgesic activity but only showed 20% anti-inflammatory activity." | 1.32 | Evaluation of the bioactivity of triterpene mixture isolated from Carmona retusa (Vahl.) Masam leaves. ( Canlas, AP; Faustino, KM; Plana, KG; Villaseñor, IM, 2004) |
| "Pentoxifylline did not inhibit the nociceptive response in the hot plate test in mice." | 1.32 | Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. ( Benevides, VM; Brito, GA; Cunha, FQ; da Rocha, FA; Ferreira, SH; Poole, S; Ribeiro, RA; Sachs, D; Vale, ML, 2004) |
| "We propose that two separate hyperalgesia pathways exist, one of which is NK1 receptor dependent, whereas the other does not require intact substance P/NK1 signalling." | 1.31 | Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene. ( Cervero, F; De Felipe, C; Hunt, SP; Laird, JM; Olivar, T; Roza, C, 2000) |
| "In vitro and in vivo approaches were used to assess whether cizolirtine could affect the spinal release of two pain-related neuropeptides, substance P (SP) and calcitonin gene-related peptide (CGRP), in rats." | 1.31 | The novel analgesic, cizolirtine, inhibits the spinal release of substance P and CGRP in rats. ( Aubel, B; Ballet, S; Bourgoin, AS; Cesselin, F; Farré, A; Hamon, M; Mauborgne, A; Poliénor, H, 2001) |
| "Pretreatment with flavone (50 mg/kg, sc) always exhibited a tendency to reverse the hyperglycemia, if any, but enhanced the antinociceptive response either after swim stress or after dextrose." | 1.31 | Modulation by insulin rather than blood glucose of the pain threshold in acute physiological and flavone induced antinociception in mice. ( Parvathavarthini, S; Rajendran, NN; Ramaswamy, S; Thirugnanasambandam, P; Viswanathan, S, 2001) |
| " At a dosage of 5 mg/20 g mouse, the hexane extract was analgesic as it reduced the number of squirms induced by acetic acid by 59." | 1.31 | Bioactivity studies on Cassia alata Linn. leaf extracts. ( Canlas, AP; Pascua, MP; Sabando, MN; Soliven, LA; Villaseñor, IM, 2002) |
| " LD50 values of the infusion and maceration extracts were 3." | 1.31 | Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats. ( Fadishei, M; Hosseinzadeh, H; Mahmoudi, M; Ramezani, M, 2002) |
| "The chloroformic fraction was the most interesting, exhibiting a good analgesic and anti-inflammatory activity." | 1.31 | Evaluation of the antinflammatory and analgesic activity of Sideritis canariensis var. pannosa in mice. ( Hernández-Pérez, M; Rabanal, RM, 2002) |
| "Acetic acid or 9% NaCl was injected intraperitoneally before the meal." | 1.30 | Tachykininergic mediation of viscerosensitive responses to acute inflammation in rats: role of CGRP. ( Buéno, L; Julia, V, 1997) |
| "Visceral pain was assessed by abdominal muscle contractions." | 1.30 | Tachykininergic mediation of viscerosensitive responses to acute inflammation in rats: role of CGRP. ( Buéno, L; Julia, V, 1997) |
| "Visceral pain was assessed by counting abdominal contractions." | 1.30 | Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats. ( Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ, 1997) |
| " Tablets "Paravit" have mark, which allows exact dosing for children of different age." | 1.30 | [The physiological properties of the action of a new analgesic and antipyretic preparation]. ( Chernykh, VP; Shapovalova, VO, 1997) |
| "Visceral pain was scored by counting abdominal contractions." | 1.30 | Involvement of prostaglandins and CGRP-dependent sensory afferents in peritoneal irritation-induced visceral pain. ( Angel, F; Chevalier, E; Dahl, SG; Diop, L; Friese, N; Rivière, PJ, 1997) |
| " The aim of the present study was to evaluate the comparative efficacy of intramuscularly injected nimesulide with that of diclofenac and to elucidate the pharmacokinetic profile of this formulation." | 1.30 | Comparative analgesic activity of nimesulide and diclofenac by intramuscular route: correlation with pharmacokinetic profile of nimesulide. ( Gupta, SK; Mathur, P; Sengupta, S; Velpandian, T, 1998) |
| " Six hours afterwards, each rat was challenged once with one of the differing it butorphanol doses to construct dose-response curves." | 1.30 | Visceral analgesic tolerance to intrathecal butorphanol in rats. ( Eichhorn, JH; He, Z; Ho, IK; Tsang, BK; Wongchanapai, W, 1998) |
| " The butorphanol-infused groups showed dose-response shifts, demonstrating the development of tolerance to this visceral analgesia." | 1.30 | Visceral analgesic tolerance to intrathecal butorphanol in rats. ( Eichhorn, JH; He, Z; Ho, IK; Tsang, BK; Wongchanapai, W, 1998) |
| "prevented BK and carrageenan-induced hyperalgesia (mean ID50 values of 6 nmol/kg and 13 nmol/kg), without affecting the hyperalgesia induced by des-Arg9-bradykinin (DABK) or by prostaglandin E2 (PGE2)." | 1.30 | Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. ( Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ, 1999) |
| "In the adjuvant arthritis test, the ED30 value (1." | 1.29 | Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs. ( Fujisawa, H; Inoue, K; Inoue, Y; Kimura, K; Kyoi, T; Motonaga, A; Ueda, F, 1994) |
| "When acetic acid was used as a stimulant, daily morphine was administered before or after the acetic acid injection, in the presence or absence of pain, tolerance developed to the same extent as in the control group, regardless of the time of morphine injection." | 1.29 | Development of tolerance to morphine antinociception in mice treated with nociceptive stimulants. ( Kaneto, H; Rahman, AF; Takahashi, M, 1993) |
| "When morphine injection was started from 5 days after the formalin injection, tolerance developed in a pattern similar to that in the control animals." | 1.29 | Development of tolerance to morphine antinociception in mice treated with nociceptive stimulants. ( Kaneto, H; Rahman, AF; Takahashi, M, 1993) |
| "Pretreatment with reserpine (2 mg/kg) significantly reduced the antinociceptive activity of FR64822, when tested against acetic acid writhing." | 1.28 | Involvement of dopamine in the mechanism of action of FR64822, a novel non-opioid antinociceptive compound. ( Nomura, K; Ohkubo, Y; Yamaguchi, I, 1991) |
| " Twice daily dosing at 30 mg/kg p." | 1.27 | Pharmacological effects of SCH 30497--a novel analgesic substance. ( Barnett, A; Berger, JG; Chipkin, RE; Iorio, LC; Latranyi, MB, 1985) |
| "acetic acid) has been investigated during the development of arthritis experimentally induced in rats by s." | 1.27 | [Reduction of the behavioral response to a viscero-peritoneal nociceptive stimulation during the development of experimental polyarthritis in the rat]. ( Calvino, B; Le Bars, D, 1986) |
| "Xylazine and morphine were included in the studies for comparison." | 1.27 | Antinociceptive activity and mechanism of action of detomidine. ( Virtanen, R, 1986) |
| "Pretreatment with naloxone (0." | 1.27 | The antinociceptive effects of histidyl-proline diketopiperazine and thyrotropin-releasing hormone in the mouse. ( Kawamura, S; Kisara, K; Sakurada, S; Sakurada, T; Sasaki, Y; Suzuki, K, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (1.96) | 18.7374 |
| 1990's | 66 (8.60) | 18.2507 |
| 2000's | 302 (39.37) | 29.6817 |
| 2010's | 339 (44.20) | 24.3611 |
| 2020's | 45 (5.87) | 2.80 |
| Authors | Studies |
|---|---|
| Ghanim, AM | 1 |
| Girgis, AS | 2 |
| Kariuki, BM | 1 |
| Samir, N | 1 |
| Said, MF | 1 |
| Abdelnaser, A | 1 |
| Nasr, S | 1 |
| Bekheit, MS | 1 |
| Abdelhameed, MF | 1 |
| Almalki, AJ | 1 |
| Ibrahim, TS | 1 |
| Panda, SS | 2 |
| Lee, YM | 1 |
| Son, E | 1 |
| Kim, SH | 2 |
| Kim, DS | 1 |
| Guo, JY | 2 |
| Song, XR | 1 |
| Wang, YN | 1 |
| Hua, HM | 1 |
| Ren, SM | 1 |
| Pan, YN | 1 |
| Ren, K | 1 |
| Sun, YF | 1 |
| Wang, DM | 1 |
| Liu, XQ | 1 |
| Sauvaget, C | 1 |
| Bazikamwe, S | 1 |
| Lucas, E | 1 |
| Ndayikengurukiye, A | 1 |
| Harerimana, S | 1 |
| Barango, P | 1 |
| de Melo Candeia, GLO | 1 |
| Costa, WK | 1 |
| de Oliveira, AM | 2 |
| Napoleão, TH | 2 |
| Guedes Paiva, PM | 1 |
| Ferreira, MRA | 2 |
| Lira Soares, LA | 1 |
| Ema, RS | 1 |
| Kabir Zihad, SMN | 1 |
| Islam, MN | 2 |
| Sifat, N | 1 |
| Rouf, R | 3 |
| Shilpi, JA | 7 |
| Uddin, SJ | 4 |
| Younis, M | 1 |
| Iqbal, J | 2 |
| Muhammad, S | 3 |
| Jan, SU | 1 |
| Jabbar, A | 1 |
| Mehjabeen, - | 2 |
| Qadir, A | 1 |
| Soomer Khan, N | 1 |
| Arslan, M | 1 |
| Shah, PA | 1 |
| Khan, Z | 1 |
| Wang, QQ | 2 |
| Sun, QR | 2 |
| Ji, XY | 2 |
| Tang, Y | 3 |
| Zhang, K | 2 |
| Wang, XQ | 2 |
| Li, HR | 2 |
| Huang, XZ | 2 |
| Zhang, B | 2 |
| Del Gaudio, MP | 1 |
| Kraus, SI | 1 |
| Melzer, TM | 1 |
| Bustos, PS | 1 |
| Ortega, MG | 1 |
| Sun, Y | 3 |
| Liu, X | 3 |
| Wang, L | 3 |
| Li, L | 4 |
| Quan, X | 1 |
| Shi, H | 1 |
| Wang, T | 2 |
| Mei, L | 1 |
| Chen, Y | 5 |
| Zhang, Y | 6 |
| Li, J | 3 |
| Meng, R | 1 |
| Wang, J | 5 |
| Dai, F | 1 |
| Hitomi, S | 2 |
| Nodai, T | 1 |
| Kokabu, S | 1 |
| Shikayama, T | 1 |
| Sago-Ito, M | 1 |
| Nakatomi, C | 1 |
| Terawaki, K | 2 |
| Omiya, Y | 2 |
| Shinoda, M | 1 |
| Ono, K | 2 |
| Costa, FV | 2 |
| Gonçalves, FL | 1 |
| Borba, JV | 1 |
| Sabadin, GR | 1 |
| Biasuz, E | 1 |
| Santos, LW | 1 |
| Sneddon, LU | 2 |
| Kalueff, AV | 2 |
| Rosemberg, DB | 2 |
| McGee, RG | 1 |
| Webster, AC | 1 |
| Lewis, SR | 1 |
| Welsford, M | 1 |
| Yu, Q | 1 |
| Zhao, Y | 4 |
| Zhang, X | 3 |
| Li, W | 2 |
| Zhang, H | 7 |
| Piao, S | 1 |
| Li, G | 2 |
| Yan, M | 1 |
| Rodrigues, P | 1 |
| Barbosa, LB | 1 |
| Bianchini, AE | 1 |
| Ferrari, FT | 1 |
| Baldisserotto, B | 1 |
| Heinzmann, BM | 1 |
| Olorukooba, AB | 1 |
| Odoma, S | 1 |
| Wu, Y | 2 |
| Shao, S | 1 |
| Guo, Q | 1 |
| Xu, C | 1 |
| Xia, H | 1 |
| Zhang, T | 2 |
| Shi, J | 1 |
| Gulnaz, AR | 1 |
| Mohammed, YHE | 2 |
| Khanum, SA | 1 |
| Sun, N | 2 |
| Feng, Y | 2 |
| Zhang, Q | 3 |
| Liu, J | 3 |
| Zhou, H | 2 |
| Zheng, G | 3 |
| Zhou, J | 3 |
| Yao, G | 3 |
| Osmakov, DI | 2 |
| Koshelev, SG | 2 |
| Palikov, VA | 2 |
| Palikova, YA | 2 |
| Shaykhutdinova, ER | 1 |
| Dyachenko, IA | 2 |
| Andreev, YA | 2 |
| Kozlov, SA | 2 |
| Oliveira de Veras, B | 1 |
| Melo de Oliveira, MB | 1 |
| Granja da Silva Oliveira, F | 1 |
| Queiroz Dos Santos, Y | 1 |
| Saturnino de Oliveira, JR | 1 |
| Lúcia de Menezes Lima, V | 1 |
| Guedes da Silva Almeida, JR | 1 |
| Maria do Amaral Ferraz Navarro, D | 1 |
| Ribeiro de Oliveira Farias de Aguiar, JC | 1 |
| Aguiar, JDS | 1 |
| Gorlach-Lira, K | 1 |
| Dias de Assis, CR | 1 |
| Vanusa da Silva, M | 1 |
| Catarina de Souza Lopes, A | 1 |
| Hao, D | 1 |
| Xu, Y | 4 |
| Zhao, M | 1 |
| Ma, J | 1 |
| Wei, Y | 1 |
| Wang, X | 7 |
| Xu, K | 2 |
| Yan, H | 1 |
| Cao, M | 1 |
| Shao, X | 1 |
| Jin, P | 2 |
| Huang, L | 2 |
| Yue, M | 1 |
| Meng, L | 1 |
| Niu, C | 1 |
| Liu, S | 1 |
| Li, Y | 4 |
| Liu, Y | 4 |
| Ma, S | 1 |
| Liu, F | 1 |
| Qu, J | 1 |
| Yu, S | 1 |
| Tekulu, GH | 1 |
| Hiluf, T | 1 |
| Brhanu, H | 1 |
| Araya, EM | 1 |
| Bitew, H | 1 |
| Haile, T | 1 |
| Spyres, MB | 1 |
| Lapoint, J | 1 |
| Zhang, R | 3 |
| Xu, B | 2 |
| Chen, D | 2 |
| Zhang, M | 3 |
| Zhao, G | 1 |
| Xiao, J | 1 |
| Zhu, H | 1 |
| Niu, J | 1 |
| Li, N | 2 |
| Fang, Q | 2 |
| Lee, D | 1 |
| Ju, MK | 1 |
| Kim, H | 1 |
| Yan, W | 1 |
| Jiang, Z | 1 |
| Fan, F | 1 |
| Yuan, HL | 1 |
| Zhao, YL | 2 |
| Qin, XJ | 1 |
| Liu, YP | 2 |
| Yu, HF | 1 |
| Zhu, PF | 2 |
| Jin, Q | 1 |
| Yang, XW | 1 |
| Luo, XD | 2 |
| Hajhashemi, V | 3 |
| Ghanadian, M | 1 |
| Palizaban, A | 1 |
| Mahnam, K | 1 |
| Eshaghi, H | 1 |
| Gheisari, B | 1 |
| Sadeghi-Aliabadi, H | 1 |
| Honkanadavar, HH | 1 |
| George, RF | 1 |
| Srour, AM | 1 |
| Aggarwal, R | 1 |
| Kaushik, P | 1 |
| Kumar, A | 3 |
| Saini, D | 1 |
| Almeida, DS | 1 |
| da Silva, DPB | 2 |
| Moreira, LKDS | 1 |
| Menegatti, R | 2 |
| Lião, LM | 2 |
| Sanz, G | 2 |
| Vaz, BG | 2 |
| Ghedini, PC | 1 |
| Costa, EA | 8 |
| Florentino, IF | 4 |
| Galvão, GM | 1 |
| Sabino, JR | 1 |
| Cardoso, CS | 1 |
| Silva, ALP | 1 |
| da Silva, ACG | 1 |
| Valadares, MC | 1 |
| Leite, JA | 1 |
| de S Gil, E | 1 |
| Syed, MH | 1 |
| Gnanakkan, A | 1 |
| Pitchiah, S | 1 |
| Alamgeer, - | 1 |
| Nasreen, P | 1 |
| Uttra, AM | 1 |
| Asif, H | 1 |
| Younis, W | 1 |
| Hasan, UH | 1 |
| Irfan, HM | 1 |
| Sharif, A | 1 |
| Al-Ostoot, FH | 1 |
| Grisha, S | 1 |
| Vivek, HK | 1 |
| Ara Khanum, S | 1 |
| Diao, F | 1 |
| Ruan, Y | 1 |
| Chen, G | 2 |
| Tang, T | 1 |
| Lin, W | 1 |
| Dong, M | 1 |
| Liu, T | 1 |
| Mei, Q | 1 |
| Noguchi, T | 1 |
| Umezaki, Y | 1 |
| Takano, R | 1 |
| Fujimoto, T | 1 |
| Domon, Y | 1 |
| Kubota, K | 2 |
| Ueda, K | 1 |
| Kawase, Y | 1 |
| Yabe, K | 1 |
| Yokoyama, M | 1 |
| Shimada, K | 1 |
| Góra, M | 1 |
| Czopek, A | 1 |
| Rapacz, A | 1 |
| Giza, A | 1 |
| Koczurkiewicz-Adamczyk, P | 1 |
| Pękala, E | 1 |
| Obniska, J | 1 |
| Kamiński, K | 1 |
| Vasincu, IM | 1 |
| Apotrosoaei, M | 1 |
| Constantin, S | 1 |
| Butnaru, M | 1 |
| Vereștiuc, L | 1 |
| Lupușoru, CE | 2 |
| Buron, F | 1 |
| Routier, S | 1 |
| Lupașcu, D | 1 |
| Taușer, RG | 1 |
| Profire, L | 1 |
| Reza, MS | 1 |
| Jashimuddin, M | 1 |
| Ahmed, J | 1 |
| Abeer, M | 1 |
| Naznin, NE | 1 |
| Jafrin, S | 1 |
| Haque, ME | 1 |
| Barek, MA | 2 |
| Ud Daula, AFMS | 2 |
| Sesaazi, CD | 1 |
| Peter, EL | 1 |
| Mtewa, AG | 1 |
| Deng, J | 1 |
| Han, J | 2 |
| Chen, J | 7 |
| Huang, Q | 2 |
| Wang, Y | 9 |
| Qi, X | 1 |
| Liu, Z | 3 |
| Leung, EL | 1 |
| Wang, D | 3 |
| Feng, Q | 1 |
| Lu, L | 1 |
| Yuan, X | 1 |
| Ma, X | 1 |
| Gowayed, MA | 1 |
| Abdel-Bary, A | 1 |
| El-Tahan, RA | 1 |
| Uddin Chy, MN | 1 |
| Adnan, M | 1 |
| Chowdhury, MR | 2 |
| Pagano, E | 1 |
| Kamal, ATMM | 1 |
| Oh, KK | 1 |
| Cho, DH | 1 |
| Capasso, R | 1 |
| Yang, X | 4 |
| Dai, Y | 1 |
| Ji, Z | 1 |
| Fu, W | 2 |
| Han, C | 1 |
| Elwood, RW | 1 |
| Dalton, N | 1 |
| Riddell, G | 1 |
| Zucoloto, AZ | 1 |
| Manchope, MF | 1 |
| Staurengo-Ferrari, L | 2 |
| Alves-Filho, JC | 1 |
| Cunha, TM | 4 |
| Antunes, MM | 1 |
| Menezes, GB | 1 |
| Cunha, FQ | 7 |
| Casagrande, R | 4 |
| Verri, WA | 4 |
| Boakye-Gyasi, E | 1 |
| Henneh, IT | 1 |
| Abotsi, WKM | 1 |
| Ameyaw, EO | 1 |
| Woode, E | 1 |
| Ponomarev, K | 1 |
| Morozova, E | 1 |
| Pavlova, A | 1 |
| Suslov, E | 1 |
| Korchagina, D | 1 |
| Nefedov, A | 1 |
| Tolstikova, T | 1 |
| Volcho, K | 1 |
| Salakhutdinov, N | 1 |
| Gutiérrez, SD | 1 |
| Kuri, SA | 1 |
| Martín-Herrera, D | 1 |
| Regalado, AI | 1 |
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| França, DS | 1 |
| Souza, AL | 1 |
| Almeida, KR | 1 |
| Dolabella, SS | 1 |
| Martinelli, C | 1 |
| Coelho, MM | 1 |
| Novakovic, SD | 1 |
| Tzoumaka, E | 1 |
| Erickson, VL | 1 |
| Erickson, KA | 1 |
| Ikeda, Y | 1 |
| Naraba, H | 1 |
| Rajendran, NN | 1 |
| Thirugnanasambandam, P | 1 |
| Parvathavarthini, S | 1 |
| Ramaswamy, S | 1 |
| Aktay, G | 1 |
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| Bianchi, B | 1 |
| McDonald, H | 1 |
| Cartmell, J | 1 |
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| Jarvis, MF | 1 |
| Pascua, MP | 1 |
| Sabando, MN | 1 |
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| Albuquerque, FA | 1 |
| Maciel, MA | 1 |
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| Amoretti, L | 1 |
| Tognolini, M | 1 |
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| Jagiełło-Wójtowicz, E | 2 |
| Kleinrok, Z | 2 |
| Chodkowska, A | 2 |
| Feldo, M | 2 |
| Nowicky, JW | 2 |
| Serrano, I | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluating Thermal Ablation in the Treatment of Cervical Neoplasia[NCT05211271] | 86 participants (Actual) | Interventional | 2018-10-01 | Completed | |||
| A Phase II, Randomized, Double Blind, Double Dummy, Active-Controlled Clinical Trial to Investigate the Efficacy and Safety of Low-Glu in Patients Newly Diagnosed With Type II Diabetes Mellitus[NCT05343767] | 198 participants (Actual) | Interventional | 2018-09-12 | Completed | |||
| Effects of Lavender Aromatherapy and Cold Application on Pain During Drain Removal[NCT04798040] | 121 participants (Actual) | Interventional | 2021-09-01 | Completed | |||
| Elderly Patients With Dementia in the Department of Acute Geriatrics: Pilot Study, Monocentric, Randomized Use of Aromatherapy as a Complementary Treatment to Psychopharmacotherapy in Psychological Disorders and BPSD Behavior[NCT03662360] | 32 participants (Actual) | Interventional | 2018-05-20 | Completed | |||
| A Randomized Prospective Placebo-Controlled Study of the Effects of Lavender Aromatherapy on Preoperative Anxiety in Breast Surgery Patients[NCT01837966] | 93 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| Placebo-Controlled Crossover Trial of Levetiracetam on Ethanol Intake[NCT01168687] | 46 participants (Actual) | Interventional | 2008-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Neuropsychiatric Inventory - Nursing Home Version (NPI-NH) test will characterize the neuropsychiatric and psychopathological symptoms of patients affected by dementia.~Events as delirium, anxiety, depression, etc. will be recorded by the frequency (from 0, absence, to 4, high frequency) and the seriousness (from 0, absence, to 3, high). The total score of the NPI-NH is given by the frequency x (multiply) seriousness (total score for each event has a range from 0 to 12). The patient final score will be given by the sum of the score of the 12 events. For each patient will be given a total score from 0 to 144.~NPI NH score has been collected in both control and aromatherapy groups at T1 and T3, in patients who needed and who did not needed Pro Re Nata." (NCT03662360)
Timeframe: Time 1 (baseline) and Time 3 (day 7)
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| T1 NPI score in patients do not need Pro Re Nata | T3 NPI score in patients needed Pro Re Nata | T3 NPI score in patients do not need Pro Re Nata | |
| GROUP A - Control Group | 21.81 | 32.87 | 20.00 |
| GROUP B - Aromatherapy Group | 25.93 | 16.5 | 7.25 |
NPI-NH assess the psychological distress in physicians, nurses and nursing assistants who managed the patients. It has a score from 0 (no discomfort) to score of 5 (extreme discomfort). The psychological distress is measured for each of the 12 events in the NPI-NH scale, for a total score from 0 to 60. (NCT03662360)
Timeframe: Time 1 (baseline) and Time 3 (day 7)
| Intervention | score on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T1 NPI NH physicians in pts with PRN | T1 NPI NH physicians in pts without PRN | T1 NPI NH nurses in pts with PRN | T1 NPI NH nurses in pts without PRN | T1 NPI NH nursing assistants in pts with PRN | T1 NPI NH nursing assistants in pts without PRN | T3 NPI NH physician in pts with PRN | T3 NPI NH physician in pts without PRN | T3 NPI NH nurses in pts with PRN | T3 NPI NH nurses in pts without PRN | T3 NPI NH nursing assistants in pts with PRN | T3 NPI NH nursing assistants in pts without PRN | |
| GROUP A - Control Group | 4.19 | 1.60 | 9.63 | 6.40 | 11.00 | 7.10 | 6.00 | 3.20 | 12.00 | 9.30 | 13.19 | 9.90 |
| GROUP B - Aromatherapy Group | 5.64 | 4.13 | 11.64 | 10.13 | 12.21 | 10.88 | 2.64 | 0.88 | 5.79 | 4.25 | 5.93 | 4.38 |
We hoped to show that lavender aroma therapy reduces preoperative anxiety in patients undergoing breast. The Trait subscale (STAI-TRAID) of the Spielberger State-Trait Anxiety Inventory was administered before and after 10 minutes of aromatherapy treatment pre-surgery. The TRAIT subscale contains 20 questions scored on a Likert scale from 1-4; item scores are summed for a total score ranging from 20 to 80, with higher scores indicating higher anxiety. Change in anxiety was calculated as the score pre-aromatherapy minus the score post-aromatherapy. Higher positive change scores indicate greater reductions in anxiety. (NCT01837966)
Timeframe: 20 minutes before surgery (pre aromatherapy) and 10 minutes before surgery (post aromatherapy)
| Intervention | units on a scale (Mean) |
|---|---|
| Lavender Oil | 0.89 |
| Placebo | .74 |
The primary outcome of this study is to determine the effect of levetiracetam on alcohol consumption as measured by change in # of drinks during each treatment period. (NCT01168687)
Timeframe: During each 14 day treatment period
| Intervention | number of drinks per treatment period (Mean) |
|---|---|
| All Subjects (n = 46) Placebo | 41.2 |
| All Subjects (n = 46) Levetiracetam | 45.4 |
5 reviews available for acetic acid and Ache
| Article | Year |
|---|---|
The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data.
Topics: Acetic Acid; Analgesics; Animals; Hypnotics and Sedatives; Mice; Neoplasms; Pain; Plant Extracts; Ti | 2023 |
The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data.
Topics: Acetic Acid; Analgesics; Animals; Hypnotics and Sedatives; Mice; Neoplasms; Pain; Plant Extracts; Ti | 2023 |
The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data.
Topics: Acetic Acid; Analgesics; Animals; Hypnotics and Sedatives; Mice; Neoplasms; Pain; Plant Extracts; Ti | 2023 |
The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data.
Topics: Acetic Acid; Analgesics; Animals; Hypnotics and Sedatives; Mice; Neoplasms; Pain; Plant Extracts; Ti | 2023 |
Interventions for the symptoms and signs resulting from jellyfish stings.
Topics: Acetic Acid; Adult; Ammonia; Child; Humans; Pain | 2023 |
Identification and management of marine envenomations\
in pediatric patients
Topics: Acetic Acid; Anti-Bacterial Agents; Antivenins; Bites and Stings; Child; Child, Preschool; Critical | 2020 |
Irukandji Syndrome: what nurses need to know.
Topics: Acetic Acid; Administration, Cutaneous; Algorithms; Animals; Australia; Benchmarking; Bites and Stin | 2006 |
Opioid and catecholaminergic mechanisms of different types of analgesia.
Topics: Acetates; Acetic Acid; Acupuncture Therapy; Analgesia; Animals; Electric Stimulation; Electroshock; | 1986 |
2 trials available for acetic acid and Ache
| Article | Year |
|---|---|
A randomized paired comparison trial of cutaneous treatments for acute jellyfish (Carybdea alata) stings.
Topics: Acetic Acid; Administration, Cutaneous; Adult; Bites and Stings; Cubozoa; Emergency Treatment; Femal | 2002 |
A prospective, double-blind, randomized cross-over study evaluating changes in urinary pH for relieving the symptoms of interstitial cystitis.
Topics: Acetic Acid; Buffers; Cross-Over Studies; Cystitis, Interstitial; Double-Blind Method; Female; Human | 2005 |
760 other studies available for acetic acid and Ache
| Article | Year |
|---|---|
Design and synthesis of ibuprofen-quinoline conjugates as potential anti-inflammatory and analgesic drug candidates.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cycloox | 2022 |
Anti-Inflammatory and Analgesic Effects of
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Iodoacetic Acid; Lipopolysaccharides; Mi | 2022 |
Isolation, molecular characterization, immunological and anticoagulatant activities of polysaccharides from frankincense and its vinegar processed product.
Topics: Acetic Acid; Animals; Boswellia; Frankincense; Oils, Volatile; Pain; Polysaccharides; Rats; Rats, Sp | 2022 |
Evaluation of effectiveness, acceptability and safety of thermal ablation in the treatment of cervical neoplasia in Burundi.
Topics: Acetic Acid; Burundi; Colposcopy; Female; Humans; Longitudinal Studies; Middle Aged; Pain; Pregnancy | 2022 |
Anti-inflammatory, antinociceptive effects and involvement of opioid receptors in the antinociceptive activity of Eugenia uniflora leaves obtained with water, ethanol, and propylene glycol mixture.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Ethanol; Eugenia; Mi | 2022 |
Analgesic, anti-inflammatory activity and metabolite profiling of the methanolic extract of Callicarpa arborea Roxb. leaves.
Topics: Acetic Acid; Albumins; Analgesics; Animals; Anti-Inflammatory Agents; Callicarpa; Edema; Humans; Met | 2023 |
Evaluation of anti-inflammatory and analgesic effects of Hertia intermedia (Boiss.) Kuntze extract.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Carrageenan; Edema | 2022 |
Antinociceptive effect and identification of berberine alkaloid in Berberis ruscifolia extracts.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Berberine; Berberis; Edema; Ethanol; Formaldehyde; Mice | 2023 |
Losartan attenuates acetic acid enema-induced visceral hypersensitivity by inhibiting the ACE1/Ang II/AT1 receptor axis in enteric glial cells.
Topics: Acetic Acid; Animals; Enema; Irritable Bowel Syndrome; Lipopolysaccharides; Losartan; Neuroglia; Pai | 2023 |
Hepcidin expression in the trigeminal ganglion and the oral mucosa in an oral ulcerative mucositis rat model.
Topics: Acetic Acid; Animals; Hepcidins; Iron; Male; Mouth Mucosa; Mucositis; Pain; Quality of Life; Rats; R | 2023 |
Acetic acid-induced pain elicits stress-, and camouflage-related responses in zebrafish: Modulatory effects of opioidergic drugs on neurobehavioral phenotypes.
Topics: Acetic Acid; Animals; Hydrocortisone; Mammals; Morphine; Naloxone; Pain; Phenotype; Zebrafish | 2023 |
The beneficial effect of Sanhuang ointment and its active constituents on experimental hemorrhoids in rats.
Topics: Acetic Acid; Animals; Hemorrhoids; Ointments; Pain; Rats; Vascular Endothelial Growth Factor A | 2024 |
Nociceptive-like behavior and analgesia in silver catfish (Rhamdia quelen).
Topics: Acetic Acid; Analgesia; Analgesics, Opioid; Animals; Catfishes; Disease Models, Animal; Injections; | 2019 |
Elucidation of the possible mechanism of analgesic action of methanol stem bark extract of Uapaca togoensis pax in mice.
Topics: Acetic Acid; Analgesics; Animals; Atropine; Coffea; Female; Glyburide; Lethal Dose 50; Male; Methano | 2019 |
Aconicatisulfonines A and B, Analgesic Zwitterionic C
Topics: Acetic Acid; Aconitum; Analgesics; Diterpenes; Models, Molecular; Molecular Conformation; Pain; Pain | 2019 |
Design, synthesis and molecular docking of benzophenone conjugated with oxadiazole sulphur bridge pyrazole pharmacophores as anti inflammatory and analgesic agents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Cyclooxyge | 2019 |
Analgesic diterpenoids with diverse carbon skeletons from the leaves of Rhododendron auriculatum.
Topics: Acetic Acid; Analgesics; Animals; Carbon; Disease Models, Animal; Diterpenes; Dose-Response Relation | 2019 |
Alkaloid Lindoldhamine Inhibits Acid-Sensing Ion Channel 1a and Reveals Anti-Inflammatory Properties.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Animals; Anti-Inflammator | 2019 |
Chemical composition and evaluation of the antinociceptive, antioxidant and antimicrobial effects of essential oil from Hymenaea cangaceira (Pinto, Mansano & Azevedo) native to Brazil: A natural medicine.
Topics: Acetic Acid; Analgesics; Animals; Anti-Bacterial Agents; Antioxidants; Brazil; Disease Models, Anima | 2020 |
RETRACTED: Biosynthesis of Clinacanthus nutans Lindau leaf extract mediated ag NPs, au NPs and their comparative strong muscle relaxant, analgesic activities for pain management in nursing care for using in intensive nursing care unit.
Topics: Acanthaceae; Acetic Acid; Analgesics; Animals; Gold; Green Chemistry Technology; Metal Nanoparticles | 2020 |
Selaginella convolute extract mediated synthesis of ZnO NPs for pain management in emerging nursing care.
Topics: Acetic Acid; Animals; Green Chemistry Technology; Locomotion; Metal Nanoparticles; Mice; Mice, Inbre | 2020 |
Grayanane diterpenoid glucosides as potent analgesics from Pieris japonica.
Topics: Acetic Acid; Analgesics; Animals; Diterpenes; Dose-Response Relationship, Drug; Ericaceae; Female; G | 2020 |
Diterpenoids with diverse carbon skeletons from the roots of Pieris formosa and their analgesic and antifeedant activities.
Topics: Acetic Acid; Analgesics; Animals; Diterpenes; Dose-Response Relationship, Drug; Ericaceae; Feeding B | 2020 |
Anti-inflammatory and anti-nociceptive property of Capparis tomentosa Lam. root extracts.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capparis; Carrageenan; Edema; Female; Hy | 2020 |
Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Drug Tolerance; Fascia; Formaldehyde; Hot Temperature; Hyp | 2020 |
Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cartilage, Arti | 2020 |
Analgesic action of Rubimaillin in vitro and in vivo.
Topics: Acetic Acid; Analgesics; Animals; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Formaldehyde; Lipopoly | 2020 |
Anti-inflammatory and analgesic activities of Neolamarckia cadamba and its bioactive monoterpenoid indole alkaloids.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Disease Models, | 2020 |
Cycloarta-23-ene-3beta,25-diol a pentacyclic steroid from Euphorbia spinidens, as COX inhibitor with molecular docking, and in vivo study of its analgesic and anti-inflammatory activities in male swiss mice and wistar rats.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Chlorocebus aethiops; Cyclo | 2020 |
Synthesis of new ibuprofen hybrid conjugates as potential anti-inflammatory and analgesic agents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygena | 2020 |
Design, Synthesis and Biological Evaluation of 5-amino-3-aryl-1-(6'-chloropyridazin-3'-yl)pyrazoles and their Derivatives as Analgesic Agents.
Topics: Acetic Acid; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug De | 2020 |
Investigation of anti-inflammatory potential of 5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione compound.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Edema; Hyperal | 2020 |
Anti-inflammatory and antinociceptive activity profile of a new lead compound - LQFM219.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; BALB 3T3 Cells; Carrageena | 2020 |
Exploration of acute toxicity, analgesic, anti-inflammatory, and anti-pyretic activities of the black tunicate, Phallusia nigra (Savigny, 1816) using mice model.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Mice; Pain; Phytotherapy; Plant E | 2021 |
Evaluation of anti-inflammatory and analgesic activities of aqueous methanolic extract of Ranunculus muricatus in albino mice.
Topics: Acetic Acid; Albumins; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, A | 2020 |
Molecular docking and synthesis of caffeic acid analogous and its anti-inflammatory, analgesic and ulcerogenic studies.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeic Acids; Carrageena | 2021 |
Jiaolong capsule protects SD rats against 2,4,6-trinitrobenzene sulfonic acid induced colitis.
Topics: Acetic Acid; Animals; Behavior, Animal; Colitis, Ulcerative; Colon; Cyclooxygenase 2; Dinoprostone; | 2021 |
A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity.
Topics: Acetic Acid; Amines; Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Rel | 2021 |
Design, Synthesis and Biological Activity of New Amides Derived from 3-Benzhydryl and 3-sec-Butyl-2,5-dioxo-pyrrolidin-1-yl-acetic Acid.
Topics: Acetic Acid; Amides; Analgesics; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationsh | 2021 |
New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Surviva | 2021 |
Pharmacological investigation of analgesic and antipyretic activities of methanol extract of the whole part of Aeginetia indica.
Topics: Acetic Acid; Analgesics; Animals; Antioxidants; Antipyretics; Behavior, Animal; Disease Models, Anim | 2021 |
The anti-nociceptive effects of ethanol extract of aerial parts of Schkuhria pinnata in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Asteraceae; Behavior, Animal; Disease Models | 2021 |
Comparison of analgesic activities of aconitine in different mice pain models.
Topics: Acetic Acid; Aconitine; Analgesics; Animals; Aspirin; Disease Models, Animal; Edema; Female; Formald | 2021 |
Structurally diverse diterpenoids with eight carbon skeletons from Rhododendron micranthum and their antinociceptive effects.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Diterpenes; Dose-Response Relationship, Drug; Fe | 2021 |
The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Dic | 2021 |
Central and peripheral pain intervention by Ophiorrhizarugosa leaves: Potential underlying mechanisms and insight into the role of pain modulators.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Central N | 2021 |
Allium macrostemon Bunge. exerts analgesic activity by inhibiting NaV1.7 channel.
Topics: Acetic Acid; Analgesics; Animals; Cell Survival; Chive; Formaldehyde; Ganglia, Spinal; HEK293 Cells; | 2021 |
Aversive responses by shore crabs to acetic acid but not to capsaicin.
Topics: Acetic Acid; Animals; Brachyura; Capsaicin; Male; Nociception; Pain | 2017 |
Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Benzoquinones; Carrage | 2017 |
Hydro-ethanolic leaf extract of Ziziphus abyssinica Hochst Ex A. Rich (Rhamnaceae) exhibits anti-nociceptive effects in murine models.
Topics: Acetic Acid; Africa; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; D | 2017 |
Synthesis and Analgesic Activity of Amines Combining Diazaadamantane and Monoterpene Fragments.
Topics: Acetic Acid; Adamantane; Administration, Oral; Amines; Analgesics; Animals; Dose-Response Relationsh | 2017 |
The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Chemical Fractionation; Female; Male; Mi | 2017 |
Antinociceptive Activity of Methanol Extract of Tabebuia hypoleuca (C. Wright ex Sauvalle) Urb. Stems.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Cuba; Female; Male; Methanol; Mice; Mice, In | 2017 |
Synergistic analgesic, anti-pyretic and anti-inflammatory effects of extra virgin olive oil and ibuprofen in different experimental models of albino mice.
Topics: Acetic Acid; Albinism; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Carrageenan; Din | 2017 |
Phytochemical and biological assessments on Lipidium meyenii (maca) and Epimidium sagittatum (horny goat weed).
Topics: Acetic Acid; Analgesics; Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Dise | 2017 |
Report: Analgesic and anti-inflammatory activity of aqueous-methanolic extract of Aerva javanica.
Topics: Acetic Acid; Amaranthaceae; Analgesics; Animals; Anti-Inflammatory Agents; Chondrus; Disease Models, | 2017 |
Synthesis, Structural Characterization and Antinociceptive Activities of New Arylated Quinolines via Suzuki-Miyaura Cross Coupling Reaction.
Topics: Acetic Acid; Analgesics; Animals; Crystallography, X-Ray; Dose-Response Relationship, Drug; Female; | 2017 |
Proteins from the Rhinella schneideri parotoid gland secretion exhibit anti-nociceptive effect against nociception induced by inflammation.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Bufonidae; Disease Models, Animal; Edema | 2017 |
Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain.
Topics: Acetic Acid; Acetylcholinesterase; Acute Disease; Analgesics; Animals; Brain; Chronic Disease; Freun | 2017 |
7-Chloro-4-phenylsulfonyl quinoline, a new antinociceptive and anti-inflammatory molecule: Structural improvement of a quinoline derivate with pharmacological activity.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Croton Oil; Edema; Hot Temperature; Huma | 2017 |
Inhibitory effects of Dianthi Herba ethanolic extract on inflammatory and nociceptive responses in murine macrophages and mouse models of abdominal writhing and ear edema.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cytokines; Dianthus; Ed | 2018 |
Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Cannabinoid Receptor Agonists; Cannabinoids; Diseas | 2018 |
Anti-ulcer and anti-Helicobacter pylori potentials of the ethyl acetate fraction of Physalis alkekengi L. var. franchetii (Solanaceae) in rodent.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Ul | 2018 |
Acute toxicity study and anti-nociceptive activity of Bauhinia acuminata Linn. leaf extracts in experimental animal models.
Topics: Acetic Acid; Analgesics; Animals; Bauhinia; Disease Models, Animal; Male; Mice; Pain; Pain Measureme | 2018 |
Analgesic activities of crude ethanolic extract and various fractions of Adansonia digitata L. grown at the sindh province of Pakistan.
Topics: Acetic Acid; Adansonia; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response | 2017 |
Discovery of Peripheral κ-Opioid Receptor Agonists as Novel Analgesics.
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Discovery; Male; Mice; Mice | 2017 |
Anti-inflammatory and analgesic activities of cupressuflavone from Cupressus macrocarpa: Impact on pro-inflammatory mediators.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Biflavonoids; Carrageenan; Cupressus; Cy | 2018 |
Screening of analgesic activity of Tunisian Urtica dioica and analysis of its major bioactive compounds by GCMS.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Discovery | 2018 |
Synthesis, characterization and antinociceptive activities of Novel 2-(2,4-dichlorophenyl)-4H-chromen-4-one.
Topics: Acetic Acid; Analgesics; Animals; Carbon-13 Magnetic Resonance Spectroscopy; Chromones; Disease Mode | 2017 |
Formulation Optimization and In-vitro and In-vivo Evaluation of Lornoxicam Ethosomal Gels with Penetration Enhancers.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Drug Compoun | 2018 |
Pharmacological activities of the organic extracts and fatty acid composition of the petroleum ether extract from Haplophyllum tuberculatum leaves.
Topics: Acetic Acid; Alkanes; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Carrageenan; | 2018 |
Antinociception of the spirocyclopiperazinium salt compound LXM-15 via activating α7 nAChR and M4 mAChR and inhibiting CaMKIIα/cAMP/CREB/CGRP signalling pathway in mice.
Topics: Acetic Acid; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Calcitonin Gene-Related P | 2018 |
Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Formaldehyde; | 2018 |
Antinociceptive effects of the endogenous cannabinoid peptide agonist VD-hemopressin(β) in mice.
Topics: Acetic Acid; Analgesics; Animals; Area Under Curve; Disease Models, Animal; Dose-Response Relationsh | 2018 |
Increased Asics Expression via the Camkii-CREB Pathway in a Novel Mouse Model of Trigeminal Pain.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Acrylamides; Amiloride; A | 2018 |
Saline extract of Pilosocereus gounellei stem has antinociceptive effect in mice without showing acute toxicity and altering motor coordination.
Topics: Acetic Acid; Analgesics; Animals; Artemia; Cactaceae; Cholesterol; Female; Formaldehyde; Hot Tempera | 2018 |
Oil from the fruits of Pterodon emarginatus Vog.: A traditional anti-inflammatory. Study combining in vivo and in silico.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Croton Oil; Cyclooxygenase | 2018 |
Anti-inflammatory and antinociceptive activities of the leaf methanol extract of Miconia minutiflora (Bonpl.) DC. and characterization of compounds by UPLC-DAD-QTOF-MS/MS.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Chr | 2019 |
Sida tuberculata extract reduces the nociceptive response by chemical noxious stimuli in mice: Implications for mechanism of action, relation to chemical composition and molecular docking.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Brazil; Formaldehyde; Male; Malvaceae; Methanol; | 2019 |
Comparative analgesic evaluation of Himalrandia tetrasperma and Wendlandia exserta of family Rubiaceae after induction of pain in mice.
Topics: Acetic Acid; Analgesics; Animals; Aspirin; Behavior, Animal; Disease Models, Animal; Hot Temperature | 2018 |
Analgesic Activity of Acid-Sensing Ion Channel 3 (ASIС3) Inhibitors: Sea Anemones Peptides Ugr9-1 and APETx2 versus Low Molecular Weight Compounds.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Analgesics; Animals; Biol | 2018 |
Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity.
Topics: Acetic Acid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Formald | 2019 |
Mefenamic acid-loaded solid SMEDDS: an innovative aspect for dose reduction and improved pharmacodynamic profile.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Avai | 2019 |
Anti-inflammatory and analgesic activity based on polymorphism of cedrol in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cotton Fiber; Edema; Female | 2019 |
Acute Administration of Desformylflustrabromine Relieves Chemically Induced Pain in CD-1 Mice.
Topics: Acetic Acid; Allosteric Regulation; Analgesics; Animals; Formaldehyde; Hydrocarbons, Brominated; Ind | 2019 |
Acute anti-inflammatory and anti-nociceptive activities of crude extracts, alkaloid fraction and evolitrine from Acronychia pedunculata leaves.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Female; M | 2019 |
Antinociceptive and anti-arthritic effects of aqueous whole plant extract of Trianthema portulacastrum in rodents: Possible mechanisms of action.
Topics: Acetic Acid; Aizoaceae; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carr | 2019 |
Comparative study of liposomes, ethosomes and transfersomes as carriers for enhancing the transdermal delivery of diflunisal: In vitro and in vivo evaluation.
Topics: Acetic Acid; Administration, Cutaneous; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; | 2019 |
Antinociceptive and antioxidant effects of extract enriched with active indole alkaloids from leaves of Tabernaemontana catharinensis A. DC.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Antioxidants; Biphenyl Compounds; Male; Mice; Pain; Pic | 2019 |
Chemical profiling of secondary metabolites of Eugenia uniflora and their antioxidant, anti-inflammatory, pain killing and anti-diabetic activities: A comprehensive approach.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Antipyretics; Carrageenan; | 2019 |
Naloxone prolongs abdominal constriction writhing-like behavior in a zebrafish-based pain model.
Topics: Abdomen; Acetic Acid; Animals; Behavior, Animal; Constriction, Pathologic; Disease Models, Animal; N | 2019 |
Antipyretic and anti-nociceptive effects of methanol extract of leaves of Fimbristylis miliacea in mice model.
Topics: Acetic Acid; Analgesics; Animals; Antipyretics; Cyperaceae; Disease Models, Animal; Female; Fever; F | 2019 |
Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core.
Topics: Acetic Acid; Analgesics; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Discovery; | 2020 |
Cannabinoid system involves in the analgesic effect of protocatechuic acid.
Topics: Acetic Acid; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxyb | 2019 |
Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Female; Male; Mice, Inbred ICR; Pain; Phytochemicals; P | 2019 |
Dietary component p-coumaric acid suppresses monosodium urate crystal-induced inflammation in rats.
Topics: Acetic Acid; Acid Phosphatase; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; beta-Glu | 2013 |
Purification and characterization of a novel antinociceptive peptide from venom of Agkistrodon halys Pallas.
Topics: Acetic Acid; Agkistrodon; Amino Acid Sequence; Analgesics; Animals; Behavior, Animal; Chemical Fract | 2013 |
Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models.
Topics: Acetic Acid; Amides; Analgesics; Animals; Behavior, Animal; Capsaicin; Female; Formaldehyde; Fumarat | 2013 |
Systemic synergism between codeine and morphine in three pain models in mice.
Topics: Acetic Acid; Acute Pain; Analgesics, Opioid; Animals; Behavior, Animal; Codeine; Disease Models, Ani | 2013 |
Anti-inflammatory and analgesic activities of Melanthera scandens.
Topics: Acetic Acid; Albumins; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Carrageenan; Edema | 2012 |
Evaluation of mechanisms involved in the antinociception of the ethanol extract from the inner bark of Caesalpinia pyramidalis in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Behavior, Animal; Caesalpinia; Capsaicin; Ethanol; Femal | 2013 |
Beneficial effects of Anadenanthera colubrina (Vell.) Brenan extract on the inflammatory and nociceptive responses in rodent models.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Fabaceae; Hot Temper | 2013 |
Antinociceptive activity of Rhoifoline A from the ethanol extract of Zanthoxylum nitidum in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Benzophenanthridines; Depression; Ethanol; Explo | 2013 |
Antinociceptive profiles and mechanisms of orally administered coumarin in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Coumarins; Formaldehyde; G | 2013 |
Lateral gradients significantly enhance static magnetic field-induced inhibition of pain responses in mice--a double blind experimental study.
Topics: Abdominal Pain; Acetic Acid; Analgesia; Animals; Behavior, Animal; Cognition; Double-Blind Method; I | 2013 |
Analgesic effects of glycoproteins from Panax ginseng root in mice.
Topics: Acetic Acid; Analgesics; Animals; Female; Glycoproteins; Hot Temperature; Male; Mice; Morphine; Moto | 2013 |
Anti-inflammatory and antinociceptive effects of hydroalcoholic extract from Pseudobombax marginatum inner bark from caatinga potiguar.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Ethanol; Formaldehyd | 2013 |
Activation of ERK signaling in rostral ventromedial medulla is dependent on afferent input from dorsal column pathway and contributes to acetic acid-induced visceral nociception.
Topics: Acetic Acid; Afferent Pathways; Anesthetics, Local; Animals; Butadienes; Enzyme Activation; Extracel | 2013 |
Bioassay-guided evaluation of Dioscorea villosa - an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Biological Assay; | 2013 |
Aqueous root extracts from Mimosa albida Humb. & Bonpl. ex Willd display antinociceptive activity in mice.
Topics: Acetic Acid; Analgesics; Animals; Anxiety; Exploratory Behavior; Hot Temperature; Male; Mice; Mice, | 2013 |
Autophagy and cathepsin L are involved in the antinociceptive effect of DMBC in a mouse acetic acid-writhing model.
Topics: Acetic Acid; Analgesics; Animals; Autophagy; Benzylidene Compounds; Cathepsin L; Cyclopentanes; Dise | 2013 |
Analgesic and antipyretic activities of Drymaria cordata (Linn.) Willd (Caryophyllaceae) extract.
Topics: 2,4-Dinitrophenol; Acetic Acid; Analgesics; Animals; Antipyretics; Body Temperature; Caryophyllaceae | 2012 |
Purification and primary structure of a mannose/glucose-binding lectin from Parkia biglobosa Jacq. seeds with antinociceptive and anti-inflammatory properties.
Topics: Acetic Acid; Amino Acid Sequence; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carr | 2013 |
Antinociceptive activity of cyclopeptide alkaloids isolated from Ziziphus oxyphylla Edgew (Rhamnaceae).
Topics: Abdomen; Acetic Acid; Alkaloids; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Form | 2013 |
In vivo analgesic activity, toxicity and phytochemical screening of the hydroalcoholic extract from the leaves of Psidium cattleianum Sabine.
Topics: Acetic Acid; Analgesics; Animals; Antioxidants; Biphenyl Compounds; Cell Line; Ethanol; Hot Temperat | 2013 |
Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antiviral Agents; Chlorocebus aethiops; | 2013 |
Comparison of active constituents, acute toxicity, anti-nociceptive and anti-inflammatory activities of Porana sinensis Hemsl., Erycibe obtusifolia Benth. and Erycibe schmidtii Craib.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Convolvulaceae; Ear; Edema; | 2013 |
Analgesic activity of DaChuanXiongFang after intranasal administration and its potential active components in vivo.
Topics: Acetic Acid; Analgesics; Animals; Drug Administration Routes; Drugs, Chinese Herbal; Female; Hot Tem | 2013 |
Four new C18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense.
Topics: Acetic Acid; Aconitine; Aconitum; Analgesics; Animals; Drugs, Chinese Herbal; Mice; Mice, Inbred Str | 2013 |
New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: synthesis and antinociceptive evaluation.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ben | 2013 |
Evaluation of the antinociceptive and anti-inflammatory effect of Caralluma dalzielii.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Apocynaceae; Formaldehyde; Hot Temperatu | 2013 |
Phytopharmacological evaluation of ethanol extract of Sida cordifolia L. roots.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Antioxidants; Ethanol; Malvaceae; Mice; Pain | 2014 |
Anti-inflammatory and analgesic activity of R.A.P. (Radix Angelicae Pubescentis) ethanol extracts.
Topics: Acetic Acid; Analgesics; Angelica; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, A | 2013 |
Antihyperglycemic and antinociceptive activity evaluation of 'khoyer' prepared from boiling the wood of Acacia catechu in water.
Topics: Acacia; Acetic Acid; Analgesics; Animals; Aspirin; Bangladesh; Behavior, Animal; Blood Glucose; Diab | 2013 |
Evaluation of anti-inflammatory, analgesic, and antipyretic effects of ethanolic extract of Pedalium murex Linn. fruits.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents; Antipyretics; Carr | 2013 |
Anti-inflammatory and antinociceptive effects of Chinese medicine SQ gout capsules and its modulation of pro-inflammatory cytokines focusing on gout arthritis.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Capsules; Cells, Cultu | 2013 |
Suppressive effect of modified Simiaowan on experimental gouty arthritis: an in vivo and in vitro study.
Topics: Acetic Acid; Analgesics; Animals; Ankle Joint; Anti-Inflammatory Agents; Arthritis, Gouty; Cell Surv | 2013 |
Antihyperglycaemic and antinociceptive activity evaluation of methanolic extract of whole plant of Amaranthus tricolour L. (Amaranthaceae).
Topics: Acetic Acid; Amaranthus; Analgesics; Animals; Blood Glucose; Diabetes Mellitus; Glucose Tolerance Te | 2013 |
The antinociceptive effect of 4-substituted derivatives of 5-(4-chlorophenyl)-2-(morpholin-4-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Hot Temperature; Male; Mice; Motor Activity; Pai | 2014 |
Antinociceptive and anti-inflammatory activities of extract and two isolated flavonoids of Carthamus tinctorius L.
Topics: Acetic Acid; Acrolein; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Carthamus tinctor | 2014 |
The analgesic and anticonvulsant effects of piperine in mice.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anticonvulsants; Benzodioxoles; Hot Temperature; Male; | 2013 |
Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Dextrans; Edema; | 2014 |
Analgesic and anti-inflammatory activities of the 2,8-dihydroxy-1,6-dimethoxyxanthone from Haploclathra paniculata (Mart) Benth (Guttiferae).
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Carrag | 2014 |
Antinociceptive effect of certain dimethoxy flavones in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationsh | 2014 |
Morphine inhibits acid-sensing ion channel currents in rat dorsal root ganglion neurons.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Action Potentials; Analge | 2014 |
Alpha amylase enzyme inhibitory and anti-inflammatory effect of Lawsonia inermis.
Topics: Acetic Acid; alpha-Amylases; Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; | 2013 |
Study on analgesic and anti-inflammatory properties of Cordia myxa fruit hydro-alcoholic extract.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Cordia; Disease Models | 2013 |
Spinal 5-HT₅A receptors mediate 5-HT-induced antinociception in several pain models in rats.
Topics: Acetic Acid; Animals; Capsaicin; Female; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Sero | 2014 |
Synthesis and pharmacological evaluation of novel limonin derivatives as anti-inflammatory and analgesic agents with high water solubility.
Topics: Acetic Acid; Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation, | 2014 |
Optimization of aceclofenac solid dispersion using Box-Behnken design: in-vitro and in-vivo evaluation.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cellulose; C | 2014 |
Anti-allergic rhinitis effect of caffeoylxanthiazonoside isolated from fruits of Xanthium strumarium L. in rodent animals.
Topics: Acetic Acid; Analgesics; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Caffeic Acids; Dis | 2014 |
Sulfated polysaccharides isolated from the green seaweed Caulerpa racemosa plays antinociceptive and anti-inflammatory activities in a way dependent on HO-1 pathway activation.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Caulerpa; Dextrans; Edema; | 2014 |
Studies on the anti-inflammatory, analgesic and antipyrexic activities of betulinic acid derived from Tetracera potatoria.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Betulinic Acid; Carrageena | 2014 |
Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica.
Topics: Acetic Acid; Anacardiaceae; Analgesics; Animals; Cyclic GMP; Ethanol; Female; Formaldehyde; Glutamic | 2014 |
Inhibition of acid-sensing ion channels by chlorogenic acid in rat dorsal root ganglion neurons.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Action Potentials; Analge | 2014 |
Synthesis and biological evaluation of N-dehydrodipeptidyl-N,N'-dicyclohexylurea analogs.
Topics: Acetic Acid; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2014 |
Pharmacological and structure-activity relationship evaluation of 4-aryl-1-diphenylacetyl(thio)semicarbazides.
Topics: Acetic Acid; Analgesics; Animals; Anticonvulsants; Male; Mice; Molecular Conformation; Molecular Doc | 2014 |
Polysaccharides isolated from Digenea simplex inhibit inflammatory and nociceptive responses.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Interleukin-1beta; M | 2014 |
Chemical composition, potential toxicity, and quality control procedures of the crude drug of Cyrtopodium macrobulbon.
Topics: Acetic Acid; Analgesics; Animals; Male; Medicine, Traditional; Mice; Mice, Inbred ICR; Molecular Str | 2014 |
Antinociceptive and anti-inflammatory activities of the sesame oil and sesamin.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dioxoles; Edema; Formaldehy | 2014 |
Conventional and microwave assisted synthesis of pyrazolone Mannich bases possessing anti-inflammatory, analgesic, ulcerogenic effect and antimicrobial properties.
Topics: Acetic Acid; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2014 |
A preliminary evaluation of antihyperglycemic and analgesic activity of Alternanthera sessilis aerial parts.
Topics: Acetic Acid; Amaranthaceae; Analgesics; Animals; Aspirin; Bangladesh; Blood Glucose; Drug Evaluation | 2014 |
Novel pyrazolopyrimidine derivatives targeting COXs and iNOS enzymes; design, synthesis and biological evaluation as potential anti-inflammatory agents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cell Line; Cell Line, Tumor | 2014 |
Evaluation of peripheral versus central effects of GABA(B) receptor activation using a novel, positive allosteric modulator of the GABA(B) receptor ADX71943, a pharmacological tool compound with a fully peripheral activity profile.
Topics: Acetic Acid; Animals; Behavior, Animal; Body Temperature; Calcium; GABA Modulators; HEK293 Cells; Hu | 2014 |
Syntheses, characterization and evaluation of novel 2,6-diarylpiperidin-4-ones as potential analgesic-antipyretic agents.
Topics: Acetic Acid; Analgesics; Animals; Antipyretics; Body Temperature; Dose-Response Relationship, Drug; | 2014 |
Eutectic, monotectic and immiscibility systems of nimesulide with water-soluble carriers: phase equilibria, solid-state characterisation and in-vivo/pharmacodynamic evaluation.
Topics: Acetic Acid; Animals; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Cyclooxygenase | 2014 |
Synergic effects of pregabalin-acetaminophen combination in somatic and visceral nociceptive reactivity.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Drug Combinations; Drug Synergism; gamma-Aminobutyr | 2014 |
Analgesic activity of diterpene alkaloids from Aconitum baikalensis.
Topics: Acetic Acid; Aconitine; Aconitum; Alkaloids; Analgesics; Animals; Animals, Outbred Strains; Arthriti | 2014 |
Isolation of a dihydrobenzofuran lignan, icariside E4, with an antinociceptive effect from Tabebuia roseo-alba (Ridley) Sandwith (Bignoniaceae) bark.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; | 2015 |
CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells.
Topics: Acetic Acid; Animals; Arthritis, Experimental; Bone Marrow Cells; Bone Marrow Transplantation; Cell | 2014 |
In vivo evaluation of analgesic, anti-inflammatory, and neuropharmacological activities of the chemical constituent from Nepeta clarkei.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Behavior, Animal | 2015 |
Anti-inflammatory and antinociceptive activity of Urera aurantiaca.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Female; Free Radical | 2015 |
Harmful misuse of white vinegar in a wrong combination.
Topics: Acetic Acid; Aspirin; Burns, Chemical; Drug Combinations; Humans; Male; Middle Aged; Pain; Treatment | 2016 |
Central nervous system activity of the ethanol leaf extract of Sida acuta in rats.
Topics: Acetic Acid; Analgesics; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Ethanol; For | 2014 |
Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
Topics: Acetic Acid; Analgesics; Anti-Inflammatory Agents; Carrageenan; Cyclic GMP; Diterpenes; Edema; Freun | 2014 |
Synthesis, hydrolysis kinetics and pharmacological evaluation of aceclofenac prodrugs.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Antipyretic and antinociceptive potential of extract/fractions of Potentilla evestita and its isolated compound, acacetin.
Topics: Acetic Acid; Analgesics; Animals; Antipyretics; Disease Models, Animal; Fever; Flavones; Male; Mice, | 2014 |
Structure of an arabinogalactan from the edible tropical fruit tamarillo (Solanum betaceum) and its antinociceptive activity.
Topics: Acetic Acid; Analgesics; Animals; Female; Formaldehyde; Fruit; Galactans; Methylation; Mice; Molecul | 2015 |
Antinociceptive and cytotoxic activities of an epiphytic medicinal orchid: Vanda tessellata Roxb.
Topics: Acetic Acid; Analgesics; Animals; Artemia; Hot Temperature; Male; Medicine, Traditional; Mice; Orchi | 2014 |
Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice.
Topics: Acetic Acid; Analgesics; Animals; Ethanol; Female; Formaldehyde; Glutamic Acid; Hedyotis; Hot Temper | 2015 |
Antinociceptive and anti-inflammatory activities of Geranium bellum and its isolated compounds.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Ellagic Acid; Female | 2014 |
Analgesic principle from Curcuma amada.
Topics: Acetic Acid; Analgesics; Animals; Curcuma; Female; Formaldehyde; Male; Mice; Pain; Plant Extracts; R | 2015 |
Anti-nociceptive, anti-inflammatory and toxicological evaluation of Fang-Ji-Huang-Qi-Tang in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aristolochia; Aristolochic Acids; Astrag | 2015 |
Phytochemical composition and antinociceptive activity of Bauhinia glauca subsp. hupehana in rats.
Topics: Acetic Acid; Analgesics; Animals; Bauhinia; Cyclic GMP; Dose-Response Relationship, Drug; Ethanol; F | 2015 |
Evaluation of antinociceptive activity of nanoliposome-encapsulated and free-form diclofenac in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; | 2015 |
Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents.
Topics: Acetic Acid; Analgesics; Animals; Benzimidazoles; Diclofenac; Disease Models, Animal; Drug Evaluatio | 2015 |
Exploring new pharmacology and toxicological screening and safety evaluation of one widely used formulation of Nidrakar Bati from South Asia region.
Topics: Acetic Acid; Analgesics; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents; Asia; Behavior, Ani | 2015 |
Toona sinensis leaf extract has antinociceptive effect comparable with non-steroidal anti-inflammatory agents in mouse writhing test.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cycloox | 2015 |
Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper in mice.
Topics: Acetic Acid; Acrolein; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Bangladesh | 2015 |
Antipyretic, anti-inflammatory and analgesic activity of Acacia hydaspica R. Parker and its phytochemical analysis.
Topics: Acacia; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Carrageenan; Edema | 2015 |
Ellagic acid enhances the antinociceptive action of venlafaxine in mouse acetic acid-induced pain: An isobolographic analysis.
Topics: Acetic Acid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Ellagic Acid; Male; Mice; Pa | 2015 |
Antinociceptive and anti-inflammatory activities of Schefflera octophylla extracts.
Topics: Acetic Acid; Analgesics; Animals; Ankle Joint; Anti-Inflammatory Agents; Araliaceae; Arthritis, Expe | 2015 |
Antinociceptive and Anti-Inflammatory Activities of Telfairia occidentalis Hydroethanolic Leaf Extract (Cucurbitaceae).
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cucurbitaceae; Edema; Femal | 2015 |
Antinociceptive and anti-tussive activities of the ethanol extract of the flowers of Meconopsis punicea Maxim.
Topics: Acetic Acid; Alkaloids; Ammonia; Analgesics; Animals; Anti-Inflammatory Agents; Cough; Flavonoids; F | 2015 |
Anti-nociceptive activity of the crude extract of Myrianthus arboreus P. Beauv (Cecropiaceae) in mice.
Topics: Acetic Acid; Analgesics; Animals; Complex Mixtures; Formaldehyde; Hot Temperature; Lethal Dose 50; M | 2015 |
Analgesic and anti-inflammatory effects of hydroalcoholic extract isolated from Semen vaccariae.
Topics: Acetic Acid; Administration, Oral; Alcohols; Analgesics; Animals; Anti-Inflammatory Agents; Capillar | 2015 |
Anti-inflammatory activity studies on the stems and roots of Jasminum lanceolarium Roxb.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Capillary P | 2015 |
Antiinflammatory and Analgesic Activities of Ethanol Extract and Isolated Compounds from Millettia pulchra.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Cyclooxygenase | 2015 |
Analgesic and anti-inflammatory activities of the ethanol extract of Taxillus tsaii Chiu in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Edema; Ethanol; | 2015 |
Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Brazil; Carrageenan; Cell Movement; Edem | 2015 |
Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents.
Topics: Acetic Acid; Administration, Oral; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Het | 2015 |
Pharmacological evidence favouring the traditional use of the root bark of Condalia buxifolia Reissek in the relief of pain and inflammation in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Edema; Female; Formald | 2015 |
Antinociceptive and anti-inflammatory effects of essential oil extracted from Chamaecyparis obtusa in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Chamaecyparis; Cytokines; Hot T | 2015 |
Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.
Topics: Acetic Acid; Animals; Azoxymethane; Carcinogenesis; Colonic Neoplasms; Colonic Polyps; Cyclooxygenas | 2015 |
Anti-nociceptive activity of a few structurally related trimethoxy flavones and possible mechanisms involved.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Flavones; Formaldehyde; Male | 2016 |
Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice.
Topics: Acetic Acid; Amides; Analgesics; Anilides; Animals; Butyric Acid; Formaldehyde; Hot Temperature; Hyp | 2016 |
Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae).
Topics: Acetic Acid; Analgesics; Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents; Cell Line, Tu | 2016 |
Design, synthesis and biological evaluation of novel analgesic agents targeting both cyclooxygenase and TRPV1.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Body Temperature; Capsaicin; Cyclooxygenase | 2016 |
Antinociceptive and anti-inflammatory potentials of kolaviron: mechanisms of action.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Atropine; Carrageenan; Edema; Female; Fl | 2016 |
The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model.
Topics: Acetic Acid; Administration, Topical; Analgesics; Animals; Disease Models, Animal; Drugs, Chinese He | 2016 |
Antipyretic, analgesic and anti-inflammatory effects of Kickxia ramosissima.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Carrageenan; Edema; Female | 2016 |
Analgesic, anti-inflammatory and anti-platelet activities of Buddleja crispa.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Blood Platelets; Carra | 2016 |
Anti-inflammatory and antinociceptive activities of Croton urucurana Baillon bark.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents; Aporphines; Biflavonoids; Bra | 2016 |
Potentiation of acid-sensing ion channel activity by peripheral group I metabotropic glutamate receptor signaling.
Topics: Acetic Acid; Acid Sensing Ion Channels; Acidosis; Animals; Capsaicin; Ganglia, Spinal; Male; Methoxy | 2016 |
Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of montelukast in the animal models of pain.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Behavior, Animal; Cyclopropanes; Disease Models, Animal; | 2016 |
Analgesic Effects of 1st Generation Anti-histamines in Mice.
Topics: Acetic Acid; Adrenergic Antagonists; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; C | 2016 |
Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn.
Topics: Acetic Acid; Analgesics; Animals; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Mice; Naloxone | 2016 |
Antinociceptive and anti-inflammatory effects of Memora nodosa and allantoin in mice.
Topics: Acetic Acid; Allantoin; Analgesics; Animals; Anti-Inflammatory Agents; Bignoniaceae; Carrageenan; Ed | 2016 |
Pomegranate seed oil nanoemulsions improve the photostability and in vivo antinociceptive effect of a non-steroidal anti-inflammatory drug.
Topics: Abdomen; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Constriction, Pa | 2016 |
Phytochemical screening, safety evaluation, anti-inflammatory and analgesic studies of the leaf extracts of Sterculia tragacantha.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Female; Flavonoi | 2016 |
Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice.
Topics: Acetic Acid; Analgesics; Animals; Artemia; Capsaicin; Female; Formaldehyde; Glutamic Acid; Hot Tempe | 2016 |
Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of Dendropanax morbifera Mediated by the Nrf2/HO-1 Pathway.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Araliaceae; Chloroform; Cytokines; Dinop | 2016 |
The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission Pathways.
Topics: Acetic Acid; Adenosine Triphosphate; Analgesics; Animals; Bone Density Conservation Agents; Capsaici | 2016 |
Antinociceptive, antioxidant and phytochemical studies of Pakistani medicinal plants.
Topics: Acetic Acid; Analgesics; Animals; Antioxidants; Biphenyl Compounds; Chenopodium; Disease Models, Ani | 2016 |
Intratesticular Bradykinin Involvement in Rat Testicular Pain Models.
Topics: Acetic Acid; Animals; Behavior, Animal; Bradykinin; Bradykinin B2 Receptor Antagonists; Disease Mode | 2018 |
Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral κ-opioid receptor agonists.
Topics: Acetic Acid; Analgesics; Animals; Drug Design; Hypnotics and Sedatives; Mice; Molecular Structure; P | 2016 |
Rational Design and Synthesis of Biologically Active Disubstituted 2(3H) Furanones and Pyrrolone Derivatives as Potent and Safer Non Steroidal Anti-inflammatory Agents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Female; Furans; Male | 2016 |
Anti-inflammatory and analgesic effects of Bi-yuan-ling granules.
Topics: Acetic Acid; Acute Lung Injury; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Chloroge | 2016 |
Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines as New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Edema; Infla | 2016 |
Analgesic and anti-inflammatory actions on bradykinin route of a polysulfated fraction from alga Ulva lactuca.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Bradykinin; Carrageenan; Chemical Fracti | 2016 |
Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Cotton Fiber; | 2016 |
Anti-oxidant, anti-inflammatory, analgesic and antipyretic activities of grapevine leaf extract (Vitis vinifera) in mice and identification of its active constituents by LC-MS/MS analyses.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Antipyretics; Behavior, An | 2016 |
Design, Synthesis, and Pharmacological Characterization of 2-(2-Furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine Derivatives: New Highly Potent A
Topics: Acetic Acid; Adenosine A2 Receptor Agonists; Analgesics; Animals; CHO Cells; Cricetulus; Cyclic AMP; | 2016 |
Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice.
Topics: Acetic Acid; Analgesics; Animals; Cyclic GMP; Dalbergia; Disease Models, Animal; Drug Evaluation, Pr | 2017 |
Evaluation of acute toxicity, sedative and analgesic effects of Taverniera glabra methanolic extract on mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Central Nervous System; Disease Models, Animal; | 2016 |
Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States.
Topics: Acetic Acid; Animals; Capsaicin; Corticosterone; Cues; Disease Models, Animal; Formaldehyde; Male; M | 2017 |
A novel zebrafish-based model of nociception.
Topics: Acetic Acid; Acrolein; Analgesics, Opioid; Animals; Antineoplastic Agents, Phytogenic; Disease Model | 2017 |
Synthesis, analgesic and anti-inflammatory evaluation of some new 3H-quinazolin-4-one derivatives.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Femal | 2008 |
Quercetin: further investigation of its antinociceptive properties and mechanisms of action.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cholinergic Agents; Disease Models, | 2008 |
Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X(2/3) receptor function and exerts an analgesic effect in pain models.
Topics: Acetic Acid; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Bone Density Conservation Ag | 2008 |
An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extract.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; E | 2008 |
Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Ficus; For | 2008 |
Analgesic and antidiarrheal properties of Ocimum selloi essential oil in mice.
Topics: Acetic Acid; Analgesics; Animals; Antidiarrheals; Diarrhea; Dose-Response Relationship, Drug; Gastro | 2008 |
Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Blood-Brain Barrier; Carrageenan; Drug Evaluation, P | 2008 |
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.
Topics: Acetic Acid; Alcohols; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; | 2008 |
Differential expression of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse hippocampus induced by various nociceptive stimuli.
Topics: Acetic Acid; Analysis of Variance; Animals; Behavior, Animal; Benzylamines; Calcium-Calmodulin-Depen | 2008 |
Anti-inflammatory and analgesic properties in a rodent model of a (1-->3),(1-->6)-linked beta-glucan isolated from Pleurotus pulmonarius.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillary Permeability | 2008 |
Role of enhanced noradrenergic transmission within the ventral bed nucleus of the stria terminalis in visceral pain-induced aversion in rats.
Topics: Acetic Acid; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Avoidance Learning; Conditi | 2009 |
The analgesic and antiplasmodial activities and toxicology of Vernonia amygdalina.
Topics: Acetic Acid; Analgesics; Animals; Antimalarials; Body Weight; Eating; Lethal Dose 50; Malaria; Mice; | 2008 |
The effect of curcumin (active substance of turmeric) on the acetic acid-induced visceral nociception in rats.
Topics: Acetic Acid; Animals; Curcumin; Male; Pain; Pain Measurement; Rats; Rats, Wistar | 2008 |
[Optimization of the supercritical fluid extraction process of Tuirezhitongsan].
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Supercritical Fluid; | 2008 |
A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygen in mice.
Topics: Acetic Acid; Analgesia; Analysis of Variance; Animals; beta-Endorphin; Citrulline; Dynorphins; Enkep | 2009 |
Antinociceptive activity of swertiamarin isolated from Enicostemma axillare.
Topics: Acetaminophen; Acetic Acid; Analgesics; Analgesics, Non-Narcotic; Animals; Gentianaceae; Glucosides; | 2009 |
Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice.
Topics: Acetic Acid; Animals; Behavior, Animal; Ceftriaxone; Colon; Disease Models, Animal; Ethanol; Excitat | 2009 |
Antinociceptive activity of methanolic extract of Epilobium hirsutum.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Diclofenac; Epilobium; Male; Medicine, Tradi | 2007 |
Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception.
Topics: Acetic Acid; Amidohydrolases; Animals; Benzamides; Carbamates; Cyclooxygenase Inhibitors; Diclofenac | 2009 |
The antinociceptive effects of midazolam on three different types of nociception in mice.
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Hot Temperature; Injections, Int | 2009 |
The analgesic and anti-inflammatory activities of the extract of Albizia lebbeck in animal model.
Topics: Acetic Acid; Administration, Oral; Albizzia; Analgesics; Animals; Anti-Inflammatory Agents; Carragee | 2009 |
Anti-inflammatory properties of cryptolepine.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2009 |
Antinociceptive activity of Gynandropsis gynandra leaves.
Topics: Acetic Acid; Analgesics; Animals; Cleome; Flavonoids; Injections, Intraperitoneal; Male; Mice; Nalox | 2009 |
Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Cinnamates; Depsides; Dose-Response Relationsh | 2009 |
Filicene obtained from Adiantum cuneatum interacts with the cholinergic, dopaminergic, glutamatergic, GABAergic, and tachykinergic systems to exert antinociceptive effect in mice.
Topics: Acetic Acid; Adiantum; Analgesics; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relatio | 2009 |
Evaluation of the antinociceptive activity of extracts of Sonchus oleraceus L. in mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose- | 2009 |
Antinociceptive and anti-inflammatory kaempferol glycosides from Sedum dendroideum.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cell Migration Inhibition; | 2009 |
Analgesic activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Din | 2009 |
Irukandji syndrome case series from Australia's Tropical Northern Territory.
Topics: Acetic Acid; Adolescent; Adult; Analgesics, Opioid; Anesthetics; Animals; Antivenins; Bites and Stin | 2009 |
Involvement of glutamate and cytokine pathways on antinociceptive effect of Pfaffia glomerata in mice.
Topics: Acetic Acid; Amaranthaceae; Analgesics; Animals; Behavior, Animal; Cycloleucine; Disease Models, Ani | 2009 |
Antinociceptive activity of Amaranthus spinosus in experimental animals.
Topics: Acetic Acid; Amaranthus; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carr | 2009 |
Characterization of the antinociceptive and anti-inflammatory activities from Cocos nucifera L. (Palmae).
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Cocos; Edema; Fruit; Male; Mice; Naloxon | 2009 |
Anti-inflammatory and analgesic effects of ethanol and aqueous extracts of Pterocephalus hookeri (C.B. Clarke) Höeck.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Dip | 2009 |
Intracerebroventricular or intrathecal injection of glycine produces analgesia in thermal nociception and chemical nociception via glycine receptors.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Behavior, Animal; Female; Glycine; Hot Temperature; Inj | 2009 |
Laetispicine, an amide alkaloid from Piper laetispicum, presents antidepressant and antinociceptive effects in mice.
Topics: Acetic Acid; Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Benzodioxoles; Depression | 2009 |
Total synthesis and analgesic activity of 6-fluoroindan-1-acetic acid and its 3-oxo derivative.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Benzaldehydes; Indans; Mice; Pain | 2009 |
The analgesic effect of decursinol.
Topics: Acetaminophen; Acetic Acid; Analgesics; Angelica; Animals; Aspirin; Benzopyrans; Butyrates; Disease | 2009 |
Antinociceptive effects of (O-methyl)-N-benzoyl tyramine (riparin I) from Aniba riparia (Nees) Mez (Lauraceae) in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Arginine; Behavior, Anim | 2009 |
Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Behavior, Animal; Benzene Derivatives; Caffeine; Diseas | 2009 |
Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties.
Topics: Acetic Acid; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Carrageenan; Dise | 2009 |
Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark.
Topics: Acetic Acid; Analgesics; Animals; Annona; Anti-Inflammatory Agents; Carrageenan; Edema; Female; Hot | 2010 |
Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum.
Topics: Acetic Acid; Analgesics; Anaphylaxis; Animals; Behavior, Animal; Chromobacterium; Dose-Response Rela | 2010 |
Analgesic and anti-inflammatory activities of ethanol root extract of Mahonia oiwakensis in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Berberine Alkaloids; C | 2009 |
Antinociceptive activity of coniine in mice.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Conium; Drug Synergism; Male; Mecamylamine; Mice; Morph | 2009 |
Analgesic and anti-inflammatory activities of methanol extract from Desmodium triflorum DC in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Drugs, Ch | 2009 |
Anti-nociceptive and anti-inflammatory activity of sophocarpine.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carra | 2009 |
Blockade of fear-induced antinociception with intra-amygdala infusion of midazolam: Influence of prior test experience.
Topics: Acetic Acid; Amygdala; Analysis of Variance; Animals; Anti-Anxiety Agents; Catheterization; Dose-Res | 2009 |
Antinociceptive activity of the essential oil of Zingiber zerumbet.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; | 2010 |
Evidence of TRPV1 receptor and PKC signaling pathway in the antinociceptive effect of amyrin octanoate.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; | 2009 |
Structure-analgesic activity relationship studies on the C(18)- and C(19)-diterpenoid alkaloids.
Topics: Acetic Acid; Aconitum; Alkaloids; Analgesics; Animals; Diterpenes; Drug Evaluation, Preclinical; Fem | 2009 |
Synergistic interaction between rilmenidine and ibuprofen in the writhing test in mice.
Topics: Acetic Acid; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Dos | 2009 |
Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception.
Topics: Acetic Acid; Analgesics; Animals; Anti-Obesity Agents; Camphanes; Cannabinoids; Cyclohexanols; Dose- | 2009 |
Antinociceptive and anti-inflammatory activities of iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillary Permeability | 2010 |
Analgesic and anti-inflammatory activities of a water extract of Trachelospermum jasminoides (Apocynaceae).
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Apocynaceae; Behavior, Ani | 2009 |
Anti-inflammatory, anti-angiogenic and anti-nociceptive activities of an ethanol extract of Salvia plebeia R. Brown.
Topics: Acetic Acid; Analgesics; Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Antioxidants; B | 2009 |
Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cell Line; Disaccharides; D | 2010 |
Evaluation of the antiangiogenic, anti-inflammatory, and antinociceptive activities of morin.
Topics: Acetic Acid; Analgesics; Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Behavior, Anima | 2010 |
Antinociceptive activity of lectins from Diocleinae seeds on acetic acid-induced writhing test in mice.
Topics: Acetic Acid; Analgesics; Animals; Dioclea; Female; Male; Mice; Pain; Plant Lectins; Seeds | 2009 |
Oxymatrine-carbenoxolone sodium inclusion compound induces antinociception and increases the expression of GABA(A)alpha1 receptors in mice.
Topics: Abdominal Muscles; Acetic Acid; Alkaloids; Analgesics; Animals; Behavior, Animal; Carbenoxolone; Cer | 2010 |
Social approach to pain in laboratory mice.
Topics: Acetic Acid; Analysis of Variance; Animals; Constriction; Disease Models, Animal; Female; Male; Mice | 2010 |
Guaifenesin enhances the analgesic potency of ibuprofen, nimesulide and celecoxib in mice.
Topics: Acetic Acid; Analgesia; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cele | 2009 |
Anti-inflammatory and analgesic activities of Chaenomeles speciosa fractions in laboratory animals.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Chl | 2009 |
Behavioral and urological evaluation of a testicular pain model.
Topics: Acetic Acid; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Indomethacin; Male; Nerve | 2010 |
A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anthracenes; Chromatography, High Pressure Liq | 2010 |
Amylin suppresses acetic acid-induced visceral pain and spinal c-fos expression in the mouse.
Topics: Acetic Acid; Amyloid; Analgesics; Animals; Brain; Calcitonin; Dose-Response Relationship, Drug; Gang | 2010 |
Analgesic effects of chemically synthesized NOD1 and NOD2 agonists in mice.
Topics: Acetic Acid; Acetylmuramyl-Alanyl-Isoglutamine; Analgesics; Animals; Diaminopimelic Acid; Drug Antag | 2011 |
The antinociceptive and anti-inflammatory activities of Piptadenia stipulacea Benth. (Fabaceae).
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents; Brazil; Fabaceae; Flavonoids; Formaldehyde | 2010 |
Assessment of anti-inflammatory and antinociceptive activities of Olea europaea L.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Benzoquinones; Capillary Permeability; C | 2010 |
In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Carrageen | 2010 |
Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents.
Topics: Acetaminophen; Acetic Acid; Algorithms; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Carbamaz | 2010 |
Synthesis of some new pyrimido[2',1':2,3]thiazolo[4,5-b]quinoxaline derivatives as anti-inflammatory and analgesic agents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Evaluat | 2010 |
Preliminary studies on the antinociceptive activity of Vaccinium ashei berry in experimental animal models.
Topics: Acetic Acid; Analgesics; Animals; Anthocyanins; Blueberry Plants; Diclofenac; Disease Models, Animal | 2010 |
Antinociceptive activity of aqueous extract of Bowdichia virgilioides in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Fabaceae; Formaldehyde; Male; Mice; Naloxone; Na | 2010 |
[Characteristics of behavioral manifestations of somatic and visceral pain during short-term immobilization stress].
Topics: Acetic Acid; Animals; Behavior, Animal; Male; Mice; Pain; Pain Measurement; Pain Threshold; Restrain | 2009 |
The pharmacological activities of Compound Salvia Plebeia Granules on treating urinary tract infection.
Topics: Acetic Acid; Analgesics; Animals; Anti-Infective Agents, Urinary; Behavior, Animal; Carrageenan; Dis | 2010 |
Synthesis of new 2,3-dihydroquinazolin-4(1H)-one derivatives for analgesic and anti-inflammatory evaluation.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Chalcones; Drug Evaluation, | 2010 |
Correlation between synergistic action of Radix Angelica dahurica extracts on analgesic effects of Corydalis alkaloid and plasma concentration of dl-THP.
Topics: Acetic Acid; Alkaloids; Analgesics; Angelica; Animals; Behavior, Animal; Berberine Alkaloids; Coryda | 2010 |
The antinociceptive effect of a benzopyran (HP1) isolated from Hypericum polyanthemum in mice hot-plate test is blocked by naloxone.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Behavior, Animal; Benzopyrans; Dose-Response Relationship, | 2010 |
Rationale and methods for assessment of pain-depressed behavior in preclinical assays of pain and analgesia.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Behavior, Animal; Drug Evaluation, Preclinical; Haloper | 2010 |
The nociception induced by glutamate in mice is potentiated by protons released into the solution.
Topics: Acetic Acid; Acid Sensing Ion Channels; Animals; Behavior, Animal; Female; Glutamic Acid; Hydrogen-I | 2010 |
Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Diclofenac; Dose-Respons | 2010 |
Spinal antinociception of synthetic omega-conotoxin SO-3, a selective N-type neuronal voltage-sensitive calcium channel blocker, and its effects on morphine analgesia in chemical stimulus tests in rodent.
Topics: Acetic Acid; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Drug Interacti | 2010 |
Hyperbaric oxygen treatment induces a 2-phase antinociceptive response of unusually long duration in mice.
Topics: Acetic Acid; Animals; Behavior, Animal; Enzyme Inhibitors; Hyperbaric Oxygenation; Injections, Intra | 2010 |
Antinociceptive, genotoxic and histopathological study of Heliopsis longipes S.F. Blake in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Asteraceae; Behavior, Animal; Brain; Chromat | 2010 |
Antipyretic, analgesic, anti-inflammatory and antioxidant activities of two major chromenes from Melicope lunu-ankenda.
Topics: Acetic Acid; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Antioxidants; | 2010 |
Antinociceptive and anti-inflammatory activities of lectin from marine red alga Pterocladiella capillacea.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease M | 2010 |
Sex-differential modulation of visceral pain by brain derived neurotrophic factor (BDNF) in rats.
Topics: Abdominal Muscles; Acetic Acid; Analysis of Variance; Animals; Antibodies; Brain-Derived Neurotrophi | 2010 |
High-intensity extended swimming exercise reduces pain-related behavior in mice: involvement of endogenous opioids and the serotonergic system.
Topics: Acetic Acid; Animals; Behavior, Animal; Fenclonine; Irritants; Male; Mice; Naloxone; Narcotic Antago | 2010 |
Analgesic and anti-inflammatory activities of the methanol extract of Kalanchoe gracilis (L.) DC stem in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response Relationship, | 2010 |
The analgesic effect and mechanism of the combination of sodium ferulate and oxymatrine.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-S | 2010 |
Antinociceptive effects of docosahexaenoic acid against various pain stimuli in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Docosahexaenoic Acids; Dose-Response Relationshi | 2010 |
Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: evidence for a role of IL-1β inhibition.
Topics: Acetic Acid; Adiantum; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Behavior, An | 2011 |
Analgesic effects of the ethanolic extract from Magnolia ovata (Magnoliaceae) trunk bark and of N-acetylxylopine, a semi-synthetic analogue of xylopine.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aporphines; Carrageenan; Disease Models, | 2011 |
Iloprost-induced nociception: determination of the site of anti-nociceptive action of cyclooxygenase inhibitors and the involvement of cyclooxygenase products in central mechanisms of nociception.
Topics: Acetic Acid; Analgesics; Animals; Cyclooxygenase Inhibitors; Dinoprostone; Female; Iloprost; Mice; M | 2010 |
Antinociceptive and anti-inflammatory effects of Costus spicatus in experimental animals.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Costus; Disease Models, Ani | 2010 |
Antinociceptive activity of steroid alkaloids isolated from Solanum trilobatum Linn.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Female; Male; Mice; Molecular Structure; Pain; Pain Mea | 2010 |
Assessment of antinociceptive, anti-inflammatory and antioxidant properties of Cymbopogon winterianus leaf essential oil.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Carrag | 2010 |
Antinociceptive effect of methanol extract of Capparis ovata in mice.
Topics: Acetic Acid; Analgesics; Animals; Capparis; Dipyrone; Dose-Response Relationship, Drug; Flowers; Hot | 2010 |
Synthesis and preliminary biological evaluation of capsaicin derivatives as potential analgesic drugs.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cap | 2010 |
Synthesis and pharmacological evaluation of novel 1-(2-(benzoyl-substituted-2-phenyl-1H-indol-5-carbony) hydrazinyloxy) vinyl nitrate derivatives as potent non-ulcerogenic, analgesic and anti-inflammatory agents.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dis | 2010 |
Antiinflammatory, analgesic and antipyretic activities of ethanolic root extract of Croton zambesicus.
Topics: Acetic Acid; Amphetamine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2010 |
Chemical structure and selected biological properties of a glucomannan from the lichenized fungus Heterodermia obscurata.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascomycota; Brazil; Disease Models, A | 2010 |
Antinociceptive activity of Hypericum grandifolium Choisy in mice.
Topics: Acetic Acid; Analgesics; Animals; Benzophenones; Chromatography, High Pressure Liquid; Female; Flavo | 2011 |
Analgesic and anti-inflammatory activities of 18-acetoxy-ent-kaur-16-ene from Annona squamosa L. bark.
Topics: Acetic Acid; Analgesics; Animals; Annona; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diterpen | 2011 |
Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach.
Topics: Acetic Acid; Action Potentials; Analgesics; Animals; Behavior, Animal; Biological Assay; Diazepam; E | 2010 |
The acute antinociceptive effect of HBO₂ is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice.
Topics: Acetic Acid; Animals; Benzoates; Cyclic GMP-Dependent Protein Kinases; Glyburide; Guanylate Cyclase; | 2011 |
Elucidation of possible mechanism of analgesic action of Valeriana wallichii DC chemotype (patchouli alcohol) in experimental animal models.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asp | 2010 |
Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Dose-Response Relation | 2011 |
The studies of anti-inflammatory and analgesic activities and pharmacokinetics of Oxytropis falcate Bunge extraction after transdermal administration in rats.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Biological Availabilit | 2011 |
Extrasegmental analgesia of heterotopic electroacupuncture stimulation on visceral pain rats.
Topics: Acetic Acid; Acupuncture Points; Afferent Pathways; Analgesia; Animals; Capsaicin; Disease Models, A | 2011 |
Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Commiphora; Dinoprosto | 2011 |
Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Dose- | 2011 |
Antinociceptive effect of extract of Emilia sonchifolia in mice.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Asteraceae; Behavior, Animal; Brazil; Disease Models, Anim | 2011 |
Antinociceptive and anti-hyperglycemic activity of methanol leaf extract of Cyperus scariosus.
Topics: Acetic Acid; Analgesics; Animals; Aspirin; Cyperus; Dose-Response Relationship, Drug; Glucose Tolera | 2011 |
Genomic loci and candidate genes underlying inflammatory nociception.
Topics: Acetic Acid; Animals; Chromosome Mapping; Confidence Intervals; Databases, Genetic; Female; Genome; | 2011 |
Antinociceptive activity of Premna corymbosa (Burm.f.)Rottl. & Willd.
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Hot Temperature; Male; M | 2010 |
Psychopharmacological properties of an aqueous extract of Tetracarpidium conophorum Hutch. & Dalziel in mice.
Topics: Acetic Acid; Alkaloids; Amphetamine; Animals; Antidepressive Agents; Euphorbiaceae; Female; Formalde | 2011 |
Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Ellagic Acid; Lythraceae; Male | 2011 |
Antinociceptive activity of methanolic extract of leaves of Achyranthes aspera Linn. (Amaranthaceae) in animal models of nociception.
Topics: Acetic Acid; Amaranthaceae; Analgesics; Animals; Disease Models, Animal; Female; Indicators and Reag | 2010 |
Enhanced analgesic effects of propacetamol and tramadol combination in rats and mice.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; | 2011 |
Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin.
Topics: Acetic Acid; Amphibian Proteins; Animals; Behavior, Animal; Carrageenan; Cyclooxygenase 2; Cyclooxyg | 2011 |
Antinociceptive effects of methyl jasmonate in experimental animals.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Cyclopentanes; Female; Formaldehyde; Male; Mice; Oxylipi | 2011 |
Gene cloning and characterization of novel antinociceptive peptide from the brain of the frog, Odorrana grahami.
Topics: Acetic Acid; Amino Acid Sequence; Amphibian Proteins; Analgesics; Animals; Base Sequence; Brain; Clo | 2011 |
Heme oxygenase/carbon monoxide-biliverdin pathway may be involved in the antinociceptive activity of etoricoxib, a selective COX-2 inhibitor.
Topics: Acetic Acid; Analgesics; Animals; Biliverdine; Carbon Monoxide; Cyclooxygenase 2 Inhibitors; Disease | 2011 |
The analgesic effects and mechanisms of orally administered eugenol.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Brain; Disease Models, Ani | 2011 |
Codeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice.
Topics: Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Celecoxib; Codein | 2011 |
Triterpenes involved in the anti-inflammatory effect of ethanolic extract of Pterodon emarginatus Vogel stem bark.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Chemical Fractionation; Croton Oil; Dise | 2012 |
Antinociceptive activity of discretamine isolated from Duguetia moricandiana.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Annonaceae; Berberine Alkaloids; Chromatogra | 2011 |
Synthesis and analgesic activity of some acetamide derivatives.
Topics: Acetamides; Acetic Acid; Analgesics; Animals; Magnetic Resonance Spectroscopy; Male; Mass Spectromet | 2012 |
Fluorine bearing sydnones with styryl ketone group: synthesis and their possible analgesic and anti-inflammatory activities.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Croton Oil; Edema; Female; | 2012 |
Possible involvement of β-endorphin in docosahexaenoic acid-induced antinociception.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; beta-Endorphin; Docosahexaenoic Acids; Male; Mic | 2011 |
Analgesic and antiinflammatory activity of kaur-16-en-19-oic acid from Annona reticulata L. bark.
Topics: Acetic Acid; Analgesics; Animals; Annona; Anti-Inflammatory Agents; Carrageenan; Diterpenes; Male; M | 2012 |
Analgesic effects and anti-inflammatory properties of the crude methanolic extract of Schwenckia americana Linn (Solanaceae).
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Re | 2011 |
Anti-inflammatory and analgesic activities of ethanolic extract of Sphaeranthus indicus Linn.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Carrageenan; Disease Models, | 2011 |
Anti-inflammatory and analgesic effects of human placenta extract.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Blotting, Western; Carrageena | 2011 |
Analgesic effects and mechanisms of anti-inflammation of taraxeren-3-one from Diospyros maritima in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Catalase; Diospyros; Edema; | 2011 |
Pharmacological profile of FK881(ASP6537), a novel potent and selective cyclooxygenase-1 inhibitor.
Topics: Acetic Acid; Animals; Arthritis, Experimental; Carrageenan; CHO Cells; Cricetinae; Cricetulus; Cyclo | 2011 |
Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2011 |
Antinociceptive and anti-inflammatory activities of crude extracts of Ipomoea involucrata leaves in mice and rats.
Topics: Acetic Acid; Albumins; Analgesics; Animals; Anti-Inflammatory Agents; Complex Mixtures; Edema; Ipomo | 2011 |
Anti-inflammatory and anti-nociceptive activities of Sipunculus nudus L. extract.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Capillary Permeabi | 2011 |
Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Benzothiazoles; Biphenyl C | 2011 |
Antinociceptive and hypnotic properties of Celastrus orbiculatus.
Topics: Acetic Acid; Animals; Celastrus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; F | 2011 |
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their zinc(II) complexes.
Topics: Acetic Acid; Aldehydes; Analgesics; Animals; Anti-Inflammatory Agents; Coordination Complexes; Cryst | 2011 |
The analgesic and anti-rheumatic effects of Thladiantha dubia fruit crude polysaccharide fraction in mice and rats.
Topics: Acetic Acid; Analgesics; Animals; Ankle Joint; Antirheumatic Agents; Arthritis, Rheumatoid; Cucurbit | 2011 |
Formulation and evaluation of in situ gelling systems for intranasal administration of gastrodin.
Topics: Absorption; Acetic Acid; Adhesiveness; Administration, Intranasal; Animals; Anura; Benzyl Alcohols; | 2011 |
Analgesic and anti-inflammatory activities of Passiflora foetida L.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Ethan | 2011 |
Phytochemical and pharmacological evaluation of prop roots of Pandanus fascicularis Lam.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carrageenan; Chro | 2011 |
Antinociceptive activity and acute toxicity study of Flaveria trinervia whole plant extracts using mice.
Topics: Acetic Acid; Alkanes; Analgesics; Animals; Chloroform; Flaveria; Lethal Dose 50; Methanol; Mice; Pai | 2011 |
Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Drug Evaluation, Preclinica | 2012 |
Anti-hyperglycemic and antinociceptive activity of methanol leaf and stem extract of Nypa fruticans Wurmb.
Topics: Acetic Acid; Analgesics; Animals; Arecaceae; Aspirin; Blood Glucose; Glucose; Glyburide; Hyperglycem | 2011 |
Bak Foong Pills induce an analgesic effect by inhibiting nociception via the somatostatin pathway in mice.
Topics: Acetic Acid; Analgesics; Animals; Dinoprostone; Down-Regulation; Drugs, Chinese Herbal; Epoprostenol | 2012 |
Involvement of metabotropic glutamate receptor 5 in pudendal inhibition of nociceptive bladder activity in cats.
Topics: Acetic Acid; Animals; Cats; Disease Models, Animal; Female; Pain; Pudendal Nerve; Pyridines; Recepto | 2011 |
Antipyretic, anti-inflammatory and analgesic properties of nilavembu kudineer choornam: a classical preparation used in the treatment of chikungunya fever.
Topics: Acetic Acid; Animals; Carrageenan; Case-Control Studies; Disease Models, Animal; Dose-Response Relat | 2011 |
Anti-inflammatory and anti-nociceptive activities of ethanolic extract and its various fractions from Adiantum capillus veneris Linn.
Topics: Acetic Acid; Adiantum; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Ethanol; Female; Inflam | 2011 |
Diuretic, anti-inflammatory, and analgesic activities of the ethanol extract from Cynoglossum lanceolatum.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Boraginaceae; Carrageenan; Disease Model | 2012 |
Analgesic and anti-inflammatory activity and pharmacokinetics of alkaloids from seeds of Strychnos nux-vomica after transdermal administration: effect of changes in alkaloid composition.
Topics: Acetic Acid; Administration, Cutaneous; Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents; Be | 2012 |
Isolation of active constituents from cherry laurel (Laurocerasus officinalis Roem.) leaves through bioassay-guided procedures.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Benzoquinones; Biological Assay; Capilla | 2012 |
Pharmacological properties and related constituents of stem bark of Pterocarpus erinaceus Poir. (Fabaceae).
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Catechin; Che | 2012 |
In vitro and in vivo evaluation of ibuprofen-paeonol conjugate.
Topics: Acetic Acid; Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceuti | 2011 |
[GC-MS analysis and analgesic activity of essential oil from fresh rhizoma of Cyperus rotundus].
Topics: Acetic Acid; Analgesics; Animals; Cyperus; Disease Models, Animal; Drugs, Chinese Herbal; Gas Chroma | 2011 |
Comparative computational studies of 3,4-dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile derivatives as potential antinociceptive agents.
Topics: Acetic Acid; Analgesics; Animals; Computer Simulation; Drug Evaluation, Preclinical; Male; Mice; Mod | 2012 |
Analgesic, anti-inflammatory, and CNS depressant activities of new constituents of Nepeta clarkei.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Behavior, Animal; | 2012 |
Antinociceptive activity of Sesbania sesban (Linn) wood extracts, a preliminary study.
Topics: Acetic Acid; Analgesics; Animals; Male; Mice; Motor Activity; Pain; Pain Measurement; Phytotherapy; | 2012 |
Antioxidant, anti-inflammatory and anti-nociceptive effects of Ammannia baccifera L. (Lythracceae), a folklore medicinal plant.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Biphenyl | 2012 |
Protective role of the triterpenoid-enriched extract of Trichosanthes dioica root against experimentally induced pain and inflammation in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response Relationship, | 2012 |
Indomethacin uptake into poly(2-hydroxyethyl methacrylate-co-3,9-divinyl-2,4,8,10-tetraoxaspiro [5.5]-undecane) network: In vitro and in vivo controlled release study.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Chemistry, Pharmaceutical; | 2012 |
A report on anti-oedemogenic activity of Byttneria herbacea roots--possible involvement of histamine receptor (type I).
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capillary Permeability; Carrageenan; Dose-Respon | 2012 |
Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice.
Topics: Acetic Acid; Androstadienes; Animals; Anthracenes; Benzoquinones; Disease Models, Animal; Flavonoids | 2012 |
Anti-nociceptive and anti-inflammatory properties of the ethanolic extract of Lagenaria breviflora whole fruit in rat and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cucurbitaceae; Disease Mode | 2011 |
Design, synthesis, computational and biological evaluation of some new hydrazino derivatives of DHA and pyranopyrazoles.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Computational Biology; Cycl | 2012 |
Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents.
Topics: Acetic Acid; Administration, Oral; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Asteraceae; B | 2012 |
Antiinflammatory, analgesic and antioxidant activities of Cyathula prostrata (Linn.) Blume (Amaranthaceae).
Topics: Acetic Acid; Amaranthaceae; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Arachidonic | 2012 |
The anti-inflammatory and antinociceptive properties of the chloroform fraction from Phyllanthus niruri plant is mediated via the peripheral nervous system.
Topics: Acetic Acid; Albumins; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Aspirin; Behavio | 2010 |
Analgesic and antipyretic activities of ethanol extract of Stereospermum suaveolens.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Antipyretics; Behavior, Animal; Bignoniaceae; Disea | 2010 |
Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Diclofena | 2012 |
Augmented activity of the pelvic nerve afferent mediated by TRP channels in dextran sulfate sodium (DSS)-induced colitis of rats.
Topics: Acetic Acid; Animals; Capsaicin; Colitis; Dextran Sulfate; Electrophysiological Phenomena; Male; Neu | 2012 |
Anti-inflammatory and analgesic activity of novel oral aspirin-loaded nanoemulsion and nano multiple emulsion formulations generated using ultrasound cavitation.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Behavior, | 2012 |
NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain.
Topics: Acetic Acid; Analgesia; Analysis of Variance; Animals; Behavior, Animal; Histamine H1 Antagonists; M | 2012 |
Isolation and biological activity of triglycerides of the fermented mushroom of Coprinus Comatus.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Biological | 2012 |
Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Behavior, A | 2012 |
Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
Topics: Acetic Acid; Administration, Oral; Animals; Asteraceae; Carbazoles; Cyclic GMP-Dependent Protein Kin | 2012 |
Anti-inflammatory effect of triterpene 3β, 6β, 16β-trihydroxylup-20(29)-ene obtained from Combretum leprosum Mart & Eich in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Ascitic Fluid; Capillary Permeability; C | 2012 |
Potentiation of acid-sensing ion channel activity by the activation of 5-HT₂ receptors in rat dorsal root ganglion neurons.
Topics: Acetic Acid; Acid Sensing Ion Channels; Animals; Cyproheptadine; Dose-Response Relationship, Drug; E | 2012 |
Antinociceptive activity of aqueous extract and isolated compounds of Lithrea molleoides.
Topics: Acetic Acid; Adrenergic alpha-2 Receptor Antagonists; Anacardiaceae; Analgesics; Animals; Behavior, | 2012 |
Bioactivity guided isolation of analgesic and anti-inflammatory constituents of Cnestis ferruginea Vahl ex DC (Connaraceae) root.
Topics: Acetic Acid; Africa; Analgesics; Animals; Anti-Inflammatory Agents; Biflavonoids; Carrageenan; Conna | 2012 |
Anti-nociceptive and anti-inflammatory effects of Croton crassifolius ethanol extract.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillaries; Carrageen | 2012 |
Evaluation of analgesic and anti-inflammatory effects of ethanol extract of Ficus iteophylla leaves in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Ethanol; Ficus; Infl | 2011 |
Antinociceptive activity of methanol extract of flowers of Impatiens balsamina.
Topics: Acetic Acid; Analgesics; Animals; Flavonoids; Flowers; Formaldehyde; Hot Temperature; Impatiens; Met | 2012 |
Synthesis of 5,6-dichloroindan-1-acids and their tetrazolyl derivatives as analgesic and anti-inflammatory agents.
Topics: Acetic Acid; Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response | 2012 |
Analgesic and anti-inflammatory activities of the methanol extract of Elaeagnus oldhamii Maxim. in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Carragee | 2012 |
Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier.
Topics: Acetic Acid; Amidohydrolases; Analgesics; Animals; Arachidonic Acids; ATP Binding Cassette Transport | 2012 |
Characterization of phenolic compounds and antinociceptive activity of Sempervivum tectorum L. leaf juice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Calibration; Chromatography, High Pressure Liqui | 2012 |
Antinociceptive effects of a chloroform extract and the alkaloid dicentrine isolated from fruits of Ocotea puberula.
Topics: Acetic Acid; Alkaloids; Analgesics, Opioid; Animals; Aporphines; Chloroform; Dose-Response Relations | 2012 |
Acute toxicity, antinociceptive activity and indole alkaloids of aqueous extract from bark of Aspidosperma cuspa (Kunth) Blake.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Aspidosperma; Female; Hot Temperature; Indole Alkaloids; M | 2012 |
Anti-inflammatory and analgesic properties of the ethanolic extract of Cnidoscolus aconitifolius in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease M | 2011 |
Geopropolis from Melipona scutellaris decreases the mechanical inflammatory hypernociception by inhibiting the production of IL-1β and TNF-α.
Topics: Acetic Acid; Analgesics; Animals; Bees; Behavior, Animal; Brazil; Carrageenan; Complex Mixtures; For | 2012 |
Quantitatively analyze composition principle of Ma Huang Tang by structural equation modeling.
Topics: Acetic Acid; Analgesics; Animals; Drugs, Chinese Herbal; Guinea Pigs; In Vitro Techniques; Male; Mic | 2012 |
Venom's antinociceptive property in the primitive ant Dinoponera quadriceps.
Topics: Acetic Acid; Analgesics; Animals; Ants; Behavior, Animal; Carrageenan; Formaldehyde; Hot Temperature | 2012 |
Anti-inflammatory and anti-nociceptive properties of Prunus padus.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Edema; Formaldehyde; H | 2012 |
Evaluation of anti-nociceptive activity of methanolic extract of Tecomaria capensis Thunb. (Bignoniaceae) leaves in rats.
Topics: Acetic Acid; Analgesics; Animals; Aspirin; Bignoniaceae; Disease Models, Animal; Dose-Response Relat | 2012 |
Comparison of the anti-inflammatory and analgesic effects of Gentiana macrophylla Pall. and Gentiana straminea Maxim., and identification of their active constituents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cell Line; Edema; Female; G | 2012 |
Anti-nociceptive activity of Pereskia bleo Kunth. (Cactaceae) leaves extracts.
Topics: Acetic Acid; Analgesics; Animals; Apigenin; Behavior, Animal; Cactaceae; Formaldehyde; Male; Mice; P | 2012 |
Anti-inflammatory and antinociceptive activities of the ethanolic extract of Bougainvillea xbuttiana.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Cytokines | 2012 |
Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist.
Topics: Acetic Acid; Analgesics; Animals; Drug Discovery; Mice; Nociception; Pain; Phenethylamines; Receptor | 2012 |
Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Arginine; Behavior, Animal; Cymenes; Disease Model | 2012 |
Analgesic effects of the non-nitrogen-containing bisphosphonates etidronate and clodronate, independent of anti-resorptive effects on bone.
Topics: Acetic Acid; Analgesics; Animals; Capsaicin; Clodronic Acid; Corticosterone; Diphosphonates; Disease | 2013 |
Anti-inflammatory, analgesic, and antioxidant activities of Pisonia aculeata: folk medicinal use to scientific approach.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carr | 2013 |
Evaluation of amentoflavone isolated from Cnestis ferruginea Vahl ex DC (Connaraceae) on production of inflammatory mediators in LPS stimulated rat astrocytoma cell line (C6) and THP-1 cells.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Astrocytoma; Biflavonoids; Carrageenan; Cell Line; C | 2013 |
Material basis for inhibition of dragon's blood on capsaicin-induced TRPV1 receptor currents in rat dorsal root ganglion neurons.
Topics: Acetic Acid; Analgesics; Animals; Capsaicin; Chalcone; Female; Ganglia, Spinal; Hot Temperature; In | 2013 |
Augmentation of analgesic effect of ibuprofen by alprazolam in experimental model of pain.
Topics: Acetic Acid; Acute Disease; Administration, Oral; Alprazolam; Analgesics, Non-Narcotic; Animals; Dis | 2002 |
Studies on new cyclic imides obtained from aminophenazone with analgesic properties. Potent effects of a 3,4-dichloromaleimide derivative.
Topics: Acetic Acid; Aminopyrine; Analgesics, Non-Narcotic; Animals; Capsaicin; Formaldehyde; Imides; Indica | 2002 |
Evaluation of the analgesic and anti-inflammatory activities of some thiazolo[4,5-d]pyrimidines.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan | 2002 |
Synthesis, antiinflammatory and analgesic activity of new hexahydropyrimidine derivatives.
Topics: Acetic Acid; Administration, Cutaneous; Administration, Oral; Analgesics, Non-Narcotic; Animals; Ant | 2002 |
4-Nitro-1,8-naphthalimides exhibit antinociceptive properties.
Topics: Acetic Acid; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Imides; Injections, I | 2002 |
Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dantrolene; | 2002 |
Bioactivity studies on beta-sitosterol and its glucoside.
Topics: Acetic Acid; Analgesics; Animals; Anthelmintics; Anti-Inflammatory Agents; Ascaris suum; Drug Evalua | 2002 |
Antinociceptive and antidiarrhoeal activity of Zanthoxylum rhetsa.
Topics: Acetic Acid; Analgesics; Animals; Antidiarrheals; Diarrhea; Female; Humans; Male; Mice; Pain; Pain M | 2002 |
A report of 49 cases of cnidarian envenoming from southeastern Brazilian coastal waters.
Topics: Acetic Acid; Administration, Topical; Animals; Bites and Stings; Brazil; Cnidarian Venoms; Cryothera | 2002 |
Analgesic principle from the bark of Careya arborea.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bangladesh; Be | 2002 |
Antinociceptive and gastroprotective effects of diterpenes from the flower buds of Egletes viscosa.
Topics: Acetic Acid; Analgesics; Animals; Anti-Ulcer Agents; Asteraceae; Diterpenes; Dose-Response Relations | 2002 |
mGlu5 receptor antagonist decreases Fos expression in spinal neurons after noxious visceral stimulation.
Topics: Acetic Acid; Animals; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Genes, fos; Mal | 2003 |
[The research of analgestic action of different processed products of Sparganium stoloniferum].
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Drugs, Chinese Herbal; Female; Hot Temperature; | 1997 |
[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents.
Topics: Abdominal Muscles; Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, I | 2003 |
Antinociceptive activity of the aerial parts of Solanum xanthocarpum.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Ma | 2003 |
The analgesic, antipyretic and anti-inflammatory activity of Diospyros variegata Kruz.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-St | 2003 |
Anti-inflammatory and antinociceptive activity of diphenyl diselenide.
Topics: Abdominal Muscles; Acetic Acid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Ste | 2003 |
Acetic acid conditioning stimulus induces long-lasting antinociception of somatic inflammatory pain.
Topics: Acetic Acid; Analgesics; Animals; Conditioning, Psychological; Inflammation; Male; Mice; Mice, Inbre | 2003 |
Antinociceptive and antipyretic activities of Pongamia pinnata leaves.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Respon | 2003 |
Anti-inflammatory and analgesic effects of a mixture of fatty acids isolated and purified from sugar cane wax oil.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cap | 2003 |
Antinociceptive, antiinflammatory and acute toxicity effects of Salvia leriifolia Benth seed extract in mice and rats.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationshi | 2003 |
Analgesic, antipyretic and anti-inflammatory effects of essential oil of Lippia multiflora.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Animals; Dose-Response Rela | 2003 |
Studies on analgesic activity of Cleome viscosa in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Cleome; Dose-Response Relationship, Drug; Fe | 2003 |
Characterization of cutaneous primary afferent fibers excited by acetic acid in a model of nociception in frogs.
Topics: Acetic Acid; Action Potentials; Afferent Pathways; Animals; Behavior, Animal; Cold Temperature; Elec | 2003 |
Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties.
Topics: Acetic Acid; Administration, Oral; Amides; Analgesics, Non-Narcotic; Animals; Ibuprofen; Injections, | 2003 |
Anti-inflammatory, analgesic and antipyretic properties of Clitoria ternatea root.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory | 2003 |
Anti-inflammatory and analgesic activity of Bouchea fluminensis.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose- | 2003 |
The nociceptive and anti-nociceptive effects of evodiamine from fruits of Evodia rutaecarpa in mice.
Topics: Acetic Acid; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Evodia; Fruit; Ileum; | 2003 |
Differential patterns of c-fos mRNA expression in the amygdaloid nuclei induced by chemical somatic and visceral noxious stimuli in rats.
Topics: Acetic Acid; Amygdala; Animals; Formaldehyde; In Situ Hybridization; Inflammation; Male; Pain; Pain | 2003 |
Do fishes have nociceptors? Evidence for the evolution of a vertebrate sensory system.
Topics: Acetic Acid; Animals; Biological Evolution; Hot Temperature; Nociceptors; Oncorhynchus mykiss; Pain; | 2003 |
Evaluation of analgesic effect of Datura fastuosa leaves and seed extracts.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Datura; Dose-Response Relationship, Drug; Ho | 2003 |
Antinociceptive and hypnotic effects of Premna tomentosa L. (Verbenaceae) in experimental animals.
Topics: Acetic Acid; Analgesics; Animals; Aspirin; Hypnotics and Sedatives; Male; Motor Activity; Pain; Pain | 2003 |
Analgesic and antiinflammatory activity of antibodies to histamine under experimental conditions.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antibodies; Histamine; Mice; Pain; Rats | 2003 |
Immunocytochemical localization of extracellular signal-regulated kinases 1 and 2 phosphorylated neurons in the brainstem of rat following visceral noxious stimulation.
Topics: Acetic Acid; Anesthetics; Animals; Brain Stem; Ether; Immunohistochemistry; Mitogen-Activated Protei | 2003 |
Evaluation of the analgesic activity of extracts of Miconia rubiginosa (Melastomataceae).
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Hot Temperature; Male; Melastoma | 2003 |
Anti-inflammatory effect of Solanum lycocarpum fruits.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cell Migration Inhibition; | 2003 |
Thalamic control of visceral nociception mediated by T-type Ca2+ channels.
Topics: Abdominal Pain; Acetic Acid; Action Potentials; Analysis of Variance; Animals; Calcium Channel Block | 2003 |
Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Capsaicin; Cassia; Dipyrone; Dose-Response Relationship | 2003 |
Analgesic effects of intra-nasal enkephalins.
Topics: Acetic Acid; Administration, Intranasal; Analgesics; Animals; Dicarboxylic Acids; Drug Synergism; Ed | 2003 |
Differential contributions of the basolateral and central nuclei of the amygdala in the negative affective component of chemical somatic and visceral pains in rats.
Topics: Acetic Acid; Affect; Amygdala; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Psycholo | 2003 |
Analgesic properties of Capraria biflora leaves aqueous extract.
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Hot Temperature; Injecti | 2003 |
[Suppression of visceral pain by action of the low intensity polarized light on acupuncture antinociceptive points].
Topics: Acetic Acid; Acupuncture Points; Acupuncture Therapy; Animals; Disease Models, Animal; Injections, I | 2003 |
Visceral hypersensitivity and altered colonic motility after subsidence of inflammation in a rat model of colitis.
Topics: Acetic Acid; Animals; Biomarkers; Colitis; Disease Models, Animal; Inflammation; Irritable Bowel Syn | 2003 |
Computed tomography-guided percutaneous acetic acid injection therapy for functioning adrenocortical adenoma.
Topics: Acetic Acid; Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Adult; Aged; Cushing Syndrome; Drug A | 2003 |
Comparison of the effect of chitosan and polyvinylpyrrolidone on dissolution properties and analgesic effect of naproxen.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Chemistry, Pharmaceutical; Chitosan; Crystal | 2004 |
Analgesic and anti-inflammatory activities evaluation of (-)-O-acetyl, (-)-O-methyl, (-)-O-dimethylethylamine cubebin and their preparation from (-)-cubebin.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dioxoles; Do | 2004 |
Synthesis, characterization and antiinflammatory-analgesic properties of 6-(alpha-amino-4-chlorobenzyl)thiazolo [3,2-b]-1,2,4-triazol-5-ols.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoquinones; Capillary Per | 2004 |
Analgesic studies on total alkaloids and alcohol extracts of Eclipta alba (Linn.) Hassk.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Eclipta; Female; Male; Mice; Pain; Pain Measurement; Ph | 2004 |
Cholinergic-NO-cGMP mediation of sildenafil-induced antinociception.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Acetylcholine; Animals; Carrageenan; Cholinergic A | 2004 |
Evaluation of the bioactivity of triterpene mixture isolated from Carmona retusa (Vahl.) Masam leaves.
Topics: Acetic Acid; Analgesics; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2004 |
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 2004 |
Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Car | 2004 |
Anti-inflammatory and analgesic activity of Peperomia pellucida (L.) HBK (Piperaceae).
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Carrageenan; Dose-Resp | 2004 |
Anti-inflammatory activity of methanolic extracts from Ventilago harmandiana Pierre.
Topics: Acetic Acid; Alkynes; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Arach | 2004 |
Analgesic and antiinflammatory activities of Erigeron floribundus.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Carrageenan; Dose-Response R | 2004 |
Effects of a chromogranin-derived peptide (CgA 47-66) in the writhing nociceptive response induced by acetic acid in rats.
Topics: Acetic Acid; Animals; Calcitonin Gene-Related Peptide; Cardiovascular Agents; Chromogranin A; Chromo | 2004 |
Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1.
Topics: Acetic Acid; Animals; Arthritis, Experimental; Dinoprostone; Escherichia coli; Inflammation; Intramo | 2004 |
Analgesic properties of the aqueous and ethanol extracts of the leaves of Kalanchoe crenata (Crassulaceae).
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Formaldehyde; Hot Temper | 2004 |
Analgesic and anti-inflammatory activities of a fraction rich in oncocalyxone A isolated from Auxemma oncocalyx.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anthraquinones; Anti-Inflammatory Agents; Boraginace | 2004 |
Behavioral phenotype of pre-proenkephalin-deficient mice on diverse congenic backgrounds.
Topics: Acetic Acid; Adrenocorticotropic Hormone; Analgesia; Animals; Anti-Anxiety Agents; Anxiety; Behavior | 2004 |
Studies on the analgesic and anti-inflammatory effects of Sideritis candicans Ait. var. eriocephala Webb aerial part.
Topics: Acetic Acid; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Ca | 2004 |
c-fos and CRF receptor gene transcription in the brain of acetic acid-induced somato-visceral pain in rats.
Topics: Acetic Acid; Animals; Brain; Genes, fos; Male; Pain; Rats; Rats, Sprague-Dawley; Receptors, Corticot | 2004 |
Experimentally induced ulcers and gastric sensory-motor function in rats.
Topics: Acetic Acid; Animals; Gastrointestinal Motility; Male; Muscle Contraction; Muscle, Smooth; Pain; Phy | 2005 |
Mechano-chemical nociceptors in the avian trigeminal mucosa.
Topics: Acetic Acid; Action Potentials; Afferent Pathways; Ammonia; Animals; Carbon Dioxide; Chemoreceptor C | 2004 |
Putative nociceptor responses to mechanical and chemical stimulation in skeletal muscles of the chicken leg.
Topics: Acetic Acid; Action Potentials; Animals; Chemoreceptor Cells; Chickens; Hindlimb; Mechanoreceptors; | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain.
Topics: Acetic Acid; Animals; Arthritis, Experimental; Carrageenan; Hot Temperature; Hyperalgesia; Iloprost; | 2004 |
Antinociceptive effect of Melastoma malabathricum ethanolic extract in mice.
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Hot Temperature; Male; Melastoma | 2004 |
Anti-inflammatory and antinociceptive activities of Trewia polycarpa roots.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Car | 2004 |
Synthesis, biological evaluation and kinetic studies of glyceride prodrugs of diclofenac.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Chromatography, High Pressu | 2004 |
Studies on the anti-inflammatory, antipyretic and analgesic properties of the leaves of Aegle marmelos Corr.
Topics: Acetic Acid; Aegle; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Behavior, Animal; C | 2005 |
Analgesic and anti-inflammatory activities of [6]-gingerol.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Catechols; Edema; Fatty Alc | 2005 |
Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities.
Topics: Acetic Acid; Animals; Carrageenan; Central Nervous System; Constriction, Pathologic; Edema; Formalde | 2004 |
Antiinflammatory activity of Synurus deltoides.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aste | 2004 |
Analgesic activity of di-caffeoylquinic acids from roots of Lychnophora ericoides (Arnica da serra).
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arnica; Dose-Response Relationship, D | 2005 |
Analgesic and topical anti-inflammatory activity of Hypericum canariense L. and Hypericum glandulosum Ait.
Topics: Acetic Acid; Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-S | 2005 |
Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways.
Topics: Acetic Acid; Analgesics; Animals; Bradykinin; Cyclic AMP-Dependent Protein Kinases; Diterpenes; Dose | 2005 |
Analgesic and antipyretic activities of the aqueous extract of Urtica macrorrhiza in experimental animals.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Animals; Dose-Response Rela | 2005 |
Antinociceptive activity of Eupatorium buniifolium aqueous extract.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Eupatorium | 2005 |
N3-phenacyluridine as a new type of antinociceptive compound in mice.
Topics: Acetic Acid; Analgesia; Animals; Hypnotics and Sedatives; Injections, Intraventricular; Male; Mice; | 2003 |
Antinociceptive effect of Nidularium procerum: a Bromeliaceae from the Brazilian coastal rain forest.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bra | 2005 |
BU74, a complex oripavine derivative with potent kappa opioid receptor agonism and delayed opioid antagonism.
Topics: Acetic Acid; Analgesics; Animals; Benzomorphans; Binding, Competitive; Bridged-Ring Compounds; Cell | 2005 |
Antinociceptive properties of acetylenic thiophene and furan derivatives: evidence for the mechanism of action.
Topics: Acetic Acid; Acetylene; Analgesics; Animals; Capsaicin; Dopamine Agents; Exploratory Behavior; Furan | 2005 |
Analgesic, antiinflammatory and antidiabetic properties of Harpagophytum procumbens DC (Pedaliaceae) secondary root aqueous extract.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blo | 2004 |
Analgesic and anti-inflammatory activity of the ethanolic extract from Spiranthera odoratissima A. St. Hillaire (Manacá) roots.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Migrati | 2004 |
Antinociceptive diterpene from Euphorbia decipiens.
Topics: Acetic Acid; Analgesics; Animals; Diterpenes; Euphorbia; Female; Male; Mice; Pain; Pain Measurement; | 2005 |
Antinociceptive activity of Ceriops decandra leaf and pneumatophore.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Ma | 2005 |
Anti-inflammatory, anti-nociceptive and antioxidant activities of Balanites aegyptiaca (L.) Delile.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Antioxidants; Balanites; B | 2005 |
Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae).
Topics: Acetic Acid; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non- | 2005 |
Adenosine receptor ligands and dizocilpine-induced antinociception in mice.
Topics: Acetic Acid; Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male | 2005 |
Preliminary pharmacological studies on Piper chaba stem bark.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidiarrheals; Carrageenan; Central | 2005 |
Anti-inflammatory and analgesic properties of water-ethanolic extract from Pothomorphe umbellata (Piperaceae) aerial parts.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Car | 2005 |
Analgesic activity of the roots and leaves extracts of Calliandra portoricensis.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Fabaceae; | 2005 |
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Behavior, Animal; Capsaicin; Cat's Claw; Dose- | 2005 |
Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Capillary Permeability; Carrageenan; Cyclopropanes; Dose | 2005 |
Antinociceptive effect of leaf essential oil from Croton sonderianus in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capsaicin; Croton; Disease Models, Animal; Dose- | 2005 |
Possible analgesic and anti-inflammatory interactions of aspartame with opioids and NSAIDs.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2005 |
Antinociceptive effects of the essential oil of Alpinia zerumbet on mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationsh | 2005 |
Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; | 2005 |
Antipyretic and analgesic activities of Caesalpinia bonducella seed kernel extract.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Animals; Body Temperature; | 2005 |
New anti-inflammatory formulation containing Synurus deltoides extract.
Topics: Acetic Acid; Angelica; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Asteracea | 2005 |
The influences of temperature and naloxone on the antinociceptive activity of Corchorus olitorius L. in mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2005 |
Synthesis and antinociceptive activity of some substituted-{5-[2-(1,2,3,4-tetrahydrocarbazol-9-yl)ethyl]tetrazol-1-yl}alkanones.
Topics: Acetic Acid; Analgesics; Animals; Drug Evaluation, Preclinical; Ketones; Mice; Molecular Structure; | 2005 |
Antinociceptive effect of the aqueous extract obtained from roots of Physalis angulata L. on mice.
Topics: Acetic Acid; Analgesics; Animals; Brazil; Male; Medicine, Traditional; Mice; Pain; Pain Measurement; | 2006 |
Antinociceptive activity of Vitex-negundo Linn leaf extract.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Aspirin; Dose-Response Relationship, Drug; Drug Inte | 2005 |
Prevention of arthritic inflammation using an oriental herbal combination BDX-1 isolated from Achyranthes bidentata and Atractylodes japonica.
Topics: Acetic Acid; Achyranthes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 2005 |
Antinociceptive action of the extract and the flavonoid quercitrin isolated from Bauhinia microstachya leaves.
Topics: Abdominal Muscles; Acetic Acid; Analgesics; Animals; Bauhinia; Carrageenan; Constriction, Pathologic | 2005 |
Visceral, inflammatory and neuropathic pain in glycine receptor alpha 3-deficient mice.
Topics: Acetic Acid; Animals; Formaldehyde; Inflammation; Irritants; Mice; Mice, Mutant Strains; Neuralgia; | 2005 |
Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice.
Topics: Acetic Acid; Analgesics; Animals; Anticonvulsants; Bicuculline; Female; Fruit; Hot Temperature; Male | 2005 |
An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Croton Oil; Ear; | 2005 |
Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract.
Topics: Acetic Acid; Albumins; Analgesics; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cyclooxygenas | 2006 |
Antinociceptive properties of the ethanolic extract and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Capsaicin; Combretum; Endorphins; Flowers; Formaldehyde; | 2006 |
Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Bradykinin; Bradykinin R | 2006 |
Systemic and spinal administration of the mu opioid, remifentanil, produces antinociception in amphibians.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Inje | 2006 |
Reversibility of opioid receptor occupancy of buprenorphine in vivo.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Buprenorphine; Cinnamates; Dose-Response Relationship, Dru | 2006 |
Antinociceptive and free radical scavenging activities of alkaloids isolated from Lindera angustifolia Chen.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; F | 2006 |
Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents.
Topics: Acetic Acid; Adrenergic Uptake Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavio | 2007 |
Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats.
Topics: Acetic Acid; Adrenal Glands; Animals; Anti-Inflammatory Agents, Non-Steroidal; Consciousness; Cortic | 2006 |
Anti-inflammatory and anti-nociceptive activities of Pluchea quitoc (DC.) ethanolic extract.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Carrag | 2006 |
Reactions of phthalimides with 1-methylethylamine: analgesic and anti-inflammatory properties of resulting carboxamides.
Topics: Acetic Acid; Amides; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Ethylamines; | 2006 |
Assessment of neuropharmacological activities of Pandanus foetidus (Pandanaceae) in mice.
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Hypnotics and Sedatives; | 2006 |
Antinociceptive effects of tetrodotoxin (TTX) in rodents.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relation | 2006 |
Antinociceptive activity and chemical composition of constituents from Caragana microphylla seeds.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Caragana; Dose-Response Relationship, Drug; | 2007 |
Constituents and biological activities of Schinus polygamus.
Topics: Acetic Acid; Anacardiaceae; Analgesics; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Ar | 2006 |
Study on the antinociceptive effects of Thymus broussonetii Boiss extracts in mice and rats.
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Naloxo | 2006 |
Targeting pain-suppressed behaviors in preclinical assays of pain and analgesia: effects of morphine on acetic acid-suppressed feeding in C57BL/6J mice.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Dopamine Antagon | 2006 |
Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats.
Topics: Acetic Acid; Adenosine Triphosphate; Analgesics; Animals; Dose-Response Relationship, Drug; Formalde | 2006 |
Anti-inflammatory and anti-nociceptive activity of risedronate in experimental pain models in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Diphosphonates; | 2006 |
Analgesic activity of the methanolic extract and total alkaloids of Glaucium paucilobum.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Hot Tem | 2006 |
[Experimental study of Bailian Caogen granule on pharmacodynamics].
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Body Temperature; Coptis; Drug Combinations; Drugs, | 2006 |
Antinociceptive effects of synthetic chalcones obtained from xanthoxyline.
Topics: Acetaminophen; Acetic Acid; Acetophenones; Administration, Oral; Analgesics; Animals; Aspirin; Chalc | 2006 |
The antinociceptive activity of Muntingia calabura aqueous extract and the involvement of L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in its observed activity in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Elaeocarpa | 2006 |
Antinociceptive effect of Hyptis pectinata leaves extracts.
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyptis; | 2006 |
[Effect of the genetic factor and nociceptive stimule on the development of visceral pain].
Topics: Acetic Acid; Animals; Behavior, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Pain; Pain | 2006 |
Anti-inflammatory, analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; beta-Glucans; Carrageenan; Edema; Ellagi | 2006 |
Antinociceptive and anti-inflammatory effects of Thespesia populnea bark extract.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; | 2007 |
Preliminary pharmacological screening of Bixa orellana L. leaves.
Topics: Acetic Acid; Animals; Anti-Bacterial Agents; Antidiarrheals; Bixaceae; Dose-Response Relationship, D | 2006 |
Antiinflammatory and analgesic effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rats and mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Diclofenac; Female; | 2006 |
Antidepressants enhance the antinociceptive effects of carbamazepine in the acetic acid-induced writhing test in mice.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Antidepressive Agents; Antidepressive Agents, Second | 2006 |
Antinociceptive activity of the pyranocoumarin seselin in mice.
Topics: Acetic Acid; Analgesics; Animals; Coumarins; Dose-Response Relationship, Drug; Formaldehyde; Hot Tem | 2006 |
Involvement of the bed nucleus of the stria terminalis in the negative affective component of visceral and somatic pain in rats.
Topics: Acetic Acid; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Psyc | 2007 |
Analgesic activity of Calotropis gigantea flower.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Calotropis; Dose-Response Relationship, Drug | 2007 |
Anti-inflammatory action of phenolic compounds from Gastrodia elata root.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Benzyl Compounds; Carrageenan; Cyc | 2006 |
Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action.
Topics: Acetic Acid; Analgesics; Animals; Benzene Derivatives; Bradykinin; Capsaicin; Edema; Female; Glutama | 2007 |
Antinociceptive effects of the aqueous extract of Brugmansia suaveolens flowers in mice.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Diclofenac; Disease Models, Animal; Drug Eva | 2007 |
Antinociceptive activity of Helicteres isora.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Male; Malv | 2007 |
In-vitro and in-vivo anti-inflammatory action of the ethanol extract of Trachelospermi caulis.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Carrageenan; Cell Line | 2007 |
The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats.
Topics: Acetic Acid; Age Factors; Anilides; Animals; Animals, Newborn; Capsaicin; Catheterization; Cinnamate | 2007 |
Analgesic activity of methanol extract of Aegle marmelos leaves.
Topics: Acetic Acid; Aegle; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Male; Mice; Pain; | 2007 |
Anti-inflammatory and analgesic effects of Hedychium coronarium Koen.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Ede | 2007 |
Antinociceptive effect and acute toxicity of the essential oil of Hyptis fruticosa in mice.
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyptis; | 2007 |
Ligustilide attenuates pain behavior induced by acetic acid or formalin.
Topics: 4-Butyrolactone; Acetic Acid; Analgesics; Animals; Drugs, Chinese Herbal; Female; Formaldehyde; Medi | 2007 |
Anti-nociceptive and anti-hyperprolactinemia activities of Fructus Viticis and its effective fractions and chemical constituents.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Female; Fruit; Hyperprolactinemia; Mice; Mic | 2007 |
Antinociceptive and antipyretic activities of the Zizyphus oxyphylla Edgew. leaves.
Topics: Acetic Acid; Analgesics; Analgesics, Non-Narcotic; Animals; Body Temperature; Dose-Response Relation | 2007 |
Involvement of cellular prion protein in the nociceptive response in mice.
Topics: Acetic Acid; Analysis of Variance; Animals; Behavior, Animal; Edema; Freund's Adjuvant; Glutamic Aci | 2007 |
Analgesic and antiinflammatory activity of Cyclamen repandum S. et S.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclamen; Edema; Male; Mice | 2007 |
Antinociceptive action of myricitrin: involvement of the K+ and Ca2+ channels.
Topics: Acetic Acid; Analgesics; Animals; Calcium Channels; Calcium Radioisotopes; Calcium Signaling; Capsai | 2007 |
Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals.
Topics: Acetic Acid; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Carrageenan; C | 2006 |
Antinociceptive activity of Derris uliginosa.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Derris; Dose-Response Relationship, Drug; Fe | 2007 |
Antinociceptive effect and acute toxicity of the Hyptis suaveolens leaves aqueous extract on mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Ho | 2007 |
Does the medial thalamus play a role in the negative affective component of visceral pain in rats?
Topics: Acetic Acid; Affect; Animals; Avoidance Learning; Excitatory Amino Acid Agonists; Injections, Intrap | 2007 |
Relative contribution of peripheral versus central opioid receptors to antinociception.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Aci | 2007 |
Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Fabaceae; Formaldehy | 2007 |
Antinociceptive and anti-inflammatory steroidal saponins from Dracaena ombet.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose- | 2007 |
Biofilm reduction by a new burn gel that targets nociception.
Topics: Acetic Acid; Acrylic Resins; Administration, Topical; Anti-Bacterial Agents; Biofilms; Burns; Chelat | 2007 |
Analgesic, anti-inflammatory and antipyretic activities of the ethanolic extract and its fractions of Cleome rutidosperma.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory | 2007 |
Isolation and characterisation of bioactive isoflavonoids from the roots of Dalbergia horrida.
Topics: Acetic Acid; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; C | 2007 |
Analgesic and antiinflammatory effects of mollic acid glucoside, a 1 alpha-hydroxycycloartenoid saponin extractive from Combretum molle R. Br. ex G. Don (Combretaceae) leaf.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Combretum; Diclofenac; Edema; Female; Hi | 2008 |
Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice.
Topics: Acetic Acid; Amines; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Cyclohexanecarbo | 2008 |
DAMGO and 6beta-glycine substituted 14-O-methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; | 2007 |
Spinal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors may mediate the analgesic effects of emulsified halogenated anaesthetics.
Topics: Acetic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Anesthetics, Inha | 2007 |
Antinociceptive activity of petroleum ether fraction from the MeOH extracts of Paederia scandens in mice.
Topics: Acetic Acid; Alkanes; Analgesics; Animals; Capsaicin; Formaldehyde; Hot Temperature; Methanol; Mice; | 2008 |
Evidence for the involvement of glutamatergic and GABAergic systems and protein kinase A pathway in the antinociceptive effect caused by p-methoxy-diphenyl diselenide in mice.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetic Acid; Analgesics; Animals; Benzene Derivatives; Capsa | 2008 |
Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines.
Topics: Acetic Acid; Alprazolam; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Dose-Response Relat | 2008 |
Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Disease Models, An | 2007 |
Ketorolac-dextran conjugates: synthesis, in vitro and in vivo evaluation.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Buffers; Carrag | 2007 |
Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cotto | 2007 |
Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors.
Topics: Acetic Acid; Algorithms; Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Dose-Response | 2008 |
Nefopam and ketoprofen synergy in rodent models of antinociception.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, A | 2008 |
LPK-26, a novel kappa-opioid receptor agonist with potent antinociceptive effects and low dependence potential.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Behavior, Animal; CHO Cells; Cricetinae; Cricetulus; Disea | 2008 |
Analgesic activity of ZC88, a novel N-type voltage-dependent calcium channel blocker, and its modulation of morphine analgesia, tolerance and dependence.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Calcium Channel Blockers; Calcium Channels, N- | 2008 |
Synthesis and pharmacological evaluation of 2-substituted benzo[b]thiophenes as anti-inflammatory and analgesic agents.
Topics: Acetic Acid; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; C | 2009 |
Pharmacological analysis of inhomogeneous static magnetic field-induced antinociceptive action in the mouse.
Topics: Acetic Acid; Animals; Anisotropy; Electric Stimulation; Electromagnetic Fields; Male; Mice; Pain; Pa | 2008 |
Synthesis of new imidazolyl acetic acid derivatives with anti-inflammatory and analgesic activities.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, A | 2008 |
Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol.
Topics: Acetic Acid; Acetophenones; Analgesics; Animals; Anti-Allergic Agents; Antipruritics; Asthma; Behavi | 2008 |
The effect of formalin pretreatment on nicotine-induced antinociceptive effect: the role of mu-opioid receptor in the hippocampus.
Topics: Acetic Acid; Analgesics; Animals; Benzoxazines; Blotting, Western; Brain; Coloring Agents; Drug Tole | 2008 |
Increased susceptibility of annexin-A1 null mice to nociceptive pain is indicative of a spinal antinociceptive action of annexin-A1.
Topics: Acetic Acid; Analgesics; Animals; Annexin A1; Behavior, Animal; Dinoprostone; Disease Models, Animal | 2008 |
The antinociceptive effects of anticonvulsants in a mouse visceral pain model.
Topics: Acetic Acid; Amines; Analgesics; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Cyclohex | 2008 |
Further studies on the xylazine-yohimbine interaction.
Topics: Abdomen; Acetates; Acetic Acid; Animals; Kinetics; Male; Mice; Muscle Cramp; Pain; Receptors, Adrene | 1984 |
Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine.
Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Drug Interactions; Female; Male; Mice; Morphine; | 1982 |
Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice.
Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Le | 1983 |
Studies on the combination of Glycyrrhizae Radix in Shakuyakukanzo-To.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents; Benzoates; Bridged-Ring Compounds; Carrage | 1984 |
Central actions of AD-1211, an analgesic lacking common opiate features.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Behavior, Animal; Benzoquinones; Bradykinin; Central Ner | 1984 |
Postural asymmetry in rats induced by stress and pain stimuli.
Topics: Acetates; Acetic Acid; Animals; Cold Temperature; Injections, Intraperitoneal; Male; Naloxone; Pain; | 1982 |
Ethnopharmacology of bear gall bladder: I.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Bile; Bile Ac | 1995 |
Idiopathic vulvodynia. Clinical evaluation of the pain threshold with acetic acid solutions.
Topics: Acetates; Acetic Acid; Adult; Aged; Case-Control Studies; Female; Humans; Middle Aged; Pain; Pain Th | 1995 |
Analgesic effect of Dioclea grandiflora constituents in rodents.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Chemical Fractionation; Dose-Response Relationship, Drug | 1995 |
Effect of fedotozine on the cardiovascular pain reflex induced by distension of the irritated colon in the anesthetized rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetates; | 1994 |
Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Ca | 1994 |
Synthesis and antiinflammatory, analgesic, and antipyretic testing of 4-[1-oxo-(3-substituted aryl)-2-propenyl]-3-phenylsydnones and of 3-[4-[3-(substituted aryl)-1-oxo-2-propenyl]phenyl]sydnones.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; As | 1995 |
Effects of intracolonic acetic acid on responses to colorectal distension in the rat.
Topics: Acetates; Acetic Acid; Animals; Blood Pressure; Catheterization; Colitis; Colon; Electromyography; G | 1995 |
Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice.
Topics: 2-Amino-5-phosphonovalerate; Acetates; Acetic Acid; Animals; Anticonvulsants; Cycloserine; Dizocilpi | 1994 |
Analgesic effects of callus culture extracts from selected species of Phyllanthus in mice.
Topics: Abdominal Muscles; Acetates; Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Fem | 1994 |
A device for automatic measurement of writhing and its application to the assessment of analgesic agents.
Topics: Acetates; Acetic Acid; Aminopyrine; Analgesics; Animals; Behavior, Animal; Caffeine; Disease Models, | 1994 |
Synthesis and analgesic activity of 2-amino-5-tert-butyl-2-oxazoline.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, | 1995 |
Anti-nociceptive effects of aconiti tuber and its alkaloids.
Topics: Acetates; Acetic Acid; Aconitine; Analgesics; Animals; Arthritis, Experimental; Cold Temperature; Di | 1994 |
Relationship between anti-aversive effects of salmon calcitonin and plasma levels of ACTH, beta-endorphin and prostaglandin E2 in mice.
Topics: Acetates; Acetic Acid; Adrenocorticotropic Hormone; Analgesics; Animals; beta-Endorphin; Calcitonin; | 1994 |
3,3'-Bi-[1,3-thiazolidine-4-one] system. VII. Synthesis and SARS of some 2-heteroaryl derivatives with antiinflammatory and related activities.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Ca | 1994 |
Development of tolerance to morphine antinociception in mice treated with nociceptive stimulants.
Topics: Acetates; Acetic Acid; Animals; Drug Tolerance; Formaldehyde; Freund's Adjuvant; Hindlimb; Male; Mic | 1993 |
Anti-inflammatory and analgesic activity of Baccharis trimera: identification of its active constituents.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanols; Carra | 1996 |
Desensitization follows excitation of bladder primary afferents by intravesical capsaicin, as shown by c-fos activation in the rat spinal cord.
Topics: Acetic Acid; Animals; Capsaicin; Female; Immunohistochemistry; Neurons, Afferent; Pain; Proto-Oncoge | 1996 |
Investigation of antifungal and analgesic activities of extracts from Sium nodiflorum.
Topics: Acetic Acid; Analgesics; Animals; Antifungal Agents; Cell Division; Culture Media; Ethanol; Male; Mi | 1996 |
The effects of systemic procaine, lidocaine and dimethocaine on nociception in mice.
Topics: Acetic Acid; Aminobenzoates; Anesthetics, Local; Animals; Hot Temperature; Injections, Subcutaneous; | 1996 |
Preliminary studies of analgesic and anti-inflammatory properties of Caesalpinia ferrea crude extract.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Carrageenan; Disease Models, Animal; Dose-Re | 1996 |
Tachykininergic mediation of viscerosensitive responses to acute inflammation in rats: role of CGRP.
Topics: Abdominal Muscles; Acetic Acid; Acute Disease; Animals; Calcitonin Gene-Related Peptide; Gastric Emp | 1997 |
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Aci | 1997 |
[The physiological properties of the action of a new analgesic and antipyretic preparation].
Topics: Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroid | 1997 |
Antinociceptive components of Ganoderma lucidum.
Topics: Acetic Acid; Analgesics; Animals; Aspirin; Basidiomycota; Heptanoic Acids; Japan; Lanosterol; Male; | 1997 |
Nipple pain: an alternative explanation.
Topics: Acetic Acid; Breast Feeding; Candidiasis, Cutaneous; Female; Humans; Laundering; Nipples; Pain | 1997 |
Involvement of prostaglandins and CGRP-dependent sensory afferents in peritoneal irritation-induced visceral pain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Aci | 1997 |
Calcitonin gene-related peptide in viscerosensitive response to colorectal distension in rats.
Topics: Abdomen; Acetic Acid; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Col | 1997 |
Reduction by antiinflammatory drugs of the response of corneal sensory nerve fibers to chemical irritation.
Topics: Acetic Acid; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; | 1997 |
Antinociceptive properties of the hydroalcoholic extract and preliminary study of a xanthone isolated from Polygala cyparissias (Polygalaceae).
Topics: Abdominal Pain; Acetic Acid; Analgesia; Analgesics; Animals; Aspirin; Bradykinin; Capsaicin; Ethanol | 1997 |
Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene.
Topics: Acetic Acid; Alleles; Animals; Biomarkers; Calcitonin Gene-Related Peptide; Formaldehyde; Ganglia, S | 1998 |
Effects of intrathecally administered aminoglycoside antibiotics, calcium-channel blockers, nickel and calcium on acetic acid-induced writhing test in mice.
Topics: Acetic Acid; Animals; Anti-Bacterial Agents; Calcium; Calcium Channel Blockers; Female; Gentamicins; | 1998 |
Comparative analgesic activity of nimesulide and diclofenac by intramuscular route: correlation with pharmacokinetic profile of nimesulide.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cycloox | 1998 |
Suppression of inflammatory responses by surfactin, a selective inhibitor of platelet cytosolic phospholipase A2.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Bacterial Proteins; | 1998 |
[Influence of infusion solution on the vascular permeability in rat skin].
Topics: Acetic Acid; Animals; Capillary Permeability; Coloring Agents; Hydrochloric Acid; Hydrogen-Ion Conce | 1998 |
Chemical and pharmacological examination of antinociceptive constituents of Wedelia paludosa.
Topics: Abdomen; Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 1998 |
Metamizol potentiates morphine effects on visceral pain and evoked c-Fos immunoreactivity in spinal cord.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Drug Sy | 1998 |
Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice.
Topics: Abdominal Muscles; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cyclooxygenase I | 1998 |
Anti-inflammatory activity of the alkaloid bukittinggine from Sapium baccatum.
Topics: Abdominal Muscles; Acetic Acid; Alkaloids; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agen | 1998 |
Visceral analgesic tolerance to intrathecal butorphanol in rats.
Topics: Acetic Acid; Analgesia; Analgesics, Opioid; Analysis of Variance; Animals; Butorphanol; Catheters, I | 1998 |
Rational drug design and synthesis of a highly selective nonpeptide delta-opioid agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl- 1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine (TAN-67).
Topics: Acetic Acid; Analgesics, Opioid; Animals; Brain; Drug Design; Guinea Pigs; In Vitro Techniques; Liga | 1998 |
The role of angiotensin II and of its receptor subtypes in the acetic acid-induced abdominal constriction test.
Topics: Acetic Acid; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibit | 1999 |
Differential effects of chemical and mechanical colonic irritation on behavioral pain response to intraperitoneal acetic acid in mice.
Topics: Abdominal Muscles; Acetic Acid; Animals; Behavior, Animal; Catheterization; Colonic Diseases; Inject | 1999 |
Alendronate induces antinociception in mice, not related with its effects in bone.
Topics: Acetic Acid; Alendronate; Analgesics; Animals; Bone Density; Dose-Response Relationship, Drug; Forma | 1999 |
L-NAME, a nitric oxide synthase inhibitor, modulates cholinergic antinociception.
Topics: Acetic Acid; Analgesics; Animals; Buspirone; Cholinergic Agents; Drug Synergism; Enzyme Inhibitors; | 1999 |
Ginsenosides that produce differential antinociception in mice.
Topics: Acetic Acid; Analgesics; Animals; Body Temperature; Central Nervous System Agents; Dose-Response Rel | 1999 |
Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1999 |
Antinociception caused by the extract of Hedyosmum brasiliense and its active principle, the sesquiterpene lactone 13-hydroxy-8,9-dehydroshizukanolide.
Topics: Acetic Acid; Analgesics; Animals; Brazil; Constriction, Pathologic; Male; Mice; Molecular Structure; | 1999 |
Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
Topics: Acetic Acid; Amiloride; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Anim | 1999 |
Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Bradykinin; Bradykinin Rec | 1999 |
Preliminary studies of analgesic and anti-inflammatory properties of Opuntia dillenii aqueous extract.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Male; Medicine, Trad | 1999 |
Antinociceptive effects of the tubercles of Anredera leptostachys.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Caribbean Region; Diazepam; Dose-Response Relati | 1999 |
Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence.
Topics: Acetic Acid; Animals; Benzomorphans; Brain; Dose-Response Relationship, Drug; Ethylketocyclazocine; | 2000 |
Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice.
Topics: Acetic Acid; Animals; Cell Count; Cytokines; Dose-Response Relationship, Drug; Iloprost; Immune Sera | 2000 |
Evidence for involvement of prostaglandin I2 as a major nociceptive mediator in acetic acid-induced writhing reaction: a study using IP-receptor disrupted mice.
Topics: 6-Ketoprostaglandin F1 alpha; Acetic Acid; Analgesics, Non-Narcotic; Animals; Ascitic Fluid; Dinopro | 1999 |
Evaluation of the activity of a novel metabotropic glutamate receptor antagonist (+/-)-2-amino-2-(3-cis and trans-carboxycyclobutyl-3-(9-thioxanthyl)propionic acid) in the in vitro neonatal spinal cord and in an in vivo pain model.
Topics: Acetic Acid; Animals; Animals, Newborn; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antag | 2000 |
[Effect of the unilateral activation of brain hemispheres on visceral pain sensitivity in BALB/c mice].
Topics: Abdomen; Acetic Acid; Animals; Brain; Functional Laterality; Male; Mice; Mice, Inbred BALB C; Pain; | 1999 |
Comparison of analgesic effects of khat (Catha edulis Forsk) extract, D-amphetamine and ibuprofen in mice.
Topics: Acetic Acid; Amphetamine; Analgesia; Analgesics; Animals; Catha; Central Nervous System Stimulants; | 2000 |
Antipyretic, antinociceptive and anti-inflammatory activity of Premna herbacea roots.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Infective Age | 2000 |
Alterations in spinal cord Fos protein expression induced by bladder stimulation following cystitis.
Topics: Acetic Acid; Anesthetics, Intravenous; Animals; Capsaicin; Choline O-Acetyltransferase; Chronic Dise | 2000 |
Antinociceptive and other behavioral effects of the steroid SC17599 are mediated by the mu-opioid receptor.
Topics: Acetic Acid; Analgesics; Animals; Hot Temperature; Male; Mice; Motor Activity; Pain; Pain Measuremen | 2000 |
The role of pH and osmolarity in evoking the acetic acid-induced wiping response in a model of nociception in frogs.
Topics: Acetic Acid; Animals; Behavior, Animal; Buffers; Disease Models, Animal; Epidermis; Formates; Hydroc | 2000 |
Altered pain responses in mice lacking alpha 1E subunit of the voltage-dependent Ca2+ channel.
Topics: Acetic Acid; Animals; Anxiety; Calcium; Calcium Channels, R-Type; Exploratory Behavior; Fear; Formal | 2000 |
A study of the trypanocidal and analgesic properties from Lychnophora granmongolense (Duarte) Semir & Leitão Filho.
Topics: Acetic Acid; Analgesics; Animals; Brazil; Chagas Disease; Male; Medicine, Traditional; Mice; Pain; P | 2000 |
Tecoma sambucifolia: anti-inflammatory and antinociceptive activities, and 'in vitro' toxicity of extracts of the 'huarumo' of peruvian incas.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplas | 2000 |
Anti-sickling, analgesic and anti-inflammatory properties of 3,5-dimethoxy-4-hydroxy benzoic acid and 2,3,4-trihydroxyacetophenone.
Topics: Acetic Acid; Acetophenones; Analgesics; Anemia, Sickle Cell; Animals; Anti-Inflammatory Agents, Non- | 2000 |
Analysis of the antinociceptive properties of marrubiin isolated from Marrubium vulgare.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Brazil; Capsaicin; Diterpenes; Female; Formaldehyd | 2000 |
Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene.
Topics: Acetic Acid; Animals; Behavior, Animal; Capsaicin; Colon; Cyclophosphamide; Cystitis; Female; Hypera | 2000 |
Studies on the anti-inflammatory and related pharmacological properties of the aqueous extract of Bridelia ferruginea stem bark.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Alkylating; Ar | 2000 |
Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark.
Topics: Acetic Acid; Africa; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Art | 2000 |
Antinociceptive properties of extracts of new species of plants of the genus Phyllanthus (Euphorbiaceae).
Topics: Abdomen; Acetic Acid; Analgesics; Animals; Behavior, Animal; Brazil; Capsaicin; Euphorbiaceae; Forma | 2000 |
Preliminary studies on the analgesic activity of latex of Calotropris procera.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Interaction | 2000 |
Analgesic and anti-inflammatory activity of the proanthocyanidin shellegueain A from Polypodium feei METT.
Topics: Acetic Acid; Analgesics; Animals; Anthocyanins; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenas | 2000 |
Effects of sesquiterpenoids from "Oriental incenses" on acetic acid-induced writhing and D2 and 5-HT2A receptors in rat brain.
Topics: Acetic Acid; Analgesics; Animals; Lactones; Male; Mice; Mice, Inbred Strains; Pain; Plant Extracts; | 2000 |
Analgesic activity of Peperomia pellucida aerial parts in mice.
Topics: Acetic Acid; Analgesics; Animals; Female; Humans; Male; Medicine, African Traditional; Mice; Pain; P | 2001 |
Peripheral and preemptive opioid antinociception in a mouse visceral pain model.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Female; Mice; Naloxone; | 2001 |
Analgesic and anti-inflammatory effects of Mangifera indica L. extract (Vimang).
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response Relationship, | 2001 |
Antinociceptive properties of N-aryl-glutaramic acids and N-aryl-glutarimides.
Topics: Acetic Acid; Analgesics; Aspirin; Chromatography, Thin Layer; Formaldehyde; Glutamic Acid; Humans; I | 2000 |
Analgesic and anti-inflammatory effects of phosphodiesterase inhibitors.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageen | 2000 |
The novel analgesic, cizolirtine, inhibits the spinal release of substance P and CGRP in rats.
Topics: Acetic Acid; Analgesics; Anesthesia; Anesthetics, Inhalation; Animals; Aspirin; Calcitonin Gene-Rela | 2001 |
Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; F | 2001 |
Dual effect of cAMP on the writhing response in mice.
Topics: Acetic Acid; Aminophylline; Animals; Anti-Inflammatory Agents; Bucladesine; Cholera Toxin; Colforsin | 2001 |
Antinociceptive effect of Elaeagnus angustifolia fruit seeds in mice.
Topics: Acetic Acid; Analgesics; Animals; Female; Male; Mice; Pain; Pain Measurement; Plant Extracts; Plants | 2001 |
Antinociceptive activity of Malvastrum coromandelinum.
Topics: Acetic Acid; Analgesics; Animals; India; Male; Malvaceae; Medicine, Traditional; Mice; Pain; Pain Me | 2001 |
Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel.
Topics: Acetic Acid; Acoustic Stimulation; Animals; Anxiety; Behavior, Animal; Calcium Channel Blockers; Cal | 2001 |
Antiinflammatory, analgesic and free radical scavenging activities of the marine microalgae Chlorella stigmatophora and Phaeodactylum tricornutum.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Chlorella; Edema; Eukaryota | 2001 |
Studies on psychopharmacological activity of Andrographis paniculata extract.
Topics: Acetic Acid; Animals; Behavior, Animal; Magnoliopsida; Mice; Pain; Pain Measurement; Pentylenetetraz | 2001 |
Analgesic and antiinflammatory activities of vernonioside B2 from Vernonia condensata.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Dose-Response Relationship, | 2001 |
Suppression of the tetrodotoxin-resistant sodium channel (PN3/SNS): a possible new treatment for bladder pain.
Topics: Acetic Acid; Animals; Drug Resistance; Female; Indicators and Reagents; NAV1.8 Voltage-Gated Sodium | 2001 |
Antinociceptive effects of bee venom acupuncture (apipuncture) in rodent animal models: a comparative study of acupoint versus non-acupoint stimulation.
Topics: Acetic Acid; Acupuncture Points; Acupuncture Therapy; Analgesics; Animals; Bee Venoms; Dose-Response | 2001 |
Antinociceptive activity of Zizyphus spina-christi root bark extract.
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Formaldehyde; Hot Temper | 2001 |
Analgesic effect of olipiphate on mouse model of chemical stimulation of peritoneum.
Topics: Acetic Acid; Analgesics; Animals; Lignin; Mice; Models, Animal; Pain; Peritoneum | 2001 |
Evaluation of the anti-inflammatory and analgesic properties of Chasmanthera dependens leaf methanol extract.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary P | 2001 |
A preliminary study on the analgesic activity of Grangea maderaspatana.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Asteraceae; Dose-Response Relationship, Drug; Male; | 2001 |
Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Analgesia; Animals; Arginine; Carrageenan; Central | 2001 |
Extracellular signal-regulated kinases 1 and 2 phosphorylated neurons in the tele- and diencephalon of rat after visceral pain stimulation: an immunocytochemical study.
Topics: Acetic Acid; Animals; Diencephalon; Immunohistochemistry; Mitogen-Activated Protein Kinase 1; Mitoge | 2001 |
Neurophysiological effects of an extract of Eschscholzia californica Cham. (Papaveraceae).
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Anxiety Agents; Behavior, Animal; Dose-Response | 2001 |
B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice.
Topics: Acetic Acid; Animals; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; | 2001 |
The involvement of the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3/SNS) in a rat model of visceral pain.
Topics: Acetic Acid; Administration, Intravesical; Animals; Disease Models, Animal; Female; Ganglia, Spinal; | 2001 |
Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice.
Topics: Acetic Acid; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; B | 2001 |
Analgesic sesquiterpene dilactone from Mikania cordata.
Topics: Acetic Acid; Analgesics; Animals; Asteraceae; Dose-Response Relationship, Drug; Lactones; Male; Mice | 2001 |
Modulation by insulin rather than blood glucose of the pain threshold in acute physiological and flavone induced antinociception in mice.
Topics: Acetic Acid; Analgesics; Animals; Blood Glucose; Flavones; Flavonoids; Glucose; Hyperglycemia; Hypog | 2001 |
Synthesis of some 1,2,4-triazolo[3,2-b]-1,3-thiazine-7-ones with potential analgesic and antiinflammatory activities.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Castor Oil; Diarrhea; Do | 2002 |
Antinociceptive constituents of Auricularia polytricha.
Topics: Acetic Acid; Analgesics; Animals; Basidiomycota; Ceramides; Cerebrosides; Mice; Molecular Structure; | 2002 |
TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics.
Topics: Abdomen; Acetic Acid; Adenosine Triphosphate; Analgesics; Animals; Antineoplastic Agents; Behavior, | 2002 |
Bioactivity studies on Cassia alata Linn. leaf extracts.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Blood | 2002 |
Investigations on the antinociceptive activity of crude extracts from Croton cajucara leaves in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Euphorbiac | 2002 |
Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Ag | 2002 |
Evaluation of the antinflammatory and analgesic activity of Sideritis canariensis var. pannosa in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Carrageenan; Chlo | 2002 |
Synthesis and pharmacological properties of benzisothiazole/benzimidazole derivatives with acidic groups.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Benzimidazoles; Escherichia coli; Female; Guinea Pi | 2002 |
Effects of ablation of N- and R-type Ca(2+) channels on pain transmission.
Topics: Acetic Acid; Animals; Behavior, Animal; Calcium Channels, N-Type; Calcium Channels, R-Type; Central | 2002 |
4H-thieno[3,4-c]pyrazole derivatives with antiinflammatory, analgesic, antipyretic and platelet antiaggregating activities.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Fever; | 1992 |
Modification of antinociceptive action of morphine by Ukrain in rodents.
Topics: Acetates; Acetic Acid; Alkaloids; Analgesics; Animals; Berberine Alkaloids; Drug Synergism; Male; Mi | 1992 |
Interaction between Ukrain and aminophenazone in analgesic tests in rodents.
Topics: Acetates; Acetic Acid; Alkaloids; Aminopyrine; Analgesics; Animals; Berberine Alkaloids; Drug Synerg | 1992 |
GABAergic and cholinergic mediation in the antinociceptive action of homotaurine.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Baclofen; gamma-Aminobutyric Acid; Immersion; Male; Mice | 1992 |
Morphine or U-50,488 suppresses Fos protein-like immunoreactivity in the spinal cord and nucleus tractus solitarii evoked by a noxious visceral stimulus in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Abdomen; A | 1992 |
Antinociceptive effect of ketanserin in mice: involvement of supraspinal 5-HT2 receptors in nociceptive transmission.
Topics: Acetates; Acetic Acid; Adrenergic alpha-Antagonists; Analgesics; Animals; Brain Chemistry; Dioxanes; | 1991 |
Research on heterocyclic compounds. XXVIII. Imidazo[1,2-c]pyrimidines.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bridged Bicyclo Compounds; | 1991 |
Involvement of dopamine in the mechanism of action of FR64822, a novel non-opioid antinociceptive compound.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Clonidine; Dopamine; Dopamine Antagonists; Male; Mice; M | 1991 |
Intraspinal opioids in frogs: a new behavioral model for the assessment of opioid action.
Topics: Acetates; Acetic Acid; Animals; Behavior, Animal; Injections; Narcotics; Pain; Rana pipiens; Spinal | 1990 |
Controlled noxious chemical stimulation: responses of rat trigeminal brainstem neurones to CO2 pulses applied to the nasal mucosa.
Topics: Acetates; Acetic Acid; Administration, Intranasal; Ammonia; Animals; Brain Stem; Carbon Dioxide; Ele | 1991 |
The rat paw formalin test: comparison of noxious agents.
Topics: Acetates; Acetic Acid; Animals; Carrageenan; Formaldehyde; Male; Nociceptors; Pain; Rats; Rats, Inbr | 1990 |
Antinociceptive effect of taurine and its inhibition by naxolone.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Mice; Naloxone; Pain; | 1990 |
Nociceptive sensitivity/behavioral reactivity regulation in rats during aversive states of different nature: its mediation by opioid peptides.
Topics: Acetates; Acetic Acid; Animals; Avoidance Learning; Behavior, Animal; Body Weight; Endorphins; Femal | 1989 |
Dopaminergic involvement in nociceptive sensitivity/behavioral reactivity regulation during aversive states of different nature in the rat.
Topics: Acetates; Acetic Acid; Animals; Apomorphine; Ascorbic Acid; Avoidance Learning; Behavior, Animal; Do | 1989 |
Copper complexes of non-steroidal antiinflammatory agents: analgesic activity and possible opioid receptor activation.
Topics: Acetates; Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Ster | 1987 |
Studies on spinal opiate receptor pharmacology. III. Analgetic effects of enkephalin dimers as measured by cutaneous-thermal and visceral-chemical evoked responses.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enke | 1985 |
Pharmacological effects of SCH 30497--a novel analgesic substance.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nervous System; D | 1985 |
[Reduction of the behavioral response to a viscero-peritoneal nociceptive stimulation during the development of experimental polyarthritis in the rat].
Topics: Acetates; Acetic Acid; Animals; Arthritis; Arthritis, Experimental; Behavior, Animal; Chronic Diseas | 1986 |
Antinociceptive activity and mechanism of action of detomidine.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Female; Imidazoles; Mice; Mice, Inbred Strains; Morphine | 1986 |
The antinociceptive effects of histidyl-proline diketopiperazine and thyrotropin-releasing hormone in the mouse.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Hot Temperature; Injections, Intraventricular; Male; Mic | 1985 |