acetic acid has been researched along with ACY2 Deficiency in 2 studies
Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
acetic acid : A simple monocarboxylic acid containing two carbons.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Canavan disease is a devastating neurodegenerative childhood disease caused by mutations in aspartoacylase, an enzyme that deacetylates N-acetylaspartate to generate free acetate in the brain." | 1.31 | Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease. ( Jacobowitz, DM; Kallarakal, AT; Kirmani, BF; Namboodiri, MA, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kirmani, BF | 1 |
| Jacobowitz, DM | 1 |
| Kallarakal, AT | 1 |
| Namboodiri, MA | 2 |
| Madhavarao, CN | 1 |
| Arun, P | 1 |
| Moffett, JR | 1 |
| Szucs, S | 1 |
| Surendran, S | 1 |
| Matalon, R | 1 |
| Garbern, J | 1 |
| Hristova, D | 1 |
| Johnson, A | 1 |
| Jiang, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1 Treatment With GTA in Two Infant With Canavan Disease[NCT00278707] | Phase 1 | 5 participants | Interventional | 2006-01-31 | Active, not recruiting | ||
| Evaluation of the Tolerance and Efficiency of a Combined Oral Therapy With Lithium and GTA in Patients With Canavan Disease[NCT00657748] | Phase 2 | 0 participants (Actual) | Interventional | 2009-09-30 | Withdrawn | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for acetic acid and ACY2 Deficiency
| Article | Year |
|---|---|
Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease.
Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Canavan Disease; Central Nervous System; Cytop | 2002 |
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.
Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Brain; Canavan Disease; DNA; Hu | 2005 |
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.
Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Brain; Canavan Disease; DNA; Hu | 2005 |
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.
Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Brain; Canavan Disease; DNA; Hu | 2005 |
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.
Topics: Acetic Acid; Amidohydrolases; Animals; Aspartic Acid; Base Sequence; Brain; Canavan Disease; DNA; Hu | 2005 |