Page last updated: 2024-10-22

acetazolamide and Water-Electrolyte Imbalance

acetazolamide has been researched along with Water-Electrolyte Imbalance in 10 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Water-Electrolyte Imbalance: Disturbances in the body's WATER-ELECTROLYTE BALANCE.

Research Excerpts

ExcerptRelevanceReference
"To describe the baseline characteristics of participants in the Acetazolamide in Decompensated Heart Failure with Volume Overload (ADVOR) trial and compare these with other contemporary diuretic trials in acute heart failure (AHF)."9.51Acetazolamide in Decompensated Heart Failure with Volume Overload trial (ADVOR): baseline characteristics. ( Blouard, P; Bruckers, L; Chenot, F; Damman, K; Dauw, J; De Ceuninck, M; Depauw, M; Derthoo, D; Dierckx, R; Droogne, W; Dupont, M; Ector, B; Filippatos, G; Gabriel, L; Goossens, K; Hofkens, PJ; Hulselmans, M; Lassus, J; Lochy, S; Martens, P; Mebazaa, A; Meekers, E; Moubayed, S; Mullens, W; Nijst, P; Pouleur, AC; Prihadi, EA; Raes, D; Ruschitzka, F; Smolders, W; Tartaglia, K; Ter Maaten, JM; Timmermans, P; Troisfontaines, P; Vachiery, JL; Van Craenenbroeck, E; Van Durme, F; Vandekerckhove, H; Verbrugge, FH; Vervloet, D; Viaene, E, 2022)
"Whether acetazolamide, a carbonic anhydrase inhibitor that reduces proximal tubular sodium reabsorption, can improve the efficiency of loop diuretics, potentially leading to more and faster decongestion in patients with acute decompensated heart failure with volume overload, is unclear."9.51Acetazolamide in Acute Decompensated Heart Failure with Volume Overload. ( Blouard, P; Bruckers, L; Chenot, F; Damman, K; Dauw, J; Derthoo, D; Dierckx, R; Droogne, W; Dupont, M; Filippatos, G; Lassus, J; Martens, P; Mebazaa, A; Meekers, E; Moubayed, S; Mullens, W; Nijst, P; Ruschitzka, F; Smolders, W; Tartaglia, K; Ter Maaten, JM; Troisfontaines, P; Verbrugge, FH, 2022)
"Acetazolamide facilitates decongestion in acute decompensated heart failure (ADHF)."8.31Natriuretic Response to Acetazolamide in Patients With Acute Heart Failure and Volume Overload. ( Augusto, SN; Damman, K; Dauw, J; Dupont, M; Filippatos, G; Lassus, J; Martens, P; Mebazaa, A; Meekers, E; Mullens, W; Nijst, P; Ruschitzka, F; Ter Maaten, JM; Verbrugge, FH, 2023)
"Decisive evidence on the optimal diuretic agent, dosing schedule, and administration route is lacking in acute heart failure (AHF) with congestion."6.87Rationale and design of the ADVOR (Acetazolamide in Decompensated Heart Failure with Volume Overload) trial. ( Bruckers, L; Damman, K; Droogne, W; Dupont, M; Filippatos, G; Lassus, J; Martens, P; Mebazaa, A; Mullens, W; Nijst, P; Ruschitzka, F; Tartaglia, K; Theunissen, E; Troisfontaines, P; Verbrugge, FH, 2018)
"To describe the baseline characteristics of participants in the Acetazolamide in Decompensated Heart Failure with Volume Overload (ADVOR) trial and compare these with other contemporary diuretic trials in acute heart failure (AHF)."5.51Acetazolamide in Decompensated Heart Failure with Volume Overload trial (ADVOR): baseline characteristics. ( Blouard, P; Bruckers, L; Chenot, F; Damman, K; Dauw, J; De Ceuninck, M; Depauw, M; Derthoo, D; Dierckx, R; Droogne, W; Dupont, M; Ector, B; Filippatos, G; Gabriel, L; Goossens, K; Hofkens, PJ; Hulselmans, M; Lassus, J; Lochy, S; Martens, P; Mebazaa, A; Meekers, E; Moubayed, S; Mullens, W; Nijst, P; Pouleur, AC; Prihadi, EA; Raes, D; Ruschitzka, F; Smolders, W; Tartaglia, K; Ter Maaten, JM; Timmermans, P; Troisfontaines, P; Vachiery, JL; Van Craenenbroeck, E; Van Durme, F; Vandekerckhove, H; Verbrugge, FH; Vervloet, D; Viaene, E, 2022)
"Whether acetazolamide, a carbonic anhydrase inhibitor that reduces proximal tubular sodium reabsorption, can improve the efficiency of loop diuretics, potentially leading to more and faster decongestion in patients with acute decompensated heart failure with volume overload, is unclear."5.51Acetazolamide in Acute Decompensated Heart Failure with Volume Overload. ( Blouard, P; Bruckers, L; Chenot, F; Damman, K; Dauw, J; Derthoo, D; Dierckx, R; Droogne, W; Dupont, M; Filippatos, G; Lassus, J; Martens, P; Mebazaa, A; Meekers, E; Moubayed, S; Mullens, W; Nijst, P; Ruschitzka, F; Smolders, W; Tartaglia, K; Ter Maaten, JM; Troisfontaines, P; Verbrugge, FH, 2022)
"Acetazolamide facilitates decongestion in acute decompensated heart failure (ADHF)."4.31Natriuretic Response to Acetazolamide in Patients With Acute Heart Failure and Volume Overload. ( Augusto, SN; Damman, K; Dauw, J; Dupont, M; Filippatos, G; Lassus, J; Martens, P; Mebazaa, A; Meekers, E; Mullens, W; Nijst, P; Ruschitzka, F; Ter Maaten, JM; Verbrugge, FH, 2023)
"Decisive evidence on the optimal diuretic agent, dosing schedule, and administration route is lacking in acute heart failure (AHF) with congestion."2.87Rationale and design of the ADVOR (Acetazolamide in Decompensated Heart Failure with Volume Overload) trial. ( Bruckers, L; Damman, K; Droogne, W; Dupont, M; Filippatos, G; Lassus, J; Martens, P; Mebazaa, A; Mullens, W; Nijst, P; Ruschitzka, F; Tartaglia, K; Theunissen, E; Troisfontaines, P; Verbrugge, FH, 2018)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19902 (20.00)18.7374
1990's1 (10.00)18.2507
2000's1 (10.00)29.6817
2010's2 (20.00)24.3611
2020's4 (40.00)2.80

Authors

AuthorsStudies
Mullens, W5
Dauw, J3
Martens, P5
Meekers, E3
Nijst, P4
Verbrugge, FH4
Chenot, F2
Moubayed, S2
Dierckx, R2
Blouard, P2
Derthoo, D2
Smolders, W2
Ector, B1
Hulselmans, M1
Lochy, S1
Raes, D1
Van Craenenbroeck, E1
Vandekerckhove, H1
Hofkens, PJ1
Goossens, K1
Pouleur, AC1
De Ceuninck, M1
Gabriel, L1
Timmermans, P1
Prihadi, EA1
Van Durme, F1
Depauw, M1
Vervloet, D1
Viaene, E1
Vachiery, JL1
Tartaglia, K3
Ter Maaten, JM3
Bruckers, L3
Droogne, W3
Troisfontaines, P3
Damman, K4
Lassus, J4
Mebazaa, A4
Filippatos, G4
Ruschitzka, F4
Dupont, M4
Augusto, SN1
García-Blas, S1
Bonanad, C1
Llàcer, P1
Ventura, S1
Núñez, JM1
Sánchez, R1
Chamorro, C1
Fácila, L1
de la Espriella, R1
Vaquer, JM1
Cordero, A1
Roqué, M1
Ortiz, V1
Racugno, P1
Bodí, V1
Valero, E1
Santas, E1
Moreno, MDC1
Miñana, G1
Carratalá, A1
Bondanza, L1
Payá, A1
Cardells, I1
Heredia, R1
Pellicer, M1
Valls, G1
Palau, P1
Bosch, MJ1
Raso, R1
Sánchez, A1
Bertomeu-González, V1
Bertomeu-Martínez, V1
Montagud-Balaguer, V1
Albiach-Montañana, C1
Pendás-Meneau, J1
Marcaida, G1
Cervantes-García, S1
San Antonio, R1
de Mingo, E1
Chorro, FJ1
Sanchis, J1
Núñez, J1
Theunissen, E1
Fontaine, B1
FRIEDBERG, V1
Schott, HC1
Hinchcliff, KW1
Thiel, G1
Brunner, F1
Wunderlich, P1
Huguenin, M1
Bienko, B1
Torhorst, J1
Peters-Haefeli, L1
Kirchertz, EJ1
Peters, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multi-center, Randomized, Double-blind, Phase IV Clinical Trial on the Diuretic Effects of Acetazolamide in Patients With Decompensated Heart Failure and Volume OveRload[NCT03505788]Phase 4519 participants (Actual)Interventional2018-11-11Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for acetazolamide and Water-Electrolyte Imbalance

ArticleYear
[Periodic paralysis: new pathophysiological aspects].
    Bulletin de l'Academie nationale de medecine, 2008, Volume: 192, Issue:8

    Topics: Acetazolamide; Combined Modality Therapy; Dietary Carbohydrates; Diuretics; Electromyography; Exerci

2008
Treatments affecting fluid and electrolyte status during exercise.
    The Veterinary clinics of North America. Equine practice, 1998, Volume: 14, Issue:1

    Topics: Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Diuretics; Fluid Therapy; Furosemide; Horse D

1998

Trials

4 trials available for acetazolamide and Water-Electrolyte Imbalance

ArticleYear
Acetazolamide in Decompensated Heart Failure with Volume Overload trial (ADVOR): baseline characteristics.
    European journal of heart failure, 2022, Volume: 24, Issue:9

    Topics: Acetazolamide; Aged; Diuretics; Female; Heart Failure; Humans; Male; Natriuretic Peptide, Brain; Pep

2022
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload.
    The New England journal of medicine, 2022, 09-29, Volume: 387, Issue:13

    Topics: Acetazolamide; Acute Disease; Carbonic Anhydrase Inhibitors; Diuretics; Double-Blind Method; Heart F

2022
Diuretic Strategies in Acute Heart Failure and Renal Dysfunction: Conventional vs Carbohydrate Antigen 125-guided Strategy. Clinical Trial Design.
    Revista espanola de cardiologia (English ed.), 2017, Volume: 70, Issue:12

    Topics: Acetazolamide; Acute Disease; CA-125 Antigen; Cardio-Renal Syndrome; Chlorthalidone; Creatinine; Diu

2017
Rationale and design of the ADVOR (Acetazolamide in Decompensated Heart Failure with Volume Overload) trial.
    European journal of heart failure, 2018, Volume: 20, Issue:11

    Topics: Acetazolamide; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up S

2018

Other Studies

4 other studies available for acetazolamide and Water-Electrolyte Imbalance

ArticleYear
Acute Decompensated Heart Failure, Volume, and Acetazolamide. Reply.
    The New England journal of medicine, 2022, 12-29, Volume: 387, Issue:26

    Topics: Acetazolamide; Acid-Base Imbalance; Heart Failure; Humans; Urologic Diseases; Water-Electrolyte Imba

2022
Natriuretic Response to Acetazolamide in Patients With Acute Heart Failure and Volume Overload.
    Journal of the American College of Cardiology, 2023, 05-23, Volume: 81, Issue:20

    Topics: Acetazolamide; Diuretics; Heart Failure; Humans; Male; Prospective Studies; Sodium; Water-Electrolyt

2023
[Medicinal control of fluid retention in pregnancy toxemias].
    Deutsche medizinische Wochenschrift (1946), 1959, Jul-03, Volume: 84, Issue:27

    Topics: Acetazolamide; Body Fluids; Carbonic Anhydrase Inhibitors; Diuretics; Female; Heart Failure; Humans;

1959
Protection of rat kidneys against HgCl2-induced acute renal failure by induction of high urine flow without renin suppression.
    Kidney international. Supplement, 1976, Volume: 6

    Topics: Acetazolamide; Acute Kidney Injury; Animals; Body Weight; Desoxycorticosterone; Diuresis; Furosemide

1976