Page last updated: 2024-10-22

acetazolamide and Tuberculosis, Meningeal

acetazolamide has been researched along with Tuberculosis, Meningeal in 6 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Tuberculosis, Meningeal: A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)

Research Excerpts

ExcerptRelevanceReference
"There has been reports on pediatric TB meningitis manifesting with fever and seizures, altered sensorium or focal deficits."1.56Tuberculous meningitis manifesting with neuroregression in a eleven month child. ( Kasinathan, A; Palanisamy, S; Serane, VK, 2020)
"Patients with non-communicating hydrocephalus received ventriculo-peritoneal shunts shortly after admission while communicating hydrocephalus was treated with oral acetazolamide (100 mg/kg/day) and furosemide (1 mg/kg/day) in 3-4 divided doses."1.31Long-term follow up of childhood tuberculous meningitis. ( Burger, M; Donald, P; Fertig, G; Schoeman, J; Springer, P; van Rensburg, AJ; van Zyl, F; Wait, J, 2002)
"Noncommunicating hydrocephalus (37 children), as determined by air encephalography, was treated by ventriculoperitoneal (VP) shunting and communicating hydrocephalus (181 children), by means of daily acetazolamide and frusemide."1.31Serial lumbar CSF presure measurements and cranial computed tomographic findings in childhood tuberculous meningitits. ( Donald, PR; Laubscher, JA; Schoeman, JF, 2000)
"Eight patients with obstructive hydrocephalus were treated surgically."1.26Hydrocephalus in tuberculous meningitis in children: treatment with acetazolamide and repeated lumbar puncture. ( Chiemchanya, S; Visudhiphan, P, 1979)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's0 (0.00)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Kasinathan, A1
Serane, VK1
Palanisamy, S1
Schoeman, J2
Wait, J2
Burger, M1
van Zyl, F1
Fertig, G1
van Rensburg, AJ1
Springer, P1
Donald, P2
RICCI, G1
COPAITICH, T1
Schoeman, JF1
Laubscher, JA1
Donald, PR1
Visudhiphan, P1
Chiemchanya, S1
van Zyl, L1
Keet, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Double Blind Placebo Controlled Trial of Adjunctive Dexamethasone for the Treatment of HIV-infected Adults With Tuberculous Meningitis[NCT03092817]Phase 3520 participants (Actual)Interventional2017-05-25Active, not recruiting
A Randomized Double Blind Placebo Controlled Non-inferiority Trial of Adjunctive Dexamethasone for the Treatment of HIV-uninfected Adults With Tuberculous Meningitis Stratified by Leukotriene A4 Hydrolase Genotype[NCT03100786]Phase 3640 participants (Anticipated)Interventional2018-02-08Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for acetazolamide and Tuberculosis, Meningeal

ArticleYear
Tuberculous hydrocephalus: comparison of different treatments with regard to ICP, ventricular size and clinical outcome.
    Developmental medicine and child neurology, 1991, Volume: 33, Issue:5

    Topics: Acetazolamide; Antitubercular Agents; Cerebral Ventricles; Cerebrospinal Fluid Shunts; Child; Child,

1991
Tuberculous hydrocephalus: comparison of different treatments with regard to ICP, ventricular size and clinical outcome.
    Developmental medicine and child neurology, 1991, Volume: 33, Issue:5

    Topics: Acetazolamide; Antitubercular Agents; Cerebral Ventricles; Cerebrospinal Fluid Shunts; Child; Child,

1991
Tuberculous hydrocephalus: comparison of different treatments with regard to ICP, ventricular size and clinical outcome.
    Developmental medicine and child neurology, 1991, Volume: 33, Issue:5

    Topics: Acetazolamide; Antitubercular Agents; Cerebral Ventricles; Cerebrospinal Fluid Shunts; Child; Child,

1991
Tuberculous hydrocephalus: comparison of different treatments with regard to ICP, ventricular size and clinical outcome.
    Developmental medicine and child neurology, 1991, Volume: 33, Issue:5

    Topics: Acetazolamide; Antitubercular Agents; Cerebral Ventricles; Cerebrospinal Fluid Shunts; Child; Child,

1991

Other Studies

5 other studies available for acetazolamide and Tuberculosis, Meningeal

ArticleYear
Tuberculous meningitis manifesting with neuroregression in a eleven month child.
    The Indian journal of tuberculosis, 2020, Volume: 67, Issue:1

    Topics: Acetazolamide; Antitubercular Agents; Carbonic Anhydrase Inhibitors; Cerebrospinal Fluid; Early Medi

2020
Long-term follow up of childhood tuberculous meningitis.
    Developmental medicine and child neurology, 2002, Volume: 44, Issue:8

    Topics: Acetazolamide; Anti-Inflammatory Agents; Antitubercular Agents; Brain; Child; Cognition Disorders; D

2002
[Trial acetazolamide therapy of hydrocephalus in tuberculous meningitis].
    La Clinica terapeutica, 1959, Volume: 16, Issue:1

    Topics: Acetazolamide; Humans; Hydrocephalus; Tuberculosis, Meningeal

1959
Serial lumbar CSF presure measurements and cranial computed tomographic findings in childhood tuberculous meningitits.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2000, Volume: 16, Issue:4

    Topics: Acetazolamide; Antitubercular Agents; Cerebrospinal Fluid Pressure; Child; Combined Modality Therapy

2000
Hydrocephalus in tuberculous meningitis in children: treatment with acetazolamide and repeated lumbar puncture.
    The Journal of pediatrics, 1979, Volume: 95, Issue:4

    Topics: Acetazolamide; Adolescent; Brain Edema; Child; Child, Preschool; Humans; Hydrocephalus; Infant; Spin

1979