Page last updated: 2024-10-22

acetazolamide and Stevens-Johnson Syndrome

acetazolamide has been researched along with Stevens-Johnson Syndrome in 8 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.

Research Excerpts

ExcerptRelevanceReference
" We sought to address the safety of acetazolamide, a chemically related compound, in patients with prior SJS/TEN and glaucoma."7.78Oral acetazolamide after Boston keratoprosthesis in Stevens-Johnson syndrome. ( Chodosh, J; Dohlman, CH; Kumar, R, 2012)
"Acetazolamide is a sulfonamide derivative and carbonic anhydrase inhibitor used to lower intraocular pressure in glaucomatous patients."6.47Stevens-Johnson syndrome induced by acetazolamide. ( Her, Y; Kil, MS; Kim, CW; Kim, SS; Park, JH, 2011)
"Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but fatal adverse mucocutaneous reactions to certain drugs."5.42Clinical features of and genetic predisposition to drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients-investigating the relation between the HLA -B*4403 allele and lamotrigine. ( Kim, SR; Koh, BS; Lee, JH; Leem, DW; Moon, IJ; Park, HJ; Park, JW; Park, KH, 2015)
" We sought to address the safety of acetazolamide, a chemically related compound, in patients with prior SJS/TEN and glaucoma."3.78Oral acetazolamide after Boston keratoprosthesis in Stevens-Johnson syndrome. ( Chodosh, J; Dohlman, CH; Kumar, R, 2012)
"Acetazolamide is a sulfonamide derivative and carbonic anhydrase inhibitor used to lower intraocular pressure in glaucomatous patients."2.47Stevens-Johnson syndrome induced by acetazolamide. ( Her, Y; Kil, MS; Kim, CW; Kim, SS; Park, JH, 2011)
"Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but fatal adverse mucocutaneous reactions to certain drugs."1.42Clinical features of and genetic predisposition to drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients-investigating the relation between the HLA -B*4403 allele and lamotrigine. ( Kim, SR; Koh, BS; Lee, JH; Leem, DW; Moon, IJ; Park, HJ; Park, JW; Park, KH, 2015)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's1 (12.50)18.2507
2000's1 (12.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Park, HJ1
Kim, SR1
Leem, DW1
Moon, IJ1
Koh, BS1
Park, KH1
Park, JW1
Lee, JH1
Kelly, TE1
Hackett, PH1
Her, Y1
Kil, MS1
Park, JH1
Kim, CW1
Kim, SS1
Kumar, R1
Dohlman, CH1
Chodosh, J1
Iyer, G1
Srinivasan, B1
Ogasawara, K1
Tomitsuka, N1
Kobayashi, M1
Komoribayashi, N1
Fukuda, T1
Saitoh, H1
Inoue, T1
Ogawa, A1
Sud, RN1
Grewal, SS1
Halevy, S1
Livni, E1

Reviews

2 reviews available for acetazolamide and Stevens-Johnson Syndrome

ArticleYear
Acetazolamide and sulfonamide allergy: a not so simple story.
    High altitude medicine & biology, 2010,Winter, Volume: 11, Issue:4

    Topics: Acetazolamide; Anemia, Hemolytic; Carbonic Anhydrase Inhibitors; Cross Reactions; Drug Hypersensitiv

2010
Stevens-Johnson syndrome induced by acetazolamide.
    The Journal of dermatology, 2011, Volume: 38, Issue:3

    Topics: Acetazolamide; Adult; Asian People; Carbonic Anhydrase Inhibitors; Female; HLA-B Antigens; Humans; S

2011

Other Studies

6 other studies available for acetazolamide and Stevens-Johnson Syndrome

ArticleYear
Clinical features of and genetic predisposition to drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients-investigating the relation between the HLA -B*4403 allele and lamotrigine.
    European journal of clinical pharmacology, 2015, Volume: 71, Issue:1

    Topics: Acetaminophen; Acetazolamide; Adult; Aged; Aged, 80 and over; Alleles; Allopurinol; Anti-Bacterial A

2015
Oral acetazolamide after Boston keratoprosthesis in Stevens-Johnson syndrome.
    BMC research notes, 2012, Apr-30, Volume: 5

    Topics: Acetazolamide; Administration, Oral; Adolescent; Adult; Boston; Carbonic Anhydrase Inhibitors; Corne

2012
Glaucoma with modified osteo-odonto keratoprosthesis.
    Cornea, 2012, Volume: 31, Issue:9

    Topics: Acetazolamide; Alveolar Process; Burns, Chemical; Carbonic Anhydrase Inhibitors; Cornea; Corneal Dis

2012
Stevens-Johnson syndrome associated with intravenous acetazolamide administration for evaluation of cerebrovascular reactivity. Case report.
    Neurologia medico-chirurgica, 2006, Volume: 46, Issue:3

    Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Cerebrovascular Circulation; Humans; Infarction, Middl

2006
Stevens Johnson syndrome due to Diamox.
    Indian journal of ophthalmology, 1981, Volume: 29, Issue:2

    Topics: Acetazolamide; Adult; Aged; Female; Glaucoma; Humans; Male; Middle Aged; Stevens-Johnson Syndrome; T

1981
The role of macrophage migration inhibition factor in toxic epidermal necrolysis.
    International journal of dermatology, 1997, Volume: 36, Issue:10

    Topics: Acetazolamide; Aged; Aged, 80 and over; Anti-Infective Agents; Anti-Infective Agents, Urinary; Diure

1997