Page last updated: 2024-10-22

acetazolamide and Sleep Wake Disorders

acetazolamide has been researched along with Sleep Wake Disorders in 11 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Sleep Wake Disorders: Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.

Research Excerpts

ExcerptRelevanceReference
"Arrhythmias were rare and similar with all treatments."6.79Effect of oxygen and acetazolamide on nocturnal cardiac conduction, repolarization, and arrhythmias in precapillary pulmonary hypertension and sleep-disturbed breathing. ( Bloch, KE; Hasler, ED; Hildenbrand, FF; Keusch, S; Müller-Mottet, S; Schumacher, DS; Speich, R; Ulrich, S, 2014)
"Arrhythmias were rare and similar with all treatments."2.79Effect of oxygen and acetazolamide on nocturnal cardiac conduction, repolarization, and arrhythmias in precapillary pulmonary hypertension and sleep-disturbed breathing. ( Bloch, KE; Hasler, ED; Hildenbrand, FF; Keusch, S; Müller-Mottet, S; Schumacher, DS; Speich, R; Ulrich, S, 2014)
"The term "nocturnal paroxysmal dystonia" has been used to describe patients who display paroxysmal episodes of dystonic-dyskinetic movements arising during nonrapid eye movement sleep, in particular stages 2-3 (Lugaresi E, Cirignotta F."1.29Posttraumatic paroxysmal nocturnal hemidystonia. ( al Deeb, SM; Bahou, Y; Biary, N; Sharif, H; Singh, B, 1994)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19904 (36.36)18.7374
1990's1 (9.09)18.2507
2000's4 (36.36)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schumacher, DS1
Müller-Mottet, S1
Hasler, ED1
Hildenbrand, FF1
Keusch, S1
Speich, R1
Bloch, KE1
Ulrich, S1
Windsor, JS1
Rodway, GW1
Varadkar, S1
Duncan, JS1
Cross, JH1
Sibon, I1
Ghorayeb, I1
Henry, P1
Weil, JV1
Edelman, NH1
Santiago, TV1
Biary, N1
Singh, B1
Bahou, Y1
al Deeb, SM1
Sharif, H1
Sutton, JR1
Houston, CS1
Mansell, AL1
McFadden, MD1
Hackett, PM1
Rigg, JR1
Powles, AC1
Rennie, D1
Waldhorn, RE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension (CSRPH)[NCT01427192]Phase 223 participants (Actual)Interventional2010-11-30Completed
Treatment of High-altitude Sleep Disturbance: A Double-blind Comparison of Temazepam Versus Acetazolamide.[NCT01519544]34 participants (Actual)Interventional2012-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for acetazolamide and Sleep Wake Disorders

ArticleYear
Sleep disturbance at altitude.
    Current opinion in pulmonary medicine, 2012, Volume: 18, Issue:6

    Topics: Acclimatization; Acetazolamide; Altitude; Benzodiazepines; Carbonic Anhydrase Inhibitors; Humans; Hy

2012
Sleep at high altitude.
    High altitude medicine & biology, 2004,Summer, Volume: 5, Issue:2

    Topics: Acetazolamide; Altitude Sickness; Benzodiazepines; Carbonic Anhydrase Inhibitors; Chronic Disease; H

2004

Trials

2 trials available for acetazolamide and Sleep Wake Disorders

ArticleYear
Effect of oxygen and acetazolamide on nocturnal cardiac conduction, repolarization, and arrhythmias in precapillary pulmonary hypertension and sleep-disturbed breathing.
    Chest, 2014, Volume: 146, Issue:5

    Topics: Acetazolamide; Administration, Oral; Aged; Arrhythmias, Cardiac; Carbonic Anhydrase Inhibitors; Cros

2014
Effect of acetazolamide on hypoxemia during sleep at high altitude.
    The New England journal of medicine, 1979, Dec-13, Volume: 301, Issue:24

    Topics: Acetazolamide; Adult; Altitude; Altitude Sickness; Female; Humans; Hypoxia; Male; Mountaineering; Ox

1979

Other Studies

7 other studies available for acetazolamide and Sleep Wake Disorders

ArticleYear
Acetazolamide and autosomal dominant nocturnal frontal lobe epilepsy.
    Epilepsia, 2003, Volume: 44, Issue:7

    Topics: Acetazolamide; Adolescent; Anticonvulsants; Child; Chromosome Aberrations; Epilepsy, Frontal Lobe; F

2003
Successful treatment of hypnic headache syndrome with acetazolamide.
    Neurology, 2003, Oct-28, Volume: 61, Issue:8

    Topics: Acetazolamide; Aged; Anti-Inflammatory Agents, Non-Steroidal; Carbonic Anhydrase Inhibitors; Diplopi

2003
Statement on high-altitude illnesses. An Advisory Committee Statement (ACS).
    Canada communicable disease report = Releve des maladies transmissibles au Canada, 2007, Apr-01, Volume: 33, Issue:ACS-5

    Topics: Acetazolamide; Acute Disease; Altitude Sickness; Canada; Dexamethasone; Humans; Methazolamide; Nifed

2007
Sleep hypoxemia at high altitude.
    The New England journal of medicine, 1980, Apr-03, Volume: 302, Issue:14

    Topics: Acetazolamide; Altitude; Humans; Hypoxia; Respiration; Sleep Wake Disorders

1980
Posttraumatic paroxysmal nocturnal hemidystonia.
    Movement disorders : official journal of the Movement Disorder Society, 1994, Volume: 9, Issue:1

    Topics: Acetazolamide; Adolescent; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Administration S

1994
High science, present and future.
    The New England journal of medicine, 1979, Dec-13, Volume: 301, Issue:24

    Topics: Acetazolamide; Altitude; Altitude Sickness; Humans; Hypoxia; Male; Middle Aged; Mountaineering; Oxyg

1979
Sleep apnea syndrome.
    American family physician, 1985, Volume: 32, Issue:3

    Topics: Acetazolamide; Adult; Diagnosis, Differential; Electrocardiography; Electroencephalography; Electroo

1985