acetazolamide has been researched along with Sleep Initiation and Maintenance Disorders in 6 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Sleep Initiation and Maintenance Disorders: Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Other agents commonly used at sea-level such as eszopiclone and diphenhydramine have not been studied at high altitude but are likely safe to use given their mechanism of action and known side effects." | 2.44 | Which medications are safe and effective for improving sleep at high altitude? ( Luks, AM, 2008) |
| "Twenty male patients with sleep apnea syndrome were treated with acetazolamide (AZM), a carbonic anhydrase inhibitor." | 1.29 | Effects of acetazolamide on the sleep apnea syndrome and its therapeutic mechanism. ( Hashizume, Y; Hirano, T; Kotorii, T; Mizuma, H; Mukai, M; Nakazawa, Y; Sakamoto, T; Tsutsumi, Y, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kong, F | 1 |
| Liu, G | 1 |
| Xu, J | 1 |
| Luks, AM | 1 |
| Sakamoto, T | 1 |
| Nakazawa, Y | 1 |
| Hashizume, Y | 1 |
| Tsutsumi, Y | 1 |
| Mizuma, H | 1 |
| Hirano, T | 1 |
| Mukai, M | 1 |
| Kotorii, T | 1 |
| Nicholson, AN | 1 |
| Smith, PA | 1 |
| Stone, BM | 1 |
| Bradwell, AR | 1 |
| Coote, JH | 1 |
| Carver, RP | 1 |
| Winsmann, FR | 1 |
| Forwand, SA | 1 |
| Landowne, M | 1 |
| Follansbee, JN | 1 |
| Hansen, JE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of High-altitude Sleep Disturbance: A Double-blind Comparison of Temazepam Versus Acetazolamide.[NCT01519544] | 34 participants (Actual) | Interventional | 2012-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for acetazolamide and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Pharmacological agents for improving sleep quality at high altitude: a systematic review and meta-analysis of randomized controlled trials.
Topics: Acetamides; Acetazolamide; Adult; Altitude; Anticonvulsants; Humans; Hypnotics and Sedatives; Pyrimi | 2018 |
Which medications are safe and effective for improving sleep at high altitude?
Topics: Acetamides; Acetazolamide; Altitude Sickness; Anti-Anxiety Agents; Azabicyclo Compounds; Benzodiazep | 2008 |
3 trials available for acetazolamide and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Altitude insomnia: studies during an expedition to the Himalayas.
Topics: Acetazolamide; Adult; Altitude Sickness; Anti-Anxiety Agents; Dose-Response Relationship, Drug; Elec | 1988 |
Effect of high elevation upon physical proficiency, cognitive functioning and subjective symptomatology.
Topics: Acetazolamide; Adult; Altitude; Back Pain; Cognition; Constipation; Depression; Headache; Humans; Hy | 1968 |
Effect of acetazolamide on acute mountain sickness.
Topics: Acetazolamide; Acute Disease; Adult; Alkalosis; Altitude; Bicarbonates; Blood; Blood Pressure; Carbo | 1968 |
1 other study available for acetazolamide and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Effects of acetazolamide on the sleep apnea syndrome and its therapeutic mechanism.
Topics: Acetazolamide; Acidosis; Adult; Aged; Carbonic Anhydrase Inhibitors; Humans; Male; Middle Aged; Narc | 1995 |