acetazolamide has been researched along with Rupture, Spontaneous in 4 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Rupture, Spontaneous: Tear or break of an organ, vessel or other soft part of the body, occurring in the absence of external force.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three patients with acute diffuse brain swelling seen on CT showed intracranial non-filling of 123I-IMP on SPECTs performed on Day 6, and all three died by Day 10." | 1.28 | Acetazolamide reactivity on cerebral blood flow in patients with subarachnoid haemorrhage. ( Araki, Y; Funakoshi, T; Imao, Y; Kimura, T; Shinoda, J, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nicoli, C | 1 |
| Wainsztein, RD | 1 |
| Trotta, LP | 1 |
| George, B | 2 |
| Mourier, KL | 2 |
| Lot, G | 2 |
| Raggueneau, JL | 1 |
| Tran Dinh, YR | 1 |
| Boissonnet, H | 1 |
| Cophignon, J | 1 |
| Shinoda, J | 1 |
| Kimura, T | 1 |
| Funakoshi, T | 1 |
| Araki, Y | 1 |
| Imao, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| C-arm Cone Beam CTA and CTP With Acetazolamide Challenge in Aneurysmal Subarachnoid Hemorrhage: Evaluating Predictability for Early Ischemia in Cerebral Vasospasm[NCT03377049] | Phase 4 | 11 participants (Actual) | Interventional | 2019-07-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinical neurological deterioration not attributable to other causes, mores specifically not due to re-bleeding, hydrocephalus, or metabolic changes. (NCT03377049)
Timeframe: Day 1-14 during the hospitalization
| Intervention | Participants (Count of Participants) |
|---|---|
| Acetazolamide Challenge | 2 |
Using perfusion map values, relative percent change will be calculated (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour
| Intervention | percent change (Mean) |
|---|---|
| Acetazolamide Challenge | 19.785 |
Using perfusion map values, relative percent change will be calculated (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour
| Intervention | percent change (Mean) |
|---|---|
| Acetazolamide Challenge | 21.659 |
The data that will be statistically compared is the pre-diamox perfusion in comparison to the post-diamox perfusion. A statistically significant change increase in CBF represents an appropriate response to Diamox. Lack of change in CBF or decrease in CBF could be suggestive of potential for developing vasospasm. (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour
| Intervention | percent change (Mean) |
|---|---|
| Acetazolamide Challenge | 20.722 |
1 review available for acetazolamide and Rupture, Spontaneous
| Article | Year |
|---|---|
[Value of the measurement of cerebral blood flow before and after diamox injection in predicting clinical vasospasm and final outcome in aneurysmal subarachnoid hemorrhage].
Topics: Acetazolamide; Cerebrovascular Circulation; Female; Humans; Intracranial Aneurysm; Male; Nimodipine; | 1991 |
3 other studies available for acetazolamide and Rupture, Spontaneous
| Article | Year |
|---|---|
Corneal topography of spontaneous perforation of acute hydrops in keratoconus.
Topics: Acetazolamide; Acute Disease; Adult; Corneal Edema; Corneal Topography; Descemet Membrane; Drug Ther | 1999 |
[Cerebral blood flow in the determination of vasospasm and surgical decision].
Topics: Acetazolamide; Aneurysm, Ruptured; Cerebrovascular Circulation; Humans; Intracranial Aneurysm; Ische | 1992 |
Acetazolamide reactivity on cerebral blood flow in patients with subarachnoid haemorrhage.
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Amphetamines; Brain Edema; Cerebrovascular Circulatio | 1991 |