acetazolamide has been researched along with Retinitis Pigmentosa in 20 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Retinitis Pigmentosa: Hereditary, progressive degeneration of the retina due to death of ROD PHOTORECEPTORS initially and subsequent death of CONE PHOTORECEPTORS. It is characterized by deposition of pigment in the retina.
| Excerpt | Relevance | Reference |
|---|---|---|
| ", West Point, PA), a carbonic anhydrase inhibitor, with that of oral acetazolamide (Diamox; Lederle Laboratories, Pearl River, NY) for the management of chronic cystoid macular edema in patients with retinitis pigmentosa." | 9.08 | Efficacy of dorzolamide hydrochloride in the management of chronic cystoid macular edema in patients with retinitis pigmentosa. ( Adelman, AE; Fiscella, RG; Fishman, GA; Grover, S, 1997) |
| "The carbonic anhydrase inhibitor acetazolamide (AZM) reduces macular oedema in some patients with retinitis pigmentosa." | 9.08 | The effect of acetazolamide on passive and active transport of fluorescein across the blood-retina barrier in retinitis pigmentosa complicated by macular oedema. ( Engler, C; Larsen, M; Li, B; Lund-Andersen, H; Moldow, B; Rosenberg, T; Sander, B, 1998) |
| "To study the effects of acetazolamide on central and peripheral visual function in patients with retinitis pigmentosa (RP) who showed no evidence of macular edema." | 9.07 | The effects of acetazolamide on visual function in retinitis pigmentosa. ( Carr, RE; Greenstein, VC; Holopigian, K; Seiple, W; Siderides, E, 1993) |
| "Twelve patients with retinitis pigmentosa and chronic macular edema were prospectively treated for 2-week periods with acetazolamide or a placebo in a masked, crossover study." | 9.06 | Acetazolamide for treatment of chronic macular edema in retinitis pigmentosa. ( Fiscella, RG; Fishman, GA; Gilbert, LD; Jampol, LM; Kimura, AE, 1989) |
| "To demonstrate the presence of a rebound effect with the use of acetazolamide for the treatment of cystoid macular edema (CME) in patients with retinitis pigmentosa (RP)." | 7.74 | Rebound of cystoid macular edema with continued use of acetazolamide in patients with retinitis pigmentosa. ( Apushkin, MA; Fishman, GA; Grover, S; Janowicz, MJ, 2007) |
| "The therapeutic effect of long-term treatment with acetazolamide (from 3 weeks to 16 months) of seven patients with retinitis pigmentosa was studied." | 7.68 | Long-term treatment of retinitis pigmentosa with acetazolamide. A pilot study. ( Aschero, M; Orzalesi, N; Pierrottet, C; Porta, A, 1993) |
| "The authors studied the therapeutic effect of acetazolamide on a patient with autosomal dominant retinitis pigmentosa complicated by retinal edema." | 7.68 | Long-term effect of acetazolamide in a patient with retinitis pigmentosa. ( Bird, AC; Chen, JC; Fitzke, FW, 1990) |
| ", West Point, PA), a carbonic anhydrase inhibitor, with that of oral acetazolamide (Diamox; Lederle Laboratories, Pearl River, NY) for the management of chronic cystoid macular edema in patients with retinitis pigmentosa." | 5.08 | Efficacy of dorzolamide hydrochloride in the management of chronic cystoid macular edema in patients with retinitis pigmentosa. ( Adelman, AE; Fiscella, RG; Fishman, GA; Grover, S, 1997) |
| "The carbonic anhydrase inhibitor acetazolamide (AZM) reduces macular oedema in some patients with retinitis pigmentosa." | 5.08 | The effect of acetazolamide on passive and active transport of fluorescein across the blood-retina barrier in retinitis pigmentosa complicated by macular oedema. ( Engler, C; Larsen, M; Li, B; Lund-Andersen, H; Moldow, B; Rosenberg, T; Sander, B, 1998) |
| "To study the effects of acetazolamide on central and peripheral visual function in patients with retinitis pigmentosa (RP) who showed no evidence of macular edema." | 5.07 | The effects of acetazolamide on visual function in retinitis pigmentosa. ( Carr, RE; Greenstein, VC; Holopigian, K; Seiple, W; Siderides, E, 1993) |
| "Twelve patients with retinitis pigmentosa and chronic macular edema were prospectively treated for 2-week periods with acetazolamide or a placebo in a masked, crossover study." | 5.06 | Acetazolamide for treatment of chronic macular edema in retinitis pigmentosa. ( Fiscella, RG; Fishman, GA; Gilbert, LD; Jampol, LM; Kimura, AE, 1989) |
| "To describe a rare case of recurring central serous chorioretinopathy associated with retinitis pigmentosa successfully treated with oral acetazolamide." | 3.83 | RECURRENT CENTRAL SEROUS CHORIORETINOPATHY ASSOCIATED WITH RETINITIS PIGMENTOSA TREATED WITH CARBONIC ANHYDRASE INHIBITORS. ( Pomykala, M; Rubin, JS; Rubin, P, 2016) |
| "The purpose of this paper was to describe a patient with pericentral retinitis pigmentosa (RP) and cystoid macular edema (CME) refractory to oral acetazolamide alone who was successfully treated with adjunctive pegaptanib sodium." | 3.75 | Intravitreal pegaptanib sodium (Macugen) for refractory cystoid macular edema in pericentral retinitis pigmentosa. ( Iaculli, C; Noci, ND; Prascina, F; Querques, G, 2009) |
| "To demonstrate the presence of a rebound effect with the use of acetazolamide for the treatment of cystoid macular edema (CME) in patients with retinitis pigmentosa (RP)." | 3.74 | Rebound of cystoid macular edema with continued use of acetazolamide in patients with retinitis pigmentosa. ( Apushkin, MA; Fishman, GA; Grover, S; Janowicz, MJ, 2007) |
| "To identify cystoid macular edema (CME) in patients with retinitis pigmentosa (RP) using optical coherence tomography (OCT) and to evaluate response to acetazolamide by serial OCT." | 3.73 | Optical coherence tomography in the diagnosis and monitoring of cystoid macular edema in patients with retinitis pigmentosa. ( Chung, H; Hwang, JU; Kim, JG; Yoon, YH, 2006) |
| "The therapeutic effect of long-term treatment with acetazolamide (from 3 weeks to 16 months) of seven patients with retinitis pigmentosa was studied." | 3.68 | Long-term treatment of retinitis pigmentosa with acetazolamide. A pilot study. ( Aschero, M; Orzalesi, N; Pierrottet, C; Porta, A, 1993) |
| "The authors studied the therapeutic effect of acetazolamide on a patient with autosomal dominant retinitis pigmentosa complicated by retinal edema." | 3.68 | Long-term effect of acetazolamide in a patient with retinitis pigmentosa. ( Bird, AC; Chen, JC; Fitzke, FW, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 8 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, Q | 1 |
| Chen, R | 1 |
| Lin, X | 1 |
| Xiang, Z | 1 |
| Strong, SA | 1 |
| Hirji, N | 1 |
| Quartilho, A | 1 |
| Kalitzeos, A | 1 |
| Michaelides, M | 2 |
| Gelman, SK | 1 |
| Gorin, MB | 1 |
| Liew, G | 1 |
| Moore, AT | 1 |
| Webster, AR | 1 |
| Pomykala, M | 1 |
| Rubin, P | 1 |
| Rubin, JS | 1 |
| Schaal, Y | 1 |
| Hondur, AM | 1 |
| Tezel, TH | 1 |
| Artunay, O | 1 |
| Yuzbasioglu, E | 1 |
| Rasier, R | 1 |
| Sengul, A | 1 |
| Bahcecioglu, H | 1 |
| Sahel, J | 1 |
| Bonnel, S | 1 |
| Mrejen, S | 1 |
| Paques, M | 1 |
| Thobani, A | 1 |
| Fishman, GA | 4 |
| Bonapace, G | 1 |
| Waheed, A | 1 |
| Shah, GN | 1 |
| Sly, WS | 1 |
| Chung, H | 1 |
| Hwang, JU | 1 |
| Kim, JG | 1 |
| Yoon, YH | 1 |
| Apushkin, MA | 1 |
| Grover, S | 2 |
| Janowicz, MJ | 1 |
| Querques, G | 1 |
| Prascina, F | 1 |
| Iaculli, C | 1 |
| Noci, ND | 1 |
| Orzalesi, N | 1 |
| Pierrottet, C | 1 |
| Porta, A | 1 |
| Aschero, M | 1 |
| Greenstein, VC | 1 |
| Holopigian, K | 1 |
| Siderides, E | 1 |
| Seiple, W | 1 |
| Carr, RE | 1 |
| Fiscella, RG | 2 |
| Adelman, AE | 1 |
| Moldow, B | 1 |
| Sander, B | 1 |
| Larsen, M | 1 |
| Engler, C | 1 |
| Li, B | 1 |
| Rosenberg, T | 1 |
| Lund-Andersen, H | 1 |
| Chen, JC | 1 |
| Fitzke, FW | 1 |
| Bird, AC | 1 |
| Gilbert, LD | 1 |
| Kimura, AE | 1 |
| Jampol, LM | 1 |
| Anderson, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Intravitreal Ranibizumab (Lucentis®) Injection in the Treatment of Non-leaking Macular Cysts in Patients With Retinal Dystrophy.[NCT03763227] | Phase 2 | 13 participants (Actual) | Interventional | 2015-07-24 | Completed | ||
| Treatment of Macular Oedema in Patients With Hereditary Retinal Dystrophies by Applying the Micropulsed Subthreshold Laser[NCT05976139] | 10 participants (Anticipated) | Interventional | 2023-09-06 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for acetazolamide and Retinitis Pigmentosa
| Article | Year |
|---|---|
Efficacy of carbonic anhydrase inhibitors in management of cystoid macular edema in retinitis pigmentosa: A meta-analysis.
Topics: Acetazolamide; Administration, Oral; Administration, Topical; Carbonic Anhydrase Inhibitors; Clinica | 2017 |
Retinitis pigmentosa and other dystrophies.
Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Fluorescein Angiography; Fundus Oculi; Glucocorticoids | 2010 |
5 trials available for acetazolamide and Retinitis Pigmentosa
| Article | Year |
|---|---|
Intravitreal ranibizumab in the treatment of cystoid macular edema associated with retinitis pigmentosa.
Topics: Acetazolamide; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Carbonic Anhydrase | 2009 |
The effects of acetazolamide on visual function in retinitis pigmentosa.
Topics: Acetazolamide; Adolescent; Adult; Aged; Contrast Sensitivity; Dark Adaptation; Electroretinography; | 1993 |
Efficacy of dorzolamide hydrochloride in the management of chronic cystoid macular edema in patients with retinitis pigmentosa.
Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Carbonic Anhy | 1997 |
The effect of acetazolamide on passive and active transport of fluorescein across the blood-retina barrier in retinitis pigmentosa complicated by macular oedema.
Topics: Acetazolamide; Adult; Biological Transport, Active; Blood-Retinal Barrier; Carbonic Anhydrase Inhibi | 1998 |
Acetazolamide for treatment of chronic macular edema in retinitis pigmentosa.
Topics: Acetazolamide; Adult; Aged; Cross-Sectional Studies; Dose-Response Relationship, Drug; Double-Blind | 1989 |
13 other studies available for acetazolamide and Retinitis Pigmentosa
| Article | Year |
|---|---|
Retrospective cohort study exploring whether an association exists between spatial distribution of cystoid spaces in cystoid macular oedema secondary to retinitis pigmentosa and response to treatment with carbonic anhydrase inhibitors.
Topics: Acetazolamide; Adolescent; Adult; Aged; Carbonic Anhydrase Inhibitors; Female; Humans; Macular Edema | 2019 |
Significant macular edema in a patient with cone dystrophy and improvement with acetazolamide treatment.
Topics: Acetazolamide; Administration, Oral; Aged; Carbonic Anhydrase Inhibitors; Humans; Macular Edema; Mal | 2014 |
Efficacy and prognostic factors of response to carbonic anhydrase inhibitors in management of cystoid macular edema in retinitis pigmentosa.
Topics: Acetazolamide; Administration, Oral; Adult; Carbonic Anhydrase Inhibitors; Cohort Studies; Delayed-A | 2015 |
RECURRENT CENTRAL SEROUS CHORIORETINOPATHY ASSOCIATED WITH RETINITIS PIGMENTOSA TREATED WITH CARBONIC ANHYDRASE INHIBITORS.
Topics: Acetazolamide; Administration, Oral; Adolescent; Carbonic Anhydrase Inhibitors; Central Serous Chori | 2016 |
Subtenon triamcinolone for cystoid macular edema due to retinitis pigmentosa unresponsive to oral acetazolamide.
Topics: Acetazolamide; Administration, Oral; Adult; Carbonic Anhydrase Inhibitors; Eye Proteins; Glucocortic | 2016 |
The use of carbonic anhydrase inhibitors in the retreatment of cystic macular lesions in retinitis pigmentosa and X-linked retinoschisis.
Topics: Acetazolamide; Adult; Aged; Carbonic Anhydrase Inhibitors; Female; Humans; Macular Edema; Male; Reti | 2011 |
Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17.
Topics: Acetazolamide; Animals; Apoptosis; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IV; COS Cells; | 2004 |
Optical coherence tomography in the diagnosis and monitoring of cystoid macular edema in patients with retinitis pigmentosa.
Topics: Acetazolamide; Adult; Aged; Carbonic Anhydrase Inhibitors; Female; Fluorescein Angiography; Follow-U | 2006 |
Rebound of cystoid macular edema with continued use of acetazolamide in patients with retinitis pigmentosa.
Topics: Acetazolamide; Administration, Oral; Adult; Carbonic Anhydrase Inhibitors; Female; Fluorescein Angio | 2007 |
Intravitreal pegaptanib sodium (Macugen) for refractory cystoid macular edema in pericentral retinitis pigmentosa.
Topics: Acetazolamide; Administration, Oral; Adult; Aptamers, Nucleotide; Carbonic Anhydrase Inhibitors; Dru | 2009 |
Long-term treatment of retinitis pigmentosa with acetazolamide. A pilot study.
Topics: Acetazolamide; Adult; Drug Administration Schedule; Edema; Female; Fluorescein Angiography; Fundus O | 1993 |
Long-term effect of acetazolamide in a patient with retinitis pigmentosa.
Topics: Acetazolamide; Female; Humans; Longitudinal Studies; Macular Edema; Middle Aged; Psychophysics; Reti | 1990 |
Ocular effects of changes in oxygen and carbon dioxide tension.
Topics: Academic Dissertations as Topic; Acetazolamide; Adaptation, Ocular; Adult; Angiography; Atmospheric | 1968 |