acetazolamide has been researched along with Respiratory Insufficiency in 31 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We searched Medline, EMBASE and CENTRAL from inception to March 2022 for randomised controlled trials comparing acetazolamide to placebo in patients with chronic obstructive pulmonary disease, obesity hypoventilation syndrome or obstructive sleep apnoea, hospitalised with acute respiratory deterioration complicated by metabolic alkalosis." | 9.41 | Acetazolamide for metabolic alkalosis complicating respiratory failure with chronic obstructive pulmonary disease or obesity hypoventilation syndrome: a systematic review. ( Bemand, TJ; Chatoor, R; Delaney, A; Natale, P; Strippoli, G, 2023) |
| "The purpose of the study was to evaluate the effectiveness of short-term treatment with acetazolamide for combined respiratory failure and metabolic alkalosis." | 9.17 | Acetazolamide improves oxygenation in patients with respiratory failure and metabolic alkalosis. ( Bruun Wyller, T; Frostad, A; Gulsvik, R; Hansen, G; Holø, L; Humerfelt, S; Lejlic, V; Saure, EW; Skjørten, I; Undhjem, K, 2013) |
| "Eleven AECOPD patients, with hypercapnic respiratory failure and MA following NIV, were treated with ACET 500 mg for two consecutive days and compared to a matched control group." | 5.43 | Effect of acetazolamide on post-NIV metabolic alkalosis in acute exacerbated COPD patients. ( Alessandrini, G; Bonini, M; Borgognoni, L; Ferrazza, AM; Fontana, V; Internullo, M; Marinelli, P; Palange, P; Santinelli, S; Sardo, L, 2016) |
| "We searched Medline, EMBASE and CENTRAL from inception to March 2022 for randomised controlled trials comparing acetazolamide to placebo in patients with chronic obstructive pulmonary disease, obesity hypoventilation syndrome or obstructive sleep apnoea, hospitalised with acute respiratory deterioration complicated by metabolic alkalosis." | 5.41 | Acetazolamide for metabolic alkalosis complicating respiratory failure with chronic obstructive pulmonary disease or obesity hypoventilation syndrome: a systematic review. ( Bemand, TJ; Chatoor, R; Delaney, A; Natale, P; Strippoli, G, 2023) |
| "The purpose of the study was to evaluate the effectiveness of short-term treatment with acetazolamide for combined respiratory failure and metabolic alkalosis." | 5.17 | Acetazolamide improves oxygenation in patients with respiratory failure and metabolic alkalosis. ( Bruun Wyller, T; Frostad, A; Gulsvik, R; Hansen, G; Holø, L; Humerfelt, S; Lejlic, V; Saure, EW; Skjørten, I; Undhjem, K, 2013) |
| "Acetazolamide can produce a small increase in arterial PO2 and fall in PCO2." | 2.41 | Carbonic anhydrase inhibitors for hypercapnic ventilatory failure in chronic obstructive pulmonary disease. ( Greenstone, M; Jones, PW, 2001) |
| "Eleven AECOPD patients, with hypercapnic respiratory failure and MA following NIV, were treated with ACET 500 mg for two consecutive days and compared to a matched control group." | 1.43 | Effect of acetazolamide on post-NIV metabolic alkalosis in acute exacerbated COPD patients. ( Alessandrini, G; Bonini, M; Borgognoni, L; Ferrazza, AM; Fontana, V; Internullo, M; Marinelli, P; Palange, P; Santinelli, S; Sardo, L, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (77.42) | 18.7374 |
| 1990's | 1 (3.23) | 18.2507 |
| 2000's | 1 (3.23) | 29.6817 |
| 2010's | 4 (12.90) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Bemand, TJ | 1 |
| Chatoor, R | 1 |
| Natale, P | 1 |
| Strippoli, G | 1 |
| Delaney, A | 1 |
| Luo, MS | 1 |
| Li, HZ | 1 |
| Huang, GJ | 1 |
| Wu, L | 1 |
| Gulsvik, R | 1 |
| Skjørten, I | 1 |
| Undhjem, K | 1 |
| Holø, L | 1 |
| Frostad, A | 1 |
| Saure, EW | 1 |
| Lejlic, V | 1 |
| Humerfelt, S | 1 |
| Hansen, G | 1 |
| Bruun Wyller, T | 1 |
| Fontana, V | 1 |
| Santinelli, S | 1 |
| Internullo, M | 1 |
| Marinelli, P | 1 |
| Sardo, L | 1 |
| Alessandrini, G | 1 |
| Borgognoni, L | 1 |
| Ferrazza, AM | 1 |
| Bonini, M | 1 |
| Palange, P | 1 |
| Ebus, S | 1 |
| Verrips, A | 1 |
| Ginjaar, IB | 1 |
| Verhagen, WI | 1 |
| AGNOLETTO, A | 1 |
| MORESCHI, N | 1 |
| KOCH, R | 1 |
| PIVOTEAU, C | 1 |
| VANROUX, R | 1 |
| SADOUL, P | 1 |
| LABADIE, P | 1 |
| OUREDNIK, A | 1 |
| DAUM, S | 2 |
| JEZEK, V | 1 |
| DOYLE, D | 1 |
| HARRIS, EA | 1 |
| SLAWSON, KB | 1 |
| SLUITER, HJ | 1 |
| KOOLHAAS, B | 1 |
| VAN DER LENDE, R | 1 |
| TAMMELING, GJ | 1 |
| BLOKZIJL, E | 1 |
| ORIE, NG | 1 |
| SERIFF, NS | 1 |
| PANAYOTOPOULOS, E | 1 |
| VALTIS, D | 1 |
| METAXAS, P | 1 |
| GOULIS, G | 1 |
| Lankisch, PG | 1 |
| Fossati, C | 1 |
| Dickinson, GE | 1 |
| Myers, ML | 1 |
| Goldbach, M | 1 |
| Sibbald, W | 1 |
| Jones, PW | 1 |
| Greenstone, M | 1 |
| Pasargiklian, M | 1 |
| Fumagalli, G | 1 |
| Ferrara, A | 1 |
| Bondoli, A | 1 |
| De Cosmo, G | 1 |
| Dordoni, L | 1 |
| Magalini, SI | 1 |
| Barth, J | 1 |
| Schatz, H | 1 |
| Altose, MD | 1 |
| Hudgel, DW | 1 |
| Krauss, H | 1 |
| Zimmermann, WE | 2 |
| Wittenburg, JP | 2 |
| Breithaupt, B | 1 |
| Dotti, A | 1 |
| Mombelloni, P | 1 |
| Fassio, PG | 1 |
| Beck, GJ | 1 |
| Grenard, S | 1 |
| Stiksa, J | 1 |
| Bürkmann, I | 1 |
| Bertrand, A | 1 |
| Janbon, F | 1 |
| Callis, A | 1 |
| Milane, J | 1 |
| Marx, HH | 1 |
| Helbig, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis[NCT00222534] | Phase 4 | 70 participants (Actual) | Interventional | 2002-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for acetazolamide and Respiratory Insufficiency
| Article | Year |
|---|---|
Acetazolamide for metabolic alkalosis complicating respiratory failure with chronic obstructive pulmonary disease or obesity hypoventilation syndrome: a systematic review.
Topics: Acetazolamide; Alkalosis; Humans; Obesity Hypoventilation Syndrome; Pulmonary Disease, Chronic Obstr | 2023 |
[Diuretics. II].
Topics: Acetazolamide; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antihypertensive Agents; Cardiac Glyc | 1981 |
Carbonic anhydrase inhibitors for hypercapnic ventilatory failure in chronic obstructive pulmonary disease.
Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Clinical Trials as Topic; Female; Humans; Hypercapnia; | 2001 |
[The treatment of acid-base imbalance in the intensive care of respiratory diseases].
Topics: Acetazolamide; Acid-Base Imbalance; Acidosis; Adrenergic beta-Agonists; Bicarbonates; Bronchial Spas | 1979 |
The pharmacology of respiratory depressants and stimulants.
Topics: Acetazolamide; Almitrine; Anti-Anxiety Agents; Benzodiazepines; Central Nervous System Depressants; | 1986 |
1 trial available for acetazolamide and Respiratory Insufficiency
| Article | Year |
|---|---|
Acetazolamide improves oxygenation in patients with respiratory failure and metabolic alkalosis.
Topics: Acetazolamide; Aged; Aged, 80 and over; Alkalosis; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Do | 2013 |
25 other studies available for acetazolamide and Respiratory Insufficiency
| Article | Year |
|---|---|
Trial sequential analysis suggested the potential overestimated effect of carbonic anhydrase inhibitor for respiratory failure and metabolic alkalosis.
Topics: Acetazolamide; Alkalosis; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Randomized Con | 2019 |
Effect of acetazolamide on post-NIV metabolic alkalosis in acute exacerbated COPD patients.
Topics: Acetazolamide; Acid-Base Equilibrium; Acute Disease; Aged; Aged, 80 and over; Alkalosis; Carbonic An | 2016 |
Gastro-enteritis in hypokalemic periodic paralysis: a life threatening condition.
Topics: Acetazolamide; Adult; Anticonvulsants; Calcium Channels; Calcium Channels, L-Type; Diarrhea; Female; | 2012 |
[Acetazolamide (diamox) in the treatment of silicosis with severe chronic respiratory insufficiency].
Topics: Acetazolamide; Chronic Disease; Respiratory Insufficiency; Silicosis | 1957 |
[Effects of chlorothiazide & acetazolamide on acid-base equilibrium in respiratory insufficiency].
Topics: Acetazolamide; Acid-Base Equilibrium; Cell Respiration; Chlorothiazide; Humans; Respiration; Respira | 1959 |
[RENAL CARBONIC ANHYDRASE: ITS PHYSIOLOGICAL ACTION; ITS INHIBITORS].
Topics: Acetazolamide; Acidosis; Ammonia; Carbonic Anhydrases; Chlorothiazide; Chlorthalidone; Dichlorphenam | 1963 |
[MEDICAL TREATMENT OF RESPIRATORY INSUFFICIENCY].
Topics: Acetazolamide; Aminobutyrates; Aminophylline; Blood Gas Analysis; Humans; Oxygen Inhalation Therapy; | 1964 |
THE RESPIRATORY ACTION OF DICHLORPHENAMIDE.
Topics: Acetazolamide; Acidosis; Biomedical Research; Blood Gas Analysis; Carbon Dioxide; Carbonic Anhydrase | 1964 |
CONSERVATIVE AND AGGRESSIVE TREATMENT OF ACUTE SEVERE RESPIRATORY INSUFFICIENCY IN PATIENTS WITH CHRONIC NON-SPECIFIC LUNG DISEASE (C.N.S.L.D.).
Topics: Acetazolamide; Acid-Base Equilibrium; Adrenal Cortex Hormones; Aminobutyrates; Aminophylline; Anti-B | 1964 |
ALVEOLAR HYPOVENTILATION WITH NORMAL LUNGS: THE SYNDROME OF PRIMARY OR CENTRAL ALVEOLAR HYPOVENTILATION.
Topics: Acetazolamide; Aminophylline; Carbon Dioxide; Humans; Hypnosis; Hypoventilation; Lung; Medulla Oblon | 1965 |
[The influence of acetazolamide on patients with chronic respiratory insufficiency].
Topics: Acetazolamide; Chronic Disease; Leadership; Pulmonary Emphysema; Respiratory Insufficiency | 1960 |
[Conservative treatment of acute pancreatitis].
Topics: Acetazolamide; Acute Disease; Acute Kidney Injury; Aftercare; Antacids; Aprotinin; Atropine; Bacteri | 1982 |
Acetazolamide in the treatment of ventilatory failure complicating acute metabolic alkalosis.
Topics: Acetazolamide; Alkalosis; Female; Furosemide; Humans; Middle Aged; Postoperative Complications; Resp | 1981 |
[Acetazolamide in respiratory insufficiency].
Topics: Acetazolamide; Acid-Base Imbalance; Acute Disease; Brain Injuries; Chronic Disease; Humans; Hypercap | 1979 |
[The indications for acetazolamide].
Topics: Acetazolamide; Acidosis, Respiratory; Alkalosis; Humans; Hypercapnia; Respiratory Insufficiency | 1992 |
[Round table discussion of the treatment of respiratory insufficiency. Madrid, 22 October 1965].
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis, Respiratory; Adrenal Cortex Hormones; Aminobutyrates | 1966 |
[Respiratory insufficiency owing to posttraumatic metabolic changes in thoracic surgery].
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis; Adult; Aged; Alkalosis; Blood Gas Analysis; Calcium | 1967 |
[The control of acid-base equilibrium in postoperative respiratory insufficiency].
Topics: Acetazolamide; Acid-Base Equilibrium; Adult; Carbon Dioxide; Esophageal and Gastric Varices; Humans; | 1967 |
[Evaluation of the effects of various diuretics in chronic lung diseases with chronic respiratory insufficiency (CRI)].
Topics: Acetazolamide; Amides; Chronic Disease; Clopamide; Diuretics; Humans; Hydrogen-Ion Concentration; Lu | 1969 |
Intensive respiratory care: advances in management of patients with obstructive pulmonary disease.
Topics: Acetazolamide; Blood; Blood Gas Analysis; Carbon Dioxide; Chronic Disease; Humans; Hydrogen-Ion Conc | 1970 |
[Micromethods in the diagnosis of respiratory insufficiency].
Topics: Acetazolamide; Arteries; Blood Gas Analysis; Capillaries; Humans; Methods; Respiratory Insufficiency | 1967 |
[A contribution on the treatment of respiratory insufficiency with carbonic anhydrase inhibitors].
Topics: Acetazolamide; Bronchitis; Humans; Hydrogen-Ion Concentration; Pulmonary Emphysema; Respiratory Insu | 1967 |
[Use of diuretics in the course of acute respiratory insufficiency in chronic broncho-pulmonary diseases: apropos of a study of clopamide, ethacrynic acid and acetazolamide].
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis, Respiratory; Amides; Bronchial Diseases; Clopamide; | 1968 |
[Shifts of the acid-base equilibrium in chronic pulmonary insufficiency].
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis, Respiratory; Digitoxin; Furosemide; Humans; Hydrogen | 1965 |
[Special problems of burns in childhood].
Topics: Acetazolamide; Acidosis, Respiratory; Bandages; Body Weight; Burns; Child; Child, Preschool; Chlorpr | 1966 |