acetazolamide and Pregnancy studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

Excerpt	Relevance	Reference
" The information regarding fetal effects of acetazolamide use during pregnancy and lactation is sparse."	9.05	Brief report: Metabolic acidosis in newborn infants following maternal use of acetazolamide during pregnancy. ( Hussain, N; Ibrahim, A, 2020)
"There is no convincing evidence for an adverse effect for acetazolamide use in human pregnancy, even when prescribed prior to the 13th week of gestation."	7.79	The use of acetazolamide during pregnancy in intracranial hypertension patients. ( Falardeau, J; Golden, S; Lobb, BM; Maxfield, SD; Tanne, E, 2013)
"To describe the pregnancy outcomes after the use of acetazolamide in pregnant patients with idiopathic intracranial hypertension (IIH)."	7.73	The use of acetazolamide in idiopathic intracranial hypertension during pregnancy. ( Capozzoli, T; Falardeau, J; Kardon, RH; Lee, AG; Pless, M; Wall, M, 2005)
"Development of metabolic acidosis, hypocalcemia and hypomagnesemia in a preterm infant whose mother was treated with acetazolamide throughout pregnancy is described."	7.68	Possible association between acetazolamide administration during pregnancy and metabolic disorders in the newborn. ( Litwin, A; Merlob, P; Mor, N, 1990)
"Acetazolamide is a carbonic anhydrase inhibitor that is used to treat idiopathic intracranial hypertension, glaucoma, and epilepsy."	5.43	Possible association between acetazolamide administration during pregnancy and multiple congenital malformations. ( Al-Jobair, AM; Al-Saleem, AI, 2016)
" The information regarding fetal effects of acetazolamide use during pregnancy and lactation is sparse."	5.05	Brief report: Metabolic acidosis in newborn infants following maternal use of acetazolamide during pregnancy. ( Hussain, N; Ibrahim, A, 2020)
"There is no convincing evidence for an adverse effect for acetazolamide use in human pregnancy, even when prescribed prior to the 13th week of gestation."	3.79	The use of acetazolamide during pregnancy in intracranial hypertension patients. ( Falardeau, J; Golden, S; Lobb, BM; Maxfield, SD; Tanne, E, 2013)
"To describe the pregnancy outcomes after the use of acetazolamide in pregnant patients with idiopathic intracranial hypertension (IIH)."	3.73	The use of acetazolamide in idiopathic intracranial hypertension during pregnancy. ( Capozzoli, T; Falardeau, J; Kardon, RH; Lee, AG; Pless, M; Wall, M, 2005)
" His mother had glaucoma and had been treated during pregnancy with oral acetazolamide, a carbonic anhydrase inhibitor."	3.71	Transient renal tubular acidosis in a neonate following transplacental acetazolamide. ( Azuma, E; Higashigawa, M; Komada, Y; Mukouhara, R; Ozawa, H; Shindo, K, 2001)
" In a second case report we describe, in a 61-year-old patient suffering from aspirin-sensitive asthma, recurrent ciliary body oedema with a marked spastic component which was triggered by the medications acetazolamide, dipivefrine and pilocarpine."	3.69	Drug-induced ciliary body oedema: a new theory. ( Krieg, PH; Schipper, I, 1996)
"Development of metabolic acidosis, hypocalcemia and hypomagnesemia in a preterm infant whose mother was treated with acetazolamide throughout pregnancy is described."	3.68	Possible association between acetazolamide administration during pregnancy and metabolic disorders in the newborn. ( Litwin, A; Merlob, P; Mor, N, 1990)
"In cancer patients with hypersplenism-related thrombocytopenia, PSAE is a safe intervention that effects a durable elevation in platelet counts across a range of malignancies and following the re-initiation of chemotherapy."	2.73	( Aasbrenn, M; Abd El-Aty, AM; Abdu, A; Abraha, HB; Achour, A; Acquaroni, M; Addeo, P; Agback, P; Agback, T; Al-Alwan, M; Al-Mazrou, A; Al-Mohanna, F; Aliste, M; Almquist, J; Andel, J; Ando, M; Angelov, A; Annuar, MSM; Antwi, K; Arroliga, AC; Arruda, SLM; Asch, SM; Averous, G; Ayaz, S; Ayer, GB; Bachellier, P; Ball, S; Banijamali, AR; Barden, TC; Bartoncini, S; Bedanie, G; Bellò, M; Benić, F; Berhe, GG; Bertiger, G; Beumer, JH; Bhandari, B; Bond, DS; Boules, M; Braüner Christensen, J; Brown-Johnson, C; Burgstaller, S; Cao, L; Capasso, C; Carlevato, R; Carvalho, AE; Ceci, F; Chagas, ATA; Chavan, SG; Chen, AP; Chen, HC; Chen, J; Chen, Q; Chen, Y; Chen, YF; Christ, ER; Chu, CW; Covey, JM; Coyne, GO'; Cristea, MC; Currie, MG; Dahdal, DN; Dai, L; Dang, Z; de Abreu, NL; de Carvalho, KMB; de la Plaza Llamas, R; Deandreis, D; Del Prete, S; Dennis, JA; Deur, J; Díaz Candelas, DA; Divyapriya, G; Djanani, A; Dodig, D; Doki, Y; Doroshow, JH; Dos Santos, RC; Durairaj, N; Dutra, ES; Eguchi, H; Eisterer, W; Ekmann, A; Elakkad, A; Evans, WE; Fan, W; Fang, Z; Faria, HP; Farris, SG; Fenoll, J; Fernandez-Botran, R; Flores, P; Fujita, J; Gan, L; Gandara, DR; Gao, X; Garcia, AA; Garrido, I; Gebru, HA; Gerger, A; Germano, P; Ghamande, S; Ghebeh, H; Giver Jensen, T; Go, A; Goichot, B; Goldwater, M; Gontero, P; Greil, R; Gruenberger, B; Guarneri, A; Guo, Y; Gupta, S; Haxholdt Lunn, T; Hayek, AJ; He, ML; Hellín, P; Hepprich, M; Hernández de Rodas, E; Hill, A; Hndeya, AG; Holdsworth, LM; Hookey, L; Howie, W; Hu, G; Huang, JD; Huang, SY; Hubmann, E; Hwang, SY; Imamura, H; Imperiale, A; Jiang, JQ; Jimenez, JL; Jin, F; Jin, H; Johnson, KL; Joseph, A; Juwara, L; Kalapothakis, E; Karami, H; Karayağiz Muslu, G; Kawabata, R; Kerwin, J; Khan, I; Khin, S; Kidanemariam, HG; Kinders, RJ; Klepov, VV; Koehler, S; Korger, M; Kovačić, S; Koyappayil, A; Kroll, MH; Kuban, J; Kummar, S; Kung, HF; Kurokawa, Y; Laengle, F; Lan, J; Leal, HG; Lee, MH; Lemos, KGE; Li, B; Li, G; Li, H; Li, X; Li, Y; Li, Z; Liebl, W; Lillaz, B; Lin, F; Lin, L; Lin, MCM; Lin, Y; Lin, YP; Lipton, RB; Liu, J; Liu, W; Liu, Z; Lu, J; Lu, LY; Lu, YJ; Ludwig, S; Luo, Y; Ma, L; Ma, W; Machado-Coelho, GLL; Mahmoodi, B; Mahoney, M; Mahvash, A; Mansour, FA; Mao, X; Marinho, CC; Masferrer, JL; Matana Kaštelan, Z; Melendez-Araújo, MS; Méndez-Chacón, E; Miletić, D; Miller, B; Miller, E; Miller, SB; Mo, L; Moazzen, M; Mohammadniaei, M; Montaz-Rosset, MS; Mousavi Khaneghah, A; Mühlethaler, K; Mukhopadhyay, S; Mulugeta, A; Nambi, IM; Navarro, S; Nazmara, S; Neumann, HJ; Newman, EM; Nguyen, HTT; Nicolato, AJPG; Nicolotti, DG; Nieva, JJ; Nilvebrant, J; Nocentini, A; Nugent, K; Nunez-Rodriguez, DL; Nygren, PÅ; Oberli, A; Oderda, M; Odisio, B; Oehler, L; Otludil, B; Overman, M; Özdemir, M; Pace, KA; Palm, H; Parchment, RE; Parise, R; Passera, R; Pavlovic, J; Pecherstorfer, M; Peng, Z; Pérez Coll, C; Petzer, A; Philipp-Abbrederis, K; Pichler, P; Piekarz, RL; Pilati, E; Pimentel, JDSM; Posch, F; Prager, G; Pressel, E; Profy, AT; Qi, P; Qi, Y; Qiu, C; Rajasekhar, B; Ramia, JM; Raynor, HA; Reis, VW; Reubi, JC; Ricardi, U; Riedl, JM; Romano, F; Rong, X; Rubinstein, L; Rumboldt, Z; Sabir, S; Safaeinili, N; Sala, BM; Sandoval Castillo, L; Sau, M; Sbhatu, DB; Schulte, T; Scott, V; Shan, H; Shao, Y; Shariatifar, N; Shaw, JG; She, Y; Shen, B; Shernyukov, A; Sheth, RA; Shi, B; Shi, R; Shum, KT; Silva, JC; Singh, A; Sinha, N; Sirajudeen, AAO; Slaven, J; Sliwa, T; Somme, F; Song, S; Steinberg, SM; Subramaniam, R; Suetta, C; Sui, Y; Sun, B; Sun, C; Sun, H; Sun, Y; Supuran, CT; Surger, M; Svartz, G; Takahashi, T; Takeno, A; Tam, AL; Tang, Z; Tanner, JA; Tannich, E; Taye, MG; Tekle, HT; Thomas, GJ; Tian, Y; Tobin, JV; Todd Milne, G; Tong, X; Une, C; Vela, N; Venkateshwaran, U; Villagrán de Tercero, CI; Wakefield, JD; Wampfler, R; Wan, M; Wang, C; Wang, J; Wang, L; Wang, S; Waser, B; Watt, RM; Wei, B; Wei, L; Weldemichael, MY; Wellmann, IA; Wen, A; Wild, D; Wilthoner, K; Winder, T; Wing, RR; Winget, M; Wöll, E; Wong, KL; Wong, KT; Wu, D; Wu, Q; Wu, Y; Xiang, T; Xiang, Z; Xu, F; Xu, L; Yamasaki, M; Yamashita, K; Yan, H; Yan, Y; Yang, C; Yang, H; Yang, J; Yang, N; Yang, Y; Yau, P; Yu, M; Yuan, Q; Zhan, S; Zhang, B; Zhang, H; Zhang, J; Zhang, N; Zhang, Y; Zhao, X; Zheng, BJ; Zheng, H; Zheng, W; Zhou, H; Zhou, X; Zhu, S; Zimmer, DP; Zionts, D; Zitella, A; Zlott, J; Zolfaghari, K; Zuo, D; Zur Loye, HC; Žuža, I, 2007)
"Symptomatic treatment of headache is recommended."	2.61	[Idiopathic intracranial hypertension - Swedish consensus guidelines]. ( Gustavsson, B; Hellgren, K; Lundvall, M; Nilsson Remahl, I; Söderman, M; Sundholm, A; Träisk, F, 2019)
"Although weight gain is expected in pregnancy, excessive weight gain may exacerbate IIH and increase maternal and fetal complications; evidence-based recommendations for non-IIH pregnancies may help in guiding optimal gestational weight gain."	1.72	Managing idiopathic intracranial hypertension in pregnancy: practical advice. ( Abbott, S; Mollan, SP; Sinclair, AJ; Tahrani, AA; Thaller, M; Wakerley, BR, 2022)
"Acetazolamide is a carbonic anhydrase inhibitor that is used to treat idiopathic intracranial hypertension, glaucoma, and epilepsy."	1.43	Possible association between acetazolamide administration during pregnancy and multiple congenital malformations. ( Al-Jobair, AM; Al-Saleem, AI, 2016)
"Labor was induced at 37 weeks for intrauterine growth retardation associated with oligohydramnios."	1.36	[Idiopathic intracranial hypertension and pregnancy. A report of two cases]. ( Boog, G; Gommier, B; Jacopin-Bruneau, L; Pierre, F, 2010)
" We examine the relationship between expressivity and penetrance using right and left forelimb data from a previously reported dose-response analysis of the C57BL/6J and WB/ReJ strains to acetazolamide."	1.29	Penetrance and expressivity of acetazolamide-ectrodactyly provide a method to define a right-left teratogenic gradient that differs between the C57BL/6J and WB/ReJ mouse strains. ( Biddle, FG; Eales, BA; Mulholland, LR, 1993)
"The Kmf of 36Cl- was not inhibited by anoxia and had a low temperature quotient (Q10 between 32 and 37 degrees C was 1."	1.29	Transfer of Cl- across placenta of anesthetized rat. ( Husain, S; Sibley, CP; Stulc, J; Stulcová, B, 1996)
"Treatment with Acetazolamide provided quick recovery in the bilateral case, whereas the unilateral exudative detachment recovered without treatment after delivery."	1.28	Exudative retinal detachment in familial pulmonary hypertension. ( Gíslason, I; Jónasson, F; Stefánsson, E, 1991)
" We deem the initial dosage of 16 mg Millicorten/day to be therapeutically effective and adequate."	1.28	[Pseudotumor cerebri in pregnancy]. ( Benz, J; Zeller, R, 1990)
"No pregnancy was adversely affected, but symptoms of pseudotumor increased in 9 of 11 pregnancies."	1.28	Pseudotumor cerebri and pregnancy. ( Cefalo, RC; Katz, VL; Peterson, R, 1989)
" One strain, SJL/J, exhibited maternal toxicity to the dosage regime and was excluded from the survey."	1.27	Genetic differences in the frequency of acetazolamide-induced ectrodactyly in the mouse exhibit directional dominance of relative embryonic resistance. ( Biddle, FG, 1988)
"We have demonstrated previously that phenylephrine, a selective postsynaptic alpha-1-adrenergic agonist, significantly potentiates the incidence of acetazolamide-induced right forelimb ectrodactyly in a dose-response manner."	1.27	Reduction of uterine blood flow by phenylephrine, an alpha-adrenergic agonist, in the day 11 pregnant rat: relationship to potentiation of acetazolamide teratogenesis. ( Scott, WJ; Ugen, KE, 1987)
"Chlorothiazide is a much more potent inhibitor of alkaline phosphatase than the other three diuretics."	1.26	Inhibition of alkaline phosphatase by several diuretics. ( Price, GH, 1980)
"Acetazolamide was administered orally by gavage to pregnant mice twice a day on days six through 15 of gestation at a dose level of 300."	1.26	Teratogenic activity in the mouse after oral administration of acetazolamide. ( Baldwin, JK; Sofia, RD; Tellone, CI, 1980)
"The frequency of hemimelia and micromelia, and of bilateral involvement, was greater in litters exposed to the high pH acetazolamide or the epinephrine-acetazolamide combinations, and was reduced by phentolamine or adrenal medullectomy."	1.26	Potentiation by the injection vehicle of the teratological action of acetazolamide in rats. ( Jones, JC; Muther, TF; Smoak, NS, 1977)
"Cadmium (CdSO4) was given ip on day 9 at 12 or 24 mumol/kg to pregnant CD-1 (non-inbred) mice."	1.26	Cadmium induced limb defects in mice: strain associated differences in sensitivity. ( Layton, MW; Layton, WM, 1979)
"Hypercapnia was induced in the fetus alone by giving acetazolamide iv to the fetus, 100-200 mg/kg."	1.26	Effects of hypercapnia on uterine and umbilical circulations in conscious pregnant sheep. ( Chez, RA; Ehrenkranz, R; McLaughlin, M; Oakes, GK; Walker, AM, 1976)

Timeframe	Studies, this research(%)	All Research%
pre-1990	121 (75.16)	18.7374
1990's	20 (12.42)	18.2507
2000's	6 (3.73)	29.6817
2010's	11 (6.83)	24.3611
2020's	3 (1.86)	2.80

Article	Year
Medical Conditions and High-Altitude Travel. The New England journal of medicine, 2022, Jan-27, Volume: 386, Issue:4 Topics: Acetazolamide; Altitude; Altitude Sickness; Brain Edema; Chronic Disease; Dexamethasone; Female; Hum	2022
Brief report: Metabolic acidosis in newborn infants following maternal use of acetazolamide during pregnancy. Journal of neonatal-perinatal medicine, 2020, Volume: 13, Issue:3 Topics: Acetazolamide; Acidosis; Carbonic Anhydrase Inhibitors; Female; Humans; Infant, Newborn; Infant, New	2020
[Idiopathic intracranial hypertension - Swedish consensus guidelines]. Lakartidningen, 2019, May-15, Volume: 116 Topics: Acetazolamide; Bariatric Surgery; Carbonic Anhydrase Inhibitors; Consensus; Critical Pathways; Diagn	2019
Idiopathic intracranial hypertension and pregnancy. Clinical obstetrics and gynecology, 2013, Volume: 56, Issue:2 Topics: Acetazolamide; Diuretics; Female; Humans; Incidence; Pregnancy; Pregnancy Complications, Cardiovascu	2013

Article	Year
Managing idiopathic intracranial hypertension in pregnancy: practical advice. Practical neurology, 2022, Volume: 22, Issue:4 Topics: Acetazolamide; Female; Humans; Intracranial Hypertension; Obesity; Pregnancy; Pseudotumor Cerebri; W	2022
Cerebrospinal fluid cutaneous fistula following obstetric epidural analgaesia. Case report. Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8 Topics: Acetazolamide; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Antibiotic Prophylaxis; Combined	2017
Management and outcome of consecutive pregnancies complicated by idiopathic intracranial hypertension. The Israel Medical Association journal : IMAJ, 2013, Volume: 15, Issue:4 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Cesarean Section; Female; Humans; Intracranial	2013
Possible association between acetazolamide administration during pregnancy and multiple congenital malformations. Drug design, development and therapy, 2016, Volume: 10 Topics: Abnormalities, Multiple; Acetazolamide; Child; Female; Humans; Limb Deformities, Congenital; Male; P	2016
Comment on the case report "Possible association between acetazolamide administration during pregnancy and multiple congenital malformations". Drug design, development and therapy, 2016, Volume: 10 Topics: Acetazolamide; Female; Humans; Pregnancy; Syndrome	2016
[Idiopathic intracranial hypertension and pregnancy. A report of two cases]. Journal de gynecologie, obstetrique et biologie de la reproduction, 2010, Volume: 39, Issue:3 Topics: Acetazolamide; Adult; Brain; Cyclohexanols; Drug Overdose; Eye Diseases; Female; Fetal Growth Retard	2010
Increases in discontinuous rib cartilage and fused carpal bone in rat fetuses exposed to the teratogens, busulfan, acetazolamide, vitamin A, and ketoconazole. Human & experimental toxicology, 2010, Volume: 29, Issue:6 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Busulfan; Carpal Bones; Cartilage; Diterpenes;	2010
Exacerbation of acetazolamide-responsive sodium channel myotonia by uterotonic agents. International journal of obstetric anesthesia, 2011, Volume: 20, Issue:1 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Cesarean Section; Drug Interactions; Female; Humans; M	2011
Progressive visual loss in a pregnant woman with idiopathic intracranial hypertension. European journal of obstetrics, gynecology, and reproductive biology, 2012, Volume: 163, Issue:1 Topics: Acetazolamide; Adult; Female; Humans; Obesity; Pregnancy; Pregnancy Complications; Pseudotumor Cereb	2012
The use of acetazolamide during pregnancy in intracranial hypertension patients. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2013, Volume: 33, Issue:1 Topics: Acetazolamide; Adult; Female; Humans; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnan	2013
Effects of inhibition of renal carbonic anhydrase by diamox in normal and toxemic pregnancies. The Journal of laboratory and clinical medicine, 1955, Volume: 46, Issue:5 Topics: Acetazolamide; Carbonic Anhydrases; Diuretics; Female; Hydro-Lyases; Kidney; Pre-Eclampsia; Pregnanc	1955
Diamox, a carbonic anhydrase inhibitor, as an oral diuretic in pregnancy. Obstetrics and gynecology, 1956, Volume: 7, Issue:3 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Diuretics; Female; Hydro-Lyases; Pre-Eclampsia; Pregna	1956
Diamox in preeclampsia. United States Armed Forces medical journal, 1956, Volume: 7, Issue:12 Topics: Acetazolamide; Female; Pre-Eclampsia; Pregnancy	1956
Diamox in preeclampsia. United States Armed Forces medical journal, 1956, Volume: 7, Issue:12 Topics: Acetazolamide; Female; Pre-Eclampsia; Pregnancy	1956
Diamox in preeclampsia. United States Armed Forces medical journal, 1956, Volume: 7, Issue:12 Topics: Acetazolamide; Female; Pre-Eclampsia; Pregnancy	1956
Diamox in preeclampsia. United States Armed Forces medical journal, 1956, Volume: 7, Issue:12 Topics: Acetazolamide; Female; Pre-Eclampsia; Pregnancy	1956
The use of diamox in the treatment of pre-eclamptic toxaemia. Journal of the Irish Medical Association, 1957, Volume: 40, Issue:236 Topics: Acetazolamide; Female; Pre-Eclampsia; Pregnancy; Toxemia	1957
The use of diamox in the treatment of pre-eclamptic toxaemia. Journal of the Irish Medical Association, 1957, Volume: 40, Issue:236 Topics: Acetazolamide; Female; Pre-Eclampsia; Pregnancy; Toxemia	1957
The use of diamox in the treatment of pre-eclamptic toxaemia. Journal of the Irish Medical Association, 1957, Volume: 40, Issue:236 Topics: Acetazolamide; Female; Pre-Eclampsia; Pregnancy; Toxemia	1957
The use of diamox in the treatment of pre-eclamptic toxaemia. Journal of the Irish Medical Association, 1957, Volume: 40, Issue:236 Topics: Acetazolamide; Female; Pre-Eclampsia; Pregnancy; Toxemia	1957
The treatment of pre-eclamptic edema with acetazoleamide (diamox). American journal of obstetrics and gynecology, 1957, Volume: 73, Issue:4 Topics: Acetazolamide; Edema; Female; Pre-Eclampsia; Pregnancy	1957
Diamox in edema of pregnancy. The Journal of the Florida Medical Association. Florida Medical Association, 1957, Volume: 43, Issue:12 Topics: Acetazolamide; Edema; Female; Humans; Pregnancy; Pregnancy Complications; Sodium; Sodium, Dietary	1957
[Acetazolamide in the treatment of edema & excessive weight gained during pregnancy]. El Dia medico, 1957, Sep-16, Volume: 29, Issue:65 Topics: Acetazolamide; Body Weight; Body Weights and Measures; Edema; Female; Humans; Pregnancy	1957
A carbonic anhydrase inhibitor for control of fluid retention in pregnancy. Obstetrics and gynecology, 1957, Volume: 10, Issue:3 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Female; Heart Failure; Pre-Eclampsia; Pregnancy	1957
The use of diamox in preeclamptic toxaemia. The Medical journal of Malaya, 1957, Volume: 11, Issue:4 Topics: Acetazolamide; Female; Pre-Eclampsia; Pregnancy	1957
Evaluation of chlorothiazide (diuril) in the toxemias of pregnancy; analysis of one hundred forty-four patients. Journal of the American Medical Association, 1958, Jan-11, Volume: 166, Issue:2 Topics: Acetazolamide; Chlorothiazide; Female; Pre-Eclampsia; Pregnancy; Toxemia	1958
Acetazoleamide (diamox) in the inhibition of postpartum breast engorgement. New York state journal of medicine, 1957, Dec-15, Volume: 57, Issue:24 Topics: Acetazolamide; Female; Humans; Hyperemia; Lactation Disorders; Postpartum Period; Pregnancy; Puerper	1957
The use of diamox in obstetrics and gynecology. North Carolina medical journal, 1958, Volume: 19, Issue:2 Topics: Acetazolamide; Female; Gynecology; Humans; North Carolina; Obstetrics; Pregnancy; Pregnancy Complica	1958
A carbonic anhydrase inhibitor as a diuretic in obstetrics. American journal of obstetrics and gynecology, 1958, Volume: 75, Issue:6 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Diuretics; Edema; Female; Obstetrics; Pre-Eclampsia; P	1958
[Treatment of pregnancy toxemias with chlorothiazide]. El Dia medico, 1958, Apr-28, Volume: 30, Issue:25 Topics: Acetazolamide; Chlorothiazide; Female; Pre-Eclampsia; Pregnancy	1958
[Clinical results of the use of acetazolamide in pregnancy toxemia]. Gaceta medica de Mexico, 1958, Volume: 88, Issue:6 Topics: Acetazolamide; Female; Pre-Eclampsia; Pregnancy	1958
An evaluation of chlorothiazide in the treatment of edema in pregnant women. American journal of obstetrics and gynecology, 1958, Volume: 76, Issue:3 Topics: Acetazolamide; Chlorothiazide; Edema; Female; Pregnancy; Pregnancy Complications	1958
Diuretic effects of chlorothiazide in toxemia of pregnancy. The Journal of laboratory and clinical medicine, 1958, Volume: 52, Issue:3 Topics: Acetazolamide; Chlorothiazide; Diuretics; Female; Pre-Eclampsia; Pregnancy	1958
[Use of a new diuretic (chlotride) in obstertrics & gynecology]. Minerva ginecologica, 1958, Jun-30, Volume: 10, Issue:12 Topics: Acetazolamide; Diuretics; Female; Gynecology; Humans; Pre-Eclampsia; Pregnancy; Premenstrual Syndrom	1958
[Possibilities of the use of a new oral diuretic, acetazolamide, in edema of pregnancy]. Minerva ginecologica, 1958, Jul-15, Volume: 10, Issue:13 Topics: Acetazolamide; Diuretics; Edema; Female; Humans; Pregnancy; Pregnancy Complications	1958
Influence of chlorothiazide on water and electrolyte excretion in preeclampsia. Journal of the American Medical Association, 1958, Dec-27, Volume: 168, Issue:17 Topics: Acetazolamide; Biological Transport; Body Fluids; Chlorothiazide; Diuresis; Diuretics; Electrolytes;	1958
Clinical and metabolic study of chlorothiazide (diuril); use in edema of normal pregnancy and of toxemia of pregnancy. Journal of the American Medical Association, 1959, Jan-03, Volume: 169, Issue:1 Topics: Acetazolamide; Chlorothiazide; Edema; Female; Pre-Eclampsia; Pregnancy; Pregnancy Complications	1959
[Use of chlorothiazide in obstetrics and gynecology]. Rivista d'ostetricia e ginecologia pratica, 1958, Volume: 40, Issue:10 Topics: Acetazolamide; Chlorothiazide; Edema; Female; Gynecology; Humans; Obstetrics; Pre-Eclampsia; Pregnan	1958
[Effects of rontyl & chlorothiazide on pregnancy edemas]. Ugeskrift for laeger, 1958, Nov-27, Volume: 120, Issue:48 Topics: Acetazolamide; Chlorothiazide; Edema; Female; Pregnancy; Pregnancy Complications	1958
Chlorothiazide in edema of pregnancy. New York state journal of medicine, 1959, Jan-01, Volume: 59, Issue:1 Topics: Acetazolamide; Chlorothiazide; Edema; Female; Pregnancy; Pregnancy Complications	1959
[Treatment of pregnancy toxemias with chlorothiazide]. Prensa medica argentina, 1958, Aug-22, Volume: 45, Issue:34 Topics: Acetazolamide; Chlorothiazide; Female; Pre-Eclampsia; Pregnancy	1958
Evaluation of diuril in 50 patients with toxemias of pregnancy. United States Armed Forces medical journal, 1959, Volume: 10, Issue:4 Topics: Acetazolamide; Chlorothiazide; Female; Pre-Eclampsia; Pregnancy; Toxemia	1959
Clinical experiences with chlorothiazide in the treatment of hypertension in pregnancy: a preliminary report. Southern medical journal, 1959, Volume: 52, Issue:5 Topics: Acetazolamide; Chlorothiazide; Female; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complicatio	1959
Chlorothiazide therapy in obstetrics and gynecology. American journal of obstetrics and gynecology, 1959, Volume: 77, Issue:6 Topics: Acetazolamide; Chlorothiazide; Female; Gynecology; Humans; Obstetrics; Pre-Eclampsia; Pregnancy; Pre	1959
Carbonic anhydrase inhibitors; their effect on water and electrolyte metabolism in toxemia of pregnancy. The Journal of the International College of Surgeons, 1959, Volume: 31, Issue:5 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Electrolytes; Female; Humans; Pre-Eclampsia; Pregnancy	1959
Chlorothiazide in the prenatal outpatient: a study of its effect upon serum electrolytes. Canadian Medical Association journal, 1959, Jul-01, Volume: 81, Issue:1 Topics: Acetazolamide; Chlorothiazide; Edema; Electrolytes; Female; Outpatients; Pregnancy; Pregnancy Compli	1959
[Activity of a new diuretic in diseases of obstetrico-gynecological interest]. Minerva medica, 1959, May-26, Volume: 50, Issue:42 Topics: Acetazolamide; Diuretics; Female; Genital Diseases, Female; Humans; Obstetric Labor Complications; P	1959
[Treatment of water-sodium retention in obstetrics & gynecology]. Minerva medica, 1959, May-26, Volume: 50, Issue:42 Topics: Acetazolamide; Body Fluids; Female; Genital Diseases, Female; Gynecology; Humans; Obstetric Labor Co	1959
[Medicinal control of fluid retention in pregnancy toxemias]. Deutsche medizinische Wochenschrift (1946), 1959, Jul-03, Volume: 84, Issue:27 Topics: Acetazolamide; Body Fluids; Carbonic Anhydrase Inhibitors; Diuretics; Female; Heart Failure; Humans;	1959
A clinical evaluation of chlorothiazide in the prevention and treatment of toxemia of pregnancy. Obstetrics and gynecology, 1959, Volume: 14, Issue:2 Topics: Acetazolamide; Biomedical Research; Chlorothiazide; Female; Pre-Eclampsia; Pregnancy	1959
[Notes on the use of hydrochlorothiazide in edema of pregnancy]. Rivista d'ostetricia e ginecologia pratica, 1959, Volume: 41, Issue:6 Topics: Acetazolamide; Edema; Female; Hydrochlorothiazide; Pregnancy; Pregnancy Complications	1959
Natriuresis and vascular tone in toxemia of pregnancy. American journal of obstetrics and gynecology, 1960, Volume: 80 Topics: Acetazolamide; Blood Vessels; Female; Humans; Natriuresis; Pre-Eclampsia; Pregnancy; Sodium; Urinaly	1960
Effects of carbonic anhydrase inhibitors in toxemia of pregnancy. Surgical forum, 1960, Volume: 10 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Female; Pre-Eclampsia; Pregnancy	1960
[Transitory myopia caused by acetazolamide during pregnancy]. Rivista d'ostetricia e ginecologia pratica, 1959, Volume: 41 Topics: Acetazolamide; Female; Humans; Myopia; Pregnancy; Pregnancy Complications	1959
THE INFANT WITH EPILEPSY. Southwestern medicine, 1963, Volume: 44 Topics: Acetazolamide; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Birth Injuries; Classific	1963
AROMATIC DRUGS AND CONGENITAL CATARACTS. Lancet (London, England), 1964, Feb-29, Volume: 1, Issue:7331 Topics: Abnormalities, Drug-Induced; Acetaminophen; Acetazolamide; Anti-Bacterial Agents; Cardiovascular Age	1964
CARDIAC AND METABOLIC DISEASE, AND INFECTIONS IN THE OBSTETRIC PATIENT. Clinical obstetrics and gynecology, 1964, Volume: 13 Topics: Acetazolamide; Acid-Base Equilibrium; Blood Circulation; Chlorothiazide; Chlorthalidone; Diet, Sodiu	1964
[ON DIURETICS IN THE TREATMENT OF EDEMA IN PREGNANCY]. [Chiryo] [Therapy], 1964, Volume: 46 Topics: Acetazolamide; Chlorothiazide; Chlorthalidone; Diuretics; Edema; Female; Mineralocorticoid Receptor	1964
THE MANAGEMENT OF HEPATIC COMA. The Medical clinics of North America, 1964, Volume: 48 Topics: Acetazolamide; Adrenal Cortex Hormones; Alkalosis; Ammonia; Blood Transfusion; Chlorothiazide; Diet;	1964
AMAUROSIS IN PREGNANCY. The Australian & New Zealand journal of obstetrics & gynaecology, 1964, Volume: 4, Issue:1 Topics: Acetazolamide; Amyl Nitrite; Blindness; Cesarean Section; Female; Ganglionic Blockers; Humans; Ophth	1964
[DIURETIC DRUGS IN THE EDEMAS OF PREGNANCY]. Revista de la Asociacion Medica Argentina, 1964, Volume: 78 Topics: Acetazolamide; Benzothiadiazines; Blood Pressure; Body Weight; Chlorothiazide; Diuretics; Edema; Fem	1964
[HISTOCHEMICAL DEMONSTRATION OF CARBONIC ANHYDRASE IN THE PANCREAS AND PLACENTA. (TECHNIC ON THE FLOATING SECTION)]. Klinische Wochenschrift, 1964, Apr-15, Volume: 42 Topics: Acetazolamide; Animals; Carbonic Anhydrases; Female; Guinea Pigs; Histocytochemistry; Mice; Pancreas	1964
DEFORMITY OF FORELIMB IN RATS: ASSOCIATION WITH HIGH DOSES OF ACETAZOLAMIDE. Science (New York, N.Y.), 1965, Jul-16, Volume: 149, Issue:3681 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Ectromelia; Extremities; Female; Forelimb; Huma	1965
The use of acetazolamide in idiopathic intracranial hypertension during pregnancy. American journal of ophthalmology, 2005, Volume: 139, Issue:5 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Female; Humans; Pregnancy; Pregnancy Complicati	2005
Combined treatment potentiates the developmental toxicity of ibuprofen and acetazolamide in rats. Drug and chemical toxicology, 2005, Volume: 28, Issue:4 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Animals, Newborn; Birth Weight; Body Weight; Ca	2005
ABC of healthy travel. During travel and acclimatisation. British medical journal (Clinical research ed.), 1983, Mar-12, Volume: 286, Issue:6368 Topics: Acclimatization; Acetazolamide; Air Pressure; Aircraft; Altitude Sickness; Circadian Rhythm; Female;	1983
Acetazolamide teratology and its association with carbonic anhydrase inhibition in the mouse. Teratogenesis, carcinogenesis, and mutagenesis, 1983, Volume: 3, Issue:2 Topics: Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Female; Kinetics; Mice; Mice, Inbred Strains;	1983
Acetazolamide teratogenesis: association of maternal respiratory acidosis and ectrodactyly in C57BL/6J mice. Teratology, 1984, Volume: 30, Issue:2 Topics: Abnormalities, Drug-Induced; Acetazolamide; Acidosis, Respiratory; Animals; Carbon Dioxide; Dose-Res	1984
Acetazolamide teratogenesis: interaction of maternal metabolic and respiratory acidosis in the induction of ectrodactyly in C57BL/6J mice. Teratology, 1984, Volume: 30, Issue:2 Topics: Abnormalities, Drug-Induced; Acetazolamide; Acidosis; Acidosis, Respiratory; Animals; Carbon Dioxide	1984
Fetal exposure to anticonvulsant drugs. Detailed pathological study of a case. Archives of pathology & laboratory medicine, 1980, Volume: 104, Issue:4 Topics: Abnormalities, Drug-Induced; Acetazolamide; Adult; Anticonvulsants; Brain; Cardiomegaly; Epilepsy; E	1980
Potentiative interactions between caffeine and various teratogenic agents. Teratology, 1982, Volume: 25, Issue:1 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Caffeine; Cycloheximide; Dactinomycin; Dose-Res	1982
Potentiation of acetazolamide induced ectrodactyly in SWV and C57BL/6J mice by cadmium sulfate. Teratology, 1984, Volume: 29, Issue:3 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Cadmium; Cadmium Compounds; Drug Synergism; Fem	1984
Malformations in nonlimb structures induced by acetazolamide and other inhibitors of carbonic anhydrase. Annals of the New York Academy of Sciences, 1984, Volume: 429 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Embryo, Mammalia	1984
Assessment of adult skeletons to detect prenatal exposure to acetazolamide in mice. Teratology, 1983, Volume: 28, Issue:1 Topics: Acetazolamide; Animals; Bone and Bones; Bone Development; Female; Humans; Mice; Osteogenesis; Pregna	1983
Interaction of dietary zinc, genetic strain, and acetazolamide in teratogenesis in mice. Teratology, 1983, Volume: 28, Issue:3 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Diet; Female; Fetal Resorption; Mice; Mice, Inb	1983
Carbonic anhydrase distribution in rodent embryos and its relationship to acetazolamide teratogenesis. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1981, Volume: 29, Issue:10 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Carbonic Anhydrases; Drug Resistance; Embryo, M	1981
Comparative studies on acetazolamide teratogenesis in pregnant rats, rabbits, and rhesus monkeys. Teratology, 1981, Volume: 24, Issue:1 Topics: Acetazolamide; Animals; Carbonic Anhydrases; Female; Fetus; Macaca mulatta; Pregnancy; Rabbits; Rats	1981
Unique pattern of limb malformations associated with carbonic anhydrase inhibition. Progress in clinical and biological research, 1983, Volume: 110 Pt A Topics: Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Extremities; Female; Humans; Limb Deformities	1983
Another specific effect of prenatal acetazolamide exposure in the mouse. Teratology, 1983, Volume: 27, Issue:1 Topics: 2,4,5-Trichlorophenoxyacetic Acid; Acetazolamide; Animals; Bromodeoxyuridine; Female; Mice; Pesticid	1983
Acetazolamide inhibition of bone resorption: lack of effect on phosphate release from bone in vitro. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1981, Volume: 13, Issue:10 Topics: Acetazolamide; Animals; Bone and Bones; Bone Resorption; Calcium; Female; Organ Culture Techniques;	1981
Inhibition of alkaline phosphatase by several diuretics. Clinica chimica acta; international journal of clinical chemistry, 1980, Feb-28, Volume: 101, Issue:2-3 Topics: Acetazolamide; Alkaline Phosphatase; Animals; Bone and Bones; Chlorothiazide; Diuretics; Ethacrynic	1980
Teratogenic activity in the mouse after oral administration of acetazolamide. Drug and chemical toxicology, 1980, Volume: 3, Issue:1 Topics: Abnormalities, Drug-Induced; Acetazolamide; Administration, Oral; Animals; Body Weight; Bone and Bon	1980
Estimation of intracellular pH by computer assisted imaging in the developing mouse forelimb bud exposed to acetazolamide. Progress in clinical and biological research, 1993, Volume: 383A Topics: Acetazolamide; Amiloride; Animals; Dimethadione; Drug Interactions; Female; Forelimb; Hydrogen-Ion C	1993
Penetrance and expressivity of acetazolamide-ectrodactyly provide a method to define a right-left teratogenic gradient that differs between the C57BL/6J and WB/ReJ mouse strains. Teratology, 1993, Volume: 47, Issue:6 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Dose-Response Relationship, Drug; Female; Forel	1993
Acetazolamide with caffeine causes exencephaly in "resistant" SWV mice. Reproductive toxicology (Elmsford, N.Y.), 1993, Volume: 7, Issue:2 Topics: Acetazolamide; Animals; Birth Weight; Brain; Caffeine; Cervical Vertebrae; Embryo, Mammalian; Female	1993
Estimating intracellular pH in developing rodent embryos using a computer imaging technique: changes in embryonic pH and proliferation rates following maternal treatment with acetazolamide. Teratology, 1995, Volume: 52, Issue:3 Topics: Abnormalities, Drug-Induced; Acetazolamide; Amiloride; Animals; Bromodeoxyuridine; Carbonic Anhydras	1995
Drug-induced ciliary body oedema: a new theory. Eye (London, England), 1996, Volume: 10 ( Pt 1) Topics: Acetazolamide; Adult; Asthma; Chlorthalidone; Ciliary Body; Diuretics; Edema; Epinephrine; Female; H	1996
Transfer of Cl- across placenta of anesthetized rat. The American journal of physiology, 1996, Volume: 271, Issue:5 Pt 2 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetazolamide; Animals; Biological Transport; Bume	1996
[Association of idiopathic intracranial hypertension-Arnold-Chiari deformity: danger!]. Bulletin de la Societe belge d'ophtalmologie, 1998, Volume: 268 Topics: Acetazolamide; Adult; Anticonvulsants; Arnold-Chiari Malformation; Eye Movements; Female; Humans; In	1998
Effects of maternal acetazolamide treatment on body weights and incisor development of the fetal rat. The Journal of veterinary medical science, 1999, Volume: 61, Issue:2 Topics: Acetazolamide; Administration, Oral; Animals; Body Weight; Carbonic Anhydrase Inhibitors; Embryonic	1999
Cerebrocortical microdysgenesis is enhanced in c57BL/6J mice exposed in utero to acetazolamide. Teratology, 1999, Volume: 60, Issue:3 Topics: Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Cerebral Cortex; Female; Mice; Mice, Inbred C	1999
Disrupting the establishment of polarizing activity by teratogen exposure. Mechanisms of development, 1999, Volume: 88, Issue:2 Topics: Acetazolamide; Amiloride; Animals; Body Patterning; Bone Morphogenetic Protein 2; Bone Morphogenetic	1999
Obstructive sleep apnoea in a puerperal patient with Hallermann-Streiff syndrome. The European respiratory journal, 1999, Volume: 14, Issue:4 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Cesarean Section; Female; Hallermann's Syndrome	1999
The three mechanisms of intracellular chloride accumulation in vascular smooth muscle of human umbilical and placental arteries. Pflugers Archiv : European journal of physiology, 2000, Volume: 441, Issue:1 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetazolamide; Antiporters; Arteries; Biological T	2000
Transient renal tubular acidosis in a neonate following transplacental acetazolamide. European journal of pediatrics, 2001, Volume: 160, Issue:5 Topics: Acetazolamide; Acidosis, Renal Tubular; Carbonic Anhydrase Inhibitors; Diuretics; Female; Glaucoma;	2001
Comparison of methods for erythroblast selection: application to selecting fetal erythroblasts from maternal blood. Cytometry, 2001, Dec-01, Volume: 45, Issue:4 Topics: Acetazolamide; Centrifugation, Density Gradient; Erythroblasts; Female; Fetal Blood; Fetomaternal Tr	2001
Potentiation by the injection vehicle of the teratological action of acetazolamide in rats. Teratology, 1977, Volume: 15, Issue:3 Topics: Abnormalities, Drug-Induced; Acetazolamide; Adrenal Medulla; Animals; Drug Synergism; Ectromelia; Ep	1977
In vivo demonstration of renal carbonic anhydrase activity in the fetal lamb. Biology of the neonate, 1978, Volume: 34, Issue:5-6 Topics: Acetazolamide; Animals; Bicarbonates; Carbonic Anhydrases; Female; Fetal Blood; Fetus; Gestational A	1978
Cadmium induced limb defects in mice: strain associated differences in sensitivity. Teratology, 1979, Volume: 19, Issue:2 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Cadmium; Dose-Response Relationship, Drug; Fema	1979
The early limb deformity caused by acetazolamide. Teratology, 1979, Volume: 20, Issue:2 Topics: Acetazolamide; Animals; Cartilage; Dose-Response Relationship, Drug; Female; Forelimb; Gestational A	1979
[Palatine clefts following puncture of the amniotic sac in the rat]. Bulletin de l'Association des anatomistes, 1977, Volume: 61, Issue:172 Topics: Acetazolamide; Amniocentesis; Animals; Cleft Palate; Female; Hydrocortisone; Pregnancy; Rats	1977
Sacrococcygeal teratoma in a neonate. Association with maternal use of acetazolamide. JAMA, 1978, Jul-21, Volume: 240, Issue:3 Topics: Acetazolamide; Adult; Female; Fetus; Glaucoma; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pre	1978
Enrichment of erythrocytes of fetal origin from adult-fetal blood mixtures via selective hemolysis of adult blood cells: an aid to antenatal diagnosis of hemoglobinopathies. Blood, 1976, Volume: 47, Issue:6 Topics: Acetazolamide; Age Factors; Amniotic Fluid; Bicarbonates; Blood Preservation; Carbonic Anhydrases; E	1976
Carbonate dehydratase (carbonic anhydrase) and the fetal lung. Ciba Foundation symposium, 1976, Issue:38 Topics: Acetazolamide; Animals; Body Fluids; Carbonic Anhydrases; Female; Fetus; Gestational Age; Lung; Preg	1976
Drug-induced limb dysplasias in fetal rabbits. Teratology, 1977, Volume: 15, Issue:2 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acetazolamide; Animals; Ectoderm; Extremities;	1977
Teratogenic effect of anticonvulsant drugs. American journal of diseases of children (1960), 1976, Volume: 130, Issue:9 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acetazolamide; Anticonvulsants; Child; Child,	1976
Intrauterine salicylate intoxication in a newborn. A case report. Clinical pediatrics, 1976, Volume: 15, Issue:10 Topics: Acetazolamide; Aspirin; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal	1976
Effects of hypercapnia on uterine and umbilical circulations in conscious pregnant sheep. Journal of applied physiology, 1976, Volume: 41, Issue:5 Pt. 1 Topics: Acetazolamide; Animals; Female; Hypercapnia; Pregnancy; Regional Blood Flow; Sheep; Umbilicus; Uteru	1976
[Treatment of severe metabolic alkalosis]. Masui. The Japanese journal of anesthesiology, 1976, Volume: 25, Issue:12 Topics: Acetazolamide; Adult; Aged; Alkalosis; Female; Humans; Hydrochloric Acid; Pregnancy	1976
Teratogenesis of acetazolamide in the CBA/J and SWV strains of mice. I. Teratology. Teratology, 1975, Volume: 11, Issue:1 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Dichlorphenamide; Dose-Response Relationship, D	1975
Teratogenesis of acetazolamide in the CBA/J and SWV strains of mice. II. Genetic control of the teratogenic response. Teratology, 1975, Volume: 11, Issue:1 Topics: Abnormalities, Drug-Induced; Acetazolamide; Alleles; Animals; Breeding; Female; Genes, Recessive; Ge	1975
Renal function and diuretic therapy in infants and children. Part II. The Journal of pediatrics, 1975, Volume: 86, Issue:5 Topics: Acetazolamide; Aldosterone; Benzothiadiazines; Carbonic Anhydrase Inhibitors; Child; Diuretics; Diur	1975
The effect of systematic treatment of toxaemia of pregnancy upon fetal prognosis. Annales chirurgiae et gynaecologiae Fenniae, 1975, Volume: 64, Issue:3 Topics: Acetazolamide; Adult; Chlorothiazide; Dihydralazine; Female; Fetal Death; Fetal Diseases; Furosemide	1975
Axial skeletal malformations induced by acetazolamide in rabbits. Teratology, 1992, Volume: 45, Issue:6 Topics: Acetazolamide; Animals; Bone and Bones; Female; Pregnancy; Rabbits; Teratogens	1992
Dependence of acetazolamide teratogenesis on fetal and not maternal genotypes. Reproductive toxicology (Elmsford, N.Y.), 1992, Volume: 6, Issue:1 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Embryonic and Fetal Development; Female; Genoty	1992
Exudative retinal detachment in familial pulmonary hypertension. Acta ophthalmologica, 1991, Volume: 69, Issue:6 Topics: Acetazolamide; Adult; Female; Fluorescein Angiography; Fundus Oculi; Humans; Hypertension, Pulmonary	1991
[Teratogenic effects of acetazolamide in mouse embryos]. Bulletin et memoires de l'Academie royale de medecine de Belgique, 1991, Volume: 146, Issue:3-5 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Embryo, Mammalian; Female; Maternal-Fetal Excha	1991
Sodium-dependent magnesium transport across in situ perfused rat placenta. The American journal of physiology, 1991, Volume: 261, Issue:2 Pt 2 Topics: Acetazolamide; Amiloride; Animals; Biological Transport; Calcium; Choline; Edetic Acid; Female; Magn	1991
Bicarbonate-induced activation of taurocholate transport across the basal plasma membrane of human term trophoblast. The American journal of physiology, 1991, Volume: 260, Issue:6 Pt 1 Topics: Acetazolamide; Bicarbonates; Biological Transport; Carbon Radioisotopes; Cell Membrane; Female; Huma	1991
Reduction of embryonic intracellular pH: a potential mechanism of acetazolamide-induced limb malformations. Toxicology and applied pharmacology, 1990, Volume: 103, Issue:2 Topics: Abnormalities, Drug-Induced; Acetazolamide; Amiloride; Amniotic Fluid; Animals; Carbon Dioxide; Drug	1990
[Pseudotumor cerebri in pregnancy]. Gynakologische Rundschau, 1990, Volume: 30, Issue:3 Topics: Acetazolamide; Adult; Brain Neoplasms; Diagnosis, Differential; Female; Fetal Death; Humans; Pregnan	1990
Possible association between acetazolamide administration during pregnancy and metabolic disorders in the newborn. European journal of obstetrics, gynecology, and reproductive biology, 1990, Volume: 35, Issue:1 Topics: Acetazolamide; Acidosis; Adult; Female; Humans; Hypocalcemia; Infant, Newborn; Magnesium; Metabolic	1990
Carbonic anhydrase activity in fetal rat bone resorbing cells: inhibition by acetazolamide infusion. Journal of developmental physiology, 1989, Volume: 12, Issue:5 Topics: Acetazolamide; Animals; Bone Resorption; Calcium; Carbonic Anhydrases; Embryonic and Fetal Developme	1989
The development of asymmetry: the sidedness of drug-induced limb abnormalities is reversed in situs inversus mice. Development (Cambridge, England), 1989, Volume: 107, Issue:3 Topics: Acetazolamide; Animals; Embryonic and Fetal Development; Extremities; Female; Functional Laterality;	1989
Pseudotumor cerebri and pregnancy. American journal of perinatology, 1989, Volume: 6, Issue:4 Topics: Acetaminophen; Acetazolamide; Codeine; Female; Furosemide; Humans; Infant, Newborn; Male; Pregnancy;	1989
Prenatal ossification as an indicator of exposure to toxic agents. Teratology, 1989, Volume: 40, Issue:4 Topics: Acetazolamide; Animals; Bromodeoxyuridine; Cervical Vertebrae; Cortisone; Female; Mice; Osteogenesis	1989
Effects of heterocyclic sulfonamides on bone metabolism. Research communications in chemical pathology and pharmacology, 1985, Volume: 50, Issue:1 Topics: Acetazolamide; Acid Phosphatase; Animals; Bone and Bones; Calcium; Carbonic Anhydrases; Cells, Cultu	1985
Acetazolamide: maternal toxicity, pattern of malformations, and litter effect. Teratology, 1988, Volume: 37, Issue:4 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Body Weight; Bone and Bones; Embryonic and Feta	1988
Genetic differences in the frequency of acetazolamide-induced ectrodactyly in the mouse exhibit directional dominance of relative embryonic resistance. Teratology, 1988, Volume: 37, Issue:4 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Female; Genes, Dominant; Humans; Mice; Mice, In	1988
Reduction of uterine blood flow by phenylephrine, an alpha-adrenergic agonist, in the day 11 pregnant rat: relationship to potentiation of acetazolamide teratogenesis. Teratology, 1987, Volume: 36, Issue:1 Topics: Acetazolamide; Animals; Drug Synergism; Female; Forelimb; Phenylephrine; Pregnancy; Rats; Rats, Inbr	1987
Acetazolamide teratogenesis in Wistar rats: potentiation and antagonism by adrenergic agents. Teratology, 1986, Volume: 34, Issue:2 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Female; Limb Deformities, Congenital; Phenoxybe	1986
The effect of carbonic anhydrase inhibition on breathing movements and electrocortical activity in fetal sheep. Respiration physiology, 1985, Volume: 61, Issue:3 Topics: Acetazolamide; Animals; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Cerebral Cortex; Chemorecepto	1985
Pathogenesis of the mouse forelimb deformity induced by acetazolamide: an electron microscopic study. Teratology, 1985, Volume: 31, Issue:2 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Ectoderm; Female; Forelimb; Mice; Microscopy, E	1985
Potentiation of acetazolamide induced ectrodactyly in Wistar rats by vasoactive agents and physical clamping of the uterus. Teratology, 1985, Volume: 31, Issue:2 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Constriction; Drug Synergism; Ergotamine; Femal	1985
[Familial paroxysmal ataxia sensitive to acetazolamide. 3 cases in a new European family]. Revue neurologique, 1985, Volume: 141, Issue:3 Topics: Acetazolamide; Adult; Cerebellar Ataxia; Female; France; Humans; Male; Pedigree; Pregnancy; Pregnanc	1985
Histological changes induced in developing limb buds of C57BL mouse embryos submitted in utero to the combined influence of acetazolamide and cadmium sulphate. Teratology, 1985, Volume: 32, Issue:3 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Cadmium; Cadmium Compounds; Drug Interactions;	1985
Placental CO2 transfer after fetal carbonic anhydrase inhibition. The American journal of physiology, 1974, Volume: 226, Issue:3 Topics: Acetazolamide; Animals; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Female;	1974
Active transport in the rabbit blastocyst. Experientia, 1970, Volume: 26, Issue:7 Topics: Acetazolamide; Adenosine Triphosphatases; Animals; Bicarbonates; Biological Transport, Active; Body	1970
Teratogenic action of acetazolamide in mice. Teratology, 1974, Volume: 10, Issue:3 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Brain; Eyelids; Female; Forelimb; Gestational A	1974
Endometrial mechanisms involved in the electrical activity associated with the secretion of uterine fluid. The Journal of physiology, 1973, Volume: 229, Issue:1 Topics: Acetazolamide; Animals; Bicarbonates; Chlorides; Electric Conductivity; Endometrium; Estrus; Female;	1973
Strain differences in susceptibility to the teratogenic effect of acetazolamide in mice. Teratology, 1973, Volume: 8, Issue:2 Topics: Abnormalities, Drug-Induced; Acetazolamide; Amniotic Fluid; Animals; Female; Forelimb; Gestational A	1973
Diuretic-hypotensive therapy and fetal prognosis in toxaemia of pregnancy. 1. Fetal prognosis in 705 selected cases. Annales chirurgiae et gynaecologiae Fenniae, 1973, Volume: 62, Issue:3 Topics: Acetazolamide; Ammonium Chloride; Antihypertensive Agents; Barbiturates; Birth Weight; Chlorothiazid	1973
Skeletal deviations in rats: malformations or variations? Teratology, 1973, Volume: 8, Issue:3 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Bone and Bones; Dactinomycin; Dose-Response Rel	1973
The sodium and potassium content of rat uterine luminal fluid. The Journal of endocrinology, 1973, Volume: 59, Issue:1 Topics: Acetazolamide; Amiloride; Animals; Biological Transport, Active; Estradiol; Estrus; Female; Male; Ou	1973
Calcium transport in the early conceptus and associated maternal tissues in the rabbit. The Biochemical journal, 1974, Volume: 138, Issue:1 Topics: Acetazolamide; Animals; Biological Transport; Blastocyst; Bone and Bones; Calcium; Calcium Radioisot	1974
Teratogenic action of carbonic anhydrase inhibitors in the rat. Teratology, 1968, Volume: 1, Issue:1 Topics: Abnormalities, Drug-Induced; Acetazolamide; Acidosis; Animals; Body Weight; Carbonic Anhydrase Inhib	1968
Hydrochlorothiazide interference with urinary estriol determination. Clinical chemistry, 1972, Volume: 18, Issue:5 Topics: Acetazolamide; Ammonium Sulfate; Enzymes; Estriol; Evaluation Studies as Topic; Female; Humans; Hydr	1972
The effect of potassium metabolism on acetazolamide-induced teratogenesis. The Johns Hopkins medical journal, 1972, Volume: 130, Issue:2 Topics: Abnormalities, Drug-Induced; Acetazolamide; Acidosis; Administration, Oral; Amiloride; Animals; Bica	1972
The effects of metabolic alterations on teratogenesis. The Johns Hopkins medical journal, 1972, Volume: 130, Issue:2 Topics: Abnormalities, Drug-Induced; Acetazolamide; Acidosis; Acidosis, Respiratory; Alloxan; Animals; Birth	1972
The teratological effect of certain thiadiazoles related to acetazolamide, with a note on sulfanilamide and thiazide diuretics. The Johns Hopkins medical journal, 1972, Volume: 130, Issue:2 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Blood Glucose; Bone and Bones; Carbonic Anhydra	1972
Greater sensitivity of female than male rat embryos to acetazolamide teratogenicity. Teratology, 1972, Volume: 6, Issue:2 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Female; Forelimb; Injections, Intraperitoneal;	1972
Teratology and carbonic anhydrase inhibition. Archives of ophthalmology (Chicago, Ill. : 1960), 1971, Volume: 85, Issue:1 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Female; Gestatio	1971
Intracellular concentrations of sodium, potassium and chloride in the lactating mammary gland and their relation to the secretory mechanism. The Journal of physiology, 1971, Volume: 216, Issue:3 Topics: Acetazolamide; Aldosterone; Animals; Carbon Isotopes; Cattle; Chlorides; Extracellular Space; Female	1971
The role of hypercapnia in acetazolamide teratogenesis. Experientia, 1971, May-15, Volume: 27, Issue:5 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Carbon Dioxide; Cricetinae; Female; Fetal Death	1971
Effects of intrauterine administration of acetazolamide in rats. Teratology, 1970, Volume: 3, Issue:3 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Embryo, Mammalian; Extraembryonic Membranes; Fe	1970
[Treatment of edema conditions in pregnancy]. Deutsche medizinische Wochenschrift (1946), 1968, Jan-19, Volume: 93, Issue:3 Topics: Acetazolamide; Diuretics; Edema; Female; Humans; Pre-Eclampsia; Pregnancy; Quaternary Ammonium Compo	1968
Echothiophate iodide treatment of glaucoma in pregnancy. Archives of ophthalmology (Chicago, Ill. : 1960), 1968, Volume: 79, Issue:3 Topics: Acetazolamide; Adult; Betamethasone; Bicarbonates; Cholinesterase Inhibitors; Cholinesterases; Echot	1968
Effects of acetazolamide on tissue cations. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1969, Volume: 130, Issue:3 Topics: Acetazolamide; Animals; Carbon Dioxide; Female; Kidney; Liver; Methods; Muscles; Myocardium; Potassi	1969
Acute pancreatitis in gynecologic and obstetric practice. American journal of obstetrics and gynecology, 1969, Sep-15, Volume: 105, Issue:2 Topics: Acetazolamide; Adolescent; Adult; Amylases; Calcium; Dextrans; Female; Gynecology; Humans; Lipase; M	1969
Forelimb deformity in rats: association with acetazolamide. Science (New York, N.Y.), 1965, Oct-01, Volume: 150, Issue:3692 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Animals, Newborn; Carbonic Anhydrase Inhibitors	1965
Forelimb deformity in rats: association with acetazolamide. Science (New York, N.Y.), 1965, Oct-01, Volume: 150, Issue:3692 Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Animals, Newborn; Carbonic Anhydrase Inhibitors	1965
Urinary estriol as an index of placental function. The Tohoku journal of experimental medicine, 1966, Jun-25, Volume: 89, Issue:2 Topics: Acetazolamide; Estriol; Female; Fetal Death; Fetal Diseases; Humans; Placenta; Pre-Eclampsia; Pregna	1966

acetazolamide and Pregnancy

Research Excerpts

Research

Studies (161)

Authors

Reviews

Trials

Other Studies

Authors	Studies
Luks, AM	1
Hackett, PH	1
Thaller, M	1
Wakerley, BR	1
Abbott, S	1
Tahrani, AA	1
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