acetazolamide and Papilledema studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Papilledema: Swelling of the OPTIC DISK, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins. Chronic papilledema may cause OPTIC ATROPHY and visual loss. (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p175)

Research Excerpts

Excerpt	Relevance	Reference
" We hypothesized that CSFp would be associated with Frisén papilledema grade (FPG) and other clinical features, and that FPG would modify the CSFp response to acetazolamide in participants in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT)."	9.20	CSF pressure, papilledema grade, and response to acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial. ( Kattah, JC; Kupersmith, MJ; McDermott, MP; Mejico, LJ; Pula, JH; Wall, M, 2015)
"Patients underwent weight loss and treatment with acetazolamide during a 24-week period."	9.08	The role of weight loss and acetazolamide in the treatment of idiopathic intracranial hypertension (pseudotumor cerebri) ( Johnson, LN; Krohel, GB; Madsen, RW; March, GA, 1998)
"A young, non-obese woman aged 24 years with normal blood pressure developed intracranial hypertension after the oral use of tetracycline."	7.73	[Intracranial hypertension with severe and irreversible reduced acuity and impaired visual fields after oral tetracycline]. ( Altinbas, A; Bakker, SL; Hoogstede, HA, 2005)
"Crohn disease may present with pseudotumor cerebri and severe ocular perfusion deficits that are reversible with oral acetazolamide therapy."	7.71	Effect of acetazolamide on ocular hemodynamics in pseudotumor cerebri associated with inflammatory bowel disease. ( Arnaud, B; Greenfield, DS; Harris, A; Pageaux, GP; Veyrac, M; Villain, MA, 2002)
"We treated four patients who had acute, severe visual loss associated with pseudotumor cerebri with intravenous methylprednisolone (250 mg four times per day) for five days followed by an oral taper, in combination with acetazolamide and ranitidine."	7.69	High-dose methylprednisolone and acetazolamide for visual loss in pseudotumor cerebri. ( Glaser, JS; Liu, GT; Schatz, NJ, 1994)
"Tacrolimus is a suitable alternative in these cases."	5.51	Resolution of papilledema associated with cyclosporine use after change to tacrolimus. ( Kwok, JM; Micieli, JA; Yu, CW, 2019)
"Frisén score fails to reflect the photographic area and OCT volume of papilledema after treatment with acetazolamide."	5.27	The Relationship Between Optic Disc Volume, Area, and Frisén Score in Patients With Idiopathic Intracranial Hypertension. ( Blanchard, LM; Feldon, SE; Fischer, WS; Hollar, RA; Sheils, CR, 2018)
" We hypothesized that CSFp would be associated with Frisén papilledema grade (FPG) and other clinical features, and that FPG would modify the CSFp response to acetazolamide in participants in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT)."	5.20	CSF pressure, papilledema grade, and response to acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial. ( Kattah, JC; Kupersmith, MJ; McDermott, MP; Mejico, LJ; Pula, JH; Wall, M, 2015)
"In IIH, acetazolamide and weight loss effectively improve RNFL thickness, TRT, and ONH volume swelling measurements resulting from papilledema."	5.20	Papilledema Outcomes from the Optical Coherence Tomography Substudy of the Idiopathic Intracranial Hypertension Treatment Trial. ( , 2015)
" The Idiopathic Intracranial Hypertension Treatment Trial was an adult, multicenter study that examined the use of acetazolamide and weight loss on the course of PIH."	5.12	Pediatric Intracranial Hypertension: A Spotlight on Imaging, the Idiopathic Intracranial Hypertension Treatment Trial, and COVID-19 Associated Cases. ( Aylward, SC; Brun, BN, 2021)
"Patients underwent weight loss and treatment with acetazolamide during a 24-week period."	5.08	The role of weight loss and acetazolamide in the treatment of idiopathic intracranial hypertension (pseudotumor cerebri) ( Johnson, LN; Krohel, GB; Madsen, RW; March, GA, 1998)
" She was diagnosed with intracranial hypertension and began treatment with acetazolamide."	4.31	A Rare Report of the Coexistence of Sickle Cell Disease, Neurofibromatosis Type 1, and Intracranial Hypertension in a Pediatric Patient. ( Jain, A; Patel, A; Winter, T, 2023)
" The most common symptom was headache (69%) and acetazolamide was the most used medication (69%)."	3.88	Pseudotumor cerebri in childhood and adolescence: data from a specialized service. ( Balbi, GGM; Fraga, MM; Len, CA; Matas, SL; Sousa, IO; Terreri, MT, 2018)
"A 57-year-old man presented with papilledema due to partially recanalized dural sinus thrombosis and was treated with anticoagulation and acetazolamide."	3.83	Development of Dural Arteriovenous Fistulas After Cerebral Venous Sinus Thrombosis. ( Derkatch, S; Margolin, EA; Micieli, JA; Pereira, VM, 2016)
"Determine potential risk factors for progressive visual field loss in the Idiopathic Intracranial Hypertension Treatment Trial, a randomized placebo-controlled trial of acetazolamide in patients with idiopathic intracranial hypertension and mild visual loss concurrently receiving a low sodium, weight reduction diet."	3.81	Risk factors for poor visual outcome in patients with idiopathic intracranial hypertension. ( Bruce, BB; Falardeau, J; Fletcher, WA; Granadier, RJ; He, H; Lam, BL; Longmuir, RA; McDermott, MP; Patel, AD; Wall, M, 2015)
" Following lumbar puncture with opening pressure of 350 mmHg, a diagnosis of pseudotumor cerebri was made and treatment with acetazolamide was started."	3.79	Unilateral papilledema in pseudotumor cerebri. ( Brosh, K; Strassman, I, 2013)
" The authors present 2 patients with Alagille syndrome who, before the age of 3 years old, developed idiopathic intracranial hypertension with documented increased intracranial pressure by lumbar puncture and papilledema, which was responsive to acetazolamide."	3.76	Idiopathic intracranial hypertension in two patients with Alagille syndrome. ( Furuya, KN; Mouzaki, M; Nichter, C; Qureshi, M; Rountree, B, 2010)
" One child with PTC demonstrated improvement in visual acuity and optic nerve appearance after acetazolamide and weight loss therapy."	3.74	Pseudotumor cerebri in children with Down syndrome. ( Bradfield, YS; Esmaili, N, 2007)
" The presence of intracranial hypertension was detected and treatment started with acetazolamide."	3.74	[Papilledema as an indicator of POEMS syndrome]. ( Alarcón, S; Barnés, C; Sánchez-Dalmau, BF; Vela, D, 2008)
"A young, non-obese woman aged 24 years with normal blood pressure developed intracranial hypertension after the oral use of tetracycline."	3.73	[Intracranial hypertension with severe and irreversible reduced acuity and impaired visual fields after oral tetracycline]. ( Altinbas, A; Bakker, SL; Hoogstede, HA, 2005)
"Crohn disease may present with pseudotumor cerebri and severe ocular perfusion deficits that are reversible with oral acetazolamide therapy."	3.71	Effect of acetazolamide on ocular hemodynamics in pseudotumor cerebri associated with inflammatory bowel disease. ( Arnaud, B; Greenfield, DS; Harris, A; Pageaux, GP; Veyrac, M; Villain, MA, 2002)
"Idiopathic intracranial hypertension (IIH, pseudotumor cerebri) was diagnosed in 4 patients who had been treated with tetracycline."	3.69	[Idiopathic intracranial hypertension and tetracycline]. ( Schwartz, M; Sharf, B; Sierpinski-Barth, J; Weller, B, 1994)
"We treated four patients who had acute, severe visual loss associated with pseudotumor cerebri with intravenous methylprednisolone (250 mg four times per day) for five days followed by an oral taper, in combination with acetazolamide and ranitidine."	3.69	High-dose methylprednisolone and acetazolamide for visual loss in pseudotumor cerebri. ( Glaser, JS; Liu, GT; Schatz, NJ, 1994)
"In the IIHTT, subjects were randomly assigned to placebo-plus-diet or maximally tolerated dosage of acetazolamide-plus-diet."	2.84	The Longitudinal Idiopathic Intracranial Hypertension Trial: Outcomes From Months 6-12. ( Auinger, P; Kupersmith, MJ; Moss, EA; Moss, HE; Thurtell, MJ; Wall, M, 2017)
"1%) tolerated the maximum allowed dosage of 4 g/d."	2.82	Safety and Tolerability of Acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial. ( Friedman, DI; Irrcher, I; McDermott, MP; Patel, AD; ten Hove, MW; Wall, M, 2016)
"The accurate diagnosis of idiopathic intracranial hypertension is essential as visual deterioration due to papilledema may be irreversible."	2.72	Diagnosis and treatment of idiopathic intracranial hypertension. ( Hoffmann, J; Raoof, N, 2021)
"Idiopathic intracranial hypertension is a vision-threatening disorder that predominantly affects obese women of childbearing age."	2.58	An update of idiopathic intracranial hypertension. ( Cestari, DM; Madriz Peralta, G, 2018)
"Obesity is an important risk factor for primary and secondary PTC in post-pubertal children."	2.53	Pediatric pseudotumor cerebri. ( Phillips, PH; Rook, BS, 2016)
"The term idiopathic intracranial hypertension (pseudotumor cerebri) describes an increase in CSF pressure without a space-occupying intracranial lesion or hydrocephalus."	2.48	[Headache from increased cerebrospinal fluid pressure]. ( Göbel, C; Göbel, H; Heinze, A, 2012)
"Unfortunately, papilledema has recurred several times over the following 2 years when attempts were made to decrease the acetazolamide dose."	1.72	Recurrent Intracranial Hypertension in a Toddler with Graves' Disease. ( de Bruin, C; Notting, IC; Peeters-Scholte, CMPCD; Vuijk, FA, 2022)
"Traumatic brain injury is one of the most common pediatric injuries; totaling more than 500,000 emergency department visits per year."	1.51	Isolated Increased Intracranial Pressure and Unilateral Papilledema in an Infant With Traumatic Brain Injury and Nondepressed Basilar Skull Fracture. ( Dunnick, J; Gesteland, P, 2019)
"Tacrolimus is a suitable alternative in these cases."	1.51	Resolution of papilledema associated with cyclosporine use after change to tacrolimus. ( Kwok, JM; Micieli, JA; Yu, CW, 2019)
"Acetazolamide was the treatment option in 98."	1.51	Pediatric intracranial hypertension. Experience from 2 Tertiary Centers. ( Ajlan, AM; Al Abdulsalam, HK; Al Twaijri, WA; Al-Showaeir, DA; Albakr, AA; Aldabjan, HM; Aldegether, MS; Alhothali, WM; Almalki, FI; Altweijri, IS; Alwadei, AH; Bashiri, FA; Hamad, MH; Hassan, HH; Hassan, SM; Kentab, AY; Salih, MA, 2019)
"Idiopathic intracranial hypertension is a diagnosis of exclusion and imaging studies should always be performed to rule out other structural and obstructive lesions."	1.51	Idiopathic intracranial hypertension presenting with isolated unilateral facial nerve palsy: a case report. ( Berry, B; Ghannam, M; Ghazaleh, D; Samara, A, 2019)
"A robust predictor of visual outcome in idiopathic intracranial hypertension (IIH) would be useful in management, but there is limited information on this point."	1.51	Visual Field Mean Deviation at Diagnosis of Idiopathic Intracranial Hypertension Predicts Visual Outcome. ( Cornblath, WT; De Lott, L; Mikkilineni, S; Trobe, JD, 2019)
"Cilioretinal artery territory infarction can occur in isolation or in association with other vascular compromise of the retinal circulation."	1.43	Cilioretinal Artery Territory Infarction Associated With Papilledema in a Patient With Neurofibromatosis Type 2. ( Afridi, SK; Graham, EM; Hammond, CJ; Mahroo, OA; Mann, SS; Mohamed, MD; Plant, GT, 2016)
" Her papilloedema resolved with long-term use of acetazolamide."	1.42	Bilateral papilloedema in Camurati-Engelmann disease. ( Austin, M; Popiela, M, 2015)
"Mercury poisoning is a rare but fatal toxicologic emergency."	1.42	Mercury poisoning as a cause of intracranial hypertension. ( Büyüktahtakın, B; Genç, Ş; Gençpınar, P; İbişoğlu, Z; Mıhçı, E; Yılmaz, A, 2015)
"After surgery, the clinical signs of elevated intracranial pressure transiently worsened."	1.40	Visual and neurologic deterioration in otogenic lateral sinus thrombosis: 15 year experience. ( Csákányi, Z; Katona, G; Kollár, K; Kovács, É; Kulcsár, A; Mellár, M; Móser, J; Rosdy, B; Várallyay, G, 2014)
"Pseudotumor cerebri or idiopathic intracranial hypertension is characterized by normal spinal fluid composition and increased intracranial pressure in the absence of a space-occupying lesion."	1.39	Viral-induced intracranial hypertension mimicking pseudotumor cerebri. ( Kassis, I; Kra-Oz, Z; Ravid, S; Shachor-Meyouhas, Y; Shahar, E, 2013)
"The patient was diagnosed with idiopathic intracranial hypertension and treated with azetazolamide."	1.39	[Idiopathic intracranial hypertension is a rare cause of headache in children]. ( Hansen, JK; Møller, HU; Viuff, AC, 2013)
"A 14 year-old Caucasian boy with idiopathic intracranial hypertension (IIH) presented with blurred vision in his left eye."	1.39	Intravitreal bevacizumab in the treatment of peripapillary choroidal neovascular membrane secondary to idiopathic intracranial hypertension. ( Kwan, AS; Lee, IJ; Maccheron, LJ, 2013)
"Patients with cystinosis have risk factors known to be associated with secondary increased intracranial pressure."	1.36	Increased intracranial pressure in patients with cystinosis. ( McGregor, ML; Rogers, DL, 2010)
"Along with the progression, bilateral 6th nerve palsy, impairment of visual acuity and bilateral papilledema appeared."	1.36	[Benign but not harmless intracranial hypertension: a case report]. ( Bonnin, N; Chazal, J; Chiambaretta, F; Dalens, H; Deméocq, F; Duclos, C; Kanold, J; Lacombe, P; Merlin, E; Viorel, A, 2010)
"On admission, she exhibited bilateral optic disc edema without headache and no visual disturbance."	1.35	[Idiopathic intracranial hypertension without headache detected during a routine health check]. ( Niino, M; Sakushima, K; Sasaki, H; Tsuji, S; Yabe, I, 2008)
"An 11 year old boy with nephropathic cystinosis developed moderate to severe bilateral optic disc edema two months after he received a deceased donor renal allograft."	1.35	A case of intracranial hypertension and papilledema associated with nephropathic cystinosis and ocular involvement. ( Parnes, A; Wassner, SJ; Weinstein, JM, 2008)
"CA-I-induced retinal edema was decreased by complement 1 inhibitor, neutralizing antibody to prekallikrein and bradykinin receptor antagonism."	1.34	Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. ( Aiello, LP; Arrigg, PG; Avery, RL; Bursell, SE; Clermont, A; Feener, EP; Fonda, SJ; Fujimoto, JG; Gao, BB; Rook, S; Srinivasan, VJ; Wojtkowski, M, 2007)
"Facial paralysis is an uncommon sequela of IIH."	1.34	Facial palsy and fallopian canal expansion associated with idiopathic intracranial hypertension. ( Brackmann, DE; Doherty, JK, 2007)
"SRNVM in idiopathic intracranial hypertension is rare (0."	1.33	Subretinal neovascular membrane in idiopathic intracranial hypertension. ( Boldt, HC; Kardon, RH; Lee, AG; Wall, M; Wendel, L, 2006)
"Although papilledema is described in various anemias, only one case of PTC with idiopathic aplastic anemia has been reported in the English literature."	1.32	Pseudotumor cerebri in idiopathic aplastic anemia. ( Nazir, SA; Siatkowski, RM, 2003)
"A 30-year-old woman had bilateral anterior ischemic optic neuropathy after undergoing large-volume liposuction."	1.32	Bilateral anterior ischemic optic neuropathy after liposuction. ( Foroozan, R; Varon, J, 2004)
"Cover test revealed an intermittent esotropia at distance, with full ocular motilities."	1.31	Pseudotumor cerebri in a pre-pubescent child--case report. ( Langford, CM, 2002)
"Minocycline and obesity are recognized as precipitating factors in pseudotumor cerebri syndrome."	1.31	[Bilateral papilledema in young women: two case reports of benign intracranial hypertension?]. ( Cochener, B; Colin, J; Kling, F, 2002)
"Treatment of sleep apnea with nocturnal oxygenation may improve the signs and symptoms of IIH in affected men."	1.31	Sleep apnea and intracranial hypertension in men. ( Eggenberger, E; Golnik, K; Kardon, R; Lee, AG; Wall, M; Yedavally, S, 2002)
"In comparison with patients who have idiopathic intracranial hypertension, our small series of 14 patients diagnosed after the age of 44 years were more often men, were less often obese, were less symptomatic, and had identifiable causes of intracranial hypertension in a substantial minority (29%)."	1.31	Clinical features of late-onset pseudotumor cerebri fulfilling the modified dandy criteria. ( Bandyopadhyay, S; Jacobson, DM, 2002)
"Presenting symptoms of idiopathic intracranial hypertension are known to vary with age."	1.31	Asymptomatic idiopathic intracranial hypertension in young children. ( Weig, SG, 2002)
"Although rare, Wegener's granulomatosis should be included in the differential diagnosis of chronic aseptic meningitis, communicating hydrocephalus, and papilledema."	1.30	Communicating hydrocephalus secondary to diffuse meningeal spread of Wegener's granulomatosis: case report and literature review. ( Medsger, TA; Scarrow, AM; Segal, R; Wasko, MC, 1998)
"To report the features of idiopathic intracranial hypertension in prepubertal children, with emphasis on presentation, treatment, and outcome."	1.30	Idiopathic intracranial hypertension in prepubertal pediatric patients: characteristics, treatment, and outcome. ( Borchert, MS; Cinciripini, GS; Donahue, S, 1999)
"Papilledema from benign intracranial hypertension can cause severe loss of visual acuity and visual field, with an optic neuropathy."	1.30	[Intra-orbital decompression of the optic nerve by opening the peri-optic meninges in the treatment of severe optic neuropathies complicating benign intracranial hypertension]. ( Adenis, JP; Arnaud, B; Candon, E; Frerebeau, P; Villain, M, 1999)
"Papilledema, is a known complication of various spinal pathologies."	1.29	Late-onset papilledema following spinal injury. Case report. ( Appel, I; Catz, A; Gepstein, R; Grosswasser, Z; Mendelson, L; Reider-Grosswasser, I, 1993)
"We report two cases of idiopathic intracranial hypertension causing chronic daily headache with migrainous features in the absence of associated papilledema."	1.29	Chronic daily headache with migrainous features due to papilledema-negative idiopathic intracranial hypertension. ( Huff, AL; Hupp, SL; Rothrock, JF, 1996)
"After pseudotumor cerebri was diagnosed and the appropriate treatment begun, the papilledema disappeared, but the visual field defect persisted."	1.27	Permanent inferior binasal quadrantanopsia in pseudotumor cerebri. ( Nichelli, P; Penne, A, 1983)
"Pseudotumor cerebri is characterized by increased intracranial pressure and papilledema, with an essentially normal neurologic examination."	1.27	Pseudotumor cerebri. ( Bowman, MA, 1987)
"A review of the most recent 23 cases of benign intracranial hypertension (BIH), admitted to the War Memorial Children's Hospital in London, Ontario, provided a compendium of the clinical manifestations of this disorder in children and adolescents."	1.27	Spectrum of benign intracranial hypertension in children and adolescents. ( Amacher, AL; Spence, JD, 1985)

Research

Studies (130)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Mean Change in Perimetric Mean Deviation

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (7.69)	18.7374
1990's	21 (16.15)	18.2507
2000's	30 (23.08)	29.6817
2010's	58 (44.62)	24.3611
2020's	11 (8.46)	2.80

Authors	Studies
Brun, BN	1
Aylward, SC	2
Vaysbrot, EE	1
Bannuru, RR	1
Christopher, MC	1
Osani, MC	1
Halperin, JJ	1
Vuijk, FA	1
de Bruin, C	1
Peeters-Scholte, CMPCD	1
Notting, IC	1
Alqahtani, Y	1
Oshi, M	1
Kamal, NM	1
Aljabri, M	1
Abosabie, S	1
Elhaj, W	1
Abosabie, SA	1
Patel, A	1
Winter, T	1
Jain, A	1
Batur Caglayan, HZ	1
Ucar, M	1
Hasanreisoglu, M	1
Nazliel, B	1
Tokgoz, N	1
Dunnick, J	1
Gesteland, P	1
Yu, CW	1
Kwok, JM	1
Micieli, JA	3
Bashiri, FA	1
Al Abdulsalam, HK	1
Hassan, SM	1
Al Twaijri, WA	1
Almalki, FI	1
Kentab, AY	1
Hamad, MH	1
Alwadei, AH	1
Al-Showaeir, DA	1
Altweijri, IS	1
Aldabjan, HM	1
Aldegether, MS	1
Albakr, AA	1
Alhothali, WM	1
Ajlan, AM	1
Hassan, HH	1
Salih, MA	1
Ybarra, M	1
Santos, TJD	1
Queiroz, ES	1
Rachid, L	1
Franco, RR	1
Cominato, L	1
Moura, FC	1
Velhote, MC	1
Damiani, D	1
Moss, HE	2
Hollar, RA	2
Fischer, WS	2
Feldon, SE	3
Daou, BJ	1
Sweid, A	1
Weinberg, JH	1
Starke, RM	1
Sergott, RC	1
Doermann, AS	1
Hauge, J	1
Zanaty, M	1
Chalouhi, N	1
Gooch, R	1
Herial, N	1
Zarzour, H	1
Jabbour, P	1
Rosenwasser, RH	1
Tjoumakaris, S	1
Kisilevsky, E	1
Yu, E	1
Margolin, E	1
Raoof, N	1
Hoffmann, J	1
Berkowitz, E	1
Kopelman, Y	1
Kadosh, D	1
Carasso, S	1
Tiosano, B	1
Kesler, A	1
Geva-Zatorsky, N	1
Kaufman, DI	1
Friedman, DI	3
Voisin, H	1
Jeanjean, L	1
Alfonsi, N	1
Ram, R	1
Jones, JY	1
Mohila, CA	1
Shah, VS	1
Raggi, A	1
Grazzi, L	1
Bianchi Marzoli, S	1
Ciasca, P	1
Chiapparini, L	1
Erbetta, A	1
Faragò, G	1
Leonardi, M	1
D'Amico, D	1
Kothari, P	1
Hassan, OM	1
Macintosh, P	1
Sheils, CR	1
Blanchard, LM	1
Mikkilineni, S	1
Trobe, JD	1
Cornblath, WT	1
De Lott, L	1
Madriz Peralta, G	1
Cestari, DM	2
Jordan, CO	1
Balbi, GGM	1
Matas, SL	1
Len, CA	1
Fraga, MM	1
Sousa, IO	1
Terreri, MT	1
Huang-Link, Y	1
Eleftheriou, A	1
Yang, G	1
Johansson, JM	1
Apostolou, A	1
Link, H	1
Jin, YP	1
Samara, A	1
Ghazaleh, D	1
Berry, B	1
Ghannam, M	1
Viuff, AC	1
Hansen, JK	1
Møller, HU	1
Brosh, K	1
Strassman, I	1
Park, S	1
Cheng, CP	1
Lim, LT	1
Gerber, D	1
Ravid, S	1
Shachor-Meyouhas, Y	1
Shahar, E	1
Kra-Oz, Z	1
Kassis, I	1
Aragonès, JM	1
Alonso-Valdés, F	1
Rosdy, B	1
Csákányi, Z	1
Kollár, K	1
Móser, J	1
Mellár, M	1
Kulcsár, A	1
Kovács, É	1
Várallyay, G	1
Katona, G	1
Rodà, D	1
Fons-Estupiña, MC	1
Vidal-Santacana, M	1
Mallery, RM	1
Liu, GT	2
Al-Obthani, M	1
Sundaram, AN	1
Gençpınar, P	1
Büyüktahtakın, B	1
İbişoğlu, Z	1
Genç, Ş	1
Yılmaz, A	1
Mıhçı, E	1
Sun, LW	1
Horton, JC	1
Molobe, LT	1
Shifa, J	1
Silava, C	1
Mojela, K	1
Cainelli, F	1
Vento, S	1
Butori, P	1
Jean-Charles, A	1
Elana, G	1
Merle, H	1
Kattah, JC	1
Pula, JH	1
Mejico, LJ	1
McDermott, MP	3
Kupersmith, MJ	3
Wall, M	9
Derkatch, S	1
Pereira, VM	1
Margolin, EA	1
Falardeau, J	1
Fletcher, WA	1
Granadier, RJ	1
Lam, BL	2
Longmuir, RA	1
Patel, AD	2
Bruce, BB	2
He, H	1
Popiela, M	1
Austin, M	1
Mahroo, OA	1
Mohamed, MD	1
Graham, EM	1
Mann, SS	1
Plant, GT	1
Afridi, SK	1
Hammond, CJ	1
Kumar, S	1
Srivastava, T	1
Tejwani, S	1
Khilnani, K	1
ten Hove, MW	1
Irrcher, I	1
Cello, KE	1
Keltner, JL	1
Johnson, CA	1
Loo, KG	1
Lim, SA	1
Lim, IL	1
Chan, DW	1
Rook, BS	1
Phillips, PH	1
Abdelfatah, MA	1
Tibussek, D	1
Distelmaier, F	1
Karenfort, M	1
Harmsen, S	1
Klee, D	1
Mayatepek, E	1
Sibony, PA	1
Wang, JK	1
Garvin, M	1
Kardon, R	2
Thurtell, MJ	2
Moss, EA	1
Auinger, P	1
Marton, E	1
Feletti, A	1
Mazzucco, GM	1
Longatti, P	1
Kuzman, MR	1
Jovanovic, N	1
Vukelja, D	1
Medved, V	1
Hotujac, L	1
Sakushima, K	1
Tsuji, S	1
Niino, M	1
Yabe, I	1
Sasaki, H	1
Zimmer, JA	1
Garg, BP	1
O'Neill, DP	1
Golomb, MR	1
Barnés, C	1
Sánchez-Dalmau, BF	1
Vela, D	1
Alarcón, S	1
Landau, K	1
Lamirel, C	1
Newman, N	1
Biousse, V	2
Mouzaki, M	1
Nichter, C	1
Qureshi, M	1
Rountree, B	1
Furuya, KN	1
Battaglia, F	1
Franques, J	1
Somma-Mauvais, H	1
Roche, PH	1
Skau, M	1
Sander, B	1
Milea, D	1
Jensen, R	1
Duclos, C	1
Bonnin, N	1
Merlin, E	1
Viorel, A	1
Lacombe, P	1
Dalens, H	1
Chiambaretta, F	1
Deméocq, F	1
Chazal, J	1
Kanold, J	1
Rogers, DL	1
McGregor, ML	1
Dessardo, NS	1
Dessardo, S	1
Sasso, A	1
Sarunić, AV	1
Dezulović, MS	1
Kaeser, PF	1
Borruat, FX	1
Göbel, H	1
Göbel, C	1
Heinze, A	1
Fraser, CL	1
Ridha, MA	1
Newman, NJ	1
Lee, IJ	1
Maccheron, LJ	1
Kwan, AS	1
Galveia, JN	1
Mendonça, AP	1
Costa, JM	1
Wraige, E	1
Chandler, C	1
Pohl, KR	1
Villain, MA	1
Pageaux, GP	1
Veyrac, M	1
Arnaud, B	2
Harris, A	1
Greenfield, DS	2
Kling, F	1
Cochener, B	1
Colin, J	1
Morrison, DG	1
Phuah, HK	1
Reddy, AT	1
Dure, LS	1
Kline, LB	1
Langford, CM	1
Nazir, SA	1
Siatkowski, RM	2
Bassuk, AG	1
Burrowes, DM	1
Velimirovic, B	1
Grant, J	1
Keating, GF	1
STARR, HJ	1
Rizzo, JF	1
Guirgis, MF	1
Lueder, GT	1
Frost, N	1
Lee, MS	1
Sweeney, P	1
Foroozan, R	1
Varon, J	1
Warner, JE	1
Katz, BJ	1
Altinbas, A	1
Hoogstede, HA	1
Bakker, SL	1
Wendel, L	1
Lee, AG	2
Boldt, HC	1
Kardon, RH	1
Gao, BB	1
Clermont, A	1
Rook, S	1
Fonda, SJ	1
Srinivasan, VJ	1
Wojtkowski, M	1
Fujimoto, JG	1
Avery, RL	1
Arrigg, PG	1
Bursell, SE	1
Aiello, LP	1
Feener, EP	1
Esmaili, N	1
Bradfield, YS	1
Brackmann, DE	1
Doherty, JK	1
Jamerson, SC	1
Arunagiri, G	1
Ellis, BD	1
Leys, MJ	1
Parnes, A	1
Wassner, SJ	1
Weinstein, JM	1
Nichelli, P	1
Penne, A	1
Brodsky, MC	1
Glasier, CM	1
Weller, B	1
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Sierpinski-Barth, J	1
Schwartz, M	1
Glaser, JS	2
Schatz, NJ	1
Catz, A	1
Appel, I	1
Reider-Grosswasser, I	1
Grosswasser, Z	1
Mendelson, L	1
Gepstein, R	1
Mokri, B	1
Jack, CR	1
Petty, GW	1
Mathew, NT	1
Ravishankar, K	1
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Huff, AL	1
Hupp, SL	1
Rothrock, JF	1
Wanichwecharungruang, B	1
Liebmann, JM	1
Ritch, R	1
Krishna, R	1
Kosmorsky, GS	1
Wright, KW	1
Scarrow, AM	1
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Medsger, TA	1
Wasko, MC	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Acetazolamide for Treating NPH in Shunt-candidates Patients: an Open Label Feasibility Trial[NCT03779594]	Phase 2	15 participants (Anticipated)	Interventional	2018-12-31	Recruiting
A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss[NCT01003639]	Phase 2/Phase 3	165 participants (Actual)	Interventional	2010-01-31	Completed
Novel Compliant Scaffold With Specific Design for the Treatment of Non-thrombotic Stenosis of Internal Jugular Veins in Patients With Chronic Headache Poor Responder to Best Medical Therapy[NCT04352218]	Phase 2	60 participants (Anticipated)	Interventional	2020-09-30	Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Treatment Effects on the Primary Outcome Variable, Mean change From Baseline to Month 6 in Perimetric Mean Deviation (PMD) in the Study Eye. Perimetric mean deviation is a measure of global visual field loss (mean deviation from age-corrected normal values), with a range of 2 to -32 dB; larger negative values indicate greater vision loss. (NCT01003639)
Timeframe: base line and 6 months

Mean Change of Papilledema Grade on Fundus Photography

Intervention	dB (Mean)
Acetazolamide	1.43
Sugar Pill	0.71

Mean change at month 6 as compared to baseline. Frisén papilledema grade is an ordinal scale that uses ocular fundus features to rate the severity of papilledema; grade 0 indicates no features of papilledema and grade 5 indicates severe papilledema. (NCT01003639)
Timeframe: Baseline and 6 Months

Visual Acuity (No. of Correct Letters)

Visual Function Questionnaire (VFQ-25)

Intervention	units on a scale (Mean)
	Study eye	Fellow eye
Acetazolamide	-1.31	-1.14
Sugar Pill	-0.61	-0.52

Intervention	correct letters (Mean)
	Study Eye	Fellow Eye
Acetazolamide	56.8	58.3
Sugar Pill	55.6	56.2

Visual Function Questionnaire (VFQ-25) total score, VFQ-25 10-item neuro-ophthalmic supplement total score: 0-100 (higher scores indicate better quality of life) (NCT01003639)
Timeframe: baseline

Article	Year
Pediatric Intracranial Hypertension: A Spotlight on Imaging, the Idiopathic Intracranial Hypertension Treatment Trial, and COVID-19 Associated Cases. Seminars in pediatric neurology, 2021, Volume: 40 Topics: Acetazolamide; Adolescent; Adult; Carbonic Anhydrase Inhibitors; Child; Combined Modality Therapy; C	2021
Diagnosis and treatment of idiopathic intracranial hypertension. Cephalalgia : an international journal of headache, 2021, Volume: 41, Issue:4 Topics: Acetazolamide; Analgesics; Headache; Headache Disorders; Humans; Intracranial Hypertension; Migraine	2021
Should Acetazolamide Be the First-Line Treatment for Patients With Idiopathic Intracranial Hypertension? Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2017, Volume: 37, Issue:2 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Decision Making; Humans; Intracranial Pressure; Magnet	2017
An update of idiopathic intracranial hypertension. Current opinion in ophthalmology, 2018, Volume: 29, Issue:6 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Humans; Intracranial Pressure; Papilledema; Pseudotumo	2018
Intracranial hypertension: a current review. Current opinion in pediatrics, 2018, Volume: 30, Issue:6 Topics: Acetazolamide; Adolescent; Carbonic Anhydrase Inhibitors; Child; Child, Preschool; Comorbidity; Eye	2018
Headache and the pseudotumor cerebri syndrome. Current pain and headache reports, 2014, Volume: 18, Issue:9 Topics: Acetazolamide; Back Pain; Diagnosis, Differential; Diuretics; Fructose; Furosemide; Headache Disorde	2014
Pediatric pseudotumor cerebri. Current opinion in ophthalmology, 2016, Volume: 27, Issue:5 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Cerebrospinal Fluid Pressure; Child; Humans; Magnetic	2016
Update on Idiopathic Intracranial Hypertension. Neurologic clinics, 2017, Volume: 35, Issue:1 Topics: Acetazolamide; Diuretics; Humans; Papilledema; Pseudotumor Cerebri; Randomized Controlled Trials as	2017
[Neuro-ophthalmology essentials]. Therapeutische Umschau. Revue therapeutique, 2009, Volume: 66, Issue:3 Topics: Acetazolamide; Adrenal Cortex Hormones; Adult; Aged; Blepharoptosis; Carbonic Anhydrase Inhibitors;	2009
[Headache from increased cerebrospinal fluid pressure]. Schmerz (Berlin, Germany), 2012, Volume: 26, Issue:3 Topics: Acetazolamide; Algorithms; Cerebrospinal Fluid Pressure; Cerebrospinal Fluid Shunts; Combined Modali	2012

Article	Year
Retinal vessel diameter changes after 6 months of treatment in the Idiopathic Intracranial Hypertension Treatment Trial. The British journal of ophthalmology, 2020, Volume: 104, Issue:10 Topics: Acetazolamide; Adult; Arterioles; Blood Pressure; Carbonic Anhydrase Inhibitors; Diet Therapy; Doubl	2020
The Relationship Between Optic Disc Volume, Area, and Frisén Score in Patients With Idiopathic Intracranial Hypertension. American journal of ophthalmology, 2018, Volume: 195 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Cerebrospinal Fluid; Double-Blind Method; Femal	2018
CSF pressure, papilledema grade, and response to acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial. Journal of neurology, 2015, Volume: 262, Issue:10 Topics: Acetazolamide; Adolescent; Adult; Carbonic Anhydrase Inhibitors; Cerebrospinal Fluid Pressure; Femal	2015
Papilledema Outcomes from the Optical Coherence Tomography Substudy of the Idiopathic Intracranial Hypertension Treatment Trial. Ophthalmology, 2015, Volume: 122, Issue:9 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Double-Blind Method; Follow-Up Studies; Humans; Nerve	2015
Safety and Tolerability of Acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2016, Volume: 36, Issue:1 Topics: Acetazolamide; Adolescent; Adult; Carbonic Anhydrase Inhibitors; Combined Modality Therapy; Diet, So	2016
Factors Affecting Visual Field Outcomes in the Idiopathic Intracranial Hypertension Treatment Trial. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2016, Volume: 36, Issue:1 Topics: Acetazolamide; Adolescent; Adult; Carbonic Anhydrase Inhibitors; Combined Modality Therapy; Diet, So	2016
The Effect of Treatment of Idiopathic Intracranial Hypertension on Prevalence of Retinal and Choroidal Folds. American journal of ophthalmology, 2017, Volume: 176 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Choroid; Dose-Response Relationship, Drug; Follow-Up S	2017
The Longitudinal Idiopathic Intracranial Hypertension Trial: Outcomes From Months 6-12. American journal of ophthalmology, 2017, Volume: 176 Topics: Acetazolamide; Administration, Oral; Adult; Carbonic Anhydrase Inhibitors; Dose-Response Relationshi	2017
Optic disc haemorrhages at baseline as a risk factor for poor outcome in the Idiopathic Intracranial Hypertension Treatment Trial. The British journal of ophthalmology, 2017, Volume: 101, Issue:9 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Cerebrospinal Fluid Pressure; Combined Modality	2017
Disease activity in idiopathic intracranial hypertension: a 3-month follow-up study. Journal of neurology, 2011, Volume: 258, Issue:2 Topics: Acetazolamide; Adult; Body Mass Index; Diuretics; Female; Follow-Up Studies; Humans; Male; Papillede	2011
The role of weight loss and acetazolamide in the treatment of idiopathic intracranial hypertension (pseudotumor cerebri) Ophthalmology, 1998, Volume: 105, Issue:12 Topics: Acetazolamide; Adult; Body Mass Index; Body Weight; Female; Humans; Middle Aged; Obesity; Papilledem	1998

Article	Year
Papilledema Secondary to Neurologic Lyme Borreliosis: A Meta-Case Series. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2021, 12-01, Volume: 41, Issue:4 Topics: Acetazolamide; Cranial Nerve Diseases; Facial Paralysis; Humans; Lyme Disease; Papilledema	2021
Recurrent Intracranial Hypertension in a Toddler with Graves' Disease. Hormone research in paediatrics, 2022, Volume: 95, Issue:1 Topics: Acetazolamide; Child, Preschool; Female; Graves Disease; Humans; Infant; Intracranial Hypertension;	2022
Pediatric myelin oligodendrocyte glycoprotein antibody associated disease-Asymmetric papilledema and elevated ICP are two of the chameleons: A case report. Medicine, 2023, Feb-22, Volume: 102, Issue:8 Topics: Acetazolamide; Headache; Humans; Intracranial Hypertension; Male; Myelin-Oligodendrocyte Glycoprotei	2023
A Rare Report of the Coexistence of Sickle Cell Disease, Neurofibromatosis Type 1, and Intracranial Hypertension in a Pediatric Patient. Journal of pediatric hematology/oncology, 2023, 04-01, Volume: 45, Issue:3 Topics: Acetazolamide; Anemia, Sickle Cell; Child; Female; Humans; Hydroxyurea; Intracranial Hypertension; N	2023
Magnetic Resonance Imaging of Idiopathic Intracranial Hypertension: Before and After Treatment. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2019, Volume: 39, Issue:3 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Female; Humans; Magnetic Resonance Imaging; Pap	2019
Isolated Increased Intracranial Pressure and Unilateral Papilledema in an Infant With Traumatic Brain Injury and Nondepressed Basilar Skull Fracture. Pediatric emergency care, 2019, Volume: 35, Issue:11 Topics: Acetazolamide; Brain Injuries, Traumatic; Female; Humans; Infant; Intracranial Pressure; Papilledema	2019
Resolution of papilledema associated with cyclosporine use after change to tacrolimus. BMJ case reports, 2019, Nov-19, Volume: 12, Issue:11 Topics: Acetazolamide; Cyclosporine; Diagnosis, Differential; Diuretics; Female; Humans; Immunosuppressive A	2019
Pediatric intracranial hypertension. Experience from 2 Tertiary Centers. Neurosciences (Riyadh, Saudi Arabia), 2019, Volume: 24, Issue:4 Topics: Acetazolamide; Child; Child, Preschool; Diuretics; Female; Headache; Hospitals, Pediatric; Humans; I	2019
BARIATRIC SURGERY AS A TREATMENT FOR IDIOPATHIC INTRACRANIAL HYPERTENSION IN A MALE ADOLESCENT: CASE REPORT. Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 2020, Volume: 38 Topics: Acetazolamide; Adolescent; Aftercare; Bariatric Surgery; Diuretics; Fundus Oculi; Headache; Humans;	2020
Effect of Shunting on Visual Outcomes and Headache in Patients with Idiopathic Intracranial Hypertension. World neurosurgery, 2020, Volume: 142 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Cerebrospinal Fluid Shunts; Cohort Studies; Dip	2020
Asymptomatic Papilledema in a 64-Year-Old Man. JAMA ophthalmology, 2020, 08-01, Volume: 138, Issue:8 Topics: Acetazolamide; Asymptomatic Diseases; Carbonic Anhydrase Inhibitors; Cerebral Veins; Humans; Intracr	2020
"More Guts Than Brains?"-The Role of Gut Microbiota in Idiopathic Intracranial Hypertension. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2022, 03-01, Volume: 42, Issue:1 Topics: Acetazolamide; Brain; Female; Gastrointestinal Microbiome; Humans; Obesity; Papilledema; Pseudotumor	2022
[Bilateral disc edema following a severe systemic viral illness]. Journal francais d'ophtalmologie, 2017, Volume: 40, Issue:8 Topics: Acetazolamide; Female; Fundus Oculi; Humans; Papilledema; Severity of Illness Index; Tomography, Opt	2017
Five-Year-Old Boy With Behavioral Changes and Papilledema. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2018, Volume: 38, Issue:1 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Cerebrospinal Fluid Pressure; Child Behavior Disorders	2018
The importance of specific rehabilitation for an obese patient with idiopathic intracranial hypertension: a case report. International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation, 2018, Volume: 41, Issue:2 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Diet, Reducing; Female; Humans; Obesity; Papill	2018
Young Man With Severe Bilateral Papilledema. JAMA ophthalmology, 2018, 07-01, Volume: 136, Issue:7 Topics: Acetazolamide; Brain; Chronic Kidney Disease-Mineral and Bone Disorder; Constriction, Pathologic; Di	2018
Visual Field Mean Deviation at Diagnosis of Idiopathic Intracranial Hypertension Predicts Visual Outcome. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2019, Volume: 39, Issue:2 Topics: Acetazolamide; Adolescent; Adult; Carbonic Anhydrase Inhibitors; Diuretics; Drug Therapy, Combinatio	2019
Pseudotumor cerebri in childhood and adolescence: data from a specialized service. Arquivos de neuro-psiquiatria, 2018, Volume: 76, Issue:11 Topics: Acetazolamide; Adolescent; Child; Child, Preschool; Female; Headache; Humans; Male; Papilledema; Pse	2018
Optical coherence tomography represents a sensitive and reliable tool for routine monitoring of idiopathic intracranial hypertension with and without papilledema. European journal of neurology, 2019, Volume: 26, Issue:5 Topics: Acetazolamide; Adult; Aged; Diuretics; Female; Humans; Intracranial Hypertension; Male; Middle Aged;	2019
Idiopathic intracranial hypertension presenting with isolated unilateral facial nerve palsy: a case report. Journal of medical case reports, 2019, Apr-19, Volume: 13, Issue:1 Topics: Acetazolamide; Adult; Facial Paralysis; Female; Headache; Humans; Magnetic Resonance Imaging; Obesit	2019
[Idiopathic intracranial hypertension is a rare cause of headache in children]. Ugeskrift for laeger, 2013, Mar-04, Volume: 175, Issue:10 Topics: Acetazolamide; Child, Preschool; Diuretics; Headache; Humans; Male; Papilledema; Pseudotumor Cerebri	2013
Unilateral papilledema in pseudotumor cerebri. Seminars in ophthalmology, 2013, Volume: 28, Issue:4 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Female; Humans; Intracranial Pressure; Obesity;	2013
Secondary intracranial hypertension from testosterone therapy in a transgender patient. Seminars in ophthalmology, 2014, Volume: 29, Issue:3 Topics: Acetazolamide; Administration, Oral; Androgens; Blood Pressure; Carbonic Anhydrase Inhibitors; Cereb	2014
Viral-induced intracranial hypertension mimicking pseudotumor cerebri. Pediatric neurology, 2013, Volume: 49, Issue:3 Topics: Acetazolamide; Adolescent; Anticonvulsants; Central Nervous System Viral Diseases; Child; Child, Pre	2013
[Benign intracranial hypertension secondary to hypoparathyroidism]. Revista de neurologia, 2014, Jan-16, Volume: 58, Issue:2 Topics: Acetazolamide; Adult; Calcitriol; Calcium Carbonate; Female; Headache; Humans; Hypocalcemia; Hypopar	2014
Visual and neurologic deterioration in otogenic lateral sinus thrombosis: 15 year experience. International journal of pediatric otorhinolaryngology, 2014, Volume: 78, Issue:8 Topics: Acetazolamide; Acute Disease; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; C-Reactive Pro	2014
[Familial idiopathic intracranial hypertension: two paediatric case reports]. Revista de neurologia, 2014, Jul-16, Volume: 59, Issue:2 Topics: Acetazolamide; Adolescent; Carbonic Anhydrase Inhibitors; Child; Female; Genetic Predisposition to D	2014
Pseudo-Foster Kennedy syndrome due to idiopathic intracranial hypertension. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2014, Volume: 49, Issue:4 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Female; Humans; Optic Nerve Diseases; Overweigh	2014
Mercury poisoning as a cause of intracranial hypertension. Journal of child neurology, 2015, Volume: 30, Issue:6 Topics: Acetazolamide; Chelation Therapy; Child; Community Mental Health Services; Humans; Intracranial Hype	2015
Papilledema associated with puberty. Clinical pediatrics, 2015, Volume: 54, Issue:5 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Child; Diagnosis, Differential; Female; Headache; Huma	2015
Primary pseudotumor cerebri syndrome in a young obese African woman. The Israel Medical Association journal : IMAJ, 2014, Volume: 16, Issue:9 Topics: Acetazolamide; Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Antihypertensive Agents; Diuretic	2014
[Pseudotumor cerebri in children with sickle cell disease]. Journal francais d'ophtalmologie, 2015, Volume: 38, Issue:1 Topics: Abducens Nerve Diseases; Acetazolamide; Adolescent; Anemia, Sickle Cell; Diplopia; Female; Headache;	2015
Development of Dural Arteriovenous Fistulas After Cerebral Venous Sinus Thrombosis. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2016, Volume: 36, Issue:1 Topics: Acetazolamide; Anticoagulants; Carbonic Anhydrase Inhibitors; Central Nervous System Vascular Malfor	2016
Risk factors for poor visual outcome in patients with idiopathic intracranial hypertension. Neurology, 2015, Sep-01, Volume: 85, Issue:9 Topics: Acetazolamide; Adult; Diet, Reducing; Diet, Sodium-Restricted; Diuretics; Female; Humans; Intracrani	2015
Bilateral papilloedema in Camurati-Engelmann disease. BMJ case reports, 2015, Aug-18, Volume: 2015 Topics: Acetazolamide; Camurati-Engelmann Syndrome; Female; Humans; Intracranial Hypertension; Optic Atrophy	2015
Cilioretinal Artery Territory Infarction Associated With Papilledema in a Patient With Neurofibromatosis Type 2. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2016, Volume: 36, Issue:1 Topics: Acetazolamide; Adolescent; Aspirin; Carbonic Anhydrase Inhibitors; Ciliary Arteries; Drug Therapy, C	2016
Cerebral proliferative angiopathy with papilledema. Clinical neurology and neurosurgery, 2015, Volume: 139 Topics: Acetazolamide; Angiography, Digital Subtraction; Anterior Cerebral Artery; Cerebral Angiography; Diu	2015
Guiding follow-up of paediatric idiopathic intracranial hypertension with optical coherence tomography. BMJ case reports, 2016, Mar-03, Volume: 2016 Topics: Acetazolamide; Adolescent; Child; Diuretics; Female; Follow-Up Studies; Humans; Papilledema; Pseudot	2016
Normal Pressure Pseudotumor Cerebri: A Series of Six Patients. Turkish neurosurgery, 2017, Volume: 27, Issue:2 Topics: Acetazolamide; Adult; Cerebrospinal Fluid Pressure; Female; Humans; Intracranial Hypertension; Neuro	2017
Probable pseudotumor cerebri complex in 25 children. Further support of a concept. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2017, Volume: 21, Issue:2 Topics: Abducens Nerve Diseases; Acetazolamide; Adolescent; Cerebrospinal Fluid Pressure; Child; Child, Pres	2017
Pseudotumor cerebri in pediatric age: role of obesity in the management of neurological impairments. Nutritional neuroscience, 2008, Volume: 11, Issue:1 Topics: Acetazolamide; Adolescent; Cerebrospinal Fluid; Child; Child, Preschool; Cranial Nerve Diseases; Die	2008
Psychiatric symptoms in idiopathic intracranial hypertension. Psychiatry and clinical neurosciences, 2008, Volume: 62, Issue:3 Topics: Acetazolamide; Adult; Borderline Personality Disorder; Depersonalization; Diagnosis, Differential; D	2008
[Idiopathic intracranial hypertension without headache detected during a routine health check]. Rinsho shinkeigaku = Clinical neurology, 2008, Volume: 48, Issue:6 Topics: Acetazolamide; Female; Fundus Oculi; Headache; Humans; Middle Aged; Papilledema; Physical Examinatio	2008
Teaching neuroImage: MRI visualization of papilledema associated with cerebral sinovenous thrombosis in a child. Neurology, 2008, Aug-12, Volume: 71, Issue:7 Topics: Acetazolamide; Child, Preschool; Colitis, Ulcerative; Diuretics; Humans; Intracranial Hypertension;	2008
[Papilledema as an indicator of POEMS syndrome]. Archivos de la Sociedad Espanola de Oftalmologia, 2008, Volume: 83, Issue:12 Topics: Acetazolamide; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Drug Therapy, Combina	2008
Choroidal infarction in fulminant idiopathic intracranial hypertension. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2010, Volume: 30, Issue:2 Topics: Acetazolamide; Choroid; Choroid Diseases; Diuretics; Female; Headache; Humans; Infarction; Ophthalmi	2010
Idiopathic intracranial hypertension in two patients with Alagille syndrome. Journal of child neurology, 2010, Volume: 25, Issue:8 Topics: Acetazolamide; Age of Onset; Alagille Syndrome; Cerebrospinal Fluid Pressure; Child, Preschool; Diur	2010
[Clinical presentation suggesting Bickerstaff encephalitis and intracranial hypertension]. Revue neurologique, 2011, Volume: 167, Issue:2 Topics: Acetazolamide; Diuretics; Electroencephalography; Electromyography; Encephalitis; Gait Disorders, Ne	2011
[Benign but not harmless intracranial hypertension: a case report]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2010, Volume: 17, Issue:12 Topics: Abducens Nerve Diseases; Acetazolamide; Adolescent; Diplopia; Diuretics; Female; Humans; Meningitis,	2010
Increased intracranial pressure in patients with cystinosis. Journal of pediatric ophthalmology and strabismus, 2010, Dec-22, Volume: 47 Online Topics: Acetazolamide; Adolescent; Child; Cystinosis; Decompression, Surgical; Diuretics; Female; Humans; In	2010
Pediatric idiopathic intracranial hypertension: clinical and demographic features. Collegium antropologicum, 2010, Volume: 34 Suppl 2 Topics: Acetazolamide; Adolescent; Child; Diuretics; Female; Humans; Male; Obesity; Ophthalmoscopy; Papilled	2010
Peripapillary neovascular membrane: a rare cause of acute vision loss in pediatric idiopathic intracranial hypertension. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2011, Volume: 15, Issue:1 Topics: Acetazolamide; Acute Disease; Administration, Oral; Adolescent; Blindness; Cerebrospinal Fluid Press	2011
Vitreous hemorrhage secondary to optociliary shunt vessels from papilledema. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2012, Volume: 32, Issue:4 Topics: Acetazolamide; Adolescent; Anticonvulsants; Female; Functional Laterality; Humans; Papilledema; Vasc	2012
Intravitreal bevacizumab in the treatment of peripapillary choroidal neovascular membrane secondary to idiopathic intracranial hypertension. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2013, Volume: 33, Issue:2 Topics: Acetazolamide; Adolescent; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Bevacizumab;	2013
Paediatric idiopathic intracranial hypertension. BMJ case reports, 2013, Jan-24, Volume: 2013 Topics: Acetazolamide; Child; Diuretics; Headache; Humans; Intracranial Hypertension; Male; Papilledema; Ven	2013
Idiopathic intracranial hypertension: is papilloedema inevitable? Archives of disease in childhood, 2002, Volume: 87, Issue:3 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Child; Child, Preschool; Diagnosis, Differential; Fema	2002
Effect of acetazolamide on ocular hemodynamics in pseudotumor cerebri associated with inflammatory bowel disease. American journal of ophthalmology, 2002, Volume: 134, Issue:5 Topics: Acetazolamide; Administration, Oral; Adult; Carbonic Anhydrase Inhibitors; Choroid; Crohn Disease; F	2002
[Bilateral papilledema in young women: two case reports of benign intracranial hypertension?]. Journal francais d'ophtalmologie, 2002, Volume: 25, Issue:8 Topics: Acetazolamide; Adolescent; Adult; Anti-Bacterial Agents; Carbonic Anhydrase Inhibitors; Female; Fluo	2002
Ophthalmologic involvement in the syndrome of headache, neurologic deficits, and cerebrospinal fluid lymphocytosis. Ophthalmology, 2003, Volume: 110, Issue:1 Topics: Abducens Nerve Diseases; Acetazolamide; Adolescent; Carbonic Anhydrase Inhibitors; Female; Headache;	2003
Pseudotumor cerebri in a pre-pubescent child--case report. Optometry (St. Louis, Mo.), 2002, Volume: 73, Issue:11 Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Child; Diplopia; Esotropia; Headache; Humans; Intracra	2002
Pseudotumor cerebri in idiopathic aplastic anemia. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2003, Volume: 7, Issue:1 Topics: Acetazolamide; Adolescent; Anemia, Aplastic; Antilymphocyte Serum; Blood Transfusion; Humans; Male;	2003
A child with spinal cord AVM presenting with raised intracranial pressure. Neurology, 2003, May-27, Volume: 60, Issue:10 Topics: Acetazolamide; Adolescent; Arteriovenous Malformations; Cervical Vertebrae; Diplopia; Dura Mater; Fe	2003
PSEUDOTUMOR CEREBRI. REPORT OF SIX CASES COMPARED WITH ONE CASE OF PSEUDOPAPILLEDEMA. The Medical annals of the District of Columbia, 1964, Volume: 33 Topics: Acetazolamide; Brain Diseases; Brain Neoplasms; Chlorothiazide; Diagnosis; Diet, Sodium-Restricted;	1964
Intracranial hypertension following epidural blood patch. Neurology, 2003, Nov-11, Volume: 61, Issue:9 Topics: Acetazolamide; Adrenal Cortex Hormones; Adult; Blood Patch, Epidural; Headache; Humans; Injections,	2003
Intracranial hypertension secondary to all-trans retinoic acid treatment for leukemia: diagnosis and management. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2003, Volume: 7, Issue:6 Topics: Acetazolamide; Adolescent; Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Female; Fundus Ocul	2003
Myxedema, papilledema, and elevated CSF protein. Neurology, 2004, Aug-24, Volume: 63, Issue:4 Topics: Acetazolamide; Anemia, Pernicious; Cerebrospinal Fluid Proteins; Confusion; Diagnosis, Differential;	2004
Bilateral anterior ischemic optic neuropathy after liposuction. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2004, Volume: 24, Issue:3 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Female; Humans; Jugular Veins; Lipectomy; Magne	2004
Metamorphopsia as an initial complaint of idiopathic intracranial hypertension. Archives of ophthalmology (Chicago, Ill. : 1960), 2005, Volume: 123, Issue:7 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Female; Fluorescein Angiography; Humans; Magnet	2005
[Intracranial hypertension with severe and irreversible reduced acuity and impaired visual fields after oral tetracycline]. Nederlands tijdschrift voor geneeskunde, 2005, Aug-20, Volume: 149, Issue:34 Topics: Acetazolamide; Administration, Oral; Adult; Diuretics; Female; Humans; Intracranial Hypertension; In	2005
Subretinal neovascular membrane in idiopathic intracranial hypertension. American journal of ophthalmology, 2006, Volume: 141, Issue:3 Topics: Acetazolamide; Combined Modality Therapy; Diuretics; Female; Furosemide; Humans; Laser Coagulation;	2006
Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. Nature medicine, 2007, Volume: 13, Issue:2 Topics: Acetazolamide; Animals; Blotting, Western; Bradykinin Receptor Antagonists; Capillary Permeability;	2007
Pseudotumor cerebri in children with Down syndrome. Ophthalmology, 2007, Volume: 114, Issue:9 Topics: Acetazolamide; Child; Child, Preschool; Diuretics; Down Syndrome; Female; Humans; Intracranial Press	2007
Facial palsy and fallopian canal expansion associated with idiopathic intracranial hypertension. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2007, Volume: 28, Issue:5 Topics: Acetazolamide; Child; Diagnosis, Differential; Facial Paralysis; Geniculate Ganglion; Hearing Loss,	2007
Intravitreal bevacizumab for the treatment of choroidal neovascularization secondary to pseudotumor cerebri. International ophthalmology, 2009, Volume: 29, Issue:3 Topics: Acetazolamide; Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Human	2009
A case of intracranial hypertension and papilledema associated with nephropathic cystinosis and ocular involvement. Binocular vision & strabismus quarterly, 2008, Volume: 23, Issue:1 Topics: Acetazolamide; Child; Cystinosis; Diuretics; Humans; Intracranial Hypertension; Kidney Transplantati	2008
Permanent inferior binasal quadrantanopsia in pseudotumor cerebri. Italian journal of neurological sciences, 1983, Volume: 4, Issue:2 Topics: Acetazolamide; Humans; Male; Middle Aged; Papilledema; Pseudotumor Cerebri; Vision Disorders	1983
Magnetic resonance visualization of the swollen optic disc in papilledema. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 1995, Volume: 15, Issue:2 Topics: Acetazolamide; Administration, Oral; Child; Diuretics; Fundus Oculi; Gadolinium; Humans; Magnetic Re	1995
[Idiopathic intracranial hypertension and tetracycline]. Harefuah, 1994, Volume: 127, Issue:1-2 Topics: Acetazolamide; Adolescent; Adult; Female; Headache; Humans; Male; Papilledema; Pseudotumor Cerebri;	1994
High-dose methylprednisolone and acetazolamide for visual loss in pseudotumor cerebri. American journal of ophthalmology, 1994, Jul-15, Volume: 118, Issue:1 Topics: Acetazolamide; Acute Disease; Administration, Oral; Adolescent; Adult; Blindness; Drug Therapy, Comb	1994
Late-onset papilledema following spinal injury. Case report. Paraplegia, 1993, Volume: 31, Issue:2 Topics: Acetazolamide; Adult; Brain; Dexamethasone; Humans; Intracranial Pressure; Male; Ophthalmoscopy; Pap	1993
Pseudotumor syndrome associated with cerebral venous sinus occlusion and antiphospholipid antibodies. Stroke, 1993, Volume: 24, Issue:3 Topics: Acetazolamide; Antibodies, Antiphospholipid; Cerebral Angiography; Cerebral Veins; Hearing Loss, Noi	1993
Coexistence of migraine and idiopathic intracranial hypertension without papilledema. Neurology, 1996, Volume: 46, Issue:5 Topics: Acetazolamide; Adolescent; Adult; Dihydroergotamine; Diuretics; Ergotamine; Female; Follow-Up Studie	1996
Chronic daily headache with migrainous features due to papilledema-negative idiopathic intracranial hypertension. Cephalalgia : an international journal of headache, 1996, Volume: 16, Issue:6 Topics: Acetazolamide; Adult; Chronic Disease; Female; Headache; Humans; Intracranial Pressure; Middle Aged;	1996
Pseudotumor cerebri appearing with unilateral papilledema after trabeculectomy. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:3 Topics: Acetazolamide; Adult; Antimetabolites; Carbonic Anhydrase Inhibitors; Female; Fluorouracil; Fundus O	1997
Pseudotumor cerebri sine papilledema with unilateral sixth nerve palsy. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 1998, Volume: 18, Issue:1 Topics: Abducens Nerve; Acetazolamide; Adolescent; Cranial Nerve Diseases; Diplopia; Female; Headache; Human	1998
Communicating hydrocephalus secondary to diffuse meningeal spread of Wegener's granulomatosis: case report and literature review. Neurosurgery, 1998, Volume: 43, Issue:6 Topics: Acetazolamide; Anti-Inflammatory Agents; Combined Modality Therapy; Cranial Nerve Diseases; Cyclopho	1998
Idiopathic intracranial hypertension in prepubertal pediatric patients: characteristics, treatment, and outcome. American journal of ophthalmology, 1999, Volume: 127, Issue:2 Topics: Acetazolamide; Cerebrospinal Fluid Pressure; Child; Child, Preschool; Diplopia; Drug Therapy, Combin	1999
[Intra-orbital decompression of the optic nerve by opening the peri-optic meninges in the treatment of severe optic neuropathies complicating benign intracranial hypertension]. Neuro-Chirurgie, 1999, Volume: 45, Issue:2 Topics: Acetazolamide; Adolescent; Adult; Combined Modality Therapy; Decompression, Surgical; Diuretics; Fem	1999
Weight loss, acetazolamide, and pseudotumor cerebri. Ophthalmology, 1999, Volume: 106, Issue:9 Topics: Acetazolamide; Body Weight; Humans; Obesity; Papilledema; Pseudotumor Cerebri; Weight Loss	1999
Divergence paralysis & intracranial hypertension due to neurobrucellosis. A case report. Binocular vision & strabismus quarterly, 1999, Volume: 14, Issue:2 Topics: Acetazolamide; Adult; Antibiotics, Antitubercular; Brucella melitensis; Brucellosis; Ceftriaxone; Ce	1999
Visual loss in idiopathic intracranial hypertension after resolution of papilledema. Ophthalmic plastic and reconstructive surgery, 1999, Volume: 15, Issue:6 Topics: Acetazolamide; Administration, Oral; Adult; Blindness; Disease Progression; Diuretics; Female; Human	1999
Weight loss in idiopathic intracranial hypertension. Ophthalmology, 1999, Volume: 106, Issue:12 Topics: Acetazolamide; Diuretics; Humans; Intracranial Hypertension; Papilledema; Weight Loss	1999
[Benign intracranial hypertension following minocycline]. Harefuah, 1998, May-15, Volume: 134, Issue:10 Topics: Acetazolamide; Adolescent; Anti-Bacterial Agents; Diuretics; Female; Headache; Humans; Minocycline;	1998
[Distinct papilledema in pseudotumor cerebri in vitamin A hypervitaminosis. A 35-year-old patient with distinct papilledema and double-image perception]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2000, Volume: 97, Issue:7 Topics: Acetazolamide; Adult; Anti-Inflammatory Agents; Anticonvulsants; Diplopia; Humans; Hypervitaminosis	2000
Papilledema and obstructive sleep apnea syndrome. Archives of ophthalmology (Chicago, Ill. : 1960), 2000, Volume: 118, Issue:12 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Cerebrospinal Fluid Pressure; Fundus Oculi; Hum	2000
Sleep apnea and intracranial hypertension in men. Ophthalmology, 2002, Volume: 109, Issue:3 Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Humans; Intracranial Pressure; Male; Middle Age	2002
Clinical features of late-onset pseudotumor cerebri fulfilling the modified dandy criteria. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2002, Volume: 22, Issue:1 Topics: Acetazolamide; Adult; Age of Onset; Aged; Aged, 80 and over; Carbonic Anhydrase Inhibitors; Diuretic	2002
Asymptomatic idiopathic intracranial hypertension in young children. Journal of child neurology, 2002, Volume: 17, Issue:3 Topics: Acetazolamide; Brain; Carbonic Anhydrase Inhibitors; Child, Preschool; Headache; Humans; Male; Papil	2002
Asymptomatic unilateral papilledema in pseudotumor cerebri. Journal of clinical neuro-ophthalmology, 1992, Volume: 12, Issue:4 Topics: Acetazolamide; Adult; Female; Fluorescein Angiography; Fundus Oculi; Humans; Papilledema; Pseudotumo	1992
Visual loss in pseudotumor cerebri from branch retinal artery occlusion. American journal of ophthalmology, 1992, Mar-15, Volume: 113, Issue:3 Topics: Acetazolamide; Adolescent; Blindness; Female; Fundus Oculi; Glucocorticoids; Humans; Papilledema; Ps	1992
Unilateral papilledema in pseudotumor cerebri. Archives of ophthalmology (Chicago, Ill. : 1960), 1990, Volume: 108, Issue:5 Topics: Acetazolamide; Female; Fluorescein Angiography; Fundus Oculi; Humans; Middle Aged; Papilledema; Pseu	1990
Malignant pseudotumor cerebri. Report of two cases. Journal of neurosurgery, 1989, Volume: 71, Issue:3 Topics: Acetazolamide; Adolescent; Adult; Cerebrospinal Fluid Pressure; Cerebrospinal Fluid Shunts; Dexameth	1989
Pseudotumor cerebri in men. Archives of neurology, 1988, Volume: 45, Issue:8 Topics: Acetazolamide; Adolescent; Adult; Body Weight; Female; Humans; Hypertension; Male; Middle Aged; Obes	1988
Pseudotumor cerebri. American family physician, 1987, Volume: 35, Issue:1 Topics: Acetazolamide; Adult; Atenolol; Cerebrospinal Fluid Shunts; Female; Humans; Intracranial Pressure; P	1987
Spectrum of benign intracranial hypertension in children and adolescents. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1985, Volume: 1, Issue:2 Topics: Acetazolamide; Adolescent; Anti-Bacterial Agents; Brain Concussion; Cerebrospinal Fluid Shunts; Chil	1985
Retinal hemorrhage at high altitude. The New England journal of medicine, 1970, May-21, Volume: 282, Issue:21 Topics: Acetazolamide; Adaptation, Physiological; Altitude; Fundus Oculi; Furosemide; Humans; Papilledema; P	1970
Preservation of visual function in papilloedema observed for 3 to 6 years in cases of benign intracranial hypertension. The British journal of ophthalmology, 1968, Volume: 52, Issue:3 Topics: Acetazolamide; Adolescent; Adult; Cerebrospinal Fluid; Child; Exudates and Transudates; Female; Fund	1968
Papilledema and idiopathic intracranial hypertension. The New England journal of medicine, 1969, Apr-24, Volume: 280, Issue:17 Topics: Acetazolamide; Adult; Dexamethasone; Female; Humans; Hypertension; Intracranial Pressure; Papilledem	1969
Perspective on an altitude problem. The New England journal of medicine, 1969, Jan-23, Volume: 280, Issue:4 Topics: Acetazolamide; Altitude; Furosemide; Humans; Hypoxia; Neurologic Manifestations; Papilledema; Pulmon	1969

acetazolamide and Papilledema