acetazolamide has been researched along with Neuralgia in 12 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we show that inhibition of spinal CA activity with acetazolamide (ACT) reduces neuropathic allodynia." | 3.76 | Acetazolamide and midazolam act synergistically to inhibit neuropathic pain. ( Asiedu, M; Kaila, K; Ossipov, MH; Price, TJ, 2010) |
| "Neuropathic pain affects up to 8% of the population with few therapeutic options for its management." | 2.53 | Carbonic anhydrase inhibition and the management of neuropathic pain. ( Supuran, CT, 2016) |
| "In vivo experiments on a model of neuropathic pain induced by oxaliplatin clearly showed 11 being an effective pain relieving agent and therefore worth of further exploitation towards the validation of the hCA VII as new target for the management of neuropathies." | 1.72 | Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain. ( Akgül, Ö; Angeli, A; Buonanno, M; Carta, F; D'Ambrosio, K; De Simone, G; Ghelardini, C; Lucarini, E; Mannelli, LDC; Monti, SM; Supuran, CT, 2022) |
| "The concomitant anti-neuropathic pain and antiproliferative effects of the new chalcogenide-based CA inhibitors represent an innovative approach for the counteraction and management of side effects associated with clinically platinum drugs as antitumor agents." | 1.62 | Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action. ( Angeli, A; Capperucci, A; Carradori, S; Carta, F; Ferraroni, M; Ghelardini, C; Lucarini, E; Lupori, L; Mannelli, L; Micheli, L; Supuran, CT; Tanini, D; Zara, S, 2021) |
| "The behavioral features of neuropathic pain are not sexually dimorphic despite sex differences in the underlying neuroimmune signaling." | 1.51 | Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes. ( De Koninck, Y; Gauthier, C; Lee, KY; Lorenzo, LE; Mapplebeck, JCS; Muley, MM; Prescott, SA; Salter, MW, 2019) |
| "In a mice model of neuropathic pain induced by oxaliplatin, some of the strong CA II/VII inhibitors induced a long lasting pain relieving effect." | 1.48 | Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects. ( Angeli, A; di Cesare Mannelli, L; Ghelardini, C; Lucarini, E; Peat, TS; Supuran, CT, 2018) |
| "In a mice model of neuropathic pain induced by oxaliplatin, one of the strong CA II/VII inhibitors reported here induced a long lasting pain relieving effect, a fact never observed earlier." | 1.42 | A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects. ( Carta, F; Di Cesare Mannelli, L; Ghelardini, C; McKenna, R; Pinard, M; Scozzafava, A; Supuran, CT, 2015) |
| " Finally, we demonstrate that systemic administration of acetazolamide to rats with PNI produces an antiallodynic effect by itself and an enhancement of the peak analgesic effect with a change in the shape of the dose-response curve of the α1-sparing benzodiazepine L-838,417." | 1.40 | Inhibition of carbonic anhydrase augments GABAA receptor-mediated analgesia via a spinal mechanism of action. ( Asiedu, MN; Hübner, CA; Kaila, K; Mejia, GL; Price, TJ, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 4 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Carta, F | 4 |
| Di Cesare Mannelli, L | 4 |
| Pinard, M | 1 |
| Ghelardini, C | 6 |
| Scozzafava, A | 1 |
| McKenna, R | 1 |
| Supuran, CT | 7 |
| Angeli, A | 4 |
| Lucarini, E | 3 |
| Peat, TS | 2 |
| Bartolucci, G | 2 |
| Menicatti, M | 1 |
| Nocentini, A | 1 |
| Alterio, V | 1 |
| Bua, S | 1 |
| Micheli, L | 2 |
| Esposito, D | 1 |
| Buonanno, M | 2 |
| Osman, SM | 1 |
| ALOthman, ZA | 1 |
| Cirilli, R | 1 |
| Pierini, M | 1 |
| Monti, SM | 2 |
| Gratteri, P | 1 |
| De Simone, G | 2 |
| Tanini, D | 1 |
| Carradori, S | 1 |
| Capperucci, A | 1 |
| Lupori, L | 1 |
| Zara, S | 1 |
| Ferraroni, M | 1 |
| Mannelli, L | 1 |
| Akgül, Ö | 1 |
| Mannelli, LDC | 1 |
| D'Ambrosio, K | 1 |
| Da Vitoria Lobo, ME | 1 |
| Weir, N | 1 |
| Hardowar, L | 1 |
| Al Ojaimi, Y | 1 |
| Madden, R | 1 |
| Gibson, A | 1 |
| Bestall, SM | 1 |
| Hirashima, M | 1 |
| Schaffer, CB | 1 |
| Donaldson, LF | 1 |
| Bates, DO | 1 |
| Hulse, RP | 1 |
| Mapplebeck, JCS | 1 |
| Lorenzo, LE | 1 |
| Lee, KY | 1 |
| Gauthier, C | 1 |
| Muley, MM | 1 |
| De Koninck, Y | 1 |
| Prescott, SA | 1 |
| Salter, MW | 1 |
| Asiedu, MN | 1 |
| Mejia, GL | 1 |
| Hübner, CA | 1 |
| Kaila, K | 2 |
| Price, TJ | 2 |
| Medrano, MC | 1 |
| Dhanasobhon, D | 1 |
| Yalcin, I | 1 |
| Schlichter, R | 1 |
| Cordero-Erausquin, M | 1 |
| Asiedu, M | 1 |
| Ossipov, MH | 1 |
1 review available for acetazolamide and Neuralgia
| Article | Year |
|---|---|
Carbonic anhydrase inhibition and the management of neuropathic pain.
Topics: Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Neuralgia; Sulfa | 2016 |
11 other studies available for acetazolamide and Neuralgia
| Article | Year |
|---|---|
A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.
Topics: Analgesics; Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Crystallography, X-Ray; Hum | 2015 |
Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.
Topics: Animals; Benzenesulfonamides; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Crystallography, X | 2018 |
Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.
Topics: Analgesics; Animals; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Crys | 2019 |
Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy.
Topics: Animals; Antineoplastic Agents; Benzenesulfonamides; Carbonic Anhydrase II; Carbonic Anhydrase Inhib | 2020 |
Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydr | 2021 |
Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain.
Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Crystallography, X-Ray; Dose-Response R | 2022 |
Hypoxia-induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain.
Topics: Acetazolamide; Animals; Carbonic Anhydrases; Glucose Transport Proteins, Facilitative; Hyperalgesia; | 2022 |
Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes.
Topics: Acetazolamide; Animals; Brain-Derived Neurotrophic Factor; Carbonic Anhydrase Inhibitors; Chlorides; | 2019 |
Inhibition of carbonic anhydrase augments GABAA receptor-mediated analgesia via a spinal mechanism of action.
Topics: Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Disease Models, Animal; | 2014 |
Loss of inhibitory tone on spinal cord dorsal horn spontaneously and nonspontaneously active neurons in a mouse model of neuropathic pain.
Topics: Acetazolamide; Action Potentials; Animals; Carbonic Anhydrase Inhibitors; Disease Models, Animal; Mi | 2016 |
Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.
Topics: Acetazolamide; Anesthetics, Intravenous; Animals; Carbonic Anhydrase Inhibitors; Disease Models, Ani | 2010 |