Page last updated: 2024-10-22

acetazolamide and Nephrotic Syndrome

acetazolamide has been researched along with Nephrotic Syndrome in 13 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Nephrotic Syndrome: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.

Research Excerpts

ExcerptRelevanceReference
"The extent and nature of furosemide (F) binding to human albumin (HA) and to the plasma of 6 children with nephrotic syndrome were studied by equilibrium dialysis at 37 degrees C and pH 7."3.65Furosemide binding to human albumin and plasma of nephrotic children. ( Prandota, J; Pruitt, AW, 1975)
"A 6-year-old girl developed symptoms of benign intracranial hypertension following reduction of oral corticosteroid therapy."1.30[Benign intracranial hypertension: an unrecognized complication of corticosteroid therapy]. ( Bader-Meunier, B; Dommergues, JP; Lorrot, M; Sébire, G, 1999)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19909 (69.23)18.7374
1990's3 (23.08)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Vizcarra-Vizcarra, CA1
Chávez-Velázquez, E1
Asato-Higa, C1
Hurtado-Aréstegui, A1
BERNARD, R1
MAESTRAGGI, P1
CASTERET, P1
SLATER, JD1
NABARRO, JD1
ARNEIL, GC1
EALES, L1
SAUNDERS, SJ1
BURCH, GE1
WHITE, HA1
CHIAVERINI, R1
CANNON, PJ1
HEINEMANN, HO1
STASON, WB1
LARAGH, JH1
Knauf, H1
Mutschler, E1
Lorrot, M1
Bader-Meunier, B1
Sébire, G1
Dommergues, JP1
Prandota, J1
Pruitt, AW1
Firth, JD1
Ledingham, JG1
Leiter, L1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Resistant Hypertension On Treatment - Sequential Nephron Blockade Compared to Dual Blockade of the Renin-angiotensin-aldosterone System Plus Bisoprolol in the Treatment of Resistant Arterial Hypertension: A Randomized Trial (ResHypOT)[NCT02832973]Phase 472 participants (Actual)Interventional2015-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for acetazolamide and Nephrotic Syndrome

ArticleYear
Combinations of diuretics in the treatment of edema.
    American heart journal, 1970, Volume: 80, Issue:3

    Topics: Acetazolamide; Benzothiadiazines; Chlorthalidone; Diuretics; Edema; Ethacrynic Acid; Furosemide; Glu

1970

Other Studies

12 other studies available for acetazolamide and Nephrotic Syndrome

ArticleYear
Treatment of Focal and Segmental Glomerulosclerosis Secondary to High Altitude Polycythemia with Acetazolamide.
    High altitude medicine & biology, 2022, Volume: 23, Issue:3

    Topics: Acetazolamide; Adult; Altitude; Altitude Sickness; COVID-19; Female; Glomerulosclerosis, Focal Segme

2022
[Acetozoleamide as diuresis inducing factor in lipoid nephrosis].
    Pediatrie, 1957, Volume: 12, Issue:1

    Topics: Acetazolamide; Diuresis; Humans; Nephrosis, Lipoid; Nephrotic Syndrome

1957
Clinical experience with chlorothiazide.
    Lancet (London, England), 1958, Jan-18, Volume: 1, Issue:7012

    Topics: Acetazolamide; Ascites; Chlorothiazide; Gastrointestinal Diseases; Heart Failure; Hypertension; Hype

1958
Nephrosis and its management.
    The Practitioner, 1958, Volume: 181, Issue:1083

    Topics: Acetazolamide; Anti-Bacterial Agents; Dermatologic Agents; Disease Management; Nephrosis; Nephrotic

1958
The treatment of the nephrotic syndrome with particular reference to the steroids and the diuretics.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1958, Dec-20, Volume: 32, Issue:51

    Topics: Acetazolamide; Adrenal Cortex Hormones; Diuretics; Humans; Nephrotic Syndrome

1958
The use of chlorothiazide in the nephrotic syndrome.
    A.M.A. archives of internal medicine, 1959, Volume: 103, Issue:3

    Topics: Acetazolamide; Chlorothiazide; Nephrotic Syndrome

1959
[DIURETIC THERAPEUTICS].
    Revista da Associacao Medica Brasileira, 1963, Volume: 9

    Topics: Acetazolamide; Aminophylline; Chlorothiazide; Diuretics; Edema; Ethylenediamines; Heart Failure; Liv

1963
ETHACRYNIC ACID: EFFECTIVENESS AND MODE OF DIURETIC ACTION IN MAN.
    Circulation, 1965, Volume: 31

    Topics: Acetazolamide; Acidosis; Acidosis, Renal Tubular; Alkalosis; Ascites; Carbonic Anhydrase Inhibitors;

1965
Sequential nephron blockade breaks resistance to diuretics in edematous states.
    Journal of cardiovascular pharmacology, 1997, Volume: 29, Issue:3

    Topics: Acetazolamide; Adult; Ascites; Diuresis; Diuretics; Edema; Female; Furosemide; Heart Failure; Humans

1997
[Benign intracranial hypertension: an unrecognized complication of corticosteroid therapy].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1999, Volume: 6, Issue:1

    Topics: Acetazolamide; Administration, Oral; Anti-Inflammatory Agents; Child; Combined Modality Therapy; Diu

1999
Furosemide binding to human albumin and plasma of nephrotic children.
    Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:2

    Topics: Acetazolamide; Aspirin; Child; Diazoxide; Dose-Response Relationship, Drug; Female; Furosemide; Huma

1975
Effect of natriuretic agents, vasoactive agents and of the inhibition of metabolism on sodium handling in the isolated perfused kidney of the nephrotic rat.
    Clinical science (London, England : 1979), 1990, Volume: 79, Issue:6

    Topics: Acetazolamide; Amiloride; Angiotensin II; Animals; Atrial Natriuretic Factor; Furosemide; Kidney; Ma

1990