acetazolamide has been researched along with Neoplasm Metastasis in 4 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histology revealed squamous cell carcinoma." | 1.62 | Iris metastasis as the initial presentation of metastatic esophageal cancer diagnosed by fine needle aspiration biopsy: A case report. ( Horiuchi, N; Kuribayashi, T; Kurihara, T; Ozawa, H; Smith, LEH; Takano, Y; Tomita, Y; Tsubota, K; Usui, Y, 2021) |
| "Its most potent inhibition rate on lung metastases was reach to 77." | 1.32 | The protein profile of acetazolamide-treated sera in mice bearing Lewis neoplasm. ( Li, XJ; Ma, B; Xiang, Y; Yu, HM, 2004) |
| "Acetazolamide can suppress tumor metastasis, at least in part, by inhibiting the expression of AQP1." | 1.31 | Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma. ( Li, T; Li, XJ; Ma, B; Xiang, Y; Yu, HM, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pacchiano, F | 1 |
| Carta, F | 1 |
| McDonald, PC | 1 |
| Lou, Y | 1 |
| Vullo, D | 1 |
| Scozzafava, A | 1 |
| Dedhar, S | 1 |
| Supuran, CT | 1 |
| Ozawa, H | 1 |
| Usui, Y | 1 |
| Takano, Y | 1 |
| Horiuchi, N | 1 |
| Kuribayashi, T | 1 |
| Kurihara, T | 1 |
| Smith, LEH | 1 |
| Tsubota, K | 1 |
| Tomita, Y | 1 |
| Xiang, Y | 2 |
| Ma, B | 2 |
| Li, T | 1 |
| Yu, HM | 2 |
| Li, XJ | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label, Multi-center, Phase 1b Study to Investigate the Safety and Tolerability of SLC-0111 (WBI-5111) in Combination With Gemcitabine in Metastatic Pancreatic Ductal Adenocarcinoma Subjects Positive for Carbonic Anhydrase IX[NCT03450018] | Phase 1/Phase 2 | 30 participants (Anticipated) | Interventional | 2019-01-10 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for acetazolamide and Neoplasm Metastasis
| Article | Year |
|---|---|
Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.
Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Benzene Derivatives; Carbonic Anhydrase IX; Carb | 2011 |
Iris metastasis as the initial presentation of metastatic esophageal cancer diagnosed by fine needle aspiration biopsy: A case report.
Topics: Acetazolamide; Administration, Oral; Aged; Anterior Chamber; Biopsy, Fine-Needle; Carbonic Anhydrase | 2021 |
Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma.
Topics: Acetazolamide; Actins; Animals; Antineoplastic Agents; Aquaporin 1; Aquaporins; Carcinoma, Lewis Lun | 2002 |
The protein profile of acetazolamide-treated sera in mice bearing Lewis neoplasm.
Topics: Acetazolamide; Administration, Oral; Animals; Antineoplastic Agents; Blood Proteins; Carbonic Anhydr | 2004 |