Page last updated: 2024-10-22

acetazolamide and Neoplasm Metastasis

acetazolamide has been researched along with Neoplasm Metastasis in 4 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

Research Excerpts

ExcerptRelevanceReference
"Histology revealed squamous cell carcinoma."1.62Iris metastasis as the initial presentation of metastatic esophageal cancer diagnosed by fine needle aspiration biopsy: A case report. ( Horiuchi, N; Kuribayashi, T; Kurihara, T; Ozawa, H; Smith, LEH; Takano, Y; Tomita, Y; Tsubota, K; Usui, Y, 2021)
"Its most potent inhibition rate on lung metastases was reach to 77."1.32The protein profile of acetazolamide-treated sera in mice bearing Lewis neoplasm. ( Li, XJ; Ma, B; Xiang, Y; Yu, HM, 2004)
"Acetazolamide can suppress tumor metastasis, at least in part, by inhibiting the expression of AQP1."1.31Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma. ( Li, T; Li, XJ; Ma, B; Xiang, Y; Yu, HM, 2002)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Pacchiano, F1
Carta, F1
McDonald, PC1
Lou, Y1
Vullo, D1
Scozzafava, A1
Dedhar, S1
Supuran, CT1
Ozawa, H1
Usui, Y1
Takano, Y1
Horiuchi, N1
Kuribayashi, T1
Kurihara, T1
Smith, LEH1
Tsubota, K1
Tomita, Y1
Xiang, Y2
Ma, B2
Li, T1
Yu, HM2
Li, XJ2

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open-label, Multi-center, Phase 1b Study to Investigate the Safety and Tolerability of SLC-0111 (WBI-5111) in Combination With Gemcitabine in Metastatic Pancreatic Ductal Adenocarcinoma Subjects Positive for Carbonic Anhydrase IX[NCT03450018]Phase 1/Phase 230 participants (Anticipated)Interventional2019-01-10Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

4 other studies available for acetazolamide and Neoplasm Metastasis

ArticleYear
Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.
    Journal of medicinal chemistry, 2011, Mar-24, Volume: 54, Issue:6

    Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Benzene Derivatives; Carbonic Anhydrase IX; Carb

2011
Iris metastasis as the initial presentation of metastatic esophageal cancer diagnosed by fine needle aspiration biopsy: A case report.
    Medicine, 2021, Jun-04, Volume: 100, Issue:22

    Topics: Acetazolamide; Administration, Oral; Aged; Anterior Chamber; Biopsy, Fine-Needle; Carbonic Anhydrase

2021
Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma.
    Acta pharmacologica Sinica, 2002, Volume: 23, Issue:8

    Topics: Acetazolamide; Actins; Animals; Antineoplastic Agents; Aquaporin 1; Aquaporins; Carcinoma, Lewis Lun

2002
The protein profile of acetazolamide-treated sera in mice bearing Lewis neoplasm.
    Life sciences, 2004, Jul-30, Volume: 75, Issue:11

    Topics: Acetazolamide; Administration, Oral; Animals; Antineoplastic Agents; Blood Proteins; Carbonic Anhydr

2004