Page last updated: 2024-10-22

acetazolamide and Myotonic Dystrophy

acetazolamide has been researched along with Myotonic Dystrophy in 4 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Myotonic Dystrophy: Neuromuscular disorder characterized by PROGRESSIVE MUSCULAR ATROPHY; MYOTONIA, and various multisystem atrophies. Mild INTELLECTUAL DISABILITY may also occur. Abnormal TRINUCLEOTIDE REPEAT EXPANSION in the 3' UNTRANSLATED REGIONS of DMPK PROTEIN gene is associated with Myotonic Dystrophy 1. DNA REPEAT EXPANSION of zinc finger protein-9 gene intron is associated with Myotonic Dystrophy 2.

Research Excerpts

ExcerptRelevanceReference
"Treatment with acetazolamide, 250 mg daily, decreased the myotonia markedly."5.26Treatment of myotonic dystrophy with acetazolamide. ( Kwieciński, H, 1980)
"Acetazolamide is effective treatment for myotonia in certain patients with myotonia congenita."1.27Effect of acetazolamide on insulin sensitivity in myotonic disorders. ( Corbett, A; Griggs, RC; Kingston, W; Moxley, RT, 1984)
"Treatment with acetazolamide, 250 mg daily, decreased the myotonia markedly."1.26Treatment of myotonic dystrophy with acetazolamide. ( Kwieciński, H, 1980)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19904 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kwieciński, H1
Corbett, A1
Kingston, W1
Griggs, RC3
Moxley, RT2
Torres, C1

Other Studies

4 other studies available for acetazolamide and Myotonic Dystrophy

ArticleYear
Treatment of myotonic dystrophy with acetazolamide.
    Journal of neurology, 1980, Volume: 222, Issue:4

    Topics: Acetazolamide; Adult; Humans; Male; Myotonic Dystrophy; Potassium

1980
Effect of acetazolamide on insulin sensitivity in myotonic disorders.
    Archives of neurology, 1984, Volume: 41, Issue:7

    Topics: Acetazolamide; Adult; Aged; Female; Glucose; Humans; Insulin; Male; Middle Aged; Myotonia Congenita;

1984
Quantitative testing of handgrip strength, myotonia, and fatigue in myotonic dystrophy.
    Journal of the neurological sciences, 1983, Volume: 60, Issue:1

    Topics: Acetazolamide; Adult; Aged; Electromyography; Female; Hand; Humans; Male; Middle Aged; Muscle Contra

1983
The myotonic disorders and the periodic paralyses.
    Advances in neurology, 1977, Volume: 17

    Topics: Acetazolamide; Benzothiadiazines; Diuretics; Humans; Male; Muscle Contraction; Myotonia; Myotonia Co

1977