Page last updated: 2024-10-22

acetazolamide and Migraine Disorders

acetazolamide has been researched along with Migraine Disorders in 31 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

Research Excerpts

ExcerptRelevanceReference
"Episodic ataxia type 2 is an autosomal dominant channelopathy, caused by genetic variants in the voltage-dependent calcium channel a-1 subunit (CACNA1A), which is characterized by intermittent episodes of vertigo and ataxia."5.72The efficacy of combining topiramate and 4-aminopyridine to reduce relapses and interictal progression in two cases of episodic ataxia type 2. ( Brieva-Ruiz, L; González-Mingot, C; López-Ortega, R, 2022)
"Acetazolamide was prescribed in seven patients; the mean duration of treatment was 6 months, and the daily dose ranged from 125 to 500 mg."5.38Acetazolamide for the prophylaxis of migraine in CADASIL: a preliminary experience. ( Bianchi, S; Donnini, I; Inzitari, D; Nannucci, S; Pantoni, L; Pescini, F; Valenti, R, 2012)
"Clinical details are given of different types of episodic ataxia: type 1, with myokymia, and attacks which usually last a few minutes, and may occur several times a day, and treatment with acetazolamide can reduce the number of attacks; type 2, with interictal nystagmus, and attacks which last for several hours to a day or more, and treatment with acetazolamide is very effective; paroxysmal choreoathetosis with episodic ataxia, with attacks lasting for about 20 min and occurring at varying intervals; and familial hemiplegic migraine, with transient hemiplegia presenting during the aura of a migraine headache, the symptoms improving on treatment with acetazolamide."4.80Episodic ataxia and channelopathies. ( Gordon, N, 1998)
"Patients with autism spectrum disorder and developmental delay or encephalopathy rarely demonstrate no or negligible hair and nail growth, suggesting a biotin-responsive clinical disorder."3.88Biotin and Acetazolamide for Treatment of an Unusual Child With Autism Plus Lack of Nail and Hair Growth. ( Benke, PJ; Duchowny, M; McKnight, D, 2018)
"The headache associated with idiopathic intracranial hypertension frequently has a migrainous phenotype."2.72Diagnosis and treatment of idiopathic intracranial hypertension. ( Hoffmann, J; Raoof, N, 2021)
"Familial hemiplegic migraine and episodic ataxia type 2 (EA2) are allelic disorders with distinct types of mutations in the CACNA1A gene."2.70Efficacy and tolerability of acetazolamide in migraine prophylaxis: a randomised placebo-controlled trial. ( Bousser, MG; Djomby, R; El-Amrani, M; Filipetti, V; Landais, P; Lutz, G; Massiou, H; Taupin, P; Vahedi, K, 2002)
"Of 131 women with hormonally related migraines unresponsive to standard medication, 67 (51."2.67Efficacy of danazol in the control of hormonal migraine. ( Bennett, RS; Daoud, Y; Lichten, EM; Whitty, AJ, 1991)
"Episodic ataxia type 2 is an autosomal dominant channelopathy, caused by genetic variants in the voltage-dependent calcium channel a-1 subunit (CACNA1A), which is characterized by intermittent episodes of vertigo and ataxia."1.72The efficacy of combining topiramate and 4-aminopyridine to reduce relapses and interictal progression in two cases of episodic ataxia type 2. ( Brieva-Ruiz, L; González-Mingot, C; López-Ortega, R, 2022)
"Vestibular migraine (VM) consists of recurrent episodes of vestibular symptoms that are accompanied by migraine in at least 50% of the episodes."1.56Analysis of the effectiveness of the prophylaxis of vestibular migraine depending on the diagnostic category and the prescribed drug. ( Álvarez-Morujo de Sande, MG; Bécares-Martínez, C; Domènech-Vadillo, E; Domínguez-Durán, E; González-Aguado, R; Guerra-Jiménez, G; Montilla-Ibáñez, MA, 2020)
"A presumed diagnosis of episodic ataxia type 2 was made and she became attack free on acetazolamide without recurrence."1.51A sleep modulated Channelopathy: a novel CACNA1A pathogenic variant identified in episodic Ataxia type 2 and a potential link to sleep alleviated migraine. ( Ahuja, AS; Atwal, PS; Rozen, TD, 2019)
"To describe a new subtype of chronic daily headache in women of a specific age group."1.48A New Subtype of Chronic Daily Headache Presenting in Older Women. ( Rozen, TD, 2018)
"Acetazolamide was effective in reducing both the frequency and severity of vertigo and headache attacks and this effect was more prominent for vertigo frequency and severity."1.43Acetazolamide in vestibular migraine prophylaxis: a retrospective study. ( Bilgen, C; Çelebisoy, N; Gökçay, F; Karahan, C; Karapolat, H; Kirazlı, T; Köse, T, 2016)
"We report a child with congenital ataxia, abnormal eye movements and developmental delay who presented severe attacks of hemiplegic migraine triggered by minor head traumas and associated with hemispheric swelling and seizures."1.40Congenital ataxia and hemiplegic migraine with cerebral edema associated with a novel gain of function mutation in the calcium channel CACNA1A. ( Al-Qusairi, L; Bonafé, L; García Segarra, N; Gautschi, I; Kallay Zetchi, C; Maeder, P; Mittaz-Crettol, L; Roulet-Perez, E; Schild, L; Van Bemmelen, MX, 2014)
"Acetazolamide was prescribed in seven patients; the mean duration of treatment was 6 months, and the daily dose ranged from 125 to 500 mg."1.38Acetazolamide for the prophylaxis of migraine in CADASIL: a preliminary experience. ( Bianchi, S; Donnini, I; Inzitari, D; Nannucci, S; Pantoni, L; Pescini, F; Valenti, R, 2012)
"Twelve age-matched migraine patients and 14 healthy subjects served as control groups."1.32The cerebral hemodynamics of headache associated with sexual activity. ( Evers, S; Frese, A; Husstedt, IW; Ringelstein, EB; Schmidt, O, 2003)
"Patients suffering from migraine showed a significant increase in global CBF values after acetazolamide provocation (paired t test, P<0."1.31Quantitative assessment of blood flow reserve using 99mTc-HMPAO in carotid stenosis. ( Bánk, J; Ficzere, A; Galuska, L; Garai, I; Olvasztó, S; Szomják, E; Tóth, C; Varga, J, 2002)
"The association of FHM and cerebellar ataxia has been reported in a small number of FHM families, all linked to chromosome 19."1.30A new CACNA1A gene mutation in acetazolamide-responsive familial hemiplegic migraine and ataxia. ( Battistini, N; Battistini, S; Carrera, P; Ferrari, M; Gelfi, C; Giannini, F; Guazzi, GC; Piatti, M; Righetti, PG; Rocchi, R; Stenirri, S, 1999)
"We report two cases of idiopathic intracranial hypertension causing chronic daily headache with migrainous features in the absence of associated papilledema."1.29Chronic daily headache with migrainous features due to papilledema-negative idiopathic intracranial hypertension. ( Huff, AL; Hupp, SL; Rothrock, JF, 1996)
"Three patients with migraine with aura had less pronounced regional hypoperfusion compared to baseline."1.28The influence of acetazolamide on cerebral low-flow regions in migraine--an interictal 99mTc-HMPAO SPECT study. ( Böttger, IG; Grotemeyer, KH; Husstedt, IW; Oberwittler, C; Schlake, HP; Schober, O, 1992)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.23)18.7374
1990's9 (29.03)18.2507
2000's7 (22.58)29.6817
2010's11 (35.48)24.3611
2020's3 (9.68)2.80

Authors

AuthorsStudies
González-Mingot, C1
López-Ortega, R1
Brieva-Ruiz, L1
Ahuja, AS1
Rozen, TD2
Atwal, PS1
Domínguez-Durán, E1
Montilla-Ibáñez, MA1
Álvarez-Morujo de Sande, MG1
Domènech-Vadillo, E1
Bécares-Martínez, C1
González-Aguado, R1
Guerra-Jiménez, G1
Raoof, N1
Hoffmann, J1
Benke, PJ1
Duchowny, M1
McKnight, D1
García Segarra, N1
Gautschi, I1
Mittaz-Crettol, L1
Kallay Zetchi, C1
Al-Qusairi, L1
Van Bemmelen, MX1
Maeder, P1
Bonafé, L1
Schild, L1
Roulet-Perez, E1
Ranieri, A1
Topa, A1
Cavaliere, M1
De Simone, R1
Mallery, RM1
Friedman, DI1
Liu, GT1
Çelebisoy, N1
Gökçay, F1
Karahan, C1
Bilgen, C1
Kirazlı, T1
Karapolat, H1
Köse, T1
Llovet-Rausell, A1
Ruiz Tolosa, F1
Kudsieh, B1
Suzuki, M1
Fujiwara, K1
Tsubuku, T1
Yabe, I1
Sasaki, H1
Fukuda, S1
Altinok, D1
Agarwal, A1
Ascadi, G1
Luat, A1
Tapos, D1
Donnini, I1
Nannucci, S1
Valenti, R1
Pescini, F1
Bianchi, S1
Inzitari, D1
Pantoni, L1
van den Maagdenberg, AM1
Plomp, JJ1
Evers, S1
Schmidt, O1
Frese, A1
Husstedt, IW2
Ringelstein, EB1
Helling, K1
Scherer, H1
Seet, RC1
Lim, EC1
Mathew, NT1
Ravishankar, K1
Sanin, LC1
Valikovics, A1
Oláh, L1
Fülesdi, B1
Káposzta, Z1
Ficzere, A2
Bereczki, D1
Csiba, L1
Huff, AL1
Hupp, SL1
Rothrock, JF1
Athwal, BS1
Lennox, GG1
Gordon, N1
Weller, M1
Dichgans, J1
Klockgether, T1
Battistini, S1
Stenirri, S1
Piatti, M1
Gelfi, C1
Righetti, PG1
Rocchi, R1
Giannini, F1
Battistini, N1
Guazzi, GC1
Ferrari, M1
Carrera, P1
Forteza, AM1
Brozman, B1
Rabinstein, AA1
Romano, JG1
Bradley, WG1
Garai, I1
Varga, J1
Szomják, E1
Tóth, C1
Bánk, J1
Olvasztó, S1
Galuska, L1
Vahedi, K1
Taupin, P1
Djomby, R1
El-Amrani, M1
Lutz, G1
Filipetti, V1
Landais, P1
Massiou, H1
Bousser, MG1
Schlake, HP1
Böttger, IG1
Grotemeyer, KH1
Oberwittler, C1
Schober, O1
Lichten, EM1
Bennett, RS1
Whitty, AJ1
Daoud, Y1
Siemes, H1
Casaer, P1

Reviews

3 reviews available for acetazolamide and Migraine Disorders

ArticleYear
Diagnosis and treatment of idiopathic intracranial hypertension.
    Cephalalgia : an international journal of headache, 2021, Volume: 41, Issue:4

    Topics: Acetazolamide; Analgesics; Headache; Headache Disorders; Humans; Intracranial Hypertension; Migraine

2021
Headache and the pseudotumor cerebri syndrome.
    Current pain and headache reports, 2014, Volume: 18, Issue:9

    Topics: Acetazolamide; Back Pain; Diagnosis, Differential; Diuretics; Fructose; Furosemide; Headache Disorde

2014
Episodic ataxia and channelopathies.
    Brain & development, 1998, Volume: 20, Issue:1

    Topics: Acetazolamide; Ataxia; Athetosis; Cerebellar Ataxia; Chorea; Hemiplegia; Humans; Ion Channels; Migra

1998

Trials

3 trials available for acetazolamide and Migraine Disorders

ArticleYear
Neuromuscular synapse function in typical migraine.
    Cephalalgia : an international journal of headache, 2003, Volume: 23, Issue:2

    Topics: Acetazolamide; Adult; Calcium Channels, N-Type; Electromyography; Female; Follow-Up Studies; Humans;

2003
Efficacy and tolerability of acetazolamide in migraine prophylaxis: a randomised placebo-controlled trial.
    Journal of neurology, 2002, Volume: 249, Issue:2

    Topics: Acetazolamide; Adolescent; Adult; Aged; Bicarbonates; Blood Pressure; Calcium Channels, P-Type; Carb

2002
Efficacy of danazol in the control of hormonal migraine.
    The Journal of reproductive medicine, 1991, Volume: 36, Issue:6

    Topics: Acetazolamide; Adult; Combined Modality Therapy; Danazol; Drug Therapy, Combination; Female; Humans;

1991

Other Studies

25 other studies available for acetazolamide and Migraine Disorders

ArticleYear
The efficacy of combining topiramate and 4-aminopyridine to reduce relapses and interictal progression in two cases of episodic ataxia type 2.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022, Volume: 43, Issue:8

    Topics: 4-Aminopyridine; Acetazolamide; Adult; Ataxia; Cerebellar Ataxia; Female; Humans; Male; Middle Aged;

2022
A sleep modulated Channelopathy: a novel CACNA1A pathogenic variant identified in episodic Ataxia type 2 and a potential link to sleep alleviated migraine.
    BMC neurology, 2019, Oct-22, Volume: 19, Issue:1

    Topics: Acetazolamide; Adult; Ataxia; Calcium Channels; Carbonic Anhydrase Inhibitors; Channelopathies; Codo

2019
Analysis of the effectiveness of the prophylaxis of vestibular migraine depending on the diagnostic category and the prescribed drug.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2020, Volume: 277, Issue:4

    Topics: Acetazolamide; Amitriptyline; Analgesics; Central Nervous System Agents; Flunarizine; Humans; Migrai

2020
A New Subtype of Chronic Daily Headache Presenting in Older Women.
    Journal of women's health (2002), 2018, Volume: 27, Issue:2

    Topics: Acetazolamide; Cerebrospinal Fluid Pressure; Female; Head-Down Tilt; Headache Disorders; Humans; Mid

2018
Biotin and Acetazolamide for Treatment of an Unusual Child With Autism Plus Lack of Nail and Hair Growth.
    Pediatric neurology, 2018, Volume: 79

    Topics: Acetazolamide; Anticonvulsants; Autism Spectrum Disorder; Biotin; Child; Female; Hair Diseases; Huma

2018
Congenital ataxia and hemiplegic migraine with cerebral edema associated with a novel gain of function mutation in the calcium channel CACNA1A.
    Journal of the neurological sciences, 2014, Jul-15, Volume: 342, Issue:1-2

    Topics: Acetazolamide; Adolescent; Animals; Ataxia; Brain Edema; Calcium Channels; Cerebellar Ataxia; Child;

2014
Recurrent epistaxis following stabbing headache responsive to acetazolamide.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014, Volume: 35 Suppl 1

    Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Chronic Disease; Epistaxis; Female; Headache Disorders

2014
Acetazolamide in vestibular migraine prophylaxis: a retrospective study.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2016, Volume: 273, Issue:10

    Topics: Acetazolamide; Adult; Aged; Analgesics; Female; Headache; Humans; Male; Middle Aged; Migraine Disord

2016
Severe ocular side effects with acetazolamide: case report.
    Archivos de la Sociedad Espanola de Oftalmologia, 2016, Volume: 91, Issue:11

    Topics: Acetazolamide; Acute Disease; Adult; Brimonidine Tartrate; Cyclopentolate; Drug Therapy, Combination

2016
Time course of downbeat positioning nystagmus in familial hemiplegic migraine type 1 treated with acetazolamide.
    Journal of the neurological sciences, 2016, Sep-15, Volume: 368

    Topics: Acetazolamide; Anticonvulsants; Cerebellar Ataxia; Family Health; Humans; Magnetic Resonance Imaging

2016
Pediatric hemiplegic migraine: susceptibility weighted and MR perfusion imaging abnormality.
    Pediatric radiology, 2010, Volume: 40, Issue:12

    Topics: Acetazolamide; Anticonvulsants; Brain; Child; Female; Hemiplegia; Humans; Magnetic Resonance Angiogr

2010
Acetazolamide for the prophylaxis of migraine in CADASIL: a preliminary experience.
    The journal of headache and pain, 2012, Volume: 13, Issue:4

    Topics: Acetazolamide; Adult; Aged; Anticonvulsants; CADASIL; Female; Humans; Male; Middle Aged; Migraine Di

2012
The cerebral hemodynamics of headache associated with sexual activity.
    Pain, 2003, Volume: 102, Issue:1-2

    Topics: Acetazolamide; Adult; Anticonvulsants; Case-Control Studies; Cerebral Cortex; Female; Headache Disor

2003
[Vertigo attacks -- current therapy].
    Laryngo- rhino- otologie, 2005, Volume: 84, Issue:11

    Topics: Acetazolamide; Adult; Aged; Betahistine; Dexamethasone; Ear, Middle; Gentamicins; Humans; Injections

2005
A case of intermittent ataxia associated with migraine headaches.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2007, Sep-11, Volume: 177, Issue:6

    Topics: Acetazolamide; Adult; Anticonvulsants; Ataxia; Diagnosis, Differential; Female; Humans; Migraine Dis

2007
Coexistence of migraine and idiopathic intracranial hypertension without papilledema.
    Neurology, 1996, Volume: 46, Issue:5

    Topics: Acetazolamide; Adolescent; Adult; Dihydroergotamine; Diuretics; Ergotamine; Female; Follow-Up Studie

1996
Cerebrovascular reactivity measured by transcranial Doppler in migraine.
    Headache, 1996, Volume: 36, Issue:5

    Topics: Acetazolamide; Adult; Blood Flow Velocity; Cerebral Arteries; Cerebrovascular Circulation; Female; H

1996
Chronic daily headache with migrainous features due to papilledema-negative idiopathic intracranial hypertension.
    Cephalalgia : an international journal of headache, 1996, Volume: 16, Issue:6

    Topics: Acetazolamide; Adult; Chronic Disease; Female; Headache; Humans; Intracranial Pressure; Middle Aged;

1996
Acetazolamide responsiveness in familial hemiplegic migraine.
    Annals of neurology, 1996, Volume: 40, Issue:5

    Topics: Acetazolamide; Adult; Brain; Cerebellar Ataxia; Female; Hemiplegia; Humans; Magnetic Resonance Imagi

1996
Acetazolamide-responsive migraine in CADASIL.
    Neurology, 1998, Volume: 50, Issue:5

    Topics: Acetazolamide; Cerebral Arterial Diseases; Dementia, Multi-Infarct; Genes, Dominant; Humans; Leukoen

1998
A new CACNA1A gene mutation in acetazolamide-responsive familial hemiplegic migraine and ataxia.
    Neurology, 1999, Jul-13, Volume: 53, Issue:1

    Topics: Acetazolamide; Adult; Aged; Amino Acid Sequence; Amino Acid Substitution; Animals; Brain; Calcium Ch

1999
Acetazolamide for the treatment of migraine with aura in CADASIL.
    Neurology, 2001, Dec-11, Volume: 57, Issue:11

    Topics: Acetazolamide; Adult; Brain; Dementia, Multi-Infarct; Diagnosis, Differential; Female; Homeostasis;

2001
Quantitative assessment of blood flow reserve using 99mTc-HMPAO in carotid stenosis.
    European journal of nuclear medicine and molecular imaging, 2002, Volume: 29, Issue:2

    Topics: Acetazolamide; Adult; Aged; Carotid Stenosis; Case-Control Studies; Cerebrovascular Circulation; Fem

2002
The influence of acetazolamide on cerebral low-flow regions in migraine--an interictal 99mTc-HMPAO SPECT study.
    Cephalalgia : an international journal of headache, 1992, Volume: 12, Issue:5

    Topics: Acetazolamide; Adult; Cerebrovascular Circulation; Female; Humans; Male; Middle Aged; Migraine Disor

1992
[Alternating hemiplegia in childhood. Clinical report and single photon emission computed tomography study].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1988, Volume: 136, Issue:8

    Topics: Acetazolamide; Aspirin; Brain Ischemia; Cerebral Cortex; Child, Preschool; Chloral Hydrate; Drug The

1988