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acetazolamide and Lung Diseases, Obstructive

acetazolamide has been researched along with Lung Diseases, Obstructive in 16 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Lung Diseases, Obstructive: Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.

Research Excerpts

ExcerptRelevanceReference
"To compare two dosing regimens of acetazolamide for the reversal of metabolic alkalosis in mechanically ventilated patients with asthma or chronic obstructive pulmonary disease."9.09Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial. ( Devlin, JW; Iannuzzi, MC; Jankowski, MA; Mazur, JE; Peters, MJ; Zarowitz, BJ, 1999)
"Acetazolamide, an inhibitor of carbonic anhydrase, which catalyzes hydration/dehydration of carbon dioxide, has been used for correction of metabolic alkalosis in patients with chronic obstructive pulmonary disease (COPD)."7.66Carbon dioxide elimination after acetazolamide in patients with chronic obstructive pulmonary disease and metabolic alkalosis. ( Berthelsen, P; Brøckner, J; Haxholdt, OS; Krintel, JJ, 1983)
"To compare two dosing regimens of acetazolamide for the reversal of metabolic alkalosis in mechanically ventilated patients with asthma or chronic obstructive pulmonary disease."5.09Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial. ( Devlin, JW; Iannuzzi, MC; Jankowski, MA; Mazur, JE; Peters, MJ; Zarowitz, BJ, 1999)
"To assess the responsiveness of the cerebral vessels to chronic hypercapnia, we measured middle cerebral artery flow velocity by transcranial Doppler ultrasound in 20 normal subjects and in 14 COLD patients before and after stimulation by progressive hypercapnia (rebreathing test) or by intravenous administration of an acetazolamide bolus."3.68Cerebral vascular responsiveness in chronic hypercapnia. ( Cavestri, R; Ciofetti, M; Clivati, A; Longhini, E, 1992)
"Acetazolamide, an inhibitor of carbonic anhydrase, which catalyzes hydration/dehydration of carbon dioxide, has been used for correction of metabolic alkalosis in patients with chronic obstructive pulmonary disease (COPD)."3.66Carbon dioxide elimination after acetazolamide in patients with chronic obstructive pulmonary disease and metabolic alkalosis. ( Berthelsen, P; Brøckner, J; Haxholdt, OS; Krintel, JJ, 1983)
"Patients with chronic obstructive pulmonary diseases (COPD) and/or central sleep apnea are sometimes treated with the carbonic anhydrase inhibitor acteazolamide to improve blood gas values."1.31Low-dose acetazolamide does affect respiratory muscle function in spontaneously breathing anesthetized rabbits. ( Kiwull, PJ; Kiwull-Schöne, HF; Teppema, LJ, 2001)
"Patients with mixed chronic respiratory acidosis and metabolic alkalosis constitute a common subgroup of patients with chronic obstructive lung disease and carbon dioxide retention; these patients benefit from correction of the metabolic alkalosis."1.26Effect of metabolic alkalosis on respiratory function in patients with chronic obstructive lung disease. ( Bear, R; Feldman, R; Goldstein, M; Halperin, M; Hammeke, M; Handelsman, S; Ho, M; Phillipson, E, 1977)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19908 (50.00)18.7374
1990's7 (43.75)18.2507
2000's1 (6.25)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Skatrud, JB2
Berssenbrugge, AD1
Dempsey, JA1
Krintel, JJ1
Haxholdt, OS1
Berthelsen, P1
Brøckner, J1
Häcki, MA1
Waldeck, G1
Brändli, O1
Vos, PJ2
Folgering, HT2
de Boo, TM1
Lemmens, WJ1
van Herwaarden, CL2
De Backer, WA1
Swenson, ER1
Mazur, JE1
Devlin, JW1
Peters, MJ1
Jankowski, MA1
Iannuzzi, MC1
Zarowitz, BJ1
Kiwull-Schöne, HF1
Teppema, LJ1
Kiwull, PJ1
Bear, R1
Goldstein, M1
Phillipson, E1
Ho, M1
Hammeke, M1
Feldman, R1
Handelsman, S1
Halperin, M1
Miller, PD1
Berns, AS1
Clivati, A1
Ciofetti, M1
Cavestri, R1
Longhini, E1
Nomura, F1
Hirata, N1
Sakakibara, T1
Tojima, H1
Kunitomo, F1
Okita, S1
Tatsumi, K1
Kimura, H1
Kuriyama, T1
Watanabe, S1
Honda, Y1
Boada, JE1
Estopa, R1
Izquierdo, J1
Dorca, J1
Manresa, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Acetazolamide on the Duration of Mechanical Ventilation in Patients With Metabolic Alkalosis. Phase III Multicenter Double-blinded Clinical Trial.[NCT01499485]Phase 3140 participants (Actual)Interventional2011-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for acetazolamide and Lung Diseases, Obstructive

ArticleYear
Effect of sleep state and chemical stimuli on breathing.
    Progress in clinical and biological research, 1983, Volume: 136

    Topics: Acetazolamide; Bicarbonates; Carbon Dioxide; Chronic Disease; Humans; Lung Diseases, Obstructive; Me

1983
Methods and clinical significance of studying chemical drives.
    Respiration physiology, 1998, Volume: 114, Issue:1

    Topics: Acetazolamide; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Chemoreceptor Cells; Humans; Hypercapn

1998

Trials

4 trials available for acetazolamide and Lung Diseases, Obstructive

ArticleYear
[Acetazolamide in hypercapnic chronic obstructive lung disease--a renaissance?].
    Schweizerische medizinische Wochenschrift, 1983, Jan-22, Volume: 113, Issue:3

    Topics: Acetazolamide; Acidosis; Double-Blind Method; Humans; Hypercapnia; Hypoxia; Lung Diseases, Obstructi

1983
Effects of chlormadinone acetate, acetazolamide and oxygen on awake and asleep gas exchange in patients with chronic obstructive pulmonary disease (COPD).
    The European respiratory journal, 1994, Volume: 7, Issue:5

    Topics: Acetazolamide; Aged; Carbon Dioxide; Chlormadinone Acetate; Double-Blind Method; Female; Humans; Lun

1994
Visual attention in patients with chronic obstructive pulmonary disease.
    Biological psychology, 1995, Nov-16, Volume: 41, Issue:3

    Topics: Acetazolamide; Aged; Anticonvulsants; Attention; Chlormadinone Acetate; Cognition Disorders; Female;

1995
Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial.
    Critical care medicine, 1999, Volume: 27, Issue:7

    Topics: Acetazolamide; Alkalosis; Asthma; Carbonic Anhydrase Inhibitors; Critical Illness; Diuretics; Double

1999

Other Studies

10 other studies available for acetazolamide and Lung Diseases, Obstructive

ArticleYear
Relative effectiveness of acetazolamide versus medroxyprogesterone acetate in correction of chronic carbon dioxide retention.
    The American review of respiratory disease, 1983, Volume: 127, Issue:4

    Topics: Acetazolamide; Carbon Dioxide; Humans; Lung Diseases, Obstructive; Lung Volume Measurements; Medroxy

1983
Carbon dioxide elimination after acetazolamide in patients with chronic obstructive pulmonary disease and metabolic alkalosis.
    Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:3

    Topics: Acetazolamide; Adult; Aged; Alkalosis; Carbon Dioxide; Female; Humans; Lung Diseases, Obstructive; M

1983
Carbonic anhydrase inhibitors and ventilation: a complex interplay of stimulation and suppression.
    The European respiratory journal, 1998, Volume: 12, Issue:6

    Topics: Acetazolamide; Altitude Sickness; Animals; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Depression

1998
Low-dose acetazolamide does affect respiratory muscle function in spontaneously breathing anesthetized rabbits.
    American journal of respiratory and critical care medicine, 2001, Volume: 163, Issue:2

    Topics: Acetazolamide; Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Infusions, Intravenous; Lu

2001
Effect of metabolic alkalosis on respiratory function in patients with chronic obstructive lung disease.
    Canadian Medical Association journal, 1977, Oct-22, Volume: 117, Issue:8

    Topics: Acetazolamide; Acidosis, Respiratory; Aged; Alkalosis; Ammonium Chloride; Bicarbonates; Blood Gas An

1977
Acute metabolic alkalosis perpetuating hypercarbia. A role for acetazolamide in chronic obstructive pulmonary disease.
    JAMA, 1977, Nov-28, Volume: 238, Issue:22

    Topics: Acetazolamide; Aged; Alkalosis; Bicarbonates; Carbon Dioxide; Chronic Disease; Diuretics; Female; He

1977
Cerebral vascular responsiveness in chronic hypercapnia.
    Chest, 1992, Volume: 102, Issue:1

    Topics: Acetazolamide; Aged; Blood Flow Velocity; Cerebral Arteries; Cerebrovascular Circulation; Chronic Di

1992
[An aged case of coronary-aorta bypass grafting surgery (CABG) with severe chronic obstructive pulmonary disease].
    Kyobu geka. The Japanese journal of thoracic surgery, 1990, Volume: 43, Issue:11

    Topics: Acetazolamide; Age Factors; Aged; Coronary Artery Bypass; Coronary Disease; Humans; Lung Diseases, O

1990
[Effect of acetazolamide on blood gas, ventilatory control and sleep in patients with chronic respiratory disease and sleep apnea syndrome].
    Nihon Kyobu Shikkan Gakkai zasshi, 1987, Volume: 25, Issue:3

    Topics: Acetazolamide; Humans; Hypercapnia; Lung Diseases, Obstructive; Sleep Apnea Syndromes

1987
Severe mixed acidosis by combined therapy with acetazolamide and timolol eyedrops.
    European journal of respiratory diseases, 1986, Volume: 68, Issue:3

    Topics: Acetazolamide; Acidosis; Aged; Drug Therapy, Combination; Glaucoma; Humans; Lung Diseases, Obstructi

1986