acetazolamide has been researched along with Lung Diseases, Obstructive in 16 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Lung Diseases, Obstructive: Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare two dosing regimens of acetazolamide for the reversal of metabolic alkalosis in mechanically ventilated patients with asthma or chronic obstructive pulmonary disease." | 9.09 | Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial. ( Devlin, JW; Iannuzzi, MC; Jankowski, MA; Mazur, JE; Peters, MJ; Zarowitz, BJ, 1999) |
| "Acetazolamide, an inhibitor of carbonic anhydrase, which catalyzes hydration/dehydration of carbon dioxide, has been used for correction of metabolic alkalosis in patients with chronic obstructive pulmonary disease (COPD)." | 7.66 | Carbon dioxide elimination after acetazolamide in patients with chronic obstructive pulmonary disease and metabolic alkalosis. ( Berthelsen, P; Brøckner, J; Haxholdt, OS; Krintel, JJ, 1983) |
| "To compare two dosing regimens of acetazolamide for the reversal of metabolic alkalosis in mechanically ventilated patients with asthma or chronic obstructive pulmonary disease." | 5.09 | Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial. ( Devlin, JW; Iannuzzi, MC; Jankowski, MA; Mazur, JE; Peters, MJ; Zarowitz, BJ, 1999) |
| "To assess the responsiveness of the cerebral vessels to chronic hypercapnia, we measured middle cerebral artery flow velocity by transcranial Doppler ultrasound in 20 normal subjects and in 14 COLD patients before and after stimulation by progressive hypercapnia (rebreathing test) or by intravenous administration of an acetazolamide bolus." | 3.68 | Cerebral vascular responsiveness in chronic hypercapnia. ( Cavestri, R; Ciofetti, M; Clivati, A; Longhini, E, 1992) |
| "Acetazolamide, an inhibitor of carbonic anhydrase, which catalyzes hydration/dehydration of carbon dioxide, has been used for correction of metabolic alkalosis in patients with chronic obstructive pulmonary disease (COPD)." | 3.66 | Carbon dioxide elimination after acetazolamide in patients with chronic obstructive pulmonary disease and metabolic alkalosis. ( Berthelsen, P; Brøckner, J; Haxholdt, OS; Krintel, JJ, 1983) |
| "Patients with chronic obstructive pulmonary diseases (COPD) and/or central sleep apnea are sometimes treated with the carbonic anhydrase inhibitor acteazolamide to improve blood gas values." | 1.31 | Low-dose acetazolamide does affect respiratory muscle function in spontaneously breathing anesthetized rabbits. ( Kiwull, PJ; Kiwull-Schöne, HF; Teppema, LJ, 2001) |
| "Patients with mixed chronic respiratory acidosis and metabolic alkalosis constitute a common subgroup of patients with chronic obstructive lung disease and carbon dioxide retention; these patients benefit from correction of the metabolic alkalosis." | 1.26 | Effect of metabolic alkalosis on respiratory function in patients with chronic obstructive lung disease. ( Bear, R; Feldman, R; Goldstein, M; Halperin, M; Hammeke, M; Handelsman, S; Ho, M; Phillipson, E, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (50.00) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Skatrud, JB | 2 |
| Berssenbrugge, AD | 1 |
| Dempsey, JA | 1 |
| Krintel, JJ | 1 |
| Haxholdt, OS | 1 |
| Berthelsen, P | 1 |
| Brøckner, J | 1 |
| Häcki, MA | 1 |
| Waldeck, G | 1 |
| Brändli, O | 1 |
| Vos, PJ | 2 |
| Folgering, HT | 2 |
| de Boo, TM | 1 |
| Lemmens, WJ | 1 |
| van Herwaarden, CL | 2 |
| De Backer, WA | 1 |
| Swenson, ER | 1 |
| Mazur, JE | 1 |
| Devlin, JW | 1 |
| Peters, MJ | 1 |
| Jankowski, MA | 1 |
| Iannuzzi, MC | 1 |
| Zarowitz, BJ | 1 |
| Kiwull-Schöne, HF | 1 |
| Teppema, LJ | 1 |
| Kiwull, PJ | 1 |
| Bear, R | 1 |
| Goldstein, M | 1 |
| Phillipson, E | 1 |
| Ho, M | 1 |
| Hammeke, M | 1 |
| Feldman, R | 1 |
| Handelsman, S | 1 |
| Halperin, M | 1 |
| Miller, PD | 1 |
| Berns, AS | 1 |
| Clivati, A | 1 |
| Ciofetti, M | 1 |
| Cavestri, R | 1 |
| Longhini, E | 1 |
| Nomura, F | 1 |
| Hirata, N | 1 |
| Sakakibara, T | 1 |
| Tojima, H | 1 |
| Kunitomo, F | 1 |
| Okita, S | 1 |
| Tatsumi, K | 1 |
| Kimura, H | 1 |
| Kuriyama, T | 1 |
| Watanabe, S | 1 |
| Honda, Y | 1 |
| Boada, JE | 1 |
| Estopa, R | 1 |
| Izquierdo, J | 1 |
| Dorca, J | 1 |
| Manresa, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Acetazolamide on the Duration of Mechanical Ventilation in Patients With Metabolic Alkalosis. Phase III Multicenter Double-blinded Clinical Trial.[NCT01499485] | Phase 3 | 140 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for acetazolamide and Lung Diseases, Obstructive
| Article | Year |
|---|---|
Effect of sleep state and chemical stimuli on breathing.
Topics: Acetazolamide; Bicarbonates; Carbon Dioxide; Chronic Disease; Humans; Lung Diseases, Obstructive; Me | 1983 |
Methods and clinical significance of studying chemical drives.
Topics: Acetazolamide; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Chemoreceptor Cells; Humans; Hypercapn | 1998 |
4 trials available for acetazolamide and Lung Diseases, Obstructive
| Article | Year |
|---|---|
[Acetazolamide in hypercapnic chronic obstructive lung disease--a renaissance?].
Topics: Acetazolamide; Acidosis; Double-Blind Method; Humans; Hypercapnia; Hypoxia; Lung Diseases, Obstructi | 1983 |
Effects of chlormadinone acetate, acetazolamide and oxygen on awake and asleep gas exchange in patients with chronic obstructive pulmonary disease (COPD).
Topics: Acetazolamide; Aged; Carbon Dioxide; Chlormadinone Acetate; Double-Blind Method; Female; Humans; Lun | 1994 |
Visual attention in patients with chronic obstructive pulmonary disease.
Topics: Acetazolamide; Aged; Anticonvulsants; Attention; Chlormadinone Acetate; Cognition Disorders; Female; | 1995 |
Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial.
Topics: Acetazolamide; Alkalosis; Asthma; Carbonic Anhydrase Inhibitors; Critical Illness; Diuretics; Double | 1999 |
10 other studies available for acetazolamide and Lung Diseases, Obstructive
| Article | Year |
|---|---|
Relative effectiveness of acetazolamide versus medroxyprogesterone acetate in correction of chronic carbon dioxide retention.
Topics: Acetazolamide; Carbon Dioxide; Humans; Lung Diseases, Obstructive; Lung Volume Measurements; Medroxy | 1983 |
Carbon dioxide elimination after acetazolamide in patients with chronic obstructive pulmonary disease and metabolic alkalosis.
Topics: Acetazolamide; Adult; Aged; Alkalosis; Carbon Dioxide; Female; Humans; Lung Diseases, Obstructive; M | 1983 |
Carbonic anhydrase inhibitors and ventilation: a complex interplay of stimulation and suppression.
Topics: Acetazolamide; Altitude Sickness; Animals; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Depression | 1998 |
Low-dose acetazolamide does affect respiratory muscle function in spontaneously breathing anesthetized rabbits.
Topics: Acetazolamide; Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Infusions, Intravenous; Lu | 2001 |
Effect of metabolic alkalosis on respiratory function in patients with chronic obstructive lung disease.
Topics: Acetazolamide; Acidosis, Respiratory; Aged; Alkalosis; Ammonium Chloride; Bicarbonates; Blood Gas An | 1977 |
Acute metabolic alkalosis perpetuating hypercarbia. A role for acetazolamide in chronic obstructive pulmonary disease.
Topics: Acetazolamide; Aged; Alkalosis; Bicarbonates; Carbon Dioxide; Chronic Disease; Diuretics; Female; He | 1977 |
Cerebral vascular responsiveness in chronic hypercapnia.
Topics: Acetazolamide; Aged; Blood Flow Velocity; Cerebral Arteries; Cerebrovascular Circulation; Chronic Di | 1992 |
[An aged case of coronary-aorta bypass grafting surgery (CABG) with severe chronic obstructive pulmonary disease].
Topics: Acetazolamide; Age Factors; Aged; Coronary Artery Bypass; Coronary Disease; Humans; Lung Diseases, O | 1990 |
[Effect of acetazolamide on blood gas, ventilatory control and sleep in patients with chronic respiratory disease and sleep apnea syndrome].
Topics: Acetazolamide; Humans; Hypercapnia; Lung Diseases, Obstructive; Sleep Apnea Syndromes | 1987 |
Severe mixed acidosis by combined therapy with acetazolamide and timolol eyedrops.
Topics: Acetazolamide; Acidosis; Aged; Drug Therapy, Combination; Glaucoma; Humans; Lung Diseases, Obstructi | 1986 |