acetazolamide has been researched along with Intracranial Aneurysm in 13 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cerebral blood flow (CBF) and response to acetazolamide were measured during the acute, subacute, and chronic stages after aneurysmal subarachnoid hemorrhage and correlated with symptomatic vasospasm and clinical outcome in 45 patients who underwent early clipping of ruptured cerebral aneurysms, of whom 18 had symptomatic vasospasm and 27 did not." | 7.70 | Cerebral blood flow and the response to acetazolamide during the acute, subacute, and chronic stages of aneurysmal subarachnoid hemorrhage. ( Nakayama, Y; Tanaka, A; Tomonaga, M; Yoshinaga, S, 1998) |
| "Blood flow velocity (BFV) in the middle cerebral artery at rest and cerebrovascular reserve capacity (CVRC) (percent rise in BFV after acetazolamide stimulation) measured by means of transcranial Doppler sonography were studied many years after aneurysmal subarachnoid hemorrhage in patients with proven cerebral vasospasm (mean BFV > 160 cm/s)." | 7.69 | Cerebrovascular reserve capacity many years after vasospasm due to aneurysmal subarachnoid hemorrhage. A transcranial Doppler study with acetazolamide test. ( Ficzere, A; Novak, L; Rozsa, L; Sheth, RN; Szabo, S, 1997) |
| "Prediction of cerebral infarction due to vasospasm (VS) following aneurysmal subarachnoid haemorrhage (SAH) was investigated using acetazolamide-activated (A-A) N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) single photon emission computed tomography (SPECT) in 79 SAH patients." | 7.68 | Prediction of cerebral infarction due to vasospasm following aneurysmal subarachnoid haemorrhage using acetazolamide-activated 123I-IMP SPECT. ( Funakoshi, T; Kimura, T; Shinoda, J, 1993) |
| "Cerebral blood flow (CBF) and response to acetazolamide were measured during the acute, subacute, and chronic stages after aneurysmal subarachnoid hemorrhage and correlated with symptomatic vasospasm and clinical outcome in 45 patients who underwent early clipping of ruptured cerebral aneurysms, of whom 18 had symptomatic vasospasm and 27 did not." | 3.70 | Cerebral blood flow and the response to acetazolamide during the acute, subacute, and chronic stages of aneurysmal subarachnoid hemorrhage. ( Nakayama, Y; Tanaka, A; Tomonaga, M; Yoshinaga, S, 1998) |
| "Blood flow velocity (BFV) in the middle cerebral artery at rest and cerebrovascular reserve capacity (CVRC) (percent rise in BFV after acetazolamide stimulation) measured by means of transcranial Doppler sonography were studied many years after aneurysmal subarachnoid hemorrhage in patients with proven cerebral vasospasm (mean BFV > 160 cm/s)." | 3.69 | Cerebrovascular reserve capacity many years after vasospasm due to aneurysmal subarachnoid hemorrhage. A transcranial Doppler study with acetazolamide test. ( Ficzere, A; Novak, L; Rozsa, L; Sheth, RN; Szabo, S, 1997) |
| "Prediction of cerebral infarction due to vasospasm (VS) following aneurysmal subarachnoid haemorrhage (SAH) was investigated using acetazolamide-activated (A-A) N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) single photon emission computed tomography (SPECT) in 79 SAH patients." | 3.68 | Prediction of cerebral infarction due to vasospasm following aneurysmal subarachnoid haemorrhage using acetazolamide-activated 123I-IMP SPECT. ( Funakoshi, T; Kimura, T; Shinoda, J, 1993) |
| "Three patients with acute diffuse brain swelling seen on CT showed intracranial non-filling of 123I-IMP on SPECTs performed on Day 6, and all three died by Day 10." | 1.28 | Acetazolamide reactivity on cerebral blood flow in patients with subarachnoid haemorrhage. ( Araki, Y; Funakoshi, T; Imao, Y; Kimura, T; Shinoda, J, 1991) |
| "A review of the most recent 23 cases of benign intracranial hypertension (BIH), admitted to the War Memorial Children's Hospital in London, Ontario, provided a compendium of the clinical manifestations of this disorder in children and adolescents." | 1.27 | Spectrum of benign intracranial hypertension in children and adolescents. ( Amacher, AL; Spence, JD, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 9 (69.23) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bøthun, ML | 2 |
| Haaland, ØA | 2 |
| Logallo, N | 2 |
| Svendsen, F | 2 |
| Thomassen, L | 2 |
| Helland, CA | 2 |
| Okudaira, Y | 2 |
| Nakanishi, H | 1 |
| Arai, H | 2 |
| Sato, K | 2 |
| Kimura, T | 2 |
| Shinoda, J | 2 |
| Funakoshi, T | 2 |
| Tran Dinh, YR | 2 |
| Lot, G | 3 |
| Benrabah, R | 1 |
| Baroudy, O | 1 |
| Cophignon, J | 2 |
| Seylaz, J | 1 |
| Yoshida, K | 1 |
| Nakamura, S | 1 |
| Watanabe, H | 1 |
| Kinoshita, K | 1 |
| Szabo, S | 1 |
| Sheth, RN | 1 |
| Novak, L | 1 |
| Rozsa, L | 1 |
| Ficzere, A | 1 |
| Tanaka, A | 1 |
| Yoshinaga, S | 1 |
| Nakayama, Y | 1 |
| Tomonaga, M | 1 |
| George, B | 2 |
| Mourier, KL | 2 |
| Raggueneau, JL | 1 |
| Boissonnet, H | 1 |
| Araki, Y | 1 |
| Imao, Y | 1 |
| Amacher, AL | 1 |
| Spence, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| C-arm Cone Beam CTA and CTP With Acetazolamide Challenge in Aneurysmal Subarachnoid Hemorrhage: Evaluating Predictability for Early Ischemia in Cerebral Vasospasm[NCT03377049] | Phase 4 | 11 participants (Actual) | Interventional | 2019-07-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinical neurological deterioration not attributable to other causes, mores specifically not due to re-bleeding, hydrocephalus, or metabolic changes. (NCT03377049)
Timeframe: Day 1-14 during the hospitalization
| Intervention | Participants (Count of Participants) |
|---|---|
| Acetazolamide Challenge | 2 |
Using perfusion map values, relative percent change will be calculated (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour
| Intervention | percent change (Mean) |
|---|---|
| Acetazolamide Challenge | 19.785 |
Using perfusion map values, relative percent change will be calculated (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour
| Intervention | percent change (Mean) |
|---|---|
| Acetazolamide Challenge | 21.659 |
The data that will be statistically compared is the pre-diamox perfusion in comparison to the post-diamox perfusion. A statistically significant change increase in CBF represents an appropriate response to Diamox. Lack of change in CBF or decrease in CBF could be suggestive of potential for developing vasospasm. (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour
| Intervention | percent change (Mean) |
|---|---|
| Acetazolamide Challenge | 20.722 |
1 review available for acetazolamide and Intracranial Aneurysm
| Article | Year |
|---|---|
[Value of the measurement of cerebral blood flow before and after diamox injection in predicting clinical vasospasm and final outcome in aneurysmal subarachnoid hemorrhage].
Topics: Acetazolamide; Cerebrovascular Circulation; Female; Humans; Intracranial Aneurysm; Male; Nimodipine; | 1991 |
12 other studies available for acetazolamide and Intracranial Aneurysm
| Article | Year |
|---|---|
Time Course of Cerebrovascular Reactivity in Patients Treated for Unruptured Intracranial Aneurysms: A One-Year Transcranial Doppler and Acetazolamide Follow-Up Study.
Topics: Acetazolamide; Blood Flow Velocity; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Male; | 2018 |
Cerebrovascular reactivity after treatment of unruptured intracranial aneurysms--A transcranial Doppler sonography and acetazolamide study.
Topics: Acetazolamide; Adult; Blood Flow Velocity; Cerebrovascular Circulation; Female; Humans; Intracranial | 2016 |
Differences in acetazolamide vasoreactivity in patients with acute and chronic occlusion of the internal carotid artery.
Topics: Acetazolamide; Carotid Artery, Internal; Carotid Stenosis; Cerebrovascular Circulation; Functional L | 2003 |
Prediction of cerebral infarction due to vasospasm following aneurysmal subarachnoid haemorrhage using acetazolamide-activated 123I-IMP SPECT.
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Amphetamines; Aneurysm, Ruptured; Brain; Cerebral Inf | 1993 |
Abnormal cerebral vasodilation in aneurysmal subarachnoid hemorrhage: use of serial 133Xe cerebral blood flow measurement plus acetazolamide to assess cerebral vasospasm.
Topics: Acetazolamide; Adult; Cerebral Angiography; Cerebrovascular Circulation; Female; Humans; Intracrania | 1993 |
Cerebral blood flow alteration by acetazolamide during carotid balloon occlusion: parameters reflecting cerebral perfusion pressure in the acetazolamide test.
Topics: Acetazolamide; Blood Pressure; Blood Volume; Brain; Brain Neoplasms; Carotid Artery, Internal; Cathe | 1996 |
Early cerebral blood flow and vascular reactivity to acetazolamide in predicting the outcome after ruptured cerebral aneurysm.
Topics: Acetazolamide; Aneurysm, Ruptured; Blood Flow Velocity; Brain; Brain Ischemia; Glasgow Coma Scale; H | 1996 |
Cerebrovascular reserve capacity many years after vasospasm due to aneurysmal subarachnoid hemorrhage. A transcranial Doppler study with acetazolamide test.
Topics: Acetazolamide; Adolescent; Adult; Blood Flow Velocity; Cerebrovascular Circulation; Female; Follow-U | 1997 |
Cerebral blood flow and the response to acetazolamide during the acute, subacute, and chronic stages of aneurysmal subarachnoid hemorrhage.
Topics: Acetazolamide; Acute Disease; Adult; Aged; Aged, 80 and over; Cerebrovascular Circulation; Chronic D | 1998 |
[Cerebral blood flow in the determination of vasospasm and surgical decision].
Topics: Acetazolamide; Aneurysm, Ruptured; Cerebrovascular Circulation; Humans; Intracranial Aneurysm; Ische | 1992 |
Acetazolamide reactivity on cerebral blood flow in patients with subarachnoid haemorrhage.
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Amphetamines; Brain Edema; Cerebrovascular Circulatio | 1991 |
Spectrum of benign intracranial hypertension in children and adolescents.
Topics: Acetazolamide; Adolescent; Anti-Bacterial Agents; Brain Concussion; Cerebrospinal Fluid Shunts; Chil | 1985 |