acetazolamide has been researched along with Hypercapnia in 84 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This placebo-controlled study indicates that acetazolamide improves CSA in patients with heart failure despite an increase in the slope of the HCVR." | 9.19 | Acetazolamide attenuates Hunter-Cheyne-Stokes breathing but augments the hypercapnic ventilatory response in patients with heart failure. ( Edwards, BA; Javaheri, S; Sands, SA, 2014) |
| "We herein report two cases in which add-on acetazolamide to furosemide was effective for diuretic-resistant volume overload and hypercapnia." | 8.12 | The Effect of Add-on Acetazolamide to Conventional Diuretics for Diuretic-resistant Edema Complicated with Hypercapnia: A Report of Two Cases. ( Hisamichi, M; Ichikawa, D; Inoue, T; Shibagaki, Y; Yazawa, M, 2022) |
| "The involvement of increased brain tissue CO2 tension in acetazolamide-induced brain acidosis was investigated by comparing the brain pH response to acetazolamide with that to hypercapnia." | 7.69 | Brain pH responses to acetazolamide and hypercapnia in cats. ( Fukata, K; Kinoshita, Y; Kohshi, K, 1997) |
| "The aim of this study was to compare the effect of vasodilative stimuli for the measurement of cerebrovascular reactivity obtained by acetazolamide and hypercapnia in patients with chronic occlusive major cerebral artery disease." | 7.69 | Dissociation of vasoreactivity to acetazolamide and hypercapnia. Comparative study in patients with chronic occlusive major cerebral artery disease. ( Houkin, K; Ishikawa, T; Kazumata, K; Kuroda, S; Mitsumori, K; Tanaka, N, 1996) |
| "Acetazolamide is an efficient alternative for treatment of patients with respiratory acidosis and metabolic alkalosis, particularly when other more common measures in this condition (discontinuation of diuretics and/or volemic replacement) have failed or are contraindicated." | 7.69 | [Efficacy of acetazolamide treatment of patients with hypercapnia and superimposed metabolic alkalosis]. ( Cancelo Suárez, P; del Portillo Rubí, A; Guillem Ares, E; Prada Mínguez, A; Prieto de Paula, JM; Sanz de la Fuente, H; Villamandos Nicás, V, 1997) |
| "Indomethacin is known to attenuate quite markedly the increase in CBF during hypercapnia." | 7.68 | Indomethacin abolishes cerebral blood flow increase in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia? ( Lassen, NA; Paulson, OB; Wang, Q, 1993) |
| "The effect of unilateral, electrical stimulation of the cervical sympathetic chain in rabbits anesthetized with pentobarbital sodium and vasodilated by hypercapnia, acetazolamide, papaverine or PGI2 was investigated to determine to what extent the sympathetic nerves to the brain and the eye cause vasoconstriction and prevent overperfusion in previously vasodilated animals." | 7.66 | Effects of sympathetic stimulation on cerebral and ocular blood flow. Modification by hypertension, hypercapnia, acetazolamide, PGI2 and papaverine. ( Beausang-Linder, M, 1982) |
| "After a three day-period of hypercapnia, carbonic anhydrase blockade by acetazolamide inhibits the development of arterial blood alcalosis during the return in normal environment, and thus eliminates the transient increase in lactacidemia due to glycolysis stimulation." | 7.65 | [Effect of acetazolamide on arterial blood lactate levels during recuperation in air from three days of hypercapnia]. ( Colas, T; Hartemann, D; Horsky, P; Saunier, C, 1975) |
| "Eleven AECOPD patients, with hypercapnic respiratory failure and MA following NIV, were treated with ACET 500 mg for two consecutive days and compared to a matched control group." | 5.43 | Effect of acetazolamide on post-NIV metabolic alkalosis in acute exacerbated COPD patients. ( Alessandrini, G; Bonini, M; Borgognoni, L; Ferrazza, AM; Fontana, V; Internullo, M; Marinelli, P; Palange, P; Santinelli, S; Sardo, L, 2016) |
| "Acetazolamide pretreatment did not alter these IOP responses to PCO2, PO2, and blood pH changes." | 5.26 | Effect of hypercapnea and hyperventilation on human intraocular pressure general anaesthesia following acetazolamide administration. ( Chondreli, S; Petounis, AD; Vadaluka-Sekioti, A, 1980) |
| "This placebo-controlled study indicates that acetazolamide improves CSA in patients with heart failure despite an increase in the slope of the HCVR." | 5.19 | Acetazolamide attenuates Hunter-Cheyne-Stokes breathing but augments the hypercapnic ventilatory response in patients with heart failure. ( Edwards, BA; Javaheri, S; Sands, SA, 2014) |
| "Acetazolamide and CO2 each lowered intraocular pressure; combining the agents provided no additive ocular hypotensive effect." | 5.08 | Acetazolamide and CO2: acute effects on cerebral and retrobulbar hemodynamics. ( Harris, A; Lieb, W; Martin, B; Picht, G; Sievers, C; Tippke, S, 1996) |
| " Although more controlled studies would be helpful, relatively clear-cut indications for the use of ventilatory stimulants exist for hypercapnic obesity-hypoventilation patients (medroxyprogesterone), myxedema (thyroid replacement), central apnea (acetazolamide), and periodic breathing in congestive heart failure (theophylline)." | 4.80 | Pharmacologic treatment of sleep-disordered breathing. ( Hudgel, DW; Thanakitcharu, S, 1998) |
| "We herein report two cases in which add-on acetazolamide to furosemide was effective for diuretic-resistant volume overload and hypercapnia." | 4.12 | The Effect of Add-on Acetazolamide to Conventional Diuretics for Diuretic-resistant Edema Complicated with Hypercapnia: A Report of Two Cases. ( Hisamichi, M; Ichikawa, D; Inoue, T; Shibagaki, Y; Yazawa, M, 2022) |
| " Inhibition of CAII by acetazolamide or methazolamide delayed the decrease in the intracellular pH observed during hypercapnia in cultured AECI, AECII, and AECI-like cells." | 3.74 | Carbonic anhydrase II and alveolar fluid reabsorption during hypercapnia. ( Briva, A; Chen, J; Lecuona, E; Sznajder, JI; Welch, LC, 2008) |
| " Using laser-Doppler flowmetry, we assessed in awake TgNotch3R90C mice and wild-type littermates the cerebrovascular reactivity to 2 potent vasodilator stimuli (acetazolamide and hypercapnia) and cerebral blood flow (CBF) autoregulation during stepwise blood pressure elevations and reductions." | 3.73 | Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy. ( Domenga, V; Joutel, A; Lacombe, P; Oligo, C; Tournier-Lasserve, E, 2005) |
| " The ratio of cerebral blood volume to cerebral blood flow (CBV/CBF) and vasoreactivity in response to hypercapnia (%CBF(hypercapnia)) and acetazolamide (ACZ) stress (%CBF(ACZ)) were measured to evaluate circulatory reserve." | 3.73 | Relationship between cerebral circulatory reserve and oxygen extraction fraction in patients with major cerebral artery occlusive disease: a positron emission tomography study. ( Hatazawa, J; Moroi, J; Nagata, K; Sato, M; Shimosegawa, E; Suzuki, A; Yata, K, 2006) |
| " The cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF), cerebral metabolic rate of oxygen (CMRO2), and vascular responses to hypercapnia and acetazolamide stress for CCD were measured in 20 patients with cerebrovascular disease by positron emission tomography with H2(15O), C15O, and 15O2." | 3.71 | Hemodynamic changes during neural deactivation in human brain: a positron emission tomography study of crossed cerebellar diaschisis. ( Hatazawa, J; Ito, H; Kanno, I; Okane, K; Shimosegawa, E; Tamura, H, 2002) |
| " Corticocerebral blood flow was measured by hydrogen polarography during hypercapnia and acetazolamide stimuli in conscious rabbits." | 3.71 | Influence of nitrovasodilators and cyclooxygenase inhibitors on cerebral vasoreactivity in conscious rabbits. ( Barzó, P; Bodosi, M; Csete, K; Papp, JG, 2001) |
| "The aim of this study was to compare the effect of vasodilative stimuli for the measurement of cerebrovascular reactivity obtained by acetazolamide and hypercapnia in patients with chronic occlusive major cerebral artery disease." | 3.69 | Dissociation of vasoreactivity to acetazolamide and hypercapnia. Comparative study in patients with chronic occlusive major cerebral artery disease. ( Houkin, K; Ishikawa, T; Kazumata, K; Kuroda, S; Mitsumori, K; Tanaka, N, 1996) |
| "Acetazolamide is an efficient alternative for treatment of patients with respiratory acidosis and metabolic alkalosis, particularly when other more common measures in this condition (discontinuation of diuretics and/or volemic replacement) have failed or are contraindicated." | 3.69 | [Efficacy of acetazolamide treatment of patients with hypercapnia and superimposed metabolic alkalosis]. ( Cancelo Suárez, P; del Portillo Rubí, A; Guillem Ares, E; Prada Mínguez, A; Prieto de Paula, JM; Sanz de la Fuente, H; Villamandos Nicás, V, 1997) |
| "Indomethacin is known to attenuate quite markedly the increase in CBF during hypercapnia." | 3.68 | Indomethacin abolishes cerebral blood flow increase in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia? ( Lassen, NA; Paulson, OB; Wang, Q, 1993) |
| "To assess the responsiveness of the cerebral vessels to chronic hypercapnia, we measured middle cerebral artery flow velocity by transcranial Doppler ultrasound in 20 normal subjects and in 14 COLD patients before and after stimulation by progressive hypercapnia (rebreathing test) or by intravenous administration of an acetazolamide bolus." | 3.68 | Cerebral vascular responsiveness in chronic hypercapnia. ( Cavestri, R; Ciofetti, M; Clivati, A; Longhini, E, 1992) |
| "We have studied the effect of acetazolamide 500 mg bd for three days on ventilatory response to CO2 (HCVR) and hypoxia under both isocapnic and poikilocapnic conditions (isocapnic and poikilocapnic HVR) in five normal subjects." | 3.68 | The effect of acetazolamide on hypercapnic and eucapnic/poikilocapnic hypoxic ventilatory responses in normal subjects. ( Bashir, Y; Kann, M; Stradling, JR, 1990) |
| "The effect of unilateral, electrical stimulation of the cervical sympathetic chain in rabbits anesthetized with pentobarbital sodium and vasodilated by hypercapnia, acetazolamide, papaverine or PGI2 was investigated to determine to what extent the sympathetic nerves to the brain and the eye cause vasoconstriction and prevent overperfusion in previously vasodilated animals." | 3.66 | Effects of sympathetic stimulation on cerebral and ocular blood flow. Modification by hypertension, hypercapnia, acetazolamide, PGI2 and papaverine. ( Beausang-Linder, M, 1982) |
| " Intracellular alkalosis was induced by exposing the bladders in vitro to NH4Cl at pH 8 or to acetazolamide." | 3.66 | Acid-base metabolism, intracellular pH and water transport by the toad bladder. ( Arruda, JA; Burt, CT; Dytko, G; Lubansky, H, 1983) |
| "CSF HCO3- increases more than plasma HCO3- in hypercapnia, and there are at least two sources for the CSF HCO3- increase--one derived from the simultaneous increase in plasma HCO3-, and the other, HCO3-formed from hydration of CO2 in the choroid plexus and glia and susceptible to inhibition by acetazolamide (J." | 3.65 | H+ transport from CNS in hypercapnia and regulation of CSF [HCO3-]. ( Choma, L; Kazemi, H, 1977) |
| "To further our understanding of central sleep apnea (CSA) at high altitude during acclimatization, we tested the hypothesis that pharmacologically altering cerebral blood flow (CBF) would alter the severity of CSA at high altitude." | 2.79 | Influence of cerebral blood flow on central sleep apnea at high altitude. ( Ainslie, PN; Basnyat, R; Burgess, KR; Dawson, A; Donnelly, J; Lucas, RA; Lucas, SJ; Peebles, KC; Shepherd, K; Swart, M; Thomas, KN, 2014) |
| "Hypoxemia and hypercapnia are more pronounced during rapid eye movement." | 2.50 | Medication effects on sleep and breathing. ( Lee-Chiong, T; Seda, G; Tsai, S, 2014) |
| "Acetazolamide can produce a small increase in arterial PO2 and fall in PCO2." | 2.41 | Carbonic anhydrase inhibitors for hypercapnic ventilatory failure in chronic obstructive pulmonary disease. ( Greenstone, M; Jones, PW, 2001) |
| "The effect of hypercapnia is an exaltation of the normal process due to increased substrate (CO2), but that of increased plasma HCO3- is due to imposition of an abnormal diffusion gradient for this ion between plasma and CSF." | 2.36 | Effect of varying CO2 equilibria on rates of HCO3- formation in cerebrospinal fluid. ( Maren, TH, 1979) |
| "Eleven AECOPD patients, with hypercapnic respiratory failure and MA following NIV, were treated with ACET 500 mg for two consecutive days and compared to a matched control group." | 1.43 | Effect of acetazolamide on post-NIV metabolic alkalosis in acute exacerbated COPD patients. ( Alessandrini, G; Bonini, M; Borgognoni, L; Ferrazza, AM; Fontana, V; Internullo, M; Marinelli, P; Palange, P; Santinelli, S; Sardo, L, 2016) |
| "Normocapnic and chronic hypercapnic COPD patients have the same ventilatory and cerebrovascular carbon dioxide responsiveness irrespective of induced metabolic state." | 1.31 | Effects of acetazolamide and furosemide on ventilation and cerebral blood volume in normocapnic and hypercapnic patients with COPD. ( Colier, WN; Folgering, H; Oeseburg, B; van de Ven, MJ; van der Sluijs, MC; Vis, P, 2002) |
| "Acetazolamide pretreatment did not alter these IOP responses to PCO2, PO2, and blood pH changes." | 1.26 | Effect of hypercapnea and hyperventilation on human intraocular pressure general anaesthesia following acetazolamide administration. ( Chondreli, S; Petounis, AD; Vadaluka-Sekioti, A, 1980) |
| "Metabolic alkalosis was identified and confirmed as a precipitator of acute hypercapnea." | 1.26 | Metabolic alkalosis complicating weaning from mechanical ventilation. ( Gallagher, TJ, 1979) |
| "Hypercapnia was induced in the fetus alone by giving acetazolamide iv to the fetus, 100-200 mg/kg." | 1.26 | Effects of hypercapnia on uterine and umbilical circulations in conscious pregnant sheep. ( Chez, RA; Ehrenkranz, R; McLaughlin, M; Oakes, GK; Walker, AM, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (40.48) | 18.7374 |
| 1990's | 16 (19.05) | 18.2507 |
| 2000's | 20 (23.81) | 29.6817 |
| 2010's | 12 (14.29) | 24.3611 |
| 2020's | 2 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Shim, HJ | 1 |
| Lee, J | 1 |
| Kim, SG | 1 |
| Inoue, T | 1 |
| Hisamichi, M | 1 |
| Ichikawa, D | 1 |
| Shibagaki, Y | 1 |
| Yazawa, M | 1 |
| Branigan, T | 1 |
| Elkhalifa, S | 1 |
| Pamenter, ME | 1 |
| Javaheri, S | 1 |
| Sands, SA | 1 |
| Edwards, BA | 1 |
| Seda, G | 1 |
| Tsai, S | 1 |
| Lee-Chiong, T | 1 |
| Caravita, S | 1 |
| Faini, A | 1 |
| Lombardi, C | 1 |
| Valentini, M | 1 |
| Gregorini, F | 1 |
| Rossi, J | 1 |
| Meriggi, P | 1 |
| Di Rienzo, M | 1 |
| Bilo, G | 1 |
| Agostoni, P | 1 |
| Parati, G | 1 |
| Burgess, KR | 1 |
| Lucas, SJ | 1 |
| Shepherd, K | 1 |
| Dawson, A | 1 |
| Swart, M | 1 |
| Thomas, KN | 1 |
| Lucas, RA | 1 |
| Donnelly, J | 1 |
| Peebles, KC | 1 |
| Basnyat, R | 1 |
| Ainslie, PN | 1 |
| Gorshkova, OP | 1 |
| Lentsman, MV | 1 |
| Artem'eva, AI | 1 |
| Dvoretskii, DP | 1 |
| Fontana, V | 1 |
| Santinelli, S | 1 |
| Internullo, M | 1 |
| Marinelli, P | 1 |
| Sardo, L | 1 |
| Alessandrini, G | 1 |
| Borgognoni, L | 1 |
| Ferrazza, AM | 1 |
| Bonini, M | 1 |
| Palange, P | 1 |
| Torring, MS | 1 |
| Holmgaard, K | 1 |
| Hessellund, A | 1 |
| Aalkjaer, C | 1 |
| Bek, T | 1 |
| Raurich, JM | 1 |
| Rialp, G | 1 |
| Ibáñez, J | 1 |
| Llompart-Pou, JA | 1 |
| Ayestarán, I | 1 |
| Powers, MA | 1 |
| Fontana, M | 1 |
| Emdin, M | 1 |
| Giannoni, A | 1 |
| Iudice, G | 1 |
| Baruah, R | 1 |
| Passino, C | 1 |
| Frydrychowski, AF | 1 |
| Wszedybyl-Winklewska, M | 1 |
| Guminski, W | 1 |
| Lass, P | 1 |
| Bandurski, T | 1 |
| Winklewski, PJ | 1 |
| Hour, BT | 1 |
| Shah, AM | 1 |
| Potharaju, AK | 1 |
| Lien, YH | 1 |
| Pánczél, G | 1 |
| Bönöczk, P | 1 |
| Nagy, Z | 1 |
| Ito, H | 1 |
| Kanno, I | 1 |
| Shimosegawa, E | 2 |
| Tamura, H | 1 |
| Okane, K | 1 |
| Hatazawa, J | 2 |
| Wagenaar, M | 2 |
| Vos, PJ | 1 |
| Heijdra, YF | 1 |
| Teppema, LJ | 1 |
| Folgering, HT | 1 |
| Vos, P | 1 |
| Heijdra, Y | 1 |
| Teppema, L | 1 |
| Folgering, H | 2 |
| Cole, RP | 1 |
| Csete, K | 2 |
| Vezekényi, Z | 1 |
| Dóczi, T | 1 |
| Papp, JG | 2 |
| Bodosi, M | 2 |
| Barzó, P | 2 |
| Vanková, M | 1 |
| Snetkov, VA | 1 |
| Knock, GA | 1 |
| Aaronson, PI | 1 |
| Ward, JP | 1 |
| Lacombe, P | 1 |
| Oligo, C | 1 |
| Domenga, V | 1 |
| Tournier-Lasserve, E | 1 |
| Joutel, A | 1 |
| Yata, K | 1 |
| Suzuki, A | 1 |
| Nagata, K | 1 |
| Sato, M | 1 |
| Moroi, J | 1 |
| Zuccarelli, MD | 1 |
| Ingermann, RL | 1 |
| Yamauchi, M | 1 |
| Dostal, J | 1 |
| Strohl, KP | 1 |
| Chen, J | 1 |
| Lecuona, E | 1 |
| Briva, A | 1 |
| Welch, LC | 1 |
| Sznajder, JI | 1 |
| Mokhlesi, B | 1 |
| Tulaimat, A | 1 |
| Collier, DJ | 1 |
| Nickol, AH | 1 |
| Milledge, JS | 1 |
| van Ruiten, HJ | 1 |
| Collier, CJ | 1 |
| Swenson, ER | 2 |
| Datta, A | 1 |
| Wolff, CB | 1 |
| Arruda, JA | 1 |
| Dytko, G | 1 |
| Lubansky, H | 1 |
| Burt, CT | 1 |
| Beausang-Linder, M | 1 |
| Petounis, AD | 1 |
| Chondreli, S | 1 |
| Vadaluka-Sekioti, A | 1 |
| Häcki, MA | 1 |
| Waldeck, G | 1 |
| Brändli, O | 1 |
| Sutton, JR | 1 |
| Gray, GW | 1 |
| Houston, CS | 1 |
| Powles, AC | 1 |
| Müller, M | 1 |
| Voges, M | 1 |
| Piepgras, U | 1 |
| Schimrigk, K | 1 |
| Graham, GD | 1 |
| Zhong, J | 1 |
| Petroff, OA | 1 |
| Constable, RT | 1 |
| Prichard, JW | 1 |
| Gore, JC | 1 |
| Wang, Q | 1 |
| Paulson, OB | 1 |
| Lassen, NA | 1 |
| Hughes, JM | 1 |
| Harris, A | 1 |
| Tippke, S | 1 |
| Sievers, C | 1 |
| Picht, G | 1 |
| Lieb, W | 1 |
| Martin, B | 1 |
| Kazumata, K | 1 |
| Tanaka, N | 1 |
| Ishikawa, T | 1 |
| Kuroda, S | 1 |
| Houkin, K | 1 |
| Mitsumori, K | 1 |
| Kohshi, K | 1 |
| Kinoshita, Y | 1 |
| Fukata, K | 1 |
| Prieto de Paula, JM | 1 |
| Villamandos Nicás, V | 1 |
| Cancelo Suárez, P | 1 |
| del Portillo Rubí, A | 1 |
| Guillem Ares, E | 1 |
| Prada Mínguez, A | 1 |
| Sanz de la Fuente, H | 1 |
| Hudgel, DW | 1 |
| Thanakitcharu, S | 1 |
| Chin, K | 1 |
| Oku, Y | 1 |
| Nishimura, K | 1 |
| Ohi, M | 1 |
| De Backer, WA | 1 |
| Vereshchagin, NV | 1 |
| Barkhatov, DIu | 1 |
| Dzhibladze, DN | 1 |
| Kawaguchi, S | 1 |
| Sakaki, T | 1 |
| Uranishi, R | 1 |
| Vovk, A | 1 |
| Duffin, J | 1 |
| Kowalchuk, JM | 1 |
| Paterson, DH | 1 |
| Cunningham, DA | 1 |
| Jones, PW | 1 |
| Greenstone, M | 1 |
| Nemoto, EM | 1 |
| Yonas, H | 1 |
| van de Ven, MJ | 1 |
| Colier, WN | 1 |
| van der Sluijs, MC | 1 |
| Oeseburg, B | 1 |
| Vis, P | 1 |
| Kazemi, H | 3 |
| Wyen, J | 1 |
| van Leuven, F | 1 |
| Leusen, I | 1 |
| Choma, L | 2 |
| Yamamoto, WS | 1 |
| Yamamoto, OS | 1 |
| Maren, TH | 1 |
| Gökhan, N | 1 |
| Gökçe, S | 1 |
| Saunier, C | 2 |
| Horsky, P | 2 |
| Hartemann, D | 2 |
| Colas, T | 1 |
| Gallagher, TJ | 1 |
| Bondoli, A | 1 |
| De Cosmo, G | 1 |
| Dordoni, L | 1 |
| Magalini, SI | 1 |
| Monclair, T | 1 |
| Mathisen, O | 1 |
| Kiil, F | 1 |
| Hannhart, B | 1 |
| Garcia-Carmona, T | 1 |
| Walker, AM | 1 |
| Oakes, GK | 1 |
| Ehrenkranz, R | 1 |
| McLaughlin, M | 1 |
| Chez, RA | 1 |
| Barth, J | 1 |
| Schatz, H | 1 |
| Clivati, A | 1 |
| Ciofetti, M | 1 |
| Cavestri, R | 1 |
| Longhini, E | 1 |
| Bashir, Y | 1 |
| Kann, M | 1 |
| Stradling, JR | 1 |
| Mathew, RJ | 1 |
| Wilson, WH | 1 |
| Tant, S | 1 |
| Tojima, H | 2 |
| Kuriyama, T | 2 |
| Fukuda, Y | 1 |
| Winaver, J | 1 |
| Walker, KA | 1 |
| Kunau, RT | 1 |
| Barclay, JK | 1 |
| Huang, SY | 1 |
| McCullough, RE | 1 |
| McCullough, RG | 1 |
| Micco, AJ | 1 |
| Manco-Johnson, M | 1 |
| Weil, JV | 1 |
| Reeves, JT | 1 |
| Kunitomo, F | 1 |
| Okita, S | 1 |
| Tatsumi, K | 1 |
| Kimura, H | 1 |
| Watanabe, S | 1 |
| Honda, Y | 1 |
| Bank, N | 1 |
| Aynedjian, HS | 1 |
| Mutz, BF | 1 |
| Sant'Ambrogio, G | 1 |
| Miserocchi, G | 1 |
| Mortola, J | 1 |
| Deonna, T | 1 |
| Arczynska, W | 1 |
| Torrado, A | 1 |
| Messeter, K | 1 |
| Hartman, BO | 1 |
| Aguedo Matorras, A | 1 |
| de Frutos Herranz, M | 1 |
| Black, AM | 1 |
| McCloskey, DI | 1 |
| Torrance, RW | 1 |
| Storch, TG | 1 |
| Layton, WM | 1 |
| Kurtzman, NA | 1 |
| Bertrand, A | 1 |
| Janbon, F | 1 |
| Callis, A | 1 |
| Milane, J | 1 |
| Anderson, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Acetazolamide on the Duration of Mechanical Ventilation in Patients With Metabolic Alkalosis. Phase III Multicenter Double-blinded Clinical Trial.[NCT01499485] | Phase 3 | 140 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| Treatment of High-altitude Sleep Disturbance: A Double-blind Comparison of Temazepam Versus Acetazolamide.[NCT01519544] | 34 participants (Actual) | Interventional | 2012-03-31 | Completed | |||
| Brain During Effort : Effects of Hypoxia With Respiratory Patients[NCT02854280] | 33 participants (Actual) | Interventional | 2013-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for acetazolamide and Hypercapnia
| Article | Year |
|---|---|
Medication effects on sleep and breathing.
Topics: Acetazolamide; Altitude; Androgens; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Be | 2014 |
Recent advances in obesity hypoventilation syndrome.
Topics: Acetazolamide; Algorithms; Animals; Bariatric Surgery; Comorbidity; Continuous Positive Airway Press | 2007 |
Pharmacologic treatment of sleep-disordered breathing.
Topics: Acetazolamide; Antihypertensive Agents; Apnea; Bronchodilator Agents; Diuretics; Dyspnea; Evidence-B | 1998 |
Methods and clinical significance of studying chemical drives.
Topics: Acetazolamide; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Chemoreceptor Cells; Humans; Hypercapn | 1998 |
[Estimation of cerebrovascular reserve in atherosclerotic lesions of the carotid arteries].
Topics: Acetazolamide; Anticonvulsants; Arteriosclerosis; Carbon Dioxide; Carotid Artery Diseases; Carotid A | 1999 |
Carbonic anhydrase inhibitors for hypercapnic ventilatory failure in chronic obstructive pulmonary disease.
Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Clinical Trials as Topic; Female; Humans; Hypercapnia; | 2001 |
Effect of varying CO2 equilibria on rates of HCO3- formation in cerebrospinal fluid.
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis; Alkalosis; Animals; Bicarbonates; Carbon Dioxide; Ca | 1979 |
The physiologic-psychologic relationship: some experiences during experiments in a medical research institution.
Topics: Acceleration; Acetazolamide; Aerospace Medicine; Altitude; Antimalarials; Blood Pressure; Carbon Dio | 1969 |
11 trials available for acetazolamide and Hypercapnia
| Article | Year |
|---|---|
Acetazolamide attenuates Hunter-Cheyne-Stokes breathing but augments the hypercapnic ventilatory response in patients with heart failure.
Topics: Acetazolamide; Aged; Blood Gas Analysis; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Chemorecepto | 2014 |
Sex and acetazolamide effects on chemoreflex and periodic breathing during sleep at altitude.
Topics: Acetazolamide; Adult; Altitude; Carbonic Anhydrase Inhibitors; Chemoreceptor Cells; Dose-Response Re | 2015 |
Influence of cerebral blood flow on central sleep apnea at high altitude.
Topics: Acclimatization; Acetazolamide; Administration, Intravenous; Administration, Oral; Adult; Altitude; | 2014 |
Effect of acetazolamide on chemosensitivity, Cheyne-Stokes respiration, and response to effort in patients with heart failure.
Topics: Acetazolamide; Aged; Carbonic Anhydrase Inhibitors; Cheyne-Stokes Respiration; Female; Heart Failure | 2011 |
Combined treatment with acetazolamide and medroxyprogesterone in chronic obstructive pulmonary disease patients.
Topics: Acetazolamide; Aged; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Double-Blind Method; Drug Therap | 2002 |
Comparison of acetazolamide and medroxyprogesterone as respiratory stimulants in hypercapnic patients with COPD.
Topics: Acetazolamide; Aged; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypercapnia; Hypoxia; | 2003 |
Alveolar PCO2 oscillations and ventilation at sea level and at high altitude.
Topics: Acclimatization; Acetazolamide; Acute Disease; Administration, Inhalation; Altitude; Bicycling; Carb | 2008 |
[Acetazolamide in hypercapnic chronic obstructive lung disease--a renaissance?].
Topics: Acetazolamide; Acidosis; Double-Blind Method; Humans; Hypercapnia; Hypoxia; Lung Diseases, Obstructi | 1983 |
Effects of acute and chronic acetazolamide on resting ventilation and ventilatory responses in men.
Topics: Acetazolamide; Acidosis, Respiratory; Adult; Bicarbonates; Carbon Dioxide; Carbonic Anhydrase Inhibi | 1993 |
Acetazolamide and CO2: acute effects on cerebral and retrobulbar hemodynamics.
Topics: Acetazolamide; Adult; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Cerebral Arteries; Drug Combina | 1996 |
Responses to hypercarbia induced by acetazolamide in panic disorder patients.
Topics: Acetazolamide; Adult; Anxiety Disorders; Cerebrovascular Circulation; Double-Blind Method; Fear; Fem | 1989 |
65 other studies available for acetazolamide and Hypercapnia
| Article | Year |
|---|---|
BOLD fMRI and hemodynamic responses to somatosensory stimulation in anesthetized mice: spontaneous breathing vs. mechanical ventilation.
Topics: Acetazolamide; Animals; Blood Vessels; Hemodynamics; Hypercapnia; Magnetic Resonance Imaging; Male; | 2020 |
The Effect of Add-on Acetazolamide to Conventional Diuretics for Diuretic-resistant Edema Complicated with Hypercapnia: A Report of Two Cases.
Topics: Acetazolamide; Diuretics; Edema; Female; Furosemide; Humans; Hypercapnia; Male | 2022 |
Behavioural responses to environmental hypercapnia in two eusocial species of African mole rats.
Topics: Acclimatization; Acetazolamide; Acid-Base Equilibrium; Adaptation, Psychological; Animals; Behavior, | 2018 |
Postischemic Responsiveness of Pial Vessels to Hypercapnia.
Topics: Acetazolamide; Animals; Arteries; Brain Ischemia; Cerebrovascular Circulation; Convalescence; Hyperc | 2015 |
Effect of acetazolamide on post-NIV metabolic alkalosis in acute exacerbated COPD patients.
Topics: Acetazolamide; Acid-Base Equilibrium; Acute Disease; Aged; Aged, 80 and over; Alkalosis; Carbonic An | 2016 |
The vasodilating effect of acetazolamide and dorzolamide involves mechanisms other than carbonic anhydrase inhibition.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetazolamide; Acidosis; Animals | 2009 |
Hypercapnic respiratory failure in obesity-hypoventilation syndrome: CO₂ response and acetazolamide treatment effects.
Topics: Acetazolamide; Aged; Alkalosis; Bicarbonates; Blood Gas Analysis; Carbon Dioxide; Carbonic Anhydrase | 2010 |
Obesity hypoventilation syndrome: bicarbonate concentration and acetazolamide.
Topics: Acetazolamide; Alkalosis; Bicarbonates; Blood Gas Analysis; Carbon Dioxide; Carbonic Anhydrase Inhib | 2010 |
Effects of acute hypercapnia on the amplitude of cerebrovascular pulsation in humans registered with a non-invasive method.
Topics: Acetazolamide; Acute Disease; Adult; Blood Flow Velocity; Carbonic Anhydrase Inhibitors; Cerebral Ar | 2012 |
Quiz page January 2013: sudden deafness in a patient treated with long-term hemodialysis.
Topics: Acetazolamide; Adult; Diabetic Nephropathies; Hearing Loss, Sudden; Humans; Hypercapnia; Intracrania | 2013 |
[Impairment of vasoreactivity in brainstem and hemispheral small vessel disease: comparative study].
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Basilar Artery; Blood Flow Velocity; Brain Stem; Carb | 2002 |
Hemodynamic changes during neural deactivation in human brain: a positron emission tomography study of crossed cerebellar diaschisis.
Topics: Acetazolamide; Adult; Aged; Blood Flow Velocity; Brain Mapping; Carbon Dioxide; Cerebellum; Cerebral | 2002 |
Carbon dioxide production during acetazolamide and medroxyprogesterone treatment.
Topics: Acetazolamide; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Humans; Hyp | 2003 |
Comparison of regional vasomotor responses to acetazolamide and CO2 in rabbit cerebrum and cerebellum, measured by a hydrogen clearance method.
Topics: Acetazolamide; Animals; Blood Pressure; Carbon Dioxide; Cerebellum; Cerebrovascular Circulation; Hea | 2004 |
Euhydric hypercapnia increases vasoreactivity of rat pulmonary arteries via HCO3- transport and depolarisation.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetazolamide; Animals; Anthracenes; Arteries; Bic | 2005 |
Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy.
Topics: Acetazolamide; Animals; Blood Pressure; CADASIL; Cerebrovascular Circulation; Disease Models, Animal | 2005 |
Relationship between cerebral circulatory reserve and oxygen extraction fraction in patients with major cerebral artery occlusive disease: a positron emission tomography study.
Topics: Acetazolamide; Adult; Aged; Brain; Cerebral Arterial Diseases; Cerebrovascular Circulation; Cerebrov | 2006 |
Exhaustive exercise, animal stress, and environmental hypercapnia on motility of sperm of steelhead trout (Oncorhynchus mykiss).
Topics: Acetazolamide; Animals; Carbon Dioxide; Environment; Hydrogen-Ion Concentration; Hypercapnia; Oncorh | 2007 |
Acetazolamide protects against posthypoxic unstable breathing in the C57BL/6J mouse.
Topics: Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Disease Models, Animal; Hypercapnia; Hypoxia; | 2007 |
Carbonic anhydrase II and alveolar fluid reabsorption during hypercapnia.
Topics: Acetazolamide; Animals; Bronchoalveolar Lavage Fluid; Carbon Dioxide; Carbonic Anhydrase II; Carboni | 2008 |
Acid-base metabolism, intracellular pH and water transport by the toad bladder.
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis; Alkalosis; Animals; Biological Transport; Body Water | 1983 |
Effects of sympathetic stimulation on cerebral and ocular blood flow. Modification by hypertension, hypercapnia, acetazolamide, PGI2 and papaverine.
Topics: Acetazolamide; Animals; Cerebrovascular Circulation; Electric Stimulation; Epoprostenol; Eye; Female | 1982 |
Effect of hypercapnea and hyperventilation on human intraocular pressure general anaesthesia following acetazolamide administration.
Topics: Acetazolamide; Adult; Anesthesia, General; Carbon Dioxide; Female; Humans; Hydrogen-Ion Concentratio | 1980 |
Effects of duration at altitude and acetazolamide on ventilation and oxygenation during sleep.
Topics: Acetazolamide; Adult; Altitude; Female; Humans; Hypercapnia; Hypoxia; Male; Oximetry; Oxygen; Physic | 1980 |
Assessment of cerebral vasomotor reactivity by transcranial Doppler ultrasound and breath-holding. A comparison with acetazolamide as vasodilatory stimulus.
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Blood Flow Velocity; Brain Ischemia; Carotid Stenosis | 1995 |
BOLD MRI monitoring of changes in cerebral perfusion induced by acetazolamide and hypercarbia in the rat.
Topics: Acetazolamide; Administration, Inhalation; Animals; Blood Volume; Carbon Dioxide; Cerebrovascular Ci | 1994 |
Indomethacin abolishes cerebral blood flow increase in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia?
Topics: Acetazolamide; Acidosis; Animals; Carbon Dioxide; Cerebrovascular Circulation; Diclofenac; Extracell | 1993 |
Dissociation of vasoreactivity to acetazolamide and hypercapnia. Comparative study in patients with chronic occlusive major cerebral artery disease.
Topics: Acetazolamide; Aged; Carbonic Anhydrase Inhibitors; Cerebral Infarction; Cerebrovascular Circulation | 1996 |
Brain pH responses to acetazolamide and hypercapnia in cats.
Topics: Acetazolamide; Acid-Base Equilibrium; Animals; Brain; Carbonic Anhydrase Inhibitors; Cats; Female; H | 1997 |
[Efficacy of acetazolamide treatment of patients with hypercapnia and superimposed metabolic alkalosis].
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis, Respiratory; Adrenal Cortex Hormones; Aged; Aged, 80 | 1997 |
Deep breathing and awake apnoea in a patient who had recurrent hypoxaemia and hypercapnia without sleep apnoea.
Topics: Acetazolamide; Adult; Apnea; Humans; Hypercapnia; Hypoxia; Magnetic Resonance Imaging; Male; Respira | 1998 |
Effects of bypass on CO2 cerebrovascular reactivity in ischaemic cerebrovascular diseases--based on the intra-operative LCBF and CO2 cerebrovascular reactivity studies.
Topics: Acetazolamide; Adult; Aged; Brain Ischemia; Carbonic Anhydrase Inhibitors; Cerebral Revascularizatio | 1999 |
Influence of nitrovasodilators and cyclooxygenase inhibitors on cerebral vasoreactivity in conscious rabbits.
Topics: Acetazolamide; Animals; Blood Pressure; Blood Vessels; Cerebrovascular Circulation; Cyclooxygenase I | 2001 |
Changes in chemoreflex characteristics following acute carbonic anhydrase inhibition in humans at rest.
Topics: Acetazolamide; Adult; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Chemoreceptor Cells; Female; Hu | 2000 |
Revisiting the question, "is the acetazolamide test valid for quantitative assessment of maximal cerebral autoregulatory vasodilation?".
Topics: Acetazolamide; Animals; Blood Flow Velocity; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Cerebrov | 2001 |
Effects of acetazolamide and furosemide on ventilation and cerebral blood volume in normocapnic and hypercapnic patients with COPD.
Topics: Acetazolamide; Administration, Oral; Alkalosis; Blood Volume; Carbon Dioxide; Cerebrovascular Circul | 2002 |
The CSF HCO3 increase in hypercapnia relationshp to HCO3, glutamate, glutamine and NH3 in brain.
Topics: Acetazolamide; Ammonia; Animals; Bicarbonates; Brain; Cerebrospinal Fluid; Glutamates; Glutamine; Hy | 1976 |
H+ transport from CNS in hypercapnia and regulation of CSF [HCO3-].
Topics: Acetazolamide; Animals; Bicarbonates; Biological Transport; Carbon Dioxide; Central Nervous System; | 1977 |
Hydrogen ion homeostasis in the CNS in respiratory acidosis.
Topics: Acetazolamide; Acidosis; Animals; Carbon Dioxide; Carbonates; Central Nervous System; Dogs; Hydrogen | 1978 |
A mathematical model of chemoreflex responses to hypercapnic stimuli.
Topics: Acetazolamide; Animals; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Carotid | 1979 |
Influence of hypercapnia on intraocular pressure in rabbits.
Topics: Acetazolamide; Acidosis, Respiratory; Animals; Blood Pressure; Carbon Dioxide; Carbonates; Hydrogen- | 1975 |
[Effect of acetazolamide on arterial blood lactate levels during recuperation in air from three days of hypercapnia].
Topics: Acetazolamide; Acid-Base Equilibrium; Animals; Carbon Dioxide; Dogs; Hydrogen-Ion Concentration; Hyp | 1975 |
Metabolic alkalosis complicating weaning from mechanical ventilation.
Topics: Acetazolamide; Alkalosis; Humans; Hypercapnia; Intermittent Positive-Pressure Ventilation; Oxygenato | 1979 |
[Acetazolamide in respiratory insufficiency].
Topics: Acetazolamide; Acid-Base Imbalance; Acute Disease; Brain Injuries; Chronic Disease; Humans; Hypercap | 1979 |
Renal metabolic rate during changes in bicarbonate-dependent sodium reabsorption in the proximal tubules.
Topics: Acetazolamide; Animals; Bicarbonates; Blood Pressure; Carbon Dioxide; Dogs; Energy Metabolism; Ethac | 1979 |
Post-hypercapnia recovery in the dog: arterial blood acid-base equilibrium and glycolysis.
Topics: Acetazolamide; Acid-Base Equilibrium; Animals; Carbon Dioxide; Dogs; Female; Glycolysis; Hypercapnia | 1977 |
Effects of hypercapnia on uterine and umbilical circulations in conscious pregnant sheep.
Topics: Acetazolamide; Animals; Female; Hypercapnia; Pregnancy; Regional Blood Flow; Sheep; Umbilicus; Uteru | 1976 |
[The indications for acetazolamide].
Topics: Acetazolamide; Acidosis, Respiratory; Alkalosis; Humans; Hypercapnia; Respiratory Insufficiency | 1992 |
Cerebral vascular responsiveness in chronic hypercapnia.
Topics: Acetazolamide; Aged; Blood Flow Velocity; Cerebral Arteries; Cerebrovascular Circulation; Chronic Di | 1992 |
The effect of acetazolamide on hypercapnic and eucapnic/poikilocapnic hypoxic ventilatory responses in normal subjects.
Topics: Acetazolamide; Adult; Altitude Sickness; Carbon Dioxide; Female; Humans; Hypercapnia; Hypoxia; Male; | 1990 |
Delayed ventilatory response to CO2 after carbonic anhydrase inhibition with acetazolamide administration in the anesthetized rat.
Topics: Acetazolamide; Anesthesia, Inhalation; Animals; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Hyper | 1988 |
Effect of acute hypercapnia on renal and proximal tubular total carbon dioxide reabsorption in the acetazolamide-treated rat.
Topics: Absorption; Acetazolamide; Animals; Bicarbonates; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Den | 1986 |
Carbonic anhydrase III inhibition in normocapnic and hypercapnic contracting mouse soleus.
Topics: Acetazolamide; Animals; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cyanates | 1987 |
Usual clinical dose of acetazolamide does not alter cerebral blood flow velocity.
Topics: Acetazolamide; Adult; Altitude Sickness; Blood Flow Velocity; Cerebrovascular Circulation; Humans; H | 1988 |
[Effect of acetazolamide on blood gas, ventilatory control and sleep in patients with chronic respiratory disease and sleep apnea syndrome].
Topics: Acetazolamide; Humans; Hypercapnia; Lung Diseases, Obstructive; Sleep Apnea Syndromes | 1987 |
Evidence for a DCCD-sensitive component of proximal bicarbonate reabsorption.
Topics: Absorption; Acetazolamide; Amiloride; Animals; Bicarbonates; Carbodiimides; Dicyclohexylcarbodiimide | 1985 |
Transient responses of pulmonary stretch receptors in the dog to inhalation of carbon dioxide.
Topics: Acetazolamide; Animals; Carbon Dioxide; Dogs; Hypercapnia; Isoproterenol; Mechanoreceptors; Pulmonar | 1974 |
Congenital failure of automatic ventilation (Ondine's curse). A case report.
Topics: Acetazolamide; Chemoreceptor Cells; Cyanosis; Dexamethasone; Diabetes Insipidus; Feeding and Eating | 1974 |
The effect of acetazolamide upon the regulation of the cerebrospinal fluid pH in the rat.
Topics: Acetazolamide; Acid-Base Equilibrium; Animals; Bicarbonates; Biological Transport; Carbon Dioxide; C | 1972 |
[Indications for THAM in hypercapnic acidosis].
Topics: Acetazolamide; Acidosis, Respiratory; Drug Synergism; Humans; Hypercapnia; Tromethamine | 1971 |
The responses of carotid body chemoreceptors in the cat to sudden changes of hypercapnic and hypoxic stimuli.
Topics: Acetazolamide; Animals; Arteries; Carbon Dioxide; Carotid Body; Carotid Sinus; Cats; Chemoreceptor C | 1971 |
The role of hypercapnia in acetazolamide teratogenesis.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Carbon Dioxide; Cricetinae; Female; Fetal Death | 1971 |
Relationship of extracellular volume and CO2 tension to renal bicarbonate reabsorption.
Topics: Acetazolamide; Acidosis, Respiratory; Animals; Arteries; Bicarbonates; Blood Pressure; Carbon Dioxid | 1970 |
[Use of diuretics in the course of acute respiratory insufficiency in chronic broncho-pulmonary diseases: apropos of a study of clopamide, ethacrynic acid and acetazolamide].
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis, Respiratory; Amides; Bronchial Diseases; Clopamide; | 1968 |
Ocular effects of changes in oxygen and carbon dioxide tension.
Topics: Academic Dissertations as Topic; Acetazolamide; Adaptation, Ocular; Adult; Angiography; Atmospheric | 1968 |