acetazolamide has been researched along with Hemorrhage, Subarachnoid in 19 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cerebral blood flow (CBF) and response to acetazolamide were measured during the acute, subacute, and chronic stages after aneurysmal subarachnoid hemorrhage and correlated with symptomatic vasospasm and clinical outcome in 45 patients who underwent early clipping of ruptured cerebral aneurysms, of whom 18 had symptomatic vasospasm and 27 did not." | 7.70 | Cerebral blood flow and the response to acetazolamide during the acute, subacute, and chronic stages of aneurysmal subarachnoid hemorrhage. ( Nakayama, Y; Tanaka, A; Tomonaga, M; Yoshinaga, S, 1998) |
| "Blood flow velocity (BFV) in the middle cerebral artery at rest and cerebrovascular reserve capacity (CVRC) (percent rise in BFV after acetazolamide stimulation) measured by means of transcranial Doppler sonography were studied many years after aneurysmal subarachnoid hemorrhage in patients with proven cerebral vasospasm (mean BFV > 160 cm/s)." | 7.69 | Cerebrovascular reserve capacity many years after vasospasm due to aneurysmal subarachnoid hemorrhage. A transcranial Doppler study with acetazolamide test. ( Ficzere, A; Novak, L; Rozsa, L; Sheth, RN; Szabo, S, 1997) |
| "Prediction of cerebral infarction due to vasospasm (VS) following aneurysmal subarachnoid haemorrhage (SAH) was investigated using acetazolamide-activated (A-A) N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) single photon emission computed tomography (SPECT) in 79 SAH patients." | 7.68 | Prediction of cerebral infarction due to vasospasm following aneurysmal subarachnoid haemorrhage using acetazolamide-activated 123I-IMP SPECT. ( Funakoshi, T; Kimura, T; Shinoda, J, 1993) |
| "Cerebral blood flow (CBF) and response to acetazolamide were measured during the acute, subacute, and chronic stages after aneurysmal subarachnoid hemorrhage and correlated with symptomatic vasospasm and clinical outcome in 45 patients who underwent early clipping of ruptured cerebral aneurysms, of whom 18 had symptomatic vasospasm and 27 did not." | 3.70 | Cerebral blood flow and the response to acetazolamide during the acute, subacute, and chronic stages of aneurysmal subarachnoid hemorrhage. ( Nakayama, Y; Tanaka, A; Tomonaga, M; Yoshinaga, S, 1998) |
| "Blood flow velocity (BFV) in the middle cerebral artery at rest and cerebrovascular reserve capacity (CVRC) (percent rise in BFV after acetazolamide stimulation) measured by means of transcranial Doppler sonography were studied many years after aneurysmal subarachnoid hemorrhage in patients with proven cerebral vasospasm (mean BFV > 160 cm/s)." | 3.69 | Cerebrovascular reserve capacity many years after vasospasm due to aneurysmal subarachnoid hemorrhage. A transcranial Doppler study with acetazolamide test. ( Ficzere, A; Novak, L; Rozsa, L; Sheth, RN; Szabo, S, 1997) |
| "Prediction of cerebral infarction due to vasospasm (VS) following aneurysmal subarachnoid haemorrhage (SAH) was investigated using acetazolamide-activated (A-A) N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) single photon emission computed tomography (SPECT) in 79 SAH patients." | 3.68 | Prediction of cerebral infarction due to vasospasm following aneurysmal subarachnoid haemorrhage using acetazolamide-activated 123I-IMP SPECT. ( Funakoshi, T; Kimura, T; Shinoda, J, 1993) |
| "Three patients with acute diffuse brain swelling seen on CT showed intracranial non-filling of 123I-IMP on SPECTs performed on Day 6, and all three died by Day 10." | 1.28 | Acetazolamide reactivity on cerebral blood flow in patients with subarachnoid haemorrhage. ( Araki, Y; Funakoshi, T; Imao, Y; Kimura, T; Shinoda, J, 1991) |
| "The xenon CT method is an asset in the diagnosis of cerebral diseases since it provides information on functional changes in addition to the morphological findings." | 1.28 | [Non-invasive measurement of cerebrovascular circulation using xenon(s) computerized tomography. A review]. ( Nabi Nemati, M, 1990) |
| "A review of the most recent 23 cases of benign intracranial hypertension (BIH), admitted to the War Memorial Children's Hospital in London, Ontario, provided a compendium of the clinical manifestations of this disorder in children and adolescents." | 1.27 | Spectrum of benign intracranial hypertension in children and adolescents. ( Amacher, AL; Spence, JD, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 9 (47.37) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jarus-Dziedzic, K | 1 |
| Głowacki, M | 1 |
| Warzecha, A | 1 |
| Jurkiewicz, J | 1 |
| Czernicki, Z | 1 |
| Fersten, E | 1 |
| Yang, L | 1 |
| Hashemi, N | 1 |
| Lee, AG | 1 |
| Chang, CC | 2 |
| Kuwana, N | 2 |
| Ito, S | 2 |
| Yokoyama, T | 1 |
| Kanno, H | 1 |
| Yamamoto, I | 1 |
| Miyati, T | 1 |
| Mase, M | 1 |
| Banno, T | 1 |
| Kasuga, T | 1 |
| Yamada, K | 1 |
| Fujita, H | 1 |
| Koshida, K | 1 |
| Sanada, S | 1 |
| Onoguchi, M | 1 |
| Bassuk, AG | 1 |
| Burrowes, DM | 1 |
| Velimirovic, B | 1 |
| Grant, J | 1 |
| Keating, GF | 1 |
| Higashi, K | 1 |
| Kimura, T | 2 |
| Shinoda, J | 2 |
| Funakoshi, T | 2 |
| Tran Dinh, YR | 2 |
| Lot, G | 2 |
| Benrabah, R | 1 |
| Baroudy, O | 1 |
| Cophignon, J | 2 |
| Seylaz, J | 1 |
| Sugino, F | 1 |
| Ogawa, T | 1 |
| Umemura, S | 1 |
| Suzuki, S | 1 |
| Kawamura, Y | 1 |
| Inao, S | 1 |
| Kuchiwaki, H | 1 |
| Yoshida, J | 1 |
| Furuse, M | 1 |
| Szabo, S | 1 |
| Sheth, RN | 1 |
| Novak, L | 1 |
| Rozsa, L | 1 |
| Ficzere, A | 1 |
| Tanaka, A | 1 |
| Yoshinaga, S | 1 |
| Nakayama, Y | 1 |
| Tomonaga, M | 1 |
| Ikegami, T | 1 |
| Vander Borght, T | 1 |
| Laloux, P | 1 |
| Maes, A | 1 |
| Salmon, E | 1 |
| Goethals, I | 1 |
| Goldman, S | 1 |
| Adams, RD | 1 |
| Mourier, KL | 1 |
| George, B | 1 |
| Raggueneau, JL | 1 |
| Boissonnet, H | 1 |
| Araki, Y | 1 |
| Imao, Y | 1 |
| Nabi Nemati, M | 1 |
| Amacher, AL | 1 |
| Spence, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| C-arm Cone Beam CTA and CTP With Acetazolamide Challenge in Aneurysmal Subarachnoid Hemorrhage: Evaluating Predictability for Early Ischemia in Cerebral Vasospasm[NCT03377049] | Phase 4 | 11 participants (Actual) | Interventional | 2019-07-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinical neurological deterioration not attributable to other causes, mores specifically not due to re-bleeding, hydrocephalus, or metabolic changes. (NCT03377049)
Timeframe: Day 1-14 during the hospitalization
| Intervention | Participants (Count of Participants) |
|---|---|
| Acetazolamide Challenge | 2 |
Using perfusion map values, relative percent change will be calculated (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour
| Intervention | percent change (Mean) |
|---|---|
| Acetazolamide Challenge | 19.785 |
Using perfusion map values, relative percent change will be calculated (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour
| Intervention | percent change (Mean) |
|---|---|
| Acetazolamide Challenge | 21.659 |
The data that will be statistically compared is the pre-diamox perfusion in comparison to the post-diamox perfusion. A statistically significant change increase in CBF represents an appropriate response to Diamox. Lack of change in CBF or decrease in CBF could be suggestive of potential for developing vasospasm. (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour
| Intervention | percent change (Mean) |
|---|---|
| Acetazolamide Challenge | 20.722 |
1 review available for acetazolamide and Hemorrhage, Subarachnoid
| Article | Year |
|---|---|
[Value of the measurement of cerebral blood flow before and after diamox injection in predicting clinical vasospasm and final outcome in aneurysmal subarachnoid hemorrhage].
Topics: Acetazolamide; Cerebrovascular Circulation; Female; Humans; Intracranial Aneurysm; Male; Nimodipine; | 1991 |
1 trial available for acetazolamide and Hemorrhage, Subarachnoid
| Article | Year |
|---|---|
Cerebral haemodynamics in patients with hydrocephalus after subarachnoid haemorrhage due to ruptured aneurysm.
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Brain; Cerebral Ventricles; Cereb | 2003 |
17 other studies available for acetazolamide and Hemorrhage, Subarachnoid
| Article | Year |
|---|---|
Cerebrovascular reactivity evaluated by transcranial doppler sonography in patients after aneurysmal subarachnoid haemorrhage treated with microsurgical clipping or endovascular coiling technique.
Topics: Acetazolamide; Adult; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Endovascular Procedur | 2011 |
Intracranial complications of idiopathic intracranial hypertension.
Topics: Acetazolamide; Adult; Anticoagulants; Cerebral Veins; Drug Therapy, Combination; Female; Humans; Mag | 2012 |
Frequency analyses of CSF flow on cine MRI in normal pressure hydrocephalus.
Topics: Acetazolamide; Adult; Anticonvulsants; Atrophy; Blood Flow Velocity; Brain; Cerebrospinal Fluid; Cer | 2003 |
A child with spinal cord AVM presenting with raised intracranial pressure.
Topics: Acetazolamide; Adolescent; Arteriovenous Malformations; Cervical Vertebrae; Diplopia; Dura Mater; Fe | 2003 |
[Surgical and medical treatment of increased intracranial pressure (author's transl)].
Topics: Acetazolamide; Adolescent; Adrenal Cortex Hormones; Adult; Animals; Barbiturates; Brain Edema; Cereb | 1980 |
Prediction of cerebral infarction due to vasospasm following aneurysmal subarachnoid haemorrhage using acetazolamide-activated 123I-IMP SPECT.
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Amphetamines; Aneurysm, Ruptured; Brain; Cerebral Inf | 1993 |
Abnormal cerebral vasodilation in aneurysmal subarachnoid hemorrhage: use of serial 133Xe cerebral blood flow measurement plus acetazolamide to assess cerebral vasospasm.
Topics: Acetazolamide; Adult; Cerebral Angiography; Cerebrovascular Circulation; Female; Humans; Intracrania | 1993 |
Effect of acetazolamide on cerebral blood flow and tympanic temperature in healthy subjects and patients with subacute subarachnoid haemorrhage.
Topics: Acetazolamide; Adult; Aged; Body Temperature; Cerebrovascular Circulation; Female; Humans; Male; Mid | 1997 |
Magnetic resonance imaging quantitation of superior sagittal sinus flow: correlation to cerebral blood flow measured by xenon-enhanced computed tomography.
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Artifacts; Brain; Brain Neoplasms; Cerebral Hemorrhag | 1997 |
Cerebrovascular reserve capacity many years after vasospasm due to aneurysmal subarachnoid hemorrhage. A transcranial Doppler study with acetazolamide test.
Topics: Acetazolamide; Adolescent; Adult; Blood Flow Velocity; Cerebrovascular Circulation; Female; Follow-U | 1997 |
Cerebral blood flow and the response to acetazolamide during the acute, subacute, and chronic stages of aneurysmal subarachnoid hemorrhage.
Topics: Acetazolamide; Acute Disease; Adult; Aged; Aged, 80 and over; Cerebrovascular Circulation; Chronic D | 1998 |
Impairment of cerebrovascular reactivity to acetazolamide in patients with normal pressure hydrocephalus.
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Brain Injuries; Brain Neoplasms; Cerebrovascular Circ | 2000 |
Guidelines for brain radionuclide imaging. Perfusion single photon computed tomography (SPECT) using Tc-99m radiopharmaceuticals and brain metabolism positron emission tomography (PET) using F-18 fluorodeoxyglucose. The Belgian Society for Nuclear Medicin
Topics: Acetazolamide; Adult; Brain; Brain Death; Cerebrovascular Disorders; Child; Craniocerebral Trauma; D | 2001 |
Recent observations on normal pressure hydrocephalus.
Topics: Acetazolamide; Aged; Cerebral Angiography; Cerebrospinal Fluid Shunts; Electroencephalography; Hemat | 1975 |
Acetazolamide reactivity on cerebral blood flow in patients with subarachnoid haemorrhage.
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Amphetamines; Brain Edema; Cerebrovascular Circulatio | 1991 |
[Non-invasive measurement of cerebrovascular circulation using xenon(s) computerized tomography. A review].
Topics: Acetazolamide; Adult; Brain Ischemia; Brain Neoplasms; Carotid Artery Diseases; Carotid Artery, Inte | 1990 |
Spectrum of benign intracranial hypertension in children and adolescents.
Topics: Acetazolamide; Adolescent; Anti-Bacterial Agents; Brain Concussion; Cerebrospinal Fluid Shunts; Chil | 1985 |