Page last updated: 2024-10-22

acetazolamide and Hematoma

acetazolamide has been researched along with Hematoma in 3 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Hematoma: A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.

Research Excerpts

ExcerptRelevanceReference
"Three patients with acute diffuse brain swelling seen on CT showed intracranial non-filling of 123I-IMP on SPECTs performed on Day 6, and all three died by Day 10."1.28Acetazolamide reactivity on cerebral blood flow in patients with subarachnoid haemorrhage. ( Araki, Y; Funakoshi, T; Imao, Y; Kimura, T; Shinoda, J, 1991)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lalla, R1
Malhotra, HS1
Garg, RK1
Verma, R1
Shinoda, J1
Kimura, T1
Funakoshi, T1
Araki, Y1
Imao, Y1
Takagi, T1
Matsumoto, T1
Kasuga, Y1
Horie, M1
Morishita, H1
Yasui, Y1
Ishikawa, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
C-arm Cone Beam CTA and CTP With Acetazolamide Challenge in Aneurysmal Subarachnoid Hemorrhage: Evaluating Predictability for Early Ischemia in Cerebral Vasospasm[NCT03377049]Phase 411 participants (Actual)Interventional2019-07-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants Who Develop Delayed Cerebral Vasospasm

Clinical neurological deterioration not attributable to other causes, mores specifically not due to re-bleeding, hydrocephalus, or metabolic changes. (NCT03377049)
Timeframe: Day 1-14 during the hospitalization

InterventionParticipants (Count of Participants)
Acetazolamide Challenge2

Percent Change in Left Hemisphere Brain Imaging Maps

Using perfusion map values, relative percent change will be calculated (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour

Interventionpercent change (Mean)
Acetazolamide Challenge19.785

Percent Change in Right Hemisphere Brain Imaging Maps

Using perfusion map values, relative percent change will be calculated (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour

Interventionpercent change (Mean)
Acetazolamide Challenge21.659

Relative Percent Change in Cerebral Blood Flow

The data that will be statistically compared is the pre-diamox perfusion in comparison to the post-diamox perfusion. A statistically significant change increase in CBF represents an appropriate response to Diamox. Lack of change in CBF or decrease in CBF could be suggestive of potential for developing vasospasm. (NCT03377049)
Timeframe: pre and post perfusion during imaging procedure, up to an hour

Interventionpercent change (Mean)
Acetazolamide Challenge20.722

Other Studies

3 other studies available for acetazolamide and Hematoma

ArticleYear
Conservative management in a rare case of spontaneous bilateral cerebellar haemorrhage.
    BMJ case reports, 2012, Jun-14, Volume: 2012

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetazolamide; Adult; Antiemetics; Cerebellum; Diuretics, O

2012
Acetazolamide reactivity on cerebral blood flow in patients with subarachnoid haemorrhage.
    Acta neurochirurgica, 1991, Volume: 109, Issue:3-4

    Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Amphetamines; Brain Edema; Cerebrovascular Circulatio

1991
[Hematoma of the basal ganglia in the newborn: non-surgical treatment].
    No to hattatsu = Brain and development, 1985, Volume: 17, Issue:4

    Topics: Acetazolamide; Basal Ganglia Diseases; Cerebral Hemorrhage; Female; Furosemide; Hematoma; Humans; In

1985