acetazolamide has been researched along with Friedreich Disease in 2 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The acetazolamide trial was terminated at 7 to 11 weeks because of reported side effects or increased ataxia in 3 of the patients." | 1.27 | Quantitative evaluation of the effects of acetazolamide in Friedreich's ataxia: a pilot study. ( Bouchard, JP; Dumas, F; Richards, CL; Tardif, D, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Richards, CL | 1 |
| Bouchard, JP | 1 |
| Dumas, F | 1 |
| Tardif, D | 1 |
| Griggs, RC | 1 |
| Moxley, RT | 1 |
| Lafrance, RA | 1 |
| McQuillen, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 2 Study of 4-Aminopyridine for the Treatment of Episodic Ataxia Type 2[NCT01543750] | Phase 2 | 0 participants (Actual) | Interventional | Withdrawn | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for acetazolamide and Friedreich Disease
| Article | Year |
|---|---|
Hereditary paroxysmal ataxia: response to acetazolamide.
Topics: Acetazolamide; Adolescent; Adult; Aged; Child, Preschool; Clinical Trials as Topic; Female; Friedrei | 1978 |
1 other study available for acetazolamide and Friedreich Disease
| Article | Year |
|---|---|
Quantitative evaluation of the effects of acetazolamide in Friedreich's ataxia: a pilot study.
Topics: Acetazolamide; Adolescent; Child; Drug Evaluation; Electromyography; Female; Friedreich Ataxia; Gait | 1984 |