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acetazolamide and Cystic Fibrosis

acetazolamide has been researched along with Cystic Fibrosis in 5 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.

Research Excerpts

ExcerptRelevanceReference
"Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, which mediates transepithelial Cl- transport in a variety of epithelia, including airway, intestine, pancreas, and sweat duct."1.30Exocytosis is not involved in activation of Cl- secretion via CFTR in Calu-3 airway epithelial cells. ( Loffing, J; McCoy, D; Moyer, BD; Stanton, BA, 1998)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chung, WJ1
Goeckeler-Fried, JL1
Havasi, V1
Chiang, A1
Rowe, SM1
Plyler, ZE1
Hong, JS1
Mazur, M1
Piazza, GA1
Keeton, AB1
White, EL1
Rasmussen, L1
Weissman, AM1
Denny, RA1
Brodsky, JL1
Sorscher, EJ1
RICHTERICH, R1
FRIOLET, B1
Loffing, J1
Moyer, BD1
McCoy, D1
Stanton, BA1
Cuthbert, AW1
Hickman, ME1
MacVinish, LJ1
Sagström, S1
McMillan, EB1
Marijianowski, M1
Mulders, H1
Roomans, GM1

Other Studies

5 other studies available for acetazolamide and Cystic Fibrosis

ArticleYear
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu

2016
THE EFFECT OF ACETAZOLAMIDE ON SWEAT ELECTROLYTES IN MUCOVISCIDOSIS.
    Metabolism: clinical and experimental, 1963, Volume: 12

    Topics: Acetazolamide; Carbonic Anhydrases; Child; Chlorides; Cystic Fibrosis; Electrolytes; Humans; Iontoph

1963
Exocytosis is not involved in activation of Cl- secretion via CFTR in Calu-3 airway epithelial cells.
    The American journal of physiology, 1998, Volume: 275, Issue:4

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetazolamide; Amiloride; Cell Membrane; Chloride

1998
Formal analysis of electrogenic sodium, potassium, chloride and bicarbonate transport in mouse colon epithelium.
    British journal of pharmacology, 1999, Volume: 126, Issue:1

    Topics: Acetazolamide; Amiloride; Animals; Bicarbonates; Biological Transport; Chlorides; Colforsin; Colon;

1999
Changes in rat and mouse salivary glands and pancreas after chronic treatment with diuretics: a potential animal model for cystic fibrosis.
    Scanning microscopy, 1990, Volume: 4, Issue:1

    Topics: Acetazolamide; Amiloride; Animals; Biological Transport; Chlorides; Cystic Fibrosis; Disease Models,

1990