acetazolamide has been researched along with Critical Illness in 7 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare two dosing regimens of acetazolamide for the reversal of metabolic alkalosis in mechanically ventilated patients with asthma or chronic obstructive pulmonary disease." | 9.09 | Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial. ( Devlin, JW; Iannuzzi, MC; Jankowski, MA; Mazur, JE; Peters, MJ; Zarowitz, BJ, 1999) |
| "Despite a paucity of supporting literature, acetazolamide is commonly used in critically ill children with metabolic alkalosis (elevated plasma bicarbonate [pHco-3] and pH)." | 7.81 | Acetazolamide therapy for metabolic alkalosis in critically ill pediatric patients. ( Bar, A; Chopra, A; Cies, J; Shore, PM; Stapleton, K; Tauber, D, 2015) |
| "Acetazolamide is an option for hypochloremic metabolic alkalosis, but there are limited reports in children." | 7.79 | Acetazolamide in critically ill neonates and children with metabolic alkalosis. ( Andrews, MG; Harrison, DL; Johnson, PN; Lammers, EM; Miller, JL, 2013) |
| "A single dose of acetazolamide effectively corrects metabolic alkalosis in critically ill patients by decreasing the serum SID." | 7.73 | Acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patients. ( Moviat, M; Pickkers, P; van der Hoeven, JG; van der Voort, PH, 2006) |
| "To compare two dosing regimens of acetazolamide for the reversal of metabolic alkalosis in mechanically ventilated patients with asthma or chronic obstructive pulmonary disease." | 5.09 | Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial. ( Devlin, JW; Iannuzzi, MC; Jankowski, MA; Mazur, JE; Peters, MJ; Zarowitz, BJ, 1999) |
| "Despite a paucity of supporting literature, acetazolamide is commonly used in critically ill children with metabolic alkalosis (elevated plasma bicarbonate [pHco-3] and pH)." | 3.81 | Acetazolamide therapy for metabolic alkalosis in critically ill pediatric patients. ( Bar, A; Chopra, A; Cies, J; Shore, PM; Stapleton, K; Tauber, D, 2015) |
| "Acetazolamide is an option for hypochloremic metabolic alkalosis, but there are limited reports in children." | 3.79 | Acetazolamide in critically ill neonates and children with metabolic alkalosis. ( Andrews, MG; Harrison, DL; Johnson, PN; Lammers, EM; Miller, JL, 2013) |
| "A single dose of acetazolamide effectively corrects metabolic alkalosis in critically ill patients by decreasing the serum SID." | 3.73 | Acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patients. ( Moviat, M; Pickkers, P; van der Hoeven, JG; van der Voort, PH, 2006) |
| "Metabolic alkalosis is characterized by the primary elevation of the serum bicarbonate concentration with a normal or elevated partial pressure of carbon dioxide." | 2.66 | Metabolic Alkalosis in the Pediatric Patient: Treatment Options in the Pediatric ICU or Pediatric Cardiothoracic ICU Setting. ( Tobias, JD, 2020) |
| "Metabolic alkalosis is the commonest form of acid-base disorder seen in critically ill patients." | 2.40 | Metabolic alkalosis in the critically ill. ( Kulkarni, V; Webster, NR, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Tobias, JD | 1 |
| Andrews, MG | 1 |
| Johnson, PN | 1 |
| Lammers, EM | 1 |
| Harrison, DL | 1 |
| Miller, JL | 1 |
| Bar, A | 1 |
| Cies, J | 1 |
| Stapleton, K | 1 |
| Tauber, D | 1 |
| Chopra, A | 1 |
| Shore, PM | 2 |
| Moviat, M | 1 |
| Pickkers, P | 1 |
| van der Voort, PH | 1 |
| van der Hoeven, JG | 1 |
| Mazur, JE | 1 |
| Devlin, JW | 1 |
| Peters, MJ | 1 |
| Jankowski, MA | 1 |
| Iannuzzi, MC | 1 |
| Zarowitz, BJ | 1 |
| Webster, NR | 1 |
| Kulkarni, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Acetazolamide on the Duration of Mechanical Ventilation in Patients With Metabolic Alkalosis. Phase III Multicenter Double-blinded Clinical Trial.[NCT01499485] | Phase 3 | 140 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for acetazolamide and Critical Illness
| Article | Year |
|---|---|
Metabolic Alkalosis in the Pediatric Patient: Treatment Options in the Pediatric ICU or Pediatric Cardiothoracic ICU Setting.
Topics: Acetazolamide; Alkalosis; Bicarbonates; Carbonic Anhydrase Inhibitors; Child; Critical Illness; Huma | 2020 |
Metabolic alkalosis in the critically ill.
Topics: Acetazolamide; Alkalosis; Critical Illness; Humans; Pulmonary Gas Exchange; Respiration | 1999 |
1 trial available for acetazolamide and Critical Illness
| Article | Year |
|---|---|
Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial.
Topics: Acetazolamide; Alkalosis; Asthma; Carbonic Anhydrase Inhibitors; Critical Illness; Diuretics; Double | 1999 |
4 other studies available for acetazolamide and Critical Illness
| Article | Year |
|---|---|
Acetazolamide in critically ill neonates and children with metabolic alkalosis.
Topics: Acetazolamide; Alkalosis; Carbonic Anhydrase Inhibitors; Child; Child, Preschool; Critical Illness; | 2013 |
Acetazolamide therapy for metabolic alkalosis in critically ill pediatric patients.
Topics: Acetazolamide; Alkalosis; Carbonic Anhydrase Inhibitors; Child, Preschool; Critical Illness; Female; | 2015 |
Does Acetazolamide Really Promote Ventilator Weaning in Critically Ill Children With Metabolic Alkalosis?
Topics: Acetazolamide; Alkalosis; Carbonic Anhydrase Inhibitors; Child; Critical Illness; Humans; Ventilator | 2016 |
Acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patients.
Topics: Acetazolamide; Acid-Base Imbalance; Adult; Aged; Alkalosis; Bicarbonates; Critical Illness; Female; | 2006 |