Page last updated: 2024-10-22

acetazolamide and Cheyne-Stokes Respiration

acetazolamide has been researched along with Cheyne-Stokes Respiration in 11 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Cheyne-Stokes Respiration: An abnormal pattern of breathing characterized by alternating periods of apnea and deep, rapid breathing. The cycle begins with slow, shallow breaths that gradually increase in depth and rate and is then followed by a period of apnea. The period of apnea can last 5 to 30 seconds, then the cycle repeats every 45 seconds to 3 minutes.

Research Excerpts

ExcerptRelevanceReference
"Acetazolamide has been used to attenuate Hunter-Cheyne-Stokes breathing with central sleep apnea (CSA) associated with heart failure."9.19Acetazolamide attenuates Hunter-Cheyne-Stokes breathing but augments the hypercapnic ventilatory response in patients with heart failure. ( Edwards, BA; Javaheri, S; Sands, SA, 2014)
"Acetazolamide has been used to attenuate Hunter-Cheyne-Stokes breathing with central sleep apnea (CSA) associated with heart failure."5.19Acetazolamide attenuates Hunter-Cheyne-Stokes breathing but augments the hypercapnic ventilatory response in patients with heart failure. ( Edwards, BA; Javaheri, S; Sands, SA, 2014)
" No apnea was seen before timolol maleate administration, and no further spells were noted after subsequent cyclocryotherapy without timolol maleate treatment."3.66Apneic spells associated with timolol therapy in a neonate. ( Bromberg, BB; Olson, RJ; Zimmerman, TJ, 1979)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19904 (36.36)18.7374
1990's0 (0.00)18.2507
2000's3 (27.27)29.6817
2010's4 (36.36)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Javaheri, S1
Sands, SA1
Edwards, BA1
Bekfani, T1
Abraham, WT1
Badr, S1
Fontana, M1
Emdin, M1
Giannoni, A1
Iudice, G1
Baruah, R1
Passino, C1
Brack, T1
Randerath, W1
Bloch, KE1
Yasuma, F1
Murohara, T1
Hayano, J1
Sanner, B1
Schäfer, T1
Findley, LJ1
Blackburn, MR1
Goldberger, AL1
Mandell, AJ1
Olson, RJ1
Bromberg, BB1
Zimmerman, TJ1
Tojima, H1
Cho, K1
Okita, S1
Kunitomo, F1
Yuguchi, Y1
Kuriyama, T1
Watanabe, S1
Honda, Y1
Gotoh, F1
Meyer, JS1
Takagi, Y1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Impact of Oxygen Therapy on Readmissions of Patients With Chronic Heart Failure With Reduced Ejection Fraction[NCT05913739]36 participants (Anticipated)Interventional2023-07-01Recruiting
Different Loop Gain Phenotypes in Patients With Chronic Systolic Heart Failure and Periodic Breathing[NCT03532412]12 participants (Actual)Observational2016-06-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for acetazolamide and Cheyne-Stokes Respiration

ArticleYear
Current and future developments in the field of central sleep apnoea.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2016, Volume: 18, Issue:8

    Topics: Acetazolamide; Cardiac Resynchronization Therapy; Cheyne-Stokes Respiration; Continuous Positive Air

2016
Central sleep apnea in patients with congestive heart failure.
    Heart failure reviews, 2009, Volume: 14, Issue:3

    Topics: Acetazolamide; Anticonvulsants; Bronchodilator Agents; Cheyne-Stokes Respiration; Heart Failure; Hum

2009
Cheyne-Stokes respiration in patients with heart failure: prevalence, causes, consequences and treatments.
    Respiration; international review of thoracic diseases, 2012, Volume: 83, Issue:2

    Topics: Acetazolamide; Carbon Dioxide; Cheyne-Stokes Respiration; Heart Failure; Humans; Oxygen Inhalation T

2012
[Central sleep apnea syndrome].
    Deutsche medizinische Wochenschrift (1946), 2008, Volume: 133, Issue:14

    Topics: Acetazolamide; Altitude Sickness; Anticonvulsants; Bronchodilator Agents; Cardiovascular Diseases; C

2008

Trials

2 trials available for acetazolamide and Cheyne-Stokes Respiration

ArticleYear
Acetazolamide attenuates Hunter-Cheyne-Stokes breathing but augments the hypercapnic ventilatory response in patients with heart failure.
    Annals of the American Thoracic Society, 2014, Volume: 11, Issue:1

    Topics: Acetazolamide; Aged; Blood Gas Analysis; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Chemorecepto

2014
Effect of acetazolamide on chemosensitivity, Cheyne-Stokes respiration, and response to effort in patients with heart failure.
    The American journal of cardiology, 2011, Jun-01, Volume: 107, Issue:11

    Topics: Acetazolamide; Aged; Carbonic Anhydrase Inhibitors; Cheyne-Stokes Respiration; Female; Heart Failure

2011

Other Studies

5 other studies available for acetazolamide and Cheyne-Stokes Respiration

ArticleYear
Long-term efficacy of acetazolamide on Cheyne-Stokes respiration in congestive heart failure.
    American journal of respiratory and critical care medicine, 2006, Aug-15, Volume: 174, Issue:4

    Topics: Acetazolamide; Cheyne-Stokes Respiration; Diuretics; Heart Failure; Humans; Sleep Apnea, Central; Tr

2006
Apneas and oscillation of cardiac ectopy in Cheyne-Stokes breathing during sleep.
    The American review of respiratory disease, 1984, Volume: 130, Issue:5

    Topics: Acetazolamide; Aged; Cardiac Complexes, Premature; Cheyne-Stokes Respiration; Electrocardiography; H

1984
Apneic spells associated with timolol therapy in a neonate.
    American journal of ophthalmology, 1979, Volume: 88, Issue:1

    Topics: Acetazolamide; Apnea; Asphyxia Neonatorum; Cheyne-Stokes Respiration; Cryosurgery; Glaucoma; Humans;

1979
[A case of Cheyne-Stokes respiration--a mechanism of ventilatory control and the effect of acetazolamide].
    Nihon Kyobu Shikkan Gakkai zasshi, 1986, Volume: 24, Issue:10

    Topics: Acetazolamide; Aged; Cheyne-Stokes Respiration; Female; Humans; Respiration; Respiration Disorders

1986
Cerebral venous and arterial blood gases during Cheyne-Stokes respiration.
    The American journal of medicine, 1969, Volume: 47, Issue:4

    Topics: Acetazolamide; Adult; Aged; Blood Gas Analysis; Carbon Dioxide; Cerebrovascular Disorders; Cheyne-St

1969