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acetazolamide and Cerebral Arteriosclerosis

acetazolamide has been researched along with Cerebral Arteriosclerosis in 15 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Research Excerpts

ExcerptRelevanceReference
"However, the recurrence of ischemic stroke was found in 4 out of 8 cases without improvement of vasodilatory capacity."5.29[Long-term prognosis and blood flow reactivity to acetazolamide in atherothrombotic brain ischemia]. ( Hasegawa, Y; Yamaguchi, T, 1993)
"36 patients with unilateral, hemodynamically significant carotid stenosis were investigated using transcranial Doppler acetazolamide-test."5.08[Assessment of cerebrovascular reactivity in patients with symptomatic and asymptomatic atherosclerotic carotid artery lesions]. ( Csiba, L; Dink, L; Fülesdi, B; Káposzta, Z; Limburg, M; Oláh, L; Orosz, L; Valikovics, A, 1998)
" antiplatelet therapy), indicating a repeat TIA or ischemic stroke attack was noted during maximal medical therapy; having poor cerebral perfusion on CT imaging; and having regional cerebrovascular reactivity (rCVR) of <20% when acetazolamide challenge was undergone."3.78Extracranial-intracranial (EC-IC) bypass of symptomatic middle cerebral artery (MCA) total occlusion for haemodynamic impairment patients. ( Chang, JH; Chen, CC; Cheng, YW; Cho, DY; Chou, CW; Lin, SZ, 2012)
"We used positron emission tomography and acetazolamide challenge tests to measure cerebral blood flow (CBF) and cerebrovascular reserve (CVR) in 8 patients with hypertension (mean age 70."3.76Blood pressure lowering with valsartan is associated with maintenance of cerebral blood flow and cerebral perfusion reserve in hypertensive patients with cerebral small vessel disease. ( Hatazawa, J; Hougaku, H; Kajimoto, K; Kato, H; Kimura, Y; Kitagawa, K; Oku, N; Sakaguchi, M; Sakoda, S; Tanaka, M, 2010)
"In multivariate analysis, previous cerebrovascular accident (odds ratio, 5."1.46The impact of carotid or intracranial atherosclerosis on perioperative stroke in patients undergoing open aortic arch surgery. ( Imasaka, KI; Tayama, E; Tomita, Y, 2017)
"However, the recurrence of ischemic stroke was found in 4 out of 8 cases without improvement of vasodilatory capacity."1.29[Long-term prognosis and blood flow reactivity to acetazolamide in atherothrombotic brain ischemia]. ( Hasegawa, Y; Yamaguchi, T, 1993)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19902 (13.33)18.7374
1990's6 (40.00)18.2507
2000's2 (13.33)29.6817
2010's5 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Imasaka, KI1
Tayama, E1
Tomita, Y1
Haga, S1
Morioka, T1
Shimogawa, T1
Akiyama, T1
Murao, K1
Kanazawa, Y1
Sayama, T1
Arakawa, S1
Kimura, Y1
Kitagawa, K1
Oku, N1
Kajimoto, K1
Kato, H1
Tanaka, M1
Sakaguchi, M1
Hougaku, H1
Sakoda, S1
Hatazawa, J1
Chou, CW1
Chang, JH1
Lin, SZ1
Cho, DY1
Cheng, YW1
Chen, CC1
Murai, Y1
Mizunari, T1
Takagi, R1
Amano, Y1
Mizumura, S1
Komaba, Y1
Okubo, S1
Kobayashi, S1
Teramoto, A1
Lee, TH1
Kim, SJ1
Kim, IJ1
Kim, YK1
Kim, DS1
Park, KP1
Eninia, GI1
Smeltere, ES1
Metra, MIa1
Mandai, K1
Sueyoshi, K1
Fukunaga, R1
Nukada, M1
Ohtani, F1
Araki, Y1
Tsukaguchi, I1
Abe, H1
Hasegawa, Y1
Yamaguchi, T1
Chamorro, A1
Saiz, A1
Vila, N1
Ascaso, C1
Blanc, R1
Alday, M1
Pujol, J1
Fülesdi, B2
Valikovics, A2
Orosz, L1
Oláh, L1
Limburg, M1
Dink, L1
Káposzta, Z2
Csiba, L2
Touho, H1
Karasawa, J1
Molina, C1
Sabín, JA1
Montaner, J1
Rovira, A1
Abilleira, S1
Codina, A1
Kerenyi, LL1
Ficzere, A1
Paragh, G1
Vorstrup, S1
Boysen, G1
Brun, B1
Engell, HC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise[NCT03722953]18 participants (Actual)Interventional2018-12-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for acetazolamide and Cerebral Arteriosclerosis

ArticleYear
[Assessment of cerebrovascular reactivity in patients with symptomatic and asymptomatic atherosclerotic carotid artery lesions].
    Orvosi hetilap, 1998, Mar-15, Volume: 139, Issue:11

    Topics: Acetazolamide; Arteriosclerosis; Blood Flow Velocity; Carotid Stenosis; Cerebrovascular Circulation;

1998

Other Studies

14 other studies available for acetazolamide and Cerebral Arteriosclerosis

ArticleYear
The impact of carotid or intracranial atherosclerosis on perioperative stroke in patients undergoing open aortic arch surgery.
    The Journal of thoracic and cardiovascular surgery, 2017, Volume: 153, Issue:5

    Topics: Acetazolamide; Aged; Aged, 80 and over; Aorta, Thoracic; Aortic Diseases; Carotid Stenosis; Cerebrov

2017
Arterial Spin Labeling Perfusion Magnetic Resonance Image with Dual Postlabeling Delay: A Correlative Study with Acetazolamide Loading (123)I-Iodoamphetamine Single-Photon Emission Computed Tomography.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016, Volume: 25, Issue:1

    Topics: Acetazolamide; Aged; Aged, 80 and over; Carotid Artery, Internal; Carotid Stenosis; Cerebral Arterie

2016
Blood pressure lowering with valsartan is associated with maintenance of cerebral blood flow and cerebral perfusion reserve in hypertensive patients with cerebral small vessel disease.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2010, Volume: 19, Issue:2

    Topics: Acetazolamide; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Cer

2010
Extracranial-intracranial (EC-IC) bypass of symptomatic middle cerebral artery (MCA) total occlusion for haemodynamic impairment patients.
    British journal of neurosurgery, 2012, Volume: 26, Issue:6

    Topics: Acetazolamide; Adult; Aged; Female; Hemodynamics; Humans; Infarction, Middle Cerebral Artery; Intrac

2012
Analysis of ischemic cerebral lesions using 3.0-T diffusion-weighted imaging and magnetic resonance angiography after revascularization surgery for ischemic disease.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:7

    Topics: Acetazolamide; Adult; Aged; Anastomosis, Surgical; Brain; Brain Ischemia; Cerebral Revascularization

2013
Statistical parametric mapping and statistical probabilistic anatomical mapping analyses of basal/acetazolamide Tc-99m ECD brain SPECT for efficacy assessment of endovascular stent placement for middle cerebral artery stenosis.
    Neuroradiology, 2007, Volume: 49, Issue:4

    Topics: Acetazolamide; Brain Mapping; Cysteine; Female; Humans; Intracranial Arteriosclerosis; Male; Middle

2007
[Effect of diuretics and dehydrants on indices of cerebral circulation].
    Klinicheskaia meditsina, 1980, Volume: 58, Issue:10

    Topics: Acetazolamide; Cerebrovascular Circulation; Diuretics; Furosemide; Humans; Hydrochlorothiazide; Intr

1980
Acetazolamide challenge for three-dimensional time-of-flight MR angiography of the brain.
    AJNR. American journal of neuroradiology, 1994, Volume: 15, Issue:4

    Topics: Acetazolamide; Adult; Aged; Angiography, Digital Subtraction; Arterial Occlusive Diseases; Arteries;

1994
[Long-term prognosis and blood flow reactivity to acetazolamide in atherothrombotic brain ischemia].
    Rinsho shinkeigaku = Clinical neurology, 1993, Volume: 33, Issue:2

    Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Brain Ischemia; Cerebrovascular Circulation; Female;

1993
Contribution of arterial blood pressure to the clinical expression of lacunar infarction.
    Stroke, 1996, Volume: 27, Issue:3

    Topics: Acetazolamide; Age Factors; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Brain Ische

1996
Hemodynamic evaluation of the effect of percutaneous transluminal angioplasty for atherosclerotic disease of the vertebrobasilar arterial system.
    Neurologia medico-chirurgica, 1998, Volume: 38, Issue:9

    Topics: Acetazolamide; Aged; Aged, 80 and over; Angioplasty, Balloon; Brain; Carbonic Anhydrase Inhibitors;

1998
Impaired cerebrovascular reactivity as a risk marker for first-ever lacunar infarction: A case-control study.
    Stroke, 1999, Volume: 30, Issue:11

    Topics: Acetazolamide; Arterioles; Blood Flow Velocity; Carbonic Anhydrase Inhibitors; Case-Control Studies;

1999
Cerebrovascular reserve capacity in patients with hyperlipidemia.
    Journal of clinical ultrasound : JCU, 2000, Volume: 28, Issue:3

    Topics: Acetazolamide; Adult; Blood Flow Velocity; Cerebrovascular Circulation; Female; Humans; Hyperlipidem

2000
Evaluation of the regional cerebral vasodilatory capacity before carotid endarterectomy by the acetazolamide test.
    Neurological research, 1987, Volume: 9, Issue:1

    Topics: Acetazolamide; Adult; Aged; Brain; Carotid Artery Diseases; Cerebrovascular Disorders; Endarterectom

1987