acetazolamide has been researched along with Cerebellar Ataxia in 28 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Cerebellar Ataxia: Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetazolamide responsive hereditary paroxysmal cerebellar ataxia (APCA) is a rare autosomal dominant disorder characterized by attacks of cerebellar ataxia and dysarthria with normal or near normal neurologic function between attacks." | 7.69 | Mapping the gene for acetazolamide responsive hereditary paryoxysmal cerebellar ataxia to chromosome 19p. ( Bulman, DE; Ebers, GC; Hahn, AF; Koopman, WJ; von Brederlow, B, 1995) |
| "Episodic ataxia type 2 is an autosomal dominant channelopathy, caused by genetic variants in the voltage-dependent calcium channel a-1 subunit (CACNA1A), which is characterized by intermittent episodes of vertigo and ataxia." | 5.72 | The efficacy of combining topiramate and 4-aminopyridine to reduce relapses and interictal progression in two cases of episodic ataxia type 2. ( Brieva-Ruiz, L; González-Mingot, C; López-Ortega, R, 2022) |
| "Paroxysmal cerebellar ataxia (PCA) is a specific disease which exhibits spasmodic cerebellar ataxia but rarely shows abnormal neurological findings in the intermission." | 5.28 | [Paroxysmal cerebellar ataxia--an evaluation using the findings from magnetic resonance imaging, positron emission tomography, and acetazolamide treatment]. ( Araki, S; Hirayama, K; Isono, O; Kawamura, M; Shiota, J, 1990) |
| "Clinical details are given of different types of episodic ataxia: type 1, with myokymia, and attacks which usually last a few minutes, and may occur several times a day, and treatment with acetazolamide can reduce the number of attacks; type 2, with interictal nystagmus, and attacks which last for several hours to a day or more, and treatment with acetazolamide is very effective; paroxysmal choreoathetosis with episodic ataxia, with attacks lasting for about 20 min and occurring at varying intervals; and familial hemiplegic migraine, with transient hemiplegia presenting during the aura of a migraine headache, the symptoms improving on treatment with acetazolamide." | 4.80 | Episodic ataxia and channelopathies. ( Gordon, N, 1998) |
| "Acetazolamide responsive hereditary paroxysmal cerebellar ataxia (APCA) is a rare autosomal dominant disorder characterized by attacks of cerebellar ataxia and dysarthria with normal or near normal neurologic function between attacks." | 3.69 | Mapping the gene for acetazolamide responsive hereditary paryoxysmal cerebellar ataxia to chromosome 19p. ( Bulman, DE; Ebers, GC; Hahn, AF; Koopman, WJ; von Brederlow, B, 1995) |
| "Acetazolamide-responsive periodic ataxia (ARPA) is a rare movement disorder, characterized by recurrent episodes of vertigo, cerebellar ataxia, and nystagmus, which has recently been characterized genetically." | 3.69 | The electroencephalogram in acetazolamide-responsive periodic ataxia. ( Chistik, V; Korczyn, AD; Neufeld, MY; Nisipeanu, P, 1996) |
| "Acetazolamide responsive hereditary paroxysmal cerebellar ataxia with myokymia is a type of autosomal dominant cerebellar ataxia which locus was found to be linked to the short arm of chromosome 12 and the etiology is unknown." | 3.69 | [Familial periodic ataxia with myokymia sensitive to acetazolamide: a family case]. ( Clemente, F; Escrivá, P; Gómez-Gosálvez, F; Mallada, J; Millet, E; Mulas, F; Palao, F; Smeyers, P, 1997) |
| "Six affected members of two families with familial periodic cerebellar ataxia were relieved of their symptoms with oral acetazolamide." | 3.68 | Familial periodic cerebellar ataxia: a problem of cerebellar intracellular pH homeostasis. ( Bain, PG; Keevil, SF; O'Brien, MD; Porter, DA, 1992) |
| "Episodic ataxia (EA), characterized by recurrent attacks of cerebellar dysfunction, is the manifestation of a group of rare autosomal dominant inherited disorders." | 3.01 | Episodic Ataxias: Primary and Secondary Etiologies, Treatment, and Classification Approaches. ( Hassan, A, 2023) |
| "Acetazolamide were initiated in 80%, and 75% of them showed improvement of episodic symptoms." | 1.91 | [Episodic ataxia type 2: a clinical, genetic and radiological study of 10 patients]. ( Alcalá-Torres, J; Arteche-López, A; Cárdenas-Del Carre, A; Pérez-de la Fuente, R; Posada-Rodríguez, IJ, 2023) |
| "Episodic ataxia type 2 is an autosomal dominant channelopathy, caused by genetic variants in the voltage-dependent calcium channel a-1 subunit (CACNA1A), which is characterized by intermittent episodes of vertigo and ataxia." | 1.72 | The efficacy of combining topiramate and 4-aminopyridine to reduce relapses and interictal progression in two cases of episodic ataxia type 2. ( Brieva-Ruiz, L; González-Mingot, C; López-Ortega, R, 2022) |
| "Episodic ataxia type 1 and 2 (EA1 and EA2) are the most well-described of the episodic ataxias." | 1.72 | Episodic ataxia type 2 (EA2) with interictal myokymia and focal dystonia. ( Ásbjörnsdóttir, B; Lindquist, SG; Møller, LB; Nielsen, EN; Nielsen, JE, 2022) |
| "Dystonia is potentially included as a further part of the phenotype spectrum of CACNA1A gene mutations." | 1.42 | Novel frameshift mutation in the CACNA1A gene causing a mixed phenotype of episodic ataxia and familiar hemiplegic migraine. ( Beyer, A; Kinder, S; Ossig, C; Smitka, M; Storch, A; von der Hagen, M; Wienecke, M, 2015) |
| "We report a child with congenital ataxia, abnormal eye movements and developmental delay who presented severe attacks of hemiplegic migraine triggered by minor head traumas and associated with hemispheric swelling and seizures." | 1.40 | Congenital ataxia and hemiplegic migraine with cerebral edema associated with a novel gain of function mutation in the calcium channel CACNA1A. ( Al-Qusairi, L; Bonafé, L; García Segarra, N; Gautschi, I; Kallay Zetchi, C; Maeder, P; Mittaz-Crettol, L; Roulet-Perez, E; Schild, L; Van Bemmelen, MX, 2014) |
| "She was treated with acetazolamide for simple glaucoma and since 14 days with ASA for acute pericarditis." | 1.30 | [Salicylism and glaucoma: reciprocal augmentation of the toxicity of acetazolamide and acetylsalicylic acid]. ( De Toffol, MC; Grimbert, M; Hazouard, E; Jonville-Berra, AP; Legras, A, 1999) |
| "The association of FHM and cerebellar ataxia has been reported in a small number of FHM families, all linked to chromosome 19." | 1.30 | A new CACNA1A gene mutation in acetazolamide-responsive familial hemiplegic migraine and ataxia. ( Battistini, N; Battistini, S; Carrera, P; Ferrari, M; Gelfi, C; Giannini, F; Guazzi, GC; Piatti, M; Righetti, PG; Rocchi, R; Stenirri, S, 1999) |
| "Paroxysmal cerebellar ataxia (PCA) is a specific disease which exhibits spasmodic cerebellar ataxia but rarely shows abnormal neurological findings in the intermission." | 1.28 | [Paroxysmal cerebellar ataxia--an evaluation using the findings from magnetic resonance imaging, positron emission tomography, and acetazolamide treatment]. ( Araki, S; Hirayama, K; Isono, O; Kawamura, M; Shiota, J, 1990) |
| "Treatment with acetazolamide resulted in abolition of paroxysms in nine of the 10 treated cases." | 1.28 | Paroxysmal cerebellar ataxia. ( Boyle, RS; Feeney, GF, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 14 (50.00) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 6 (21.43) | 24.3611 |
| 2020's | 4 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| González-Mingot, C | 1 |
| López-Ortega, R | 1 |
| Brieva-Ruiz, L | 1 |
| Nielsen, EN | 1 |
| Ásbjörnsdóttir, B | 1 |
| Møller, LB | 1 |
| Nielsen, JE | 1 |
| Lindquist, SG | 1 |
| Hassan, A | 1 |
| Alcalá-Torres, J | 1 |
| Pérez-de la Fuente, R | 1 |
| Cárdenas-Del Carre, A | 1 |
| Arteche-López, A | 1 |
| Posada-Rodríguez, IJ | 1 |
| Abbasi, S | 2 |
| Abbasi, A | 2 |
| Sarbaz, Y | 2 |
| García Segarra, N | 1 |
| Gautschi, I | 1 |
| Mittaz-Crettol, L | 1 |
| Kallay Zetchi, C | 1 |
| Al-Qusairi, L | 1 |
| Van Bemmelen, MX | 1 |
| Maeder, P | 1 |
| Bonafé, L | 1 |
| Schild, L | 1 |
| Roulet-Perez, E | 1 |
| Kinder, S | 1 |
| Ossig, C | 1 |
| Wienecke, M | 1 |
| Beyer, A | 1 |
| von der Hagen, M | 1 |
| Storch, A | 1 |
| Smitka, M | 1 |
| Suzuki, M | 1 |
| Fujiwara, K | 1 |
| Tsubuku, T | 1 |
| Yabe, I | 1 |
| Sasaki, H | 1 |
| Fukuda, S | 1 |
| Choi, KD | 1 |
| Jen, JC | 1 |
| Choi, SY | 1 |
| Shin, JH | 1 |
| Kim, HS | 1 |
| Kim, HJ | 1 |
| Kim, JS | 1 |
| Choi, JH | 1 |
| Matsuyama, Z | 1 |
| Murase, M | 1 |
| Shimizu, H | 1 |
| Aoki, Y | 1 |
| Hayashi, M | 1 |
| Hozumi, I | 1 |
| Inuzuka, T | 1 |
| Strupp, M | 1 |
| Zwergal, A | 1 |
| Brandt, T | 1 |
| Lubbers, WJ | 1 |
| Brunt, ER | 1 |
| Scheffer, H | 1 |
| Litt, M | 1 |
| Stulp, R | 1 |
| Browne, DL | 1 |
| van Weerden, TW | 1 |
| Poza, JJ | 1 |
| Martí Massó, JF | 1 |
| Amato, E | 1 |
| von Brederlow, B | 1 |
| Hahn, AF | 1 |
| Koopman, WJ | 1 |
| Ebers, GC | 1 |
| Bulman, DE | 1 |
| Neufeld, MY | 1 |
| Nisipeanu, P | 1 |
| Chistik, V | 1 |
| Korczyn, AD | 1 |
| Athwal, BS | 1 |
| Lennox, GG | 1 |
| Van Bogaert, P | 1 |
| Szliwowski, HB | 1 |
| Gómez-Gosálvez, F | 1 |
| Smeyers, P | 1 |
| Escrivá, P | 1 |
| Clemente, F | 1 |
| Mallada, J | 1 |
| Mulas, F | 1 |
| Palao, F | 1 |
| Millet, E | 1 |
| Gordon, N | 1 |
| Namekawa, M | 1 |
| Takiyama, Y | 1 |
| Ueno, N | 1 |
| Nishizawa, M | 1 |
| Hazouard, E | 1 |
| Grimbert, M | 1 |
| Jonville-Berra, AP | 1 |
| De Toffol, MC | 1 |
| Legras, A | 1 |
| Battistini, S | 1 |
| Stenirri, S | 1 |
| Piatti, M | 1 |
| Gelfi, C | 1 |
| Righetti, PG | 1 |
| Rocchi, R | 1 |
| Giannini, F | 1 |
| Battistini, N | 1 |
| Guazzi, GC | 1 |
| Ferrari, M | 1 |
| Carrera, P | 1 |
| Bain, PG | 2 |
| O'Brien, MD | 2 |
| Keevil, SF | 1 |
| Porter, DA | 1 |
| Larkin, GB | 1 |
| Calver, DM | 1 |
| Araki, S | 1 |
| Kawamura, M | 1 |
| Shiota, J | 1 |
| Isono, O | 1 |
| Hirayama, K | 1 |
| Feeney, GF | 1 |
| Boyle, RS | 1 |
| Trillet, M | 1 |
| Gouttard, M | 1 |
| Schott, B | 1 |
3 reviews available for acetazolamide and Cerebellar Ataxia
| Article | Year |
|---|---|
Episodic Ataxias: Primary and Secondary Etiologies, Treatment, and Classification Approaches.
Topics: Acetazolamide; Ataxia; Cerebellar Ataxia; Humans; Mutation | 2023 |
Episodic ataxia type 2.
Topics: 4-Aminopyridine; Acetazolamide; Animals; Calcium Channels; Carbonic Anhydrase Inhibitors; Cerebellar | 2007 |
Episodic ataxia and channelopathies.
Topics: Acetazolamide; Ataxia; Athetosis; Cerebellar Ataxia; Chorea; Hemiplegia; Humans; Ion Channels; Migra | 1998 |
1 trial available for acetazolamide and Cerebellar Ataxia
| Article | Year |
|---|---|
EEG findings in acetazolamide-responsive hereditary paroxysmal ataxia.
Topics: Acetazolamide; Adolescent; Adult; Aged; Anticonvulsants; Cerebellar Ataxia; Child; Electroencephalog | 1996 |
24 other studies available for acetazolamide and Cerebellar Ataxia
| Article | Year |
|---|---|
The efficacy of combining topiramate and 4-aminopyridine to reduce relapses and interictal progression in two cases of episodic ataxia type 2.
Topics: 4-Aminopyridine; Acetazolamide; Adult; Ataxia; Cerebellar Ataxia; Female; Humans; Male; Middle Aged; | 2022 |
Episodic ataxia type 2 (EA2) with interictal myokymia and focal dystonia.
Topics: Acetazolamide; Adolescent; Ataxia; Calcium Channels; Cerebellar Ataxia; Dystonic Disorders; Female; | 2022 |
[Episodic ataxia type 2: a clinical, genetic and radiological study of 10 patients].
Topics: Acetazolamide; Ataxia; Cerebellar Ataxia; Delayed Diagnosis; Female; Humans; Mutation; Retrospective | 2023 |
Combination of BK channel opener and Kv4 channel inhibitor for treatment of cerebellar ataxia in mutant med mice.
Topics: 4-Aminopyridine; Acetazolamide; Animals; Cerebellar Ataxia; Large-Conductance Calcium-Activated Pota | 2013 |
Introducing treatment strategy for cerebellar ataxia in mutant med mice: combination of acetazolamide and 4-aminopyridine.
Topics: 4-Aminopyridine; Acetazolamide; Action Potentials; Animals; Cerebellar Ataxia; Disease Models, Anima | 2014 |
Congenital ataxia and hemiplegic migraine with cerebral edema associated with a novel gain of function mutation in the calcium channel CACNA1A.
Topics: Acetazolamide; Adolescent; Animals; Ataxia; Brain Edema; Calcium Channels; Cerebellar Ataxia; Child; | 2014 |
Novel frameshift mutation in the CACNA1A gene causing a mixed phenotype of episodic ataxia and familiar hemiplegic migraine.
Topics: Acetazolamide; Age of Onset; Calcium Channels; Carbonic Anhydrase Inhibitors; Cerebellar Ataxia; Chi | 2015 |
Time course of downbeat positioning nystagmus in familial hemiplegic migraine type 1 treated with acetazolamide.
Topics: Acetazolamide; Anticonvulsants; Cerebellar Ataxia; Family Health; Humans; Magnetic Resonance Imaging | 2016 |
Late-onset episodic ataxia associated with SLC1A3 mutation.
Topics: Acetazolamide; Adult; Age of Onset; Amino Acid Sequence; Amino Acid Substitution; Anticonvulsants; B | 2017 |
A novel insertion mutation of acetazolamide-responsive episodic ataxia in a Japanese family.
Topics: Acetazolamide; Adult; Amino Acid Sequence; Anticonvulsants; Base Sequence; Calcium Channels; Cerebel | 2003 |
Hereditary myokymia and paroxysmal ataxia linked to chromosome 12 is responsive to acetazolamide.
Topics: Acetazolamide; Adult; Cerebellar Ataxia; Chromosomes, Human, Pair 12; Electroencephalography; Electr | 1995 |
Late onset familial periodic cerebellar ataxia.
Topics: Acetazolamide; Age of Onset; Cerebellar Ataxia; Electroencephalography; Family; Female; Humans; Midd | 1995 |
Mapping the gene for acetazolamide responsive hereditary paryoxysmal cerebellar ataxia to chromosome 19p.
Topics: Acetazolamide; Cerebellar Ataxia; Chromosome Mapping; Chromosomes, Human, Pair 19; Family Health; Fe | 1995 |
The electroencephalogram in acetazolamide-responsive periodic ataxia.
Topics: Acetazolamide; Adolescent; Adult; Anticonvulsants; Cerebellar Ataxia; Cerebral Cortex; Electroenceph | 1996 |
Acetazolamide responsiveness in familial hemiplegic migraine.
Topics: Acetazolamide; Adult; Brain; Cerebellar Ataxia; Female; Hemiplegia; Humans; Magnetic Resonance Imagi | 1996 |
[Familial periodic ataxia with myokymia sensitive to acetazolamide: a family case].
Topics: Acetazolamide; Anticonvulsants; Cerebellar Ataxia; Child; Chromosome Aberrations; Chromosome Disorde | 1997 |
[A sporadic case of episodic ataxia with nystagmus (EA-2)].
Topics: Acetazolamide; Adult; Anticonvulsants; Calcium Channels; Cerebellar Ataxia; Humans; Male; Mutation; | 1998 |
[Salicylism and glaucoma: reciprocal augmentation of the toxicity of acetazolamide and acetylsalicylic acid].
Topics: Acetazolamide; Acidosis; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carbonic Anhydrase Inhibi | 1999 |
A new CACNA1A gene mutation in acetazolamide-responsive familial hemiplegic migraine and ataxia.
Topics: Acetazolamide; Adult; Aged; Amino Acid Sequence; Amino Acid Substitution; Animals; Brain; Calcium Ch | 1999 |
Familial periodic cerebellar ataxia: a problem of cerebellar intracellular pH homeostasis.
Topics: Acetazolamide; Adolescent; Adult; Cerebellar Ataxia; Cerebellum; Female; Humans; Hydrogen-Ion Concen | 1992 |
Persistent superior oblique paresis as a manifestation of familial periodic cerebellar ataxia.
Topics: Acetazolamide; Adolescent; Cerebellar Ataxia; Diplopia; Female; Humans; Male; Paralysis | 1991 |
[Paroxysmal cerebellar ataxia--an evaluation using the findings from magnetic resonance imaging, positron emission tomography, and acetazolamide treatment].
Topics: Acetazolamide; Adult; Brain; Cerebellar Ataxia; Humans; Magnetic Resonance Imaging; Male; Oxygen Con | 1990 |
Paroxysmal cerebellar ataxia.
Topics: Acetazolamide; Adult; Cerebellar Ataxia; Child; Child, Preschool; Female; Humans; Male; Middle Aged; | 1989 |
[Familial paroxysmal ataxia sensitive to acetazolamide. 3 cases in a new European family].
Topics: Acetazolamide; Adult; Cerebellar Ataxia; Female; France; Humans; Male; Pedigree; Pregnancy; Pregnanc | 1985 |