acetazolamide has been researched along with Bone Loss, Osteoclastic in 33 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A limited, dual-photon absorptiometry, single-center study of bone mineral density (BMD) was conducted on white female glaucoma subjects who were chronic users of the carbonic anhydrase (CA) inhibitors acetazolamide (Az) or methazolamide (Mz)." | 3.68 | Effect of chronic carbonic anhydrase inhibitor therapy on bone mineral density in white women. ( Fuqua, MF; Nardin, GF; Pierce, WM; Sabah-Maren, E; Stern, SH, 1991) |
| "Nocodazole was introduced to inhibit the secretion of hydrolytic enzymes, and acetazolamide was added to inhibit acid production by the osteoclasts." | 1.31 | Dissolution of poorly crystalline apatite crystals by osteoclasts determined on artificial thin-film apatite. ( Kim, HM; Kim, JK; Kim, Y; Kim, YS; Ko, JS; Park, SJ; Rey, C; Woo, KM, 2001) |
| "In mouse calvaria cultures, bone resorption was inhibited dose dependently by acetazolamide at pHe 7." | 1.30 | Carbonic anhydrase II plays a major role in osteoclast differentiation and bone resorption by effecting the steady state intracellular pH and Ca2+. ( Hentunen, TA; Laitala-Leinonen, T; Lehenkari, P; Tuukkanen, J; Väänänen, HK, 1998) |
| "These findings suggest that bone resorption by procathepsin L secretion and its processing are regulated by proton production and proton secretion." | 1.29 | Inhibitory mechanisms of H(+)-ATPase inhibitor bafilomycin A1 and carbonic anhydrase II inhibitor acetazolamide on experimental bone resorption. ( Hiura, K; Kakegawa, H; Katunuma, N; Miki, Y; Ohba, T; Ohba, Y; Sumitani, K; Tagami-Kondoh, K; Takano-Yamamoto, T, 1996) |
| "In vitro stimulation of bone resorption was observed with the glucocorticoids hydrocortisone and dexamethasone." | 1.29 | Stimulation of neonatal mouse calvarial bone resorption by the glucocorticoids hydrocortisone and dexamethasone. ( Conaway, HH; Grigorie, D; Lerner, UH, 1996) |
| "Acetazolamide treatment for 10 h at 10 mg/h resulted in a significant fall in serum calcium in the five drug-treated animals (14." | 1.28 | Treatment of humoral hypercalcemia of malignancy in rats with inhibitors of carbonic anhydrase. ( Brown, GM; Insogna, KL; Mitnick, MA; Morris, CA, 1990) |
| "Amphotericin B is a polyene antifungal agent that binds to membrane sterols, creating aqueous pores that permit ion fluxes sufficient to cause cell lysis." | 1.28 | Mechanism of amphotericin B stimulation of net calcium efflux from neonatal mouse calvariae. ( Blair, NF; Bushinsky, DA; Krieger, NS, 1990) |
| "The participation of collagenase in bone resorption has been investigated by assaying the procollagenase extracted from fetal mouse calvaria cultured under a variety of conditions, and by evaluating its ability to degrade bone collagen." | 1.27 | Bone-resorbing agents affect the production and distribution of procollagenase as well as the activity of collagenase in bone tissue. ( Delaisse, JM; Eeckhout, Y; Vaes, G, 1988) |
| "Lactic acid release was increased during the 96 hr of incubation in proportion to the calcium release in the media." | 1.27 | Forskolin-induced bone resorption in neonatal mouse calvaria in vitro. ( Gunasekaran, S; Hall, GE; Kenny, AD, 1986) |
| "The role of carbonic anhydrase in bone resorption induced by parathyroid hormone (PTH) and dibutyryl cyclic AMP (DBcAMP) was studied using an in vitro neonatal mouse half-calvarial culture system." | 1.27 | Bone resorption induced by parathyroid hormone and dibutyryl cyclic AMP: role of carbonic anhydrase. ( Hall, GE; Kenny, AD, 1986) |
| "Bone resorption was assessed by release of stable calcium into the medium." | 1.27 | Role of carbonic anhydrase in bone resorption induced by 1,25 dihydroxyvitamin D3 in vitro. ( Hall, GE; Kenny, AD, 1985) |
| "Calcitonin and acetazolamide inhibit bone resorption in the ureter-ligated rat." | 1.26 | Sulfonamide inhibition of bone resorption: lack of a hypophosphatemia. ( Lineberry, MD; Pierce, WM; Waite, LC, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (63.64) | 18.7374 |
| 1990's | 9 (27.27) | 18.2507 |
| 2000's | 2 (6.06) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Müller, WE | 1 |
| Schröder, HC | 1 |
| Schlossmacher, U | 1 |
| Grebenjuk, VA | 1 |
| Ushijima, H | 1 |
| Wang, X | 1 |
| Waite, LC | 5 |
| Pierce, WM | 4 |
| Lineberry, MD | 1 |
| Sidqui, M | 1 |
| Collin, P | 1 |
| Vitte, C | 1 |
| Forest, N | 1 |
| Ohba, Y | 1 |
| Ohba, T | 1 |
| Sumitani, K | 1 |
| Tagami-Kondoh, K | 1 |
| Hiura, K | 1 |
| Miki, Y | 1 |
| Kakegawa, H | 1 |
| Takano-Yamamoto, T | 1 |
| Katunuma, N | 1 |
| Conaway, HH | 2 |
| Grigorie, D | 1 |
| Lerner, UH | 1 |
| Lehenkari, P | 1 |
| Hentunen, TA | 1 |
| Laitala-Leinonen, T | 1 |
| Tuukkanen, J | 1 |
| Väänänen, HK | 1 |
| Kim, HM | 1 |
| Kim, YS | 1 |
| Woo, KM | 1 |
| Park, SJ | 1 |
| Rey, C | 1 |
| Kim, Y | 1 |
| Kim, JK | 1 |
| Ko, JS | 1 |
| Spadaro, JA | 1 |
| Bergstrom, WH | 1 |
| Hall, TJ | 1 |
| Higgins, W | 1 |
| Tardif, C | 1 |
| Chambers, TJ | 1 |
| Nardin, GF | 1 |
| Fuqua, MF | 1 |
| Sabah-Maren, E | 1 |
| Stern, SH | 1 |
| Brown, GM | 1 |
| Morris, CA | 1 |
| Mitnick, MA | 1 |
| Insogna, KL | 1 |
| Gram, J | 1 |
| Bollerslev, J | 1 |
| Nielsen, HK | 1 |
| Larsen, HF | 1 |
| Mosekilde, L | 1 |
| Blair, NF | 1 |
| Krieger, NS | 1 |
| Bushinsky, DA | 1 |
| Hott, M | 1 |
| Marie, PJ | 1 |
| Raisz, LG | 2 |
| Delaisse, JM | 1 |
| Eeckhout, Y | 1 |
| Vaes, G | 1 |
| Guillemin, G | 1 |
| Patat, JL | 1 |
| Fournie, J | 1 |
| Chetail, M | 1 |
| Gunasekaran, S | 1 |
| Hall, GE | 4 |
| Kenny, AD | 7 |
| Sakai, T | 1 |
| Shimazaki, M | 1 |
| Chanoki, Y | 1 |
| Okuno, H | 1 |
| Shimazu, A | 1 |
| Simmons, HA | 1 |
| Thompson, WJ | 1 |
| Shepard, KL | 1 |
| Anderson, PS | 1 |
| Rodan, GA | 1 |
| Jilka, RL | 1 |
| Hamilton, JW | 1 |
| Volkert, WA | 1 |
| Mahgoub, A | 1 |
| Stern, PH | 1 |
| Stahl, PD | 1 |
| Minkin, C | 1 |
| Jennings, JM | 1 |
| Jorgensen, FS | 1 |
1 review available for acetazolamide and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Carbonic anhydrase and bone resorption.
Topics: Acetazolamide; Amides; Animals; Animals, Newborn; Benzoates; Bone and Bones; Bone Resorption; Calciu | 1973 |
1 trial available for acetazolamide and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
The effect of carbonic anhydrase inhibition on calcium and bone homeostasis in healthy postmenopausal women.
Topics: Acetazolamide; Bone Development; Bone Resorption; Calcium; Carbonic Anhydrases; Female; Homeostasis; | 1990 |
31 other studies available for acetazolamide and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Induction of carbonic anhydrase in SaOS-2 cells, exposed to bicarbonate and consequences for calcium phosphate crystal formation.
Topics: Acetazolamide; Ascorbic Acid; Bicarbonates; Bone Resorption; Calcium Phosphates; Carbonic Anhydrase | 2013 |
Sulfonamide inhibition of bone resorption: lack of a hypophosphatemia.
Topics: Acetazolamide; Acidosis; Animals; Bone Resorption; Calcitonin; Carbon Dioxide; Female; Hypocalcemia; | 1980 |
Acetazolamide inhibition of bone resorption: lack of effect on phosphate release from bone in vitro.
Topics: Acetazolamide; Animals; Bone and Bones; Bone Resorption; Calcium; Female; Organ Culture Techniques; | 1981 |
Osteoblast adherence and resorption activity of isolated osteoclasts on calcium sulphate hemihydrate.
Topics: Acetazolamide; Acid Phosphatase; Alkaline Phosphatase; Animals; Bone Resorption; Calcitonin; Calcium | 1995 |
Inhibitory mechanisms of H(+)-ATPase inhibitor bafilomycin A1 and carbonic anhydrase II inhibitor acetazolamide on experimental bone resorption.
Topics: Acetazolamide; Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Bone Resorption; Carbonic | 1996 |
Stimulation of neonatal mouse calvarial bone resorption by the glucocorticoids hydrocortisone and dexamethasone.
Topics: Acetazolamide; Acetylglucosaminidase; Animals; Animals, Newborn; Anti-Inflammatory Agents; Bone Reso | 1996 |
Carbonic anhydrase II plays a major role in osteoclast differentiation and bone resorption by effecting the steady state intracellular pH and Ca2+.
Topics: Acetazolamide; Acid Phosphatase; Animals; Bone Resorption; Calcium; Carbonic Anhydrase Inhibitors; C | 1998 |
Dissolution of poorly crystalline apatite crystals by osteoclasts determined on artificial thin-film apatite.
Topics: Acetazolamide; Animals; Apatites; Biocompatible Materials; Bone Marrow Cells; Bone Resorption; Calci | 2001 |
In vivo and in vitro effects of a pulsed electromagnetic field on net calcium flux in rat calvarial bone.
Topics: Acetazolamide; Animals; Animals, Newborn; Biological Assay; Bone Resorption; Calcitonin; Calcium; El | 2002 |
A comparison of the effects of inhibitors of carbonic anhydrase on osteoclastic bone resorption and purified carbonic anhydrase isozyme II.
Topics: Acetazolamide; Bone Resorption; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dimethyl Sulfoxi | 1991 |
Effect of chronic carbonic anhydrase inhibitor therapy on bone mineral density in white women.
Topics: Acetazolamide; Bone Density; Bone Resorption; Female; Glaucoma; Humans; Methazolamide; Time Factors; | 1991 |
Treatment of humoral hypercalcemia of malignancy in rats with inhibitors of carbonic anhydrase.
Topics: Acetazolamide; Animals; Bone Resorption; Carbonic Anhydrase Inhibitors; Cyclic AMP; Hypercalcemia; K | 1990 |
Mechanism of amphotericin B stimulation of net calcium efflux from neonatal mouse calvariae.
Topics: Acetazolamide; Amphotericin B; Animals; Animals, Newborn; Bone Resorption; Calcitonin; Calcium; Cult | 1990 |
Carbonic anhydrase activity in fetal rat bone resorbing cells: inhibition by acetazolamide infusion.
Topics: Acetazolamide; Animals; Bone Resorption; Calcium; Carbonic Anhydrases; Embryonic and Fetal Developme | 1989 |
Antiresorptive strategies in osteoporosis treatment.
Topics: Acetazolamide; Animals; Bone Resorption; Calcitonin; Carbonic Anhydrase Inhibitors; Diphosphonates; | 1989 |
Bone-resorbing agents affect the production and distribution of procollagenase as well as the activity of collagenase in bone tissue.
Topics: Acetazolamide; Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcitriol; Cells, Cultured; Co | 1988 |
The use of coral as a bone graft substitute.
Topics: Acetazolamide; Animals; Bone and Bones; Bone Resorption; Carbonic Anhydrases; Cnidaria; Dogs; Prosth | 1987 |
Forskolin-induced bone resorption in neonatal mouse calvaria in vitro.
Topics: Acetazolamide; Acid Phosphatase; Alkaline Phosphatase; Animals; Animals, Newborn; Bone Resorption; C | 1986 |
Bone resorption induced by parathyroid hormone and dibutyryl cyclic AMP: role of carbonic anhydrase.
Topics: Acetazolamide; Animals; Bone Resorption; Bucladesine; Calcium; Carbonic Anhydrases; Mice; Organ Cult | 1986 |
Role of carbonic anhydrase in bone resorption: effect of acetazolamide on basal and parathyroid hormone-induced bone metabolism.
Topics: Acetazolamide; Animals; Bone Resorption; Calcium; Carbonic Anhydrases; Cell Survival; Cells, Culture | 1987 |
A role of osteoclasts in the repair process after bone defect with special reference to carbonic anhydrase.
Topics: Acetazolamide; Animals; Bone Regeneration; Bone Resorption; Carbonic Anhydrase Inhibitors; Carbonic | 1986 |
Effects of a potent carbonic anhydrase inhibitor on bone resorption in organ culture.
Topics: Acetazolamide; Animals; Bone and Bones; Bone Resorption; Calcitriol; Calcium Radioisotopes; Carbon D | 1988 |
Bone-targeted carbonic anhydrase inhibitors: effect of a proinhibitor on bone resorption in vitro.
Topics: Acetazolamide; Animals; Bone Resorption; Carbonic Anhydrase Inhibitors; Depression, Chemical; Rats; | 1987 |
Role of carbonic anhydrase in bone resorption induced by 1,25 dihydroxyvitamin D3 in vitro.
Topics: Acetazolamide; Acid Phosphatase; Alkaline Phosphatase; Animals; Bone and Bones; Bone Resorption; Cal | 1985 |
Evidence for two pathways for stimulation of collagenolysis in bone.
Topics: Acetazolamide; Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Cartilage; In Vitro Te | 1985 |
Inhibition of bone resorption by acetazolamide in the rat.
Topics: Acetazolamide; Acidosis, Respiratory; Analysis of Variance; Animals; Bone Resorption; Calcium; Calci | 1970 |
Immobilization and bone mass in rats. Effects of parathyroidectomy and acetazolamide.
Topics: Acetazolamide; Animals; Bone and Bones; Bone Resorption; Denervation; Female; Humerus; Hypercalcemia | 1973 |
Carbon dioxide and the effect of parathyroid hormone on bone in vitro.
Topics: Acetazolamide; Animals; Bicarbonates; Bone and Bones; Bone Resorption; Buffers; Calcium Radioisotope | 1974 |
Studies on the mechanism of action of thyrocalcitonin: inhibition with acetazolamide.
Topics: Acetazolamide; Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Carbonic Anhydrases; D | 1969 |
Carbonic anhydrase and bone remodeling: sulfonamide inhibition of bone resorption in organ culture.
Topics: Acetazolamide; Animals; Autoradiography; Bone and Bones; Bone Resorption; Calcium; Calcium Isotopes; | 1972 |
An investigation of the early hypercalcaemia seen after nephrectomy in rats.
Topics: Acetazolamide; Acidosis; Adrenal Glands; Adrenalectomy; Animals; Bone Resorption; Calcium; Hydrogen- | 1972 |