acetazolamide has been researched along with Autosomal Dominant Cerebellar Ataxia, Type II in 7 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We identified a patient with a positive family history for episodic ataxia, who was originally diagnosed with epilepsy and treated with valproic acid." | 3.73 | CACNA1A mutation in a EA-2 patient responsive to acetazolamide and valproic acid. ( Bulman, DE; Friedman, JH; Scoggan, KA, 2006) |
| "The clinical features of spinocerebellar ataxia type 6 are variable." | 1.33 | Infantile spinocerebellar ataxia type 6: relationship to episodic ataxia type 6. ( Gosalakkal, JA; Swamy, PM, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Melzer, N | 1 |
| Classen, J | 1 |
| Reiners, K | 1 |
| Buttmann, M | 1 |
| Solodkin, A | 1 |
| Gomez, CM | 1 |
| Scoggan, KA | 1 |
| Friedman, JH | 1 |
| Bulman, DE | 1 |
| Gosalakkal, JA | 1 |
| Swamy, PM | 1 |
| Yabe, I | 2 |
| Sasaki, H | 2 |
| Yamashita, I | 2 |
| Takei, A | 2 |
| Fukazawa, T | 1 |
| Hamada, T | 1 |
| Tashiro, K | 2 |
| Durig, JS | 1 |
| Jen, JC | 1 |
| Demer, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dysmetria in Motor Function in SCA: Mechanisms and Rehabilitation[NCT02488031] | 19 participants (Actual) | Interventional | 2016-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for acetazolamide and Autosomal Dominant Cerebellar Ataxia, Type II
| Article | Year |
|---|---|
Spinocerebellar ataxia type 6.
Topics: Acetazolamide; Anticonvulsants; Calcium Channels; Humans; Models, Biological; Neuroimaging; Peptides | 2012 |
2 trials available for acetazolamide and Autosomal Dominant Cerebellar Ataxia, Type II
| Article | Year |
|---|---|
[A clinical trial of acetazolamide for SCA6].
Topics: Acetazolamide; Adult; Aged; Anticonvulsants; Female; Humans; Male; Middle Aged; Spinocerebellar Atax | 1999 |
Clinical trial of acetazolamide in SCA6, with assessment using the Ataxia Rating Scale and body stabilometry.
Topics: Acetazolamide; Adult; Aged; Anticonvulsants; Disease Progression; Female; Humans; Male; Middle Aged; | 2001 |
4 other studies available for acetazolamide and Autosomal Dominant Cerebellar Ataxia, Type II
| Article | Year |
|---|---|
Fluctuating neuromuscular transmission defects and inverse acetazolamide response in episodic ataxia type 2 associated with the novel CaV2.1 single amino acid substitution R2090Q.
Topics: Acetazolamide; Amino Acid Substitution; Blepharoptosis; Calcium Channels, N-Type; Carbonic Anhydrase | 2010 |
CACNA1A mutation in a EA-2 patient responsive to acetazolamide and valproic acid.
Topics: Acetazolamide; Adult; Amino Acid Sequence; Animals; Anticonvulsants; Calcium Channels; Diagnosis, Di | 2006 |
Infantile spinocerebellar ataxia type 6: relationship to episodic ataxia type 6.
Topics: Acetazolamide; Anticonvulsants; Brain; Chromosomes, Human, Pair 19; Humans; Infant, Newborn; Male; S | 2006 |
Ocular motility in genetically defined autosomal dominant cerebellar ataxia.
Topics: Acetazolamide; Adult; Aged; DNA; Electrooculography; Eye Movements; Female; Genes, Dominant; Genotyp | 2002 |