acetazolamide has been researched along with Astrocytoma, Grade IV in 7 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The natural product primary sulfonamide, psammaplin C (1), when used in combination with clinically used chemotherapeutic drugs, including temozolomide, reverses multidrug resistance and increases survival in glioblastoma, a highly aggressive primary brain tumor." | 7.91 | Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma. ( Bua, S; Kopecka, J; Mujumdar, P; Poulsen, SA; Riganti, C; Supuran, CT, 2019) |
| "Temozolomide (TMZ) is used for treating glioblastoma." | 5.35 | Modulatory effects of acetazolomide and dexamethasone on temozolomide-mediated apoptosis in human glioblastoma T98G and U87MG cells. ( Banik, NL; Das, A; Ray, SK, 2008) |
| "The natural product primary sulfonamide, psammaplin C (1), when used in combination with clinically used chemotherapeutic drugs, including temozolomide, reverses multidrug resistance and increases survival in glioblastoma, a highly aggressive primary brain tumor." | 3.91 | Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma. ( Bua, S; Kopecka, J; Mujumdar, P; Poulsen, SA; Riganti, C; Supuran, CT, 2019) |
| " Furthermore, the non-cytolytic and non-cytotoxic metronomic dosage of hydroxyurea and temozolomide had increased the DBM therapy outcome by strengthening anti-tumor capability." | 1.62 | A retrospective observational study on cases of anaplastic brain tumors treated with the Di Bella Method: A rationale and effectiveness. ( Borghetto, V; Costanzo, E; Di Bella, G, 2021) |
| "Temozolomide (TMZ) is used for treating glioblastoma." | 1.35 | Modulatory effects of acetazolomide and dexamethasone on temozolomide-mediated apoptosis in human glioblastoma T98G and U87MG cells. ( Banik, NL; Das, A; Ray, SK, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Said, HM | 1 |
| Hagemann, C | 1 |
| Carta, F | 1 |
| Katzer, A | 1 |
| Polat, B | 1 |
| Staab, A | 1 |
| Scozzafava, A | 1 |
| Anacker, J | 1 |
| Vince, GH | 1 |
| Flentje, M | 1 |
| Supuran, CT | 2 |
| Mujumdar, P | 1 |
| Kopecka, J | 1 |
| Bua, S | 1 |
| Riganti, C | 1 |
| Poulsen, SA | 1 |
| Di Bella, G | 1 |
| Borghetto, V | 1 |
| Costanzo, E | 1 |
| Choi, J | 1 |
| Moquin, A | 2 |
| Bomal, E | 1 |
| Na, L | 1 |
| Maysinger, D | 2 |
| Kakkar, A | 1 |
| Amiri, A | 1 |
| Le, PU | 1 |
| Machkalyan, G | 1 |
| Petrecca, K | 1 |
| Gillard, JW | 1 |
| Yoganathan, N | 1 |
| Watling, CJ | 1 |
| Cairncross, JG | 1 |
| Das, A | 1 |
| Banik, NL | 1 |
| Ray, SK | 1 |
7 other studies available for acetazolamide and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma.
Topics: Acetazolamide; Antigens, Neoplasm; Brain Neoplasms; Carbonic Anhydrase Inhibitors; Carbonic Anhydras | 2013 |
Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; | 2019 |
A retrospective observational study on cases of anaplastic brain tumors treated with the Di Bella Method: A rationale and effectiveness.
Topics: Acetazolamide; Antioxidants; Brain Neoplasms; Ditiocarb; Glioblastoma; Humans; Hydroxyurea; Melatoni | 2021 |
Telodendrimers for Physical Encapsulation and Covalent Linking of Individual or Combined Therapeutics.
Topics: Acetazolamide; Carbonic Anhydrase IX; Cell Line, Tumor; Cell Survival; Dacarbazine; Dendrimers; Drug | 2017 |
Inhibition of carbonic anhydrase IX in glioblastoma multiforme.
Topics: Acetazolamide; Antineoplastic Agents; Brain Neoplasms; Carbonic Anhydrase Inhibitors; Carbonic Anhyd | 2016 |
Acetazolamide therapy for symptomatic plateau waves in patients with brain tumors. Report of three cases.
Topics: Acetazolamide; Adult; Brain Neoplasms; Diuretics; Female; Glioblastoma; Humans; Intracranial Hyperte | 2002 |
Modulatory effects of acetazolomide and dexamethasone on temozolomide-mediated apoptosis in human glioblastoma T98G and U87MG cells.
Topics: Acetazolamide; Apoptosis; Aquaporin 1; Brain Edema; Brain Neoplasms; Calpain; Carbonic Anhydrases; C | 2008 |