Page last updated: 2024-10-22

acetazolamide and Asthma

acetazolamide has been researched along with Asthma in 9 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"To compare two dosing regimens of acetazolamide for the reversal of metabolic alkalosis in mechanically ventilated patients with asthma or chronic obstructive pulmonary disease."9.09Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial. ( Devlin, JW; Iannuzzi, MC; Jankowski, MA; Mazur, JE; Peters, MJ; Zarowitz, BJ, 1999)
"The aim of the study was to assess effects of acetazolamide in prevention of acute mountain sickness (AMS) and on overnight oxygenation, in patients with asthma treated at the altitude of 3,200 m."9.07Effects of acetazolamide on overnight oxygenation and acute mountain sickness in patients with asthma. ( Brimkulov, N; Cieslicki, J; Kudaiberdiev, Z; Mirrakhlmov, M; Moldotashev, I; Shmidt, G; Tobiasz, M; Zielinski, J, 1993)
" We compared the protective effect of acetazolamide, a diuretic without significant effect on the loop cotransporter, with the protection provided by inhaled furosemide in a cold, dry air hyperventilation model of asthma."9.07Acetazolamide and furosemide attenuate asthma induced by hyperventilation of cold, dry air. ( Drazen, JM; Israel, E; Niven, RW; O'Donnell, WJ; Rosenberg, M, 1992)
"To compare two dosing regimens of acetazolamide for the reversal of metabolic alkalosis in mechanically ventilated patients with asthma or chronic obstructive pulmonary disease."5.09Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial. ( Devlin, JW; Iannuzzi, MC; Jankowski, MA; Mazur, JE; Peters, MJ; Zarowitz, BJ, 1999)
"The aim of the study was to assess effects of acetazolamide in prevention of acute mountain sickness (AMS) and on overnight oxygenation, in patients with asthma treated at the altitude of 3,200 m."5.07Effects of acetazolamide on overnight oxygenation and acute mountain sickness in patients with asthma. ( Brimkulov, N; Cieslicki, J; Kudaiberdiev, Z; Mirrakhlmov, M; Moldotashev, I; Shmidt, G; Tobiasz, M; Zielinski, J, 1993)
" We compared the protective effect of acetazolamide, a diuretic without significant effect on the loop cotransporter, with the protection provided by inhaled furosemide in a cold, dry air hyperventilation model of asthma."5.07Acetazolamide and furosemide attenuate asthma induced by hyperventilation of cold, dry air. ( Drazen, JM; Israel, E; Niven, RW; O'Donnell, WJ; Rosenberg, M, 1992)
" In a second case report we describe, in a 61-year-old patient suffering from aspirin-sensitive asthma, recurrent ciliary body oedema with a marked spastic component which was triggered by the medications acetazolamide, dipivefrine and pilocarpine."3.69Drug-induced ciliary body oedema: a new theory. ( Krieg, PH; Schipper, I, 1996)
"High-altitude pulmonary edema is a non-cardiac edema that often precedes acute mountain sickness."2.42[Visiting high altitudes--healthy persons and patients with risk diseases]. ( Fischer, R, 2004)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's5 (55.56)18.2507
2000's1 (11.11)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kwon, YJ1
Allen, JL1
Liu, GT1
McCormack, SE1
Fischer, R1
O'Connor, BJ1
Yeo, CT1
Chen-Worsdell, YM1
Barnes, PJ1
Chung, KF1
Mirrakhlmov, M1
Brimkulov, N1
Cieslicki, J1
Tobiasz, M1
Kudaiberdiev, Z1
Moldotashev, I1
Shmidt, G1
Zielinski, J1
Krieg, PH1
Schipper, I1
Mazur, JE1
Devlin, JW1
Peters, MJ1
Jankowski, MA1
Iannuzzi, MC1
Zarowitz, BJ1
O'Donnell, WJ1
Rosenberg, M1
Niven, RW1
Drazen, JM1
Israel, E1
Patsch, J1
Bruchhausen, D1
Haschem, J1
Dardenne, MU1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Acetazolamide on the Duration of Mechanical Ventilation in Patients With Metabolic Alkalosis. Phase III Multicenter Double-blinded Clinical Trial.[NCT01499485]Phase 3140 participants (Actual)Interventional2011-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for acetazolamide and Asthma

ArticleYear
[Visiting high altitudes--healthy persons and patients with risk diseases].
    MMW Fortschritte der Medizin, 2004, Feb-19, Volume: 146, Issue:8

    Topics: Acclimatization; Acetazolamide; Acute Disease; Altitude; Altitude Sickness; Anti-Inflammatory Agents

2004

Trials

4 trials available for acetazolamide and Asthma

ArticleYear
Effect of acetazolamide and amiloride against sodium metabisulphite-induced bronchoconstriction in mild asthma.
    Thorax, 1994, Volume: 49, Issue:11

    Topics: Acetazolamide; Adult; Amiloride; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Carbonic

1994
Effects of acetazolamide on overnight oxygenation and acute mountain sickness in patients with asthma.
    The European respiratory journal, 1993, Volume: 6, Issue:4

    Topics: Acclimatization; Acetazolamide; Adult; Altitude; Altitude Sickness; Asthma; Female; Humans; Hypovent

1993
Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial.
    Critical care medicine, 1999, Volume: 27, Issue:7

    Topics: Acetazolamide; Alkalosis; Asthma; Carbonic Anhydrase Inhibitors; Critical Illness; Diuretics; Double

1999
Acetazolamide and furosemide attenuate asthma induced by hyperventilation of cold, dry air.
    The American review of respiratory disease, 1992, Volume: 146, Issue:6

    Topics: Acetazolamide; Administration, Inhalation; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Cold

1992

Other Studies

4 other studies available for acetazolamide and Asthma

ArticleYear
Presumed Pseudotumor Cerebri Syndrome After Withdrawal of Inhaled Glucocorticoids.
    Pediatrics, 2016, Volume: 137, Issue:6

    Topics: Acetazolamide; Administration, Inhalation; Asthma; Child; Diplopia; Female; Glucocorticoids; Growth;

2016
Drug-induced ciliary body oedema: a new theory.
    Eye (London, England), 1996, Volume: 10 ( Pt 1)

    Topics: Acetazolamide; Adult; Asthma; Chlorthalidone; Ciliary Body; Diuretics; Edema; Epinephrine; Female; H

1996
[Blood oxygen pressure as a criterion of pulmonary function and therapy].
    Wiener medizinische Wochenschrift (1946), 1971, Jun-19, Volume: 121, Issue:25

    Topics: Acetazolamide; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Anti-Bacterial Agents; A

1971
[Changes in the brinchial resistance in asthmatics following application of pilocarpine in the conjunctival sac].
    Deutsche medizinische Wochenschrift (1946), 1969, Aug-15, Volume: 94, Issue:33

    Topics: Acetazolamide; Asthma; Bronchial Spasm; Conjunctiva; Dosage Forms; Glaucoma; Humans; Medical History

1969