Page last updated: 2024-10-22

acetazolamide and Apnea, Central

acetazolamide has been researched along with Apnea, Central in 16 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Research Excerpts

ExcerptRelevanceReference
"Acetazolamide has been used to attenuate Hunter-Cheyne-Stokes breathing with central sleep apnea (CSA) associated with heart failure."9.19Acetazolamide attenuates Hunter-Cheyne-Stokes breathing but augments the hypercapnic ventilatory response in patients with heart failure. ( Edwards, BA; Javaheri, S; Sands, SA, 2014)
"To determine the therapeutic efficacy of acetazolamide on central sleep apnea associated with heart failure."9.12Acetazolamide improves central sleep apnea in heart failure: a double-blind, prospective study. ( Javaheri, S, 2006)
"Acetazolamide has been used to attenuate Hunter-Cheyne-Stokes breathing with central sleep apnea (CSA) associated with heart failure."5.19Acetazolamide attenuates Hunter-Cheyne-Stokes breathing but augments the hypercapnic ventilatory response in patients with heart failure. ( Edwards, BA; Javaheri, S; Sands, SA, 2014)
"To determine the therapeutic efficacy of acetazolamide on central sleep apnea associated with heart failure."5.12Acetazolamide improves central sleep apnea in heart failure: a double-blind, prospective study. ( Javaheri, S, 2006)
"To further our understanding of central sleep apnea (CSA) at high altitude during acclimatization, we tested the hypothesis that pharmacologically altering cerebral blood flow (CBF) would alter the severity of CSA at high altitude."2.79Influence of cerebral blood flow on central sleep apnea at high altitude. ( Ainslie, PN; Basnyat, R; Burgess, KR; Dawson, A; Donnelly, J; Lucas, RA; Lucas, SJ; Peebles, KC; Shepherd, K; Swart, M; Thomas, KN, 2014)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's0 (0.00)18.2507
2000's6 (37.50)29.6817
2010's6 (37.50)24.3611
2020's3 (18.75)2.80

Authors

AuthorsStudies
Rocha, A1
Pinto, ACPN1
Pachito, DV1
Drager, LF1
Lorenzi-Filho, G1
Atallah, ÁN1
Naghan, PA1
Raeisi, K1
Khoundabi, B1
Foroughi, M1
Malekmohammad, M1
Mohebbi, M1
Bagheri, A1
Fahimi, F1
Brown, LK1
Netzer, N1
Netzer, PG1
Hanika, KS1
Pramsohler, S1
Eliasson, AH1
Kitamura, T1
Miyazaki, S1
Kadotani, H1
Kanemura, T1
Okawa, M1
Tanaka, T1
Komada, I1
Hatano, T1
Suzuki, H1
Javaheri, S2
Sands, SA1
Edwards, BA1
Burgess, KR1
Lucas, SJ1
Shepherd, K1
Dawson, A1
Swart, M1
Thomas, KN1
Lucas, RA1
Donnelly, J1
Peebles, KC1
Basnyat, R1
Ainslie, PN1
Gaffney, C1
McNally, P1
Bekfani, T1
Abraham, WT1
Badr, S1
Glidewell, RN1
Orr, WC1
Imes, N1
SERIFF, NS1
Yasuma, F1
Murohara, T1
Hayano, J1
Sanner, B1
Schäfer, T1
Grunstein, RR1
Hedner, J1
Grote, L1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption[NCT02371473]Phase 412 participants (Anticipated)Interventional2014-11-30Enrolling by invitation
Impact of Oxygen Therapy on Readmissions of Patients With Chronic Heart Failure With Reduced Ejection Fraction[NCT05913739]36 participants (Anticipated)Interventional2023-07-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for acetazolamide and Apnea, Central

ArticleYear
Pharmacological treatment for central sleep apnoea in adults.
    The Cochrane database of systematic reviews, 2023, 02-27, Volume: 2

    Topics: Acetazolamide; Adult; Aged; Apnea; Buspirone; Carbonic Anhydrase Inhibitors; Disorders of Excessive

2023
Current and future developments in the field of central sleep apnoea.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2016, Volume: 18, Issue:8

    Topics: Acetazolamide; Cardiac Resynchronization Therapy; Cheyne-Stokes Respiration; Continuous Positive Air

2016
Central sleep apnea in patients with congestive heart failure.
    Heart failure reviews, 2009, Volume: 14, Issue:3

    Topics: Acetazolamide; Anticonvulsants; Bronchodilator Agents; Cheyne-Stokes Respiration; Heart Failure; Hum

2009
[Central sleep apnea syndrome].
    Deutsche medizinische Wochenschrift (1946), 2008, Volume: 133, Issue:14

    Topics: Acetazolamide; Altitude Sickness; Anticonvulsants; Bronchodilator Agents; Cardiovascular Diseases; C

2008
Treatment options for sleep apnoea.
    Drugs, 2001, Volume: 61, Issue:2

    Topics: Acetazolamide; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Humans; Hypoxia; Positive-

2001

Trials

4 trials available for acetazolamide and Apnea, Central

ArticleYear
The effect of acetazolamide on the improvement of central apnea caused by abusing opioid drugs in the clinical trial.
    Sleep & breathing = Schlaf & Atmung, 2020, Volume: 24, Issue:4

    Topics: Acetazolamide; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Mi

2020
Acetazolamide attenuates Hunter-Cheyne-Stokes breathing but augments the hypercapnic ventilatory response in patients with heart failure.
    Annals of the American Thoracic Society, 2014, Volume: 11, Issue:1

    Topics: Acetazolamide; Aged; Blood Gas Analysis; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Chemorecepto

2014
Influence of cerebral blood flow on central sleep apnea at high altitude.
    Sleep, 2014, Oct-01, Volume: 37, Issue:10

    Topics: Acclimatization; Acetazolamide; Administration, Intravenous; Administration, Oral; Adult; Altitude;

2014
Acetazolamide improves central sleep apnea in heart failure: a double-blind, prospective study.
    American journal of respiratory and critical care medicine, 2006, Jan-15, Volume: 173, Issue:2

    Topics: Acetazolamide; Aged; Blood Gas Analysis; Cross-Over Studies; Diuretics; Double-Blind Method; Electro

2006

Other Studies

7 other studies available for acetazolamide and Apnea, Central

ArticleYear
Acetazolamide for central sleep apnea: teaching an old drug new tricks?
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2021, 06-01, Volume: 17, Issue:6

    Topics: Acetazolamide; Humans; Pharmaceutical Preparations; Polysomnography; Sleep Apnea Syndromes; Sleep Ap

2021
Pharmaceuticals are back in the Game for OSA Treatment : Highlights from the 2019 American Thoracic Society (ATS) Conference in Dallas, Texas, and 2019 Affiliated Professional Sleep Societies Meeting (APSS) in San Antonio, Texas.
    Sleep & breathing = Schlaf & Atmung, 2019, Volume: 23, Issue:4

    Topics: Acetazolamide; Arousal; Attention; Blood Pressure; Carbon Dioxide; Continuous Positive Airway Pressu

2019
Type I Chiari malformation presenting central sleep apnea.
    Auris, nasus, larynx, 2014, Volume: 41, Issue:2

    Topics: Acetazolamide; Arnold-Chiari Malformation; Carbonic Anhydrase Inhibitors; Child; Decompression, Surg

2014
Successful use of acetazolamide for central apnea in a child with Pitt-Hopkins syndrome.
    American journal of medical genetics. Part A, 2015, Volume: 167, Issue:6

    Topics: Acetazolamide; Anticonvulsants; Facies; Humans; Hyperventilation; Intellectual Disability; Male; Pol

2015
Acetazolamide as an adjunct to CPAP treatment: a case of complex sleep apnea in a patient on long-acting opioid therapy.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2009, Feb-15, Volume: 5, Issue:1

    Topics: Acetazolamide; Administration, Cutaneous; Administration, Oral; Adult; Analgesics, Opioid; Carbonic

2009
ALVEOLAR HYPOVENTILATION WITH NORMAL LUNGS: THE SYNDROME OF PRIMARY OR CENTRAL ALVEOLAR HYPOVENTILATION.
    Annals of the New York Academy of Sciences, 1965, Mar-24, Volume: 121

    Topics: Acetazolamide; Aminophylline; Carbon Dioxide; Humans; Hypnosis; Hypoventilation; Lung; Medulla Oblon

1965
Long-term efficacy of acetazolamide on Cheyne-Stokes respiration in congestive heart failure.
    American journal of respiratory and critical care medicine, 2006, Aug-15, Volume: 174, Issue:4

    Topics: Acetazolamide; Cheyne-Stokes Respiration; Diuretics; Heart Failure; Humans; Sleep Apnea, Central; Tr

2006