acetazolamide has been researched along with Amelia in 3 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The frequency of hemimelia and micromelia, and of bilateral involvement, was greater in litters exposed to the high pH acetazolamide or the epinephrine-acetazolamide combinations, and was reduced by phentolamine or adrenal medullectomy." | 1.26 | Potentiation by the injection vehicle of the teratological action of acetazolamide in rats. ( Jones, JC; Muther, TF; Smoak, NS, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LAYTON, WM | 1 |
| HALLESY, DW | 1 |
| Muther, TF | 1 |
| Jones, JC | 1 |
| Smoak, NS | 1 |
| Wilson, JG | 1 |
| Maren, TH | 1 |
| Takano, K | 1 |
| Ellison, A | 1 |
3 other studies available for acetazolamide and Amelia
| Article | Year |
|---|---|
DEFORMITY OF FORELIMB IN RATS: ASSOCIATION WITH HIGH DOSES OF ACETAZOLAMIDE.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Ectromelia; Extremities; Female; Forelimb; Huma | 1965 |
Potentiation by the injection vehicle of the teratological action of acetazolamide in rats.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Adrenal Medulla; Animals; Drug Synergism; Ectromelia; Ep | 1977 |
Teratogenic action of carbonic anhydrase inhibitors in the rat.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Acidosis; Animals; Body Weight; Carbonic Anhydrase Inhib | 1968 |