acetazolamide has been researched along with Alkalosis, Respiratory in 14 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Alkalosis, Respiratory: A state due to excess loss of carbon dioxide from the body. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to investigate whether or not there is a causal relationship between the metabolic acidosis and the ocular hypotension induced by acetazolamide, we undertook to correlate over a period of time the blood-acidifying and ocular-hypotonizing effects of administering the lowest intravenous effective dose of acetazolamide; to treat the metabolic acidosis induced by acetazolamide by means of the intravenous introduction of bases, and pulmonary hyperventilation (respiratory alkalosis); to evaluate the effects on the intraocular pressure (IOP) by neutralizing the acetazolamide-induced metabolic acidosis by means of a continuous infusion of sodium bicarbonate; to determine the relationship between the metabolic acidosis induced by blood-acidifying agents, which do not inhibit carbonic anhydrase, and the IOP; and to determine the changes in the acid-base status of the aqueous humor induced by acetazolamide and other blood-acidifying drugs." | 7.65 | Acetazolamide, metabolic acidosis, and intraocular pressure. ( Bietti, G; Pecori-Giraldi, J; Virno, M, 1975) |
| "10 at each work load); 2) hyperventilation following acetazolamide (which returned pH to control values despite ventilation and PaCO2 identical to condition 1); and 3) metabolic acidosis induced by acetazolamide (with spontaneous ventilation)." | 5.06 | Effect of respiratory alkalosis during exercise on blood lactate. ( Davies, SF; Iber, C; Keene, SA; McArthur, CD; Path, MJ, 1986) |
| "In order to investigate whether or not there is a causal relationship between the metabolic acidosis and the ocular hypotension induced by acetazolamide, we undertook to correlate over a period of time the blood-acidifying and ocular-hypotonizing effects of administering the lowest intravenous effective dose of acetazolamide; to treat the metabolic acidosis induced by acetazolamide by means of the intravenous introduction of bases, and pulmonary hyperventilation (respiratory alkalosis); to evaluate the effects on the intraocular pressure (IOP) by neutralizing the acetazolamide-induced metabolic acidosis by means of a continuous infusion of sodium bicarbonate; to determine the relationship between the metabolic acidosis induced by blood-acidifying agents, which do not inhibit carbonic anhydrase, and the IOP; and to determine the changes in the acid-base status of the aqueous humor induced by acetazolamide and other blood-acidifying drugs." | 3.65 | Acetazolamide, metabolic acidosis, and intraocular pressure. ( Bietti, G; Pecori-Giraldi, J; Virno, M, 1975) |
| "Acetazolamide has been used for decades as a respiratory stimulant for patients with chronic obstructive pulmonary disease (COPD) and metabolic alkalosis, but no large randomized placebo-controlled trial is available to confirm this approach." | 2.82 | Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial. ( Bornstain, C; Clavel, M; Djibre, M; Duguet, A; Esvan, M; Faisy, C; Gacouin, A; Gibot, S; Heming, N; Katsahian, S; Lerolle, N; Meziani, F; Planquette, B; Rabbat, A; Ricard, JD; Ricome, JL; Sanchez, O; Schneider, F; Urien, S, 2016) |
| "Consecutive states of acute respiratory alkalosis and acidosis were created by changing the inspired CO2 from 0% (room air) to 8% CO2." | 1.27 | Functional role of carbonic anhydrase in intestinal electrolyte transport. ( Birnbaum, GJ; Charney, AN; Johnstone, JN; Wagner, JD, 1986) |
| "The observation that some patients with mixed sleep apnea appear to have central apnea while relatively alkalotic and obstructive apnea while acidotic emphasizes the need for more careful and detailed characterization of apneic disorders with respect to their responses to body states and therapeutic agents." | 1.27 | Effect of metabolic acidosis upon sleep apnea. ( D'Souza, V; Diamond, E; Druz, WS; Sharp, JT, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (71.43) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Faisy, C | 2 |
| Meziani, F | 1 |
| Planquette, B | 1 |
| Clavel, M | 1 |
| Gacouin, A | 1 |
| Bornstain, C | 1 |
| Schneider, F | 1 |
| Duguet, A | 1 |
| Gibot, S | 1 |
| Lerolle, N | 1 |
| Ricard, JD | 1 |
| Sanchez, O | 1 |
| Djibre, M | 1 |
| Ricome, JL | 1 |
| Rabbat, A | 1 |
| Heming, N | 2 |
| Urien, S | 1 |
| Esvan, M | 1 |
| Katsahian, S | 1 |
| Contou, D | 1 |
| de Prost, N | 1 |
| Mekontso Dessap, A | 1 |
| Mishra, S | 1 |
| Azim, A | 1 |
| Baronia, A | 1 |
| Yano, R | 1 |
| Wichser, J | 1 |
| Kazemi, H | 1 |
| Olzowy, M | 1 |
| Lee, CA | 1 |
| Stroot, VR | 1 |
| Schaper, CA | 1 |
| Bietti, G | 1 |
| Virno, M | 1 |
| Pecori-Giraldi, J | 1 |
| Charney, AN | 1 |
| Wagner, JD | 1 |
| Birnbaum, GJ | 1 |
| Johnstone, JN | 1 |
| Davies, SF | 1 |
| Iber, C | 1 |
| Keene, SA | 1 |
| McArthur, CD | 1 |
| Path, MJ | 1 |
| Sharp, JT | 1 |
| Druz, WS | 1 |
| D'Souza, V | 1 |
| Diamond, E | 1 |
| Miller, ME | 1 |
| Rorth, M | 1 |
| Parving, HH | 1 |
| Howard, D | 1 |
| Reddington, I | 1 |
| Valeri, CR | 1 |
| Stohlman, F | 1 |
| Finne, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Trial to Evaluate Effectiveness of Acetazolamide in COPD Patients Developing Metabolic Alkalosis During Invasive Mechanical Ventilation[NCT01627639] | Phase 4 | 380 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for acetazolamide and Alkalosis, Respiratory
| Article | Year |
|---|---|
Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial.
Topics: Acetazolamide; Aged; Alkalosis, Respiratory; Bicarbonates; Carbon Dioxide; Carbonic Anhydrase Inhibi | 2016 |
[Prevention of altitude sickness].
Topics: Acclimatization; Acetazolamide; Adult; Alkalosis, Respiratory; Altitude Sickness; Blood Pressure; Ca | 1975 |
Effect of respiratory alkalosis during exercise on blood lactate.
Topics: Acetazolamide; Acidosis; Adult; Alkalosis, Respiratory; Biofeedback, Psychology; Female; Humans; Hyd | 1986 |
11 other studies available for acetazolamide and Alkalosis, Respiratory
| Article | Year |
|---|---|
Acetazolamide and Invasive Mechanical Ventilation for Patients With COPD.
Topics: Acetazolamide; Alkalosis, Respiratory; Carbonic Anhydrase Inhibitors; Female; Humans; Male; Pulmonar | 2016 |
Acetazolamide and Invasive Mechanical Ventilation for Patients With COPD.
Topics: Acetazolamide; Alkalosis, Respiratory; Carbonic Anhydrase Inhibitors; Female; Humans; Male; Pulmonar | 2016 |
Acetazolamide and Invasive Mechanical Ventilation for Patients With COPD--Reply.
Topics: Acetazolamide; Alkalosis, Respiratory; Carbonic Anhydrase Inhibitors; Female; Humans; Male; Pulmonar | 2016 |
[Effect of acetazolamide on acute respiratory alkalosis (author's transl)].
Topics: Acetazolamide; Acute Disease; Adult; Alkalosis, Respiratory; Animals; Child; Child, Preschool; Dogs; | 1981 |
CSF bicarbonate regulation in respiratory acidosis and alkalosis.
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis, Respiratory; Alkalosis, Respiratory; Ammonia; Ammoni | 1975 |
What to do when acid-base problems hang in the balance.
Topics: Acetazolamide; Acid-Base Imbalance; Acidosis; Acidosis, Respiratory; Adult; Alkalosis; Alkalosis, Re | 1975 |
Acetazolamide, metabolic acidosis, and intraocular pressure.
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis; Alkalosis, Respiratory; Animals; Ascorbic Acid; Buff | 1975 |
Functional role of carbonic anhydrase in intestinal electrolyte transport.
Topics: Acetazolamide; Acidosis, Respiratory; Alkalosis, Respiratory; Animals; Biological Transport; Carbon | 1986 |
Effect of metabolic acidosis upon sleep apnea.
Topics: Acetazolamide; Acidosis, Respiratory; Administration, Oral; Adult; Aged; Alkalosis, Respiratory; Fem | 1985 |
pH effect on erythropoietin response to hypoxia.
Topics: Acetazolamide; Acid-Base Equilibrium; Adult; Alkalosis, Respiratory; Altitude; Blood; Capillaries; C | 1973 |
[Changes in the oxyhemoglobin dissociation curve as a compensation mechanism in hypoxia].
Topics: Acetazolamide; Alkalosis, Respiratory; Animals; Blood; Erythropoietin; Female; Hemoglobins; Hydrogen | 1973 |