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acetazolamide and Acquired Nephrogenic Diabetes Insipidus

acetazolamide has been researched along with Acquired Nephrogenic Diabetes Insipidus in 4 studies

Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Research Excerpts

ExcerptRelevanceReference
"To reduce lithium-induced nephrogenic diabetes insipidus (lithium-NDI), patients with bipolar disorder are treated with thiazide and amiloride, which are thought to induce antidiuresis by a compensatory increase in prourine uptake in proximal tubules."1.43Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus. ( Alsady, M; Baumgarten, R; de Groot, T; Deen, PM; Devuyst, O; Kortenoeven, ML; Loffing, J; Sinke, AP; Wetzels, JF, 2016)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Groot, T3
Doornebal, J1
Christensen, BM1
Cockx, S1
Sinke, AP2
Baumgarten, R3
Bedford, JJ1
Walker, RJ1
Wetzels, JFM1
Deen, PMT2
Alsady, M2
Kortenoeven, MLA1
Carmone, C1
Neijman, K1
Bekkenkamp-Grovenstein, M1
Engelke, U1
Wevers, R1
Korstanje, R1
Kortenoeven, ML1
Devuyst, O1
Loffing, J1
Wetzels, JF1
Deen, PM1
Gordon, CE1
Vantzelfde, S1
Francis, JM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Correction of Hypernatremia by Intravenous Hypotonic Solution Compared to Enteral Water, Randomized Clinical Trial[NCT06061783]178 participants (Anticipated)Interventional2023-11-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

4 other studies available for acetazolamide and Acquired Nephrogenic Diabetes Insipidus

ArticleYear
Lithium-induced NDI: acetazolamide reduces polyuria but does not improve urine concentrating ability.
    American journal of physiology. Renal physiology, 2017, 09-01, Volume: 313, Issue:3

    Topics: Acetazolamide; Aged; Animals; Aquaporin 2; Blood Pressure; Diabetes Insipidus, Nephrogenic; Disease

2017
Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.
    American journal of physiology. Renal physiology, 2018, 02-01, Volume: 314, Issue:2

    Topics: Acetazolamide; Animals; Antimanic Agents; Aquaporin 2; Carbonic Anhydrase Inhibitors; Carbonic Anhyd

2018
Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus.
    Journal of the American Society of Nephrology : JASN, 2016, Volume: 27, Issue:7

    Topics: Acetazolamide; Amiloride; Animals; Aquaporin 2; Diabetes Insipidus, Nephrogenic; Diuretics; Female;

2016
Acetazolamide in Lithium-Induced Nephrogenic Diabetes Insipidus.
    The New England journal of medicine, 2016, 11-17, Volume: 375, Issue:20

    Topics: Acetazolamide; Animals; Diabetes Insipidus, Nephrogenic; Disease Models, Animal; Humans; Lithium Com

2016