acetazolamide has been researched along with Acidosis, Lactic in 3 studies
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Acidosis, Lactic: Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetazolamide can produce severe lactic acidosis with an increased lactate-to-pyruvate ratio, ketosis with a low beta-hydroxybutyrate-to-acetoacetate ratio, and a urinary organic acid profile typical of pyruvate carboxylase deficiency." | 3.71 | Pathogenic mechanism, prophylaxis, and therapy of symptomatic acidosis induced by acetazolamide. ( Bagnoli, F; Filippi, L; Margollicci, M; Rubaltelli, FF; Tronchin, M; Zammarchi, E, 2002) |
| "The clinical symptoms in MELAS are not the result of a mitochondrial angiopathy but are the consequences of a mitochondrial cytopathy affecting neurons or glia." | 2.69 | Cerebral blood flow and glucose metabolism in mitochondrial disorders. ( Diószeghy, P; Gulyás, B; Mechler, F; Molnár, MJ; Molnár, S; Trón, L; Valikovics, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rousseau, P | 1 |
| Fuentevilla-Clifton, A | 1 |
| Molnár, MJ | 1 |
| Valikovics, A | 1 |
| Molnár, S | 1 |
| Trón, L | 1 |
| Diószeghy, P | 1 |
| Mechler, F | 1 |
| Gulyás, B | 1 |
| Filippi, L | 1 |
| Bagnoli, F | 1 |
| Margollicci, M | 1 |
| Zammarchi, E | 1 |
| Tronchin, M | 1 |
| Rubaltelli, FF | 1 |
1 trial available for acetazolamide and Acidosis, Lactic
| Article | Year |
|---|---|
Cerebral blood flow and glucose metabolism in mitochondrial disorders.
Topics: Acetazolamide; Acidosis, Lactic; Adult; Aged; Blood Flow Velocity; Brain; Carbonic Anhydrase Inhibit | 2000 |
2 other studies available for acetazolamide and Acidosis, Lactic
| Article | Year |
|---|---|
Acetazolamide and salicylate interaction in the elderly: a case report.
Topics: Acetazolamide; Acidosis, Lactic; Aged; Anorexia; Confusion; Coronary Disease; Diabetes Mellitus, Typ | 1993 |
Pathogenic mechanism, prophylaxis, and therapy of symptomatic acidosis induced by acetazolamide.
Topics: Acetazolamide; Acidosis, Lactic; Animals; Animals, Newborn; Carbonic Anhydrase Inhibitors; Citric Ac | 2002 |