acetaminophen has been researched along with Vascular Diseases in 16 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Vascular Diseases: Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.
| Excerpt | Relevance | Reference |
|---|---|---|
| "He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated." | 5.34 | Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007) |
| "Malignancy is an uncommon cause of ALF, and thus imaging studies may not be useful in this setting, but liver biopsy may be beneficial in selected cases." | 2.44 | Epidemiology of acute liver failure. ( Khashab, M; Kwo, PY; Tector, AJ, 2007) |
| "He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated." | 1.34 | Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007) |
| "The gene for sickle cell disease is carried by 8% of the African-American population in the United States." | 1.28 | Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. ( Pollack, CV; Sanders, DY; Severance, HW, 1992) |
| "The necrosis is probably multifactorial in origin, with ischaemia and sepsis contributing factors." | 1.28 | Necrotizing myopathy in critically-ill patients. ( Bone, JM; Campbell, IT; Coakley, JH; Green, CJ; Griffiths, RD; Helliwell, TR; McClelland, P; Wagenmakers, AJ, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (56.25) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moore, PK | 1 |
| Marshall, M | 1 |
| Erhan, E | 1 |
| Inal, MT | 1 |
| Aydinok, Y | 1 |
| Balkan, C | 1 |
| Yegul, I | 1 |
| Khashab, M | 1 |
| Tector, AJ | 1 |
| Kwo, PY | 1 |
| Karttunen, T | 1 |
| Autio-Harmainen, H | 1 |
| Sutinen, S | 1 |
| Fortina, F | 1 |
| Agllata, S | 1 |
| Ragazzoni, E | 1 |
| Sacco, A | 1 |
| Cardillo, V | 1 |
| Travaglini, S | 1 |
| Brini, P | 1 |
| Cavagnino, A | 1 |
| Lewis, JH | 1 |
| Abrahams, C | 1 |
| Furman, KI | 1 |
| Salant, D | 1 |
| Sanders, DY | 1 |
| Severance, HW | 1 |
| Pollack, CV | 1 |
| Helliwell, TR | 1 |
| Coakley, JH | 1 |
| Wagenmakers, AJ | 1 |
| Griffiths, RD | 1 |
| Campbell, IT | 1 |
| Green, CJ | 1 |
| McClelland, P | 1 |
| Bone, JM | 1 |
| Schubert, GE | 1 |
| Bethke, BA | 1 |
| Bonnamour, C | 1 |
| Peaud, PY | 1 |
| Plauchu, M | 1 |
| Uklonskaia, LI | 1 |
| Kudriavtsev, VD | 1 |
| Sushkevich, LN | 1 |
| Cherkasov, VF | 1 |
| Soloway, HB | 1 |
| Guerra, JC | 1 |
| Chaddad, F | 1 |
| Goes, S | 1 |
| Simi, JC | 1 |
| Tudhope, GR | 1 |
| Figueirôa, CL | 1 |
| Peleteiro, EV | 1 |
| Sarmento, ML | 1 |
| Mello, E | 1 |
| Farias, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis[NCT00094887] | Phase 2 | 150 participants (Actual) | Interventional | 2004-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Length of hospitalization is defined as the length of time from admission to discharge order (NCT00094887)
Timeframe: within 40 days
| Intervention | Days (Median) |
|---|---|
| Inhaled Nitric Oxide | 4.06 |
| Placebo | 3.11 |
(NCT00094887)
Timeframe: within 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 5 |
| Placebo | 7 |
Number of participants who required a blood transfusion before discharge because of acute chest syndrome/pneumonia (NCT00094887)
Timeframe: within 40 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 8 |
| Placebo | 7 |
"VOC resolution was defined by all of the following conditions:~Pain relief - Visual Analog Scale (VAS) pain scores of 6 or less, (6 as worst and 0 as best)~Freedom from parenteral narcotic use,~Ability to walk unless the subject was not able to walk for any reason other than acute VOC prior to the onset of crisis,~Subject and/or family's belief that the painful crisis could be managed at home with or without oral analgesic use, and the physician concurred with that assessment." (NCT00094887)
Timeframe: within 30 days
| Intervention | Hours (Median) |
|---|---|
| Inhaled Nitric Oxide | 61.83 |
| Placebo | 55.16 |
The number of participants readmitted to the hospital for any reason within 30 days after discharge (NCT00094887)
Timeframe: during first 24 hours and during 30 day follow-up
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| during first 24 hours | during 30-day follow-up | |
| Inhaled Nitric Oxide | 0 | 9 |
| Placebo | 0 | 17 |
The total dose (mg) of opioid medications received during the trial (NCT00094887)
Timeframe: within 8 hours and within 40 days
| Intervention | mg (Median) | |
|---|---|---|
| within 8 hours | within 40 days | |
| Inhaled Nitric Oxide | 16.25 | 153.75 |
| Placebo | 17.25 | 211.37 |
3 reviews available for acetaminophen and Vascular Diseases
| Article | Year |
|---|---|
Nitric oxide releasing acetaminophen (nitroacetaminophen).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease M | 2003 |
Epidemiology of acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug-Related Side Effects and Adverse React | 2007 |
Drug-induced liver disease.
Topics: Acetaminophen; Alanine Transaminase; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2000 |
1 trial available for acetaminophen and Vascular Diseases
| Article | Year |
|---|---|
[Clinical observation on the analgesic effect of the acetaminophen-phenylbutazone combination in angiology].
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Arteriosclerosis; Arteriovenous Fistula; Blood V | 1968 |
12 other studies available for acetaminophen and Vascular Diseases
| Article | Year |
|---|---|
Tramadol infusion for the pain management in sickle cell disease: a case report.
Topics: Abdominal Pain; Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anemia, Sickle Cell; Ch | 2007 |
Capillarosclerosis of the urinary tract associated with the use of paracetamol and cyclophosphamide.
Topics: Acetaminophen; Adult; Aged; Capillaries; Cyclophosphamide; Female; Humans; Male; Middle Aged; Urinar | 1982 |
[Chronic pain during dialysis. Pharmacologic therapy and its costs].
Topics: Acetaminophen; Analgesics; Arthralgia; Buprenorphine; Chronic Disease; Codeine; Disability Evaluatio | 1999 |
Dermal micro-angiopathy in patients with analgesic nephropathy.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Aged; Capillaries; Female; Humans; Kidney Failure, Chroni | 1978 |
Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department.
Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics; Anemia, Sickle Cell; Anti-Inflammatory | 1992 |
Necrotizing myopathy in critically-ill patients.
Topics: Acetaminophen; Aortic Aneurysm; Bacterial Infections; Critical Care; Eclampsia; Female; Humans; Immu | 1991 |
Capillarosclerosis of the renal pelvis: autopsy study for estimating the incidence of phenacetin and paracetamol abuse.
Topics: Acetaminophen; Adult; Aged; Capillaries; Epidemiologic Methods; Female; Germany, West; Humans; Kidne | 1986 |
[Clinical study of a new antalgic: Propofan].
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Caffeine; Dextropropoxyphene; Female; Headache; His | 1972 |
[Effect of anti-inflammatory and antiproteolytic agents on vascular disorders in the intestines of animals irradiated in superlethal doses].
Topics: Acetaminophen; Aminocaproates; Aminopyrine; Animals; Aprotinin; Female; Intestines; Male; Phenylbuta | 1973 |
Drug-induced bleeding.
Topics: Acetaminophen; Anemia, Aplastic; Anticoagulants; Aspirin; Blood Platelets; Bone Marrow; Capillary Fr | 1974 |
Comparison of flufenamic acid with aspirin and paracetamol in terms of gastrointestinal blood loss.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chromium Isotopes; Fe | 1966 |
[Parazolidin in vascular diseases].
Topics: Acetaminophen; Humans; Phenylbutazone; Vascular Diseases | 1968 |