Page last updated: 2024-10-22

acetaminophen and Urogenital Prolapse

acetaminophen has been researched along with Urogenital Prolapse in 3 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
"To compare the effect of preoperative intravenous (IV) acetaminophen compared with placebo on pain scores after pelvic organ prolapse surgery."9.30Intravenous Acetaminophen Before Pelvic Organ Prolapse Repair: A Randomized Controlled Trial. ( Shepherd, JP; Turner, LC; Zyczynski, HM, 2019)
"To compare the effect of preoperative intravenous (IV) acetaminophen compared with placebo on pain scores after pelvic organ prolapse surgery."5.30Intravenous Acetaminophen Before Pelvic Organ Prolapse Repair: A Randomized Controlled Trial. ( Shepherd, JP; Turner, LC; Zyczynski, HM, 2019)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's2 (66.67)2.80

Authors

AuthorsStudies
Gabriel, I1
Abdalian, T1
Minassian, VA1
Ramaseshan, AS1
O'Sullivan, DM1
Steinberg, AC1
Tunitsky-Bitton, E1
Turner, LC1
Zyczynski, HM1
Shepherd, JP1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Impact of IV Acetaminophen on Postoperative Pain in Women Undergoing Pelvic Organ Prolapse Repair: A Double-Blind Randomized Placebo Controlled Trial[NCT02155738]Phase 4204 participants (Actual)Interventional2014-07-31Completed
The Impact of Tamsulosin on Duration of Post-Operative Urinary Retention in Women Undergoing Pelvic Reconstructive Surgery- A Double Blind, Randomized, Placebo-Controlled Study[NCT04597372]Phase 2154 participants (Anticipated)Interventional2021-11-03Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline in Postoperative Pain

"VAS or Visual Analog Score is a quantitative measure, in this study, of pain that the subject is currently experiencing. The VAS is presented as a straight line which measures 100mm. The subject is instructed to mark an 'X' through this line reflecting the amount of pain that they are currently experiencing. Zero would indicate no pain, while '100' would indicate the most severe pain ever. Thus the total range for this scale would be 0-100 mm. Higher values indicate more pain; lower value indicate less pain.~For this outcome measure, the VAS scores from Baseline and the VAS scores from 24 hours after the end of surgery are being used. The change from baseline in postoperative pain equals the 24 hour VAS score minus the baseline VAS score.~The Change from Baseline would be the 24-hour VAS score minus the Baseline VAS score. Higher values indicate more pain; lower values indicate less pain." (NCT02155738)
Timeframe: 24 hours

Interventionunits on a scale (Mean)
Vaginal Surgery - Placebo20.5
Vaginal Surgery - IV Acetaminophen29.2
Laparoscopic Surgery - Placebo20.7
Laparoscopic Surgery - IV Acetaminophen20.1

Cumulative Narcotic Consumption Over the First 24 Hours

Equianalgesic dosage tables will be used to convert intra- and postoperative narcotics into morphine equivalents to compare narcotic requirements for the first week after surgery. Higher numbers indicate higher narcotic usage. (NCT02155738)
Timeframe: First 24 hours

Interventionmg (Mean)
Vaginal Surgery - Placebo32.5
Vaginal Surgery - IV Acetaminophen31.6
Laparoscopic Surgery - Placebo47.4
Laparoscopic Surgery - IV Acetaminophen44.5

Interference of Pain With Physical, Mental and Social Activities

"Interference of pain with physical, mental and social activities will be measured by the Patient Reported Outcomes Measures Information Systems-Pain Interference-Short Form 8a (PROMIS PI-SF-8a) administered on POD#7.~This instrument measures the self reported consequences of pain on relevant aspects of one's life. This scale is considered to be universal rather than disease specific. Each question has five response options ranging in value from 1-5. The total raw score for the scale is the sum of all values. The total raw score can range from 8-40. All questions much be answered to obtain a valid score.~A higher PROMIS score indicates more 'hurt' or pain." (NCT02155738)
Timeframe: 1 week

Interventionunits on a scale (Mean)
Vaginal Surgery - Placebo18.4
Vaginal Surgery - IV Acetaminophen22.0
Laparoscopic Surgery - Placebo22.9
Laparoscopic Surgery - IV Acetaminophen25.2

Trials

1 trial available for acetaminophen and Urogenital Prolapse

ArticleYear
Intravenous Acetaminophen Before Pelvic Organ Prolapse Repair: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2019, Volume: 133, Issue:3

    Topics: Acetaminophen; Administration, Intravenous; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analg

2019
Intravenous Acetaminophen Before Pelvic Organ Prolapse Repair: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2019, Volume: 133, Issue:3

    Topics: Acetaminophen; Administration, Intravenous; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analg

2019
Intravenous Acetaminophen Before Pelvic Organ Prolapse Repair: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2019, Volume: 133, Issue:3

    Topics: Acetaminophen; Administration, Intravenous; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analg

2019
Intravenous Acetaminophen Before Pelvic Organ Prolapse Repair: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2019, Volume: 133, Issue:3

    Topics: Acetaminophen; Administration, Intravenous; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analg

2019

Other Studies

2 other studies available for acetaminophen and Urogenital Prolapse

ArticleYear
Perioperative use of pain medications in vaginal versus laparoscopic pelvic organ prolapse surgery.
    International urogynecology journal, 2022, Volume: 33, Issue:9

    Topics: Acetaminophen; Analgesics, Opioid; Female; Humans; Laparoscopy; Pain, Postoperative; Pelvic Organ Pr

2022
A comprehensive model for pain management in patients undergoing pelvic reconstructive surgery: a prospective clinical practice study.
    American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:2

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste

2020