acetaminophen has been researched along with Tonsillitis in 16 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Tonsillitis: Inflammation of the tonsils, especially the PALATINE TONSILS but the ADENOIDS (pharyngeal tonsils) and lingual tonsils may also be involved. Tonsillitis usually is caused by bacterial infection. Tonsillitis may be acute, chronic, or recurrent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A single oral dose of paracetamol or ketoprofen lysine salt are safe and effective analgesic treatments for children with sore throat in daily pediatric ambulatory care." | 9.15 | A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. ( Carozzino, L; Del Vecchio, A; Della Casa Alberighi, O; Dionisio, P; Freschi, F; Jamone, R; Martini, A; Picollo, G; Ruperto, N; Salvatori, E; Zera, M, 2011) |
| "A single oral dose of paracetamol or ketoprofen lysine salt are safe and effective analgesic treatments for children with sore throat in daily pediatric ambulatory care." | 5.15 | A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. ( Carozzino, L; Del Vecchio, A; Della Casa Alberighi, O; Dionisio, P; Freschi, F; Jamone, R; Martini, A; Picollo, G; Ruperto, N; Salvatori, E; Zera, M, 2011) |
| "Celecoxib is a cyclooxygenase-2-specific inhibitor indicated to treat acute pain and pain secondary to osteoarthritis and rheumatoid arthritis." | 2.82 | Celecoxib Versus Placebo in Tonsillectomy: A Prospective, Randomized, Double-Blind Placebo-Controlled Trial. ( Bodeker, KL; Trask, DK; Van Daele, DJ, 2016) |
| " There were no adverse reactions in either group." | 2.68 | [Comparative, randomized, parallel clinical study of the effectiveness and safety of aceclofenac vs. paracetamol in the treatment of viral pharyngoamygdalitis]. ( Conti, M, 1997) |
| "To determine the risk of postoperative hemorrhage associated with the use of analgesic drugs including paracetamol, metamizole sodium and ibuprofen after pediatric tonsillectomy." | 1.38 | The effect of paracetamol, metamizole sodium and ibuprofen on postoperative hemorrhage following pediatric tonsillectomy. ( Kapusuz, Z; Özkiriş, M; Saydam, L; Yildirim, YS, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jotić, A | 1 |
| Savić Vujović, K | 1 |
| Milovanović, J | 1 |
| Vujović, A | 1 |
| Radin, Z | 1 |
| Milić, N | 1 |
| Vučković, S | 1 |
| Medić, B | 1 |
| Prostran, M | 1 |
| Ramos, SD | 1 |
| Mukerji, S | 1 |
| Pine, HS | 1 |
| Van Daele, DJ | 1 |
| Bodeker, KL | 1 |
| Trask, DK | 1 |
| Collis, DH | 1 |
| Sanu, A | 1 |
| Dahi-Taleghani, M | 1 |
| Mousavifard, S | 1 |
| Tahmoureszade, S | 1 |
| Dabbagh, A | 1 |
| Ruperto, N | 1 |
| Carozzino, L | 1 |
| Jamone, R | 1 |
| Freschi, F | 1 |
| Picollo, G | 1 |
| Zera, M | 1 |
| Della Casa Alberighi, O | 1 |
| Salvatori, E | 1 |
| Del Vecchio, A | 1 |
| Dionisio, P | 1 |
| Martini, A | 1 |
| Özkiriş, M | 1 |
| Kapusuz, Z | 1 |
| Yildirim, YS | 1 |
| Saydam, L | 1 |
| FICHSEL, H | 1 |
| GARCIAHERRERA, E | 1 |
| Hultcrantz, E | 2 |
| Ericsson, E | 2 |
| Rallis, E | 1 |
| Balatsouras, DG | 1 |
| Kouskoukis, C | 1 |
| Verros, C | 1 |
| Homsioglou, E | 1 |
| Wadsby, M | 1 |
| Conti, M | 1 |
| Salonen, A | 1 |
| Kokki, H | 1 |
| Nuutinen, J | 1 |
| Thamlikitkul, V | 1 |
| Dechatiwongse, T | 1 |
| Theerapong, S | 1 |
| Chantrakul, C | 1 |
| Boonroj, P | 1 |
| Punkrut, W | 1 |
| Ekpalakorn, W | 1 |
| Boontaeng, N | 1 |
| Taechaiya, S | 1 |
| Petcharoen, S | 1 |
| Bertin, L | 1 |
| Pons, G | 1 |
| d'Athis, P | 1 |
| Lasfargues, G | 1 |
| Maudelonde, C | 1 |
| Duhamel, JF | 1 |
| Olive, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Perioperative Use of Celecoxib to Improve Pain Control in Patients Undergoing Tonsillectomy: a Randomized, Double Blind, Placebo-controlled Trial[NCT00583453] | Phase 2 | 18 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Randomized, Comparative, Double Blind Controlled Phase II Clinical Trial, to Evaluate the Efficacy of ApE in Patients With Multiple Sclerosis (MS).[NCT02280876] | Phase 1/Phase 2 | 30 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The incidence of post-operative hemorrhage, defined as post-operative bleeding requiring medical intervention or hospitalization during the 10 day post-operative follow-up period. (NCT00583453)
Timeframe: From operative day through 10 days post-operative
| Intervention | Participants (Count of Participants) |
|---|---|
| Celecoxib 200 mg Tablets | 0 |
| Placebo With Same Dosing Schedule as the Active Comparator Arm | 0 |
Participant reported acetaminophen use and its equivalent. Medication use was collected from reported participant journals. (NCT00583453)
Timeframe: From operative day through 10 days post-operative
| Intervention | mg (Mean) | |||
|---|---|---|---|---|
| Day 1 | Average, days 2 to 4 | Average, days 5 to 7 | Average, days 8 to 10 | |
| Celecoxib as Experimerimental Intervention | 2074 | 2245 | 2028 | 1418 |
| Placebo Control, Active Comparator | 3006 | 2934 | 3610 | 2483 |
Activity level, reported by participant utilizing a 10-point ordinal scale (0 = no activity, 10 = return to normal activities). Activity level was measured was collected once daily. (NCT00583453)
Timeframe: From operative day through 10 days post-operative
| Intervention | Activity score (units on a scale) (Mean) | |||
|---|---|---|---|---|
| Day 1 | Average, days 2 to 4 | Average, days 5 to 7 | Average, days 8 to 10 | |
| Celecoxib as Experimerimental Intervention | 2.8 | 3.1 | 5.4 | 7.4 |
| Placebo Control, Active Comparator | 4.5 | 4.1 | 3.7 | 5.7 |
Pain score as reported by participant, measured on a 10 point scale, where 0 = none and 10 = unbearable, collected once daily. (NCT00583453)
Timeframe: day of procedure through post-operative day 10
| Intervention | pain score (units on a scale) (Mean) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Maximum pain, day 1 | maximum pain, averaged across days 2 to 4 | maximum pain, averaged across days 5 to 7 | maximum pain, averaged across days 8 to 10 | Average pain, day 1 | Average pain, averaged across days 2 to 4 | Average pain, averaged across days 5 to 7 | Average pain, averaged across days 8 to 10 | Pain with drinking, day 1 | Pain with drinking, averaged across days 2 to 4 | Pain with drinking, averaged across days 5 to 7 | Pain with drinking, averaged across days 8 to 10 | Activity, day 1 | |
| Celecoxib 200 mg Tablets | 5.0 | 5.1 | 4.4 | 3.6 | 6.1 | 6.2 | 6.1 | 4.9 | 5.7 | 5.4 | 4.9 | 3.9 | 2.8 |
| Placebo With Same Dosing Schedule as the Active Comparator Arm | 6.0 | 6.0 | 5.9 | 4.0 | 7.3 | 7.6 | 7.4 | 5.7 | 6.7 | 6.6 | 5.9 | 4.1 | 4.5 |
Participant reported mophine equivalent use (NCT00583453)
Timeframe: From operative day through 10 days post-operative
| Intervention | mg (Mean) | |||
|---|---|---|---|---|
| Day 1 | Average, days 2 to 4 | Average, days 5 to 7 | Average, days 8 to 10 | |
| Celecoxib as Experimerimental Intervention | 28.9 | 30.4 | 27.8 | 13.2 |
| Placebo Control, Active Comparator | 55.0 | 72.4 | 69.7 | 38.3 |
1 review available for acetaminophen and Tonsillitis
| Article | Year |
|---|---|
Tonsillectomy and adenoidectomy.
Topics: Acetaminophen; Adenoidectomy; Analgesics, Non-Narcotic; Child; Codeine; Humans; Narcotics; Pain, Pos | 2013 |
10 trials available for acetaminophen and Tonsillitis
| Article | Year |
|---|---|
Pain Management After Surgical Tonsillectomy: Is There a Favorable Analgesic?
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Child; Female; Humans; I | 2019 |
Celecoxib Versus Placebo in Tonsillectomy: A Prospective, Randomized, Double-Blind Placebo-Controlled Trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Celecoxib; Chronic Disease; Cycl | 2016 |
Rectal acetaminophen versus peritonsillar infiltration of bupivacaine for postoperative analgesia after adenotonsillectomy in children.
Topics: Acetaminophen; Acute Disease; Administration, Rectal; Adolescent; Analgesics, Non-Narcotic; Anesthes | 2011 |
A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Ambulatory Care; Analgesics, Non-Narcotic; Anti- | 2011 |
Pediatric tonsillotomy with the radiofrequency technique: less morbidity and pain.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; | 2004 |
Pre-surgical child behavior ratings and pain management after two different techniques of tonsil surgery.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Anti-Inflammato | 2006 |
[Comparative, randomized, parallel clinical study of the effectiveness and safety of aceclofenac vs. paracetamol in the treatment of viral pharyngoamygdalitis].
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Male; Mid | 1997 |
The effect of ketoprofen on recovery after tonsillectomy in children: a 3-week follow-up study.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2002 |
Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults.
Topics: Acetaminophen; Adolescent; Adult; Child; Double-Blind Method; Female; Humans; Male; Pharyngitis; Pla | 1991 |
Randomized, double-blind, multicenter, controlled trial of ibuprofen versus acetaminophen (paracetamol) and placebo for treatment of symptoms of tonsillitis and pharyngitis in children.
Topics: Acetaminophen; Administration, Oral; Child; Deglutition; Double-Blind Method; Drug Tolerance; Female | 1991 |
5 other studies available for acetaminophen and Tonsillitis
| Article | Year |
|---|---|
Zygomatic haematoma in an 11-month-old helps diagnose retropharyngeal abscess, with concurrent tonsillitis and subsequent infant tonsillectomy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anorexia; Anti-Bacterial Agents; Cefotaxime; Dexamethasone; | 2016 |
The effect of paracetamol, metamizole sodium and ibuprofen on postoperative hemorrhage following pediatric tonsillectomy.
Topics: Acetaminophen; Analgesics; Child; Child, Preschool; Dipyrone; Female; Humans; Ibuprofen; Male; Pain, | 2012 |
[EXPERIENCES WITH A NEW ANTIPYRETIC AND ANALGESIC IN A NEW RECTAL CAPSULE FORM].
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Bronchitis; Bronchopneumonia; Cap | 1963 |
[RECTAL USE OF NAPA AS ANTIPYRETIC IN PEDIATRICS].
Topics: Acetaminophen; Antipyretics; Bronchitis; Child; Drug Therapy; Fever; Gastroenteritis; Humans; Infant | 1964 |
Drug eruptions in children with ENT infections.
Topics: Acetaminophen; Adolescent; Amoxicillin-Potassium Clavulanate Combination; Cephalosporins; Child; Chi | 2006 |