Page last updated: 2024-10-22

acetaminophen and Tetanus

acetaminophen has been researched along with Tetanus in 3 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Tetanus: A disease caused by tetanospasmin, a powerful protein toxin produced by CLOSTRIDIUM TETANI. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. Generalized tetanus, the most common form, is characterized by tetanic muscular contractions and hyperreflexia. Localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form.

Research Excerpts

ExcerptRelevanceReference
" Since fever is an important issue with vaccine tolerability, we performed this open-label study on the efficacy and safety of prophylactic use of paracetamol (acetaminophen, BenuronĀ®) in children administered routine 7-valent pneumococcal conjugate vaccine (PCV-7) coadministered with hexavalent vaccine (diphtheria-tetanus-acellular pertussis-hepatitis B, poliovirus, Haemophilus influenzae type b vaccine [DTPa-HBV-IPV/Hib]) in Germany."5.17An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Hae ( Baker, S; Gruber, WC; Juergens, C; Rose, MA; Schmoele-Thoma, B; Zielen, S, 2013)
"Low grade fever is a known adverse effect of vaccination."2.84Effect of prophylactic or therapeutic administration of paracetamol on immune response to DTwP-HepB-Hib combination vaccine in Indian infants. ( Bavdekar, SB; Chhatwal, J; D'Cor, NA; Dhaded, SM; Dhingra, MS; Dubey, AP; Dupuy, M; Gandhi, DJ; Gupta, M; Jayanth, MV; Kundu, R; Lalwani, SK; Mangarule, SA; Mathew, LG; Patnaik, BN; Ravi, MD; Ravinuthala, S; Reddy E, J; Rout, SP; Sharma, SD; Sil, A, 2017)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sil, A1
Ravi, MD1
Patnaik, BN1
Dhingra, MS1
Dupuy, M1
Gandhi, DJ1
Dhaded, SM1
Dubey, AP1
Kundu, R1
Lalwani, SK1
Chhatwal, J1
Mathew, LG1
Gupta, M1
Sharma, SD1
Bavdekar, SB1
Rout, SP1
Jayanth, MV1
D'Cor, NA1
Mangarule, SA1
Ravinuthala, S1
Reddy E, J1
Rose, MA1
Juergens, C1
Schmoele-Thoma, B1
Gruber, WC1
Baker, S1
Zielen, S1
Oldfield, BJ1
Stewart, RW1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation: the NEED LESS PAIN Study"[NCT02807623]300 participants (Actual)Interventional2016-09-30Completed
A Randomized Controlled Open-Label Phase IV Multi Center Study to Assess the Effect of Antipyretic Prophylactic Treatment on the Rate of Febrile Reactions Following Concomitant Contralateral Administration of a 7-Valent Pneumococcal Conjugate Vaccine (Pre[NCT00294294]Phase 4300 participants Interventional2005-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Participants With Edema

Swelling at vaccination site (NCT02807623)
Timeframe: baseline, 48-72 hours, and 21- 28 days (3 points)

InterventionParticipants (Count of Participants)
Baseline0
48-72 Hours After Vaccination0
21-28 Days After Vaccination0

Participants With Erythema

Reddening of the skin at vaccination site reported as the total number of participants with erythema over the duration of the study. (NCT02807623)
Timeframe: baseline, 48- 72 hours, 21-28 days (3 points)

InterventionParticipants (Count of Participants)
Baseline0
48-72 Hours After Vaccination0
21-28 Days After Vaccination0

Lactate

A Lactate meter was used to test the exercise group for lactate readings. Two lactate tests was performed for the exercise group at Visit 1, both pre and post Influenza vaccination. The first lactate reading was taken after the blood draw.The second lactate reading was obtained from a fingerstick from the hand opposite to the vaccination arm, ideally within 3-8 minutes after the study subject completes pushups. (NCT02807623)
Timeframe: Immediately prior to Influenza vaccine and 3-8 minutes after Influenza vaccine was administered and after push-ups were completed.

Interventionmmol/L (Mean)
Lactate before pushupsLactate after pushups
Compound Exercise of Push-ups1.517.69

Level of Pain

Level of Pain will be measured by validated pain scale, using a scale of 0 ( best, no pain) to 10 (worst, as bad as imaginable, completely interferes). (NCT02807623)
Timeframe: baseline, 48-72 hours and at 21-28 days ( 3 points )

,,
Interventionunits on a scale (Mean)
Visit 1Visit 2Visit 3
Compound Exercise of Push-ups.14.19.13
Ibuprofen.39.56.28
Placebo.19.22.06

Serologic Response - A/California/7/2009

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups214.80345.09
Ibuprofen171.00239.25
Placebo216.75343.03

Serologic Response - A/Hong Kong / 4801/2014

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups149.22232.58
Ibuprofen177.78243.13
Placebo221.09296.66

Serologic Response - B/Brisbane/60/2008

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups26.0041.02
Ibuprofen17.4125.47
Placebo26.0934.09

Serologic Response - B/Phuket/3073/2013

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups32.8949.07
Ibuprofen40.1647.34
Placebo36.6944.78

Reviews

1 review available for acetaminophen and Tetanus

ArticleYear
Common Misconceptions, Advancements, and Updates in Pediatric Vaccination Administration.
    Southern medical journal, 2016, Volume: 109, Issue:1

    Topics: Acetaminophen; Adolescent; Bacterial Infections; Child; Child, Preschool; Family; Female; Guidelines

2016

Trials

2 trials available for acetaminophen and Tetanus

ArticleYear
Effect of prophylactic or therapeutic administration of paracetamol on immune response to DTwP-HepB-Hib combination vaccine in Indian infants.
    Vaccine, 2017, 05-19, Volume: 35, Issue:22

    Topics: Acetaminophen; Antibodies, Bacterial; Diphtheria; Diphtheria-Tetanus-Pertussis Vaccine; Female; Feve

2017
An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Hae
    BMC pediatrics, 2013, Jun-21, Volume: 13

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Bacterial Capsules; Child, Preschool; Diphtheria; Diphtheri

2013
An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Hae
    BMC pediatrics, 2013, Jun-21, Volume: 13

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Bacterial Capsules; Child, Preschool; Diphtheria; Diphtheri

2013
An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Hae
    BMC pediatrics, 2013, Jun-21, Volume: 13

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Bacterial Capsules; Child, Preschool; Diphtheria; Diphtheri

2013
An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Hae
    BMC pediatrics, 2013, Jun-21, Volume: 13

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Bacterial Capsules; Child, Preschool; Diphtheria; Diphtheri

2013