acetaminophen has been researched along with Stomach Ulcer in 41 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The rate of gastric ulcers in subjects receiving paracetamol (0/21, 0%) alone or aspirin (3/19, 16%) or both (2/20, 10%) was not different." | 5.16 | Does concomitant use of paracetamol potentiate the gastroduodenal mucosal injury associated with aspirin? A prospective, randomised, pilot study. ( Berkes, J; Boike, JR; Goldstein, JL; Kao, R; Markle, B; Meyer, D; Niebruegge, J; Rosenberg, J; Stein, AC, 2012) |
| " Paracetamol and aspirin were used to induce hepatotoxicity and gastric ulcer in rats, respectively." | 4.12 | Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models. ( Ahsan, H; Anjum, I; Ismail, S; Kahrizi, D; Movafagh, A; Naveed Mushtaq, M; Ramzan, HM; Razzaq, A; Shabbir, U; Shoukat, A, 2022) |
| " Among the 12 prepared compounds, Compounds 3d, e, i and j exhibited significant anti-inflammatory activity in model of acute inflammation such as carrageenan-induced rat edema paw while compounds 3d and e showed considerable activity in model of chronic inflammation such as adjuvant-induced arthritis and were compared with diclofenac (13." | 3.75 | Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents. ( Aragade, P; Khode, S; Maddi, V; Mamledesai, S; Palkar, M; Ronad, PK; Satyanarayana, D; Thippeswamy, AH, 2009) |
| "Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear." | 3.67 | Peptic ulcer and non-steroidal anti-inflammatory agents. ( Dobson, AJ; Duggan, JM; Fahey, P; Johnson, H, 1986) |
| "(R)- flurbiprofen was not statistically significant." | 2.69 | Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)- ketoprofen, (R)- flurbiprofen, racemic ketoprofen, and paracetamol: a randomized, single-blind, placebo-controlled trial. ( Caubet, JF; Handley, DA; Jerussi, TP; McCray, JE, 1998) |
| "Ketoprofen is a potent nonsteroidal antiinflammatory agent (NSAID) recently approved for OTC use as an analgesic/antipyretic at doses of 75 mg versus the usual dose of < or = 300 mg daily." | 2.69 | An endoscopic comparison of gastroduodenal injury with over-the-counter doses of ketoprofen and acetaminophen. ( Codispoti, JR; Lanza, FL; Nelson, EB, 1998) |
| "Chronic gastric ulcer is linked to aspirin intake in patients with rheumatic disease, and epidemiologically in all heavy aspirin users; paradoxically, in only one epidemiologic study was a significant association found between acetaminophen intake and chronic gastric ulcer." | 2.36 | Gastrointestinal effects of antipyretic analgesics. ( Ivey, KJ, 1983) |
| " Following clinical observations that this drug combination induces significant adverse effects, its gastric toxicity was investigated in rats." | 1.28 | Potentiation of gastric toxicity of ibuprofen by paracetamol in the rat. ( Bhattacharya, SK; Goel, RK; Tandon, R, 1991) |
| " FS 205-397 will offer potent analgesic and antipyretic therapy in man based on an innovative biochemical principle which eliminates the undesirable toxic effects associated with most other non-narcotic analgesics." | 1.27 | FS 205-397: a new antipyretic analgesic with a paracetamol-like profile of activity but lack of acute hepatotoxicity in mice. ( Achini, R; Foote, RW; Römer, D, 1988) |
| "Acetaminophen has been proposed as an agent which protects the gastric mucosa against damage induced by aspirin and other non-steroidal anti-inflammatory agents." | 1.27 | Effect of acetaminophen on human gastric mucosal injury caused by ibuprofen. ( Lanza, FL; Nelson, RS; Rack, MF; Royer, GL; Schwartz, JH; Seckman, CE, 1986) |
| "Aspirin alone was the least frequently ingested." | 1.26 | Analgesic ingestion and chronic peptic ulcer. ( Ariotti, DE; Fenton, BH; MacLennan, R; McIntosh, JH; Piper, DW, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (56.10) | 18.7374 |
| 1990's | 9 (21.95) | 18.2507 |
| 2000's | 4 (9.76) | 29.6817 |
| 2010's | 4 (9.76) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Khode, S | 1 |
| Maddi, V | 1 |
| Aragade, P | 1 |
| Palkar, M | 1 |
| Ronad, PK | 1 |
| Mamledesai, S | 1 |
| Thippeswamy, AH | 1 |
| Satyanarayana, D | 1 |
| Ismail, S | 1 |
| Naveed Mushtaq, M | 1 |
| Shabbir, U | 1 |
| Razzaq, A | 1 |
| Ramzan, HM | 1 |
| Shoukat, A | 1 |
| Ahsan, H | 1 |
| Movafagh, A | 1 |
| Kahrizi, D | 1 |
| Anjum, I | 1 |
| Fukushima, E | 1 |
| Monoi, N | 1 |
| Mikoshiba, S | 1 |
| Hirayama, Y | 1 |
| Serizawa, T | 1 |
| Adachi, K | 2 |
| Koide, M | 1 |
| Ohdera, M | 1 |
| Murakoshi, M | 1 |
| Kato, H | 1 |
| Braund, R | 1 |
| Abbott, JH | 1 |
| Boike, JR | 1 |
| Kao, R | 1 |
| Meyer, D | 1 |
| Markle, B | 1 |
| Rosenberg, J | 1 |
| Niebruegge, J | 1 |
| Stein, AC | 1 |
| Berkes, J | 1 |
| Goldstein, JL | 1 |
| Milosevic, S | 1 |
| Tran, K | 1 |
| O'Brien, B | 1 |
| Brandt, K | 1 |
| Ebara, S | 1 |
| Shirasaka, D | 1 |
| Aoyama, N | 1 |
| Kachi, M | 1 |
| Miki, I | 1 |
| Morita, Y | 1 |
| Tamura, T | 1 |
| Kasuga, M | 1 |
| Ivey, KJ | 1 |
| Engelhardt, G | 2 |
| Humes, JL | 1 |
| Winter, CA | 1 |
| Sadowski, SJ | 1 |
| Kuehl, FA | 1 |
| Van Kolfschoten, AA | 2 |
| Zandberg, P | 2 |
| Jager, LP | 3 |
| Van Noordwijk, J | 3 |
| Konturek, SJ | 1 |
| Brzozowski, T | 1 |
| Piastucki, I | 1 |
| Radecki, T | 1 |
| Harasawa, S | 3 |
| Kikuchi, K | 1 |
| Senoue, I | 1 |
| Nomiyama, T | 2 |
| Miwa, T | 2 |
| Piper, DW | 3 |
| McIntosh, JH | 3 |
| Ariotti, DE | 1 |
| Fenton, BH | 1 |
| MacLennan, R | 1 |
| Omura, H | 1 |
| Kamisaki, Y | 1 |
| Kawasaki, H | 1 |
| Itoh, T | 1 |
| Mauz, AB | 1 |
| Pairet, M | 1 |
| Jerussi, TP | 1 |
| Caubet, JF | 1 |
| McCray, JE | 1 |
| Handley, DA | 1 |
| Villar, D | 1 |
| Buck, WB | 1 |
| Gonzalez, JM | 1 |
| Lanza, FL | 2 |
| Codispoti, JR | 1 |
| Nelson, EB | 1 |
| Seegers, AJ | 1 |
| Daas, M | 1 |
| Gupta, MB | 1 |
| Gupta, GP | 1 |
| Bhargava, KP | 1 |
| Tani, N | 1 |
| Suzuki, S | 1 |
| Miwa, M | 1 |
| Sakita, R | 1 |
| Worthley, L | 1 |
| Cho, CH | 3 |
| Ogle, CW | 3 |
| Bhattacharya, SK | 2 |
| Goel, RK | 1 |
| Tandon, R | 1 |
| Janjua, MZ | 1 |
| Draz, U | 1 |
| Shiina, Y | 1 |
| Hasebe, T | 1 |
| Poon, YK | 2 |
| Koizumi, F | 1 |
| Kawamura, T | 1 |
| Ishimori, A | 1 |
| Ebina, H | 1 |
| Satoh, M | 1 |
| Ligumsky, M | 1 |
| Sestieri, M | 1 |
| Karmeli, F | 1 |
| Rachmilewitz, D | 1 |
| Müller, P | 1 |
| Dammann, HG | 1 |
| Simon, B | 1 |
| Foote, RW | 1 |
| Achini, R | 1 |
| Römer, D | 1 |
| Fung, CS | 1 |
| Berry, G | 1 |
| Fukumoto, S | 1 |
| Amano, Y | 1 |
| Fukuda, R | 1 |
| Gobaru, Y | 1 |
| Ashizawa, N | 1 |
| Yoshida, H | 1 |
| Watanabe, M | 1 |
| Shimada, Y | 1 |
| Duggan, JM | 1 |
| Dobson, AJ | 1 |
| Johnson, H | 1 |
| Fahey, P | 1 |
| Royer, GL | 1 |
| Nelson, RS | 1 |
| Rack, MF | 1 |
| Seckman, CE | 1 |
| Schwartz, JH | 1 |
| Byth, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Acetaminophen Potentiate the Gastroduodenal Mucosal Injury of Aspirin? A Prospective, Randomized, Pilot Study.[NCT00594867] | Phase 4 | 94 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for acetaminophen and Stomach Ulcer
| Article | Year |
|---|---|
A rare cause of high anion gap metabolic acidosis.
Topics: Abdominal Pain; Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Amino Acid Metabolism, Inborn | 2013 |
[Paracetamol in the treatment of osteoarthritis pain].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg | 2003 |
Gastrointestinal effects of antipyretic analgesics.
Topics: Acetaminophen; Adenosine Triphosphate; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bicarbonate | 1983 |
Ibuprofen, aspirin and acetaminophen toxicosis and treatment in dogs and cats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1998 |
The pharmacological differences and similarities between stress- and ethanol-induced gastric mucosal damage.
Topics: Acetaminophen; Animals; Anti-Ulcer Agents; Calcium Channel Blockers; Cold Temperature; Disease Model | 1992 |
5 trials available for acetaminophen and Stomach Ulcer
| Article | Year |
|---|---|
Does concomitant use of paracetamol potentiate the gastroduodenal mucosal injury associated with aspirin? A prospective, randomised, pilot study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2012 |
Gastric emptying in patients with gastric ulcers--effects of oral and intramuscular administration of anticholinergic drug.
Topics: Acetaminophen; Administration, Oral; Adult; Atropine Derivatives; Dose-Response Relationship, Drug; | 1982 |
Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)- ketoprofen, (R)- flurbiprofen, racemic ketoprofen, and paracetamol: a randomized, single-blind, placebo-controlled trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Duodenal Dise | 1998 |
An endoscopic comparison of gastroduodenal injury with over-the-counter doses of ketoprofen and acetaminophen.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 1998 |
[Endoscopic study of gastric tolerance of paracetamol and acetylsalicylic acid. A placebo-controlled double-blind study on healthy subjects].
Topics: Acetaminophen; Adult; Aspirin; Double-Blind Method; Duodenum; Gastroscopy; Humans; Male; Random Allo | 1988 |
31 other studies available for acetaminophen and Stomach Ulcer
| Article | Year |
|---|---|
Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; Edema; Female; Male; Mic | 2009 |
Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models.
Topics: Acetaminophen; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Chemical and Drug Induced Liver In | 2022 |
Protective effects of acetaminophen on ibuprofen-induced gastric mucosal damage in rats with associated suppression of matrix metalloproteinase.
Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Do | 2014 |
Recommending NSAIDs and paracetamol: A survey of New Zealand physiotherapists' knowledge and behaviours.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Health Knowledge, Attitudes, Pr | 2011 |
The relationship between gastric emptying determined by the breath test and H. pylori.
Topics: Acetaminophen; Adult; Aged; Breath Tests; Caprylates; Carbon Radioisotopes; Dyspepsia; Female; Gastr | 2007 |
Pain medications. What you should know.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Hum | 2007 |
[Animal experimental studies on the question of the interaction of paracetamol and acetylsalicylic acid].
Topics: Acetaminophen; Animals; Aspirin; Body Temperature; Exudates and Transudates; Female; Glutathione; Li | 1984 |
Multiple sites on prostaglandin cyclooxygenase are determinants in the action of nonsteroidal antiinflammatory agents.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Diflunisal; Indomethaci | 1981 |
Protection by paracetamol against various gastric irritants in the rat.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Male; Rats; Rats, Inbred S | 1983 |
Prevention of ethanol and aspirin-induced gastric mucosal lesions by paracetamol and salicylate in rats: role of endogenous prostaglandins.
Topics: Acetaminophen; Animals; Aspirin; Epoprostenol; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; | 1982 |
The influence of paracetamol on the erosive activity of indomethacin in the rat stomach.
Topics: Acetaminophen; Administration, Oral; Animals; Aspirin; Indomethacin; Injections, Subcutaneous; Male; | 1982 |
Analgesic ingestion and chronic peptic ulcer.
Topics: Acetaminophen; Analgesics; Aspirin; Australia; Duodenal Ulcer; Female; Humans; Male; Peptic Ulcer; R | 1981 |
Effect of acetaminophen on stress-induced gastric mucosal lesions in rats.
Topics: Acetaminophen; Animals; Dinoprostone; Drug Combinations; Gastric Mucosa; Glutathione; Indomethacin; | 1994 |
Role of caffeine in combined analgesic drugs from the point of view of experimental pharmacology.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
Gastric erosions induced by analgesic drug mixtures in the rat.
Topics: Acetaminophen; Animals; Aspirin; Caffeine; Drug Combinations; Female; Lethal Dose 50; Phenacetin; Ra | 1978 |
Role of biogenic amines in the ulcerogenic action of analgin and paracetamol in albino rats.
Topics: Acetaminophen; Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biogenic Amines; Fem | 1978 |
Gastric emptying in normal subjects and patients with peptic ulcer: a study using the acetaminophen method.
Topics: Acetaminophen; Adult; Duodenal Ulcer; Gastric Emptying; Humans; Male; Middle Aged; Stomach Ulcer; Ti | 1979 |
Letter: (a) Stress ulcer prophylaxis; (b) paracetamol antidote.
Topics: Acetaminophen; Administration, Oral; Humans; Stomach Ulcer; Stress, Physiological | 1975 |
Potentiation of gastric toxicity of ibuprofen by paracetamol in the rat.
Topics: Acetaminophen; Administration, Oral; Animals; Drug Synergism; Gastric Mucosa; Ibuprofen; Male; Rats; | 1991 |
The effect of paracetamol on naprosyn induced damage to gastric mucosa in albino rat.
Topics: Acetaminophen; Animals; Gastric Mucosa; Male; Naproxen; Prostaglandins; Rats; Stomach Ulcer | 1991 |
[Non-ulcer dyspepsia].
Topics: Acetaminophen; Adenosine Triphosphate; Adult; Aged; Duodenal Ulcer; Dyspepsia; Gastric Acid; Gastric | 1991 |
The protective mechanisms of paracetamol against ethanol-induced gastric mucosal damage in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Ethanol; Ethylmaleimide; Injections, Subcutaneous; Mal | 1989 |
Paracetamol confers resistance to ethanol-induced gastric mucosal damage in rats.
Topics: Acetaminophen; Animals; Ethanol; Gastric Mucosa; Male; Rats; Rats, Inbred Strains; Reference Values; | 1988 |
Plasma paracetamol concentrations measured by fluorescence polarization immunoassay and gastric emptying time.
Topics: Acetaminophen; Duodenal Ulcer; Fluorescent Antibody Technique; Gastric Emptying; Gastritis; Humans; | 1988 |
Protection by mild irritants against indomethacin-induced gastric mucosal damage in the rat: role of prostaglandin synthesis.
Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Animals; Dinoprostone; Ethanol; Gastric Acid; Gastric M | 1986 |
FS 205-397: a new antipyretic analgesic with a paracetamol-like profile of activity but lack of acute hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Infectious; Disease Mode | 1988 |
Smoking, nonsteroidal anti-inflammatory drugs, and acetaminophen in gastric ulcer. A study of associations and of the effects of previous diagnosis on exposure patterns.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Duodenal Ulc | 1988 |
Gastric emptying in deformed stomach.
Topics: Acetaminophen; Adult; Aged; Domperidone; Female; Gastric Acid; Gastric Emptying; Humans; Male; Middl | 1987 |
Peptic ulcer and non-steroidal anti-inflammatory agents.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Aspirin; Duodenal Ulcer; Female; Humans; Male; Middle | 1986 |
Effect of acetaminophen on human gastric mucosal injury caused by ibuprofen.
Topics: Acetaminophen; Adult; Female; Gastric Mucosa; Humans; Ibuprofen; Male; Middle Aged; Stomach Ulcer; T | 1986 |
Environmental factors in aetiology of chronic gastric ulcer: a case control study of exposure variables before the first symptoms.
Topics: Acetaminophen; Alcohol Drinking; Analgesics; Anti-Inflammatory Agents; Aspirin; Chronic Disease; Fem | 1985 |