acetaminophen has been researched along with Stevens-Johnson Syndrome in 33 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated the association between 2 mood stabilizers (carbamazepine and valproate) and other medications (including other anticonvulsants) and the risks of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) among patients with bipolar disorder." | 7.74 | The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study. ( Chang, CJ; Chao, PF; Gau, CS; Gau, SS; Lin, YJ, 2008) |
| "Acetaminophen (paracetamol) is a widely used analgesic and antipyretic." | 6.72 | A review of published cases of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with the use of acetaminophen. ( Milosavljević, JZ; Milosavljević, MN; Pejčić, AV, 2021) |
| "Acetaminophen is an over-the-counter drug used worldwide to treat pain and reduce fever." | 5.48 | Is acetaminophen associated with a risk of Stevens-Johnson syndrome and toxic epidermal necrolysis? Analysis of the French Pharmacovigilance Database. ( Gras-Champel, V; Guy, C; Jean-Pastor, MJ; Lebrun-Vignes, B; Zenut, M, 2018) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but fatal adverse mucocutaneous reactions to certain drugs." | 5.42 | Clinical features of and genetic predisposition to drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients-investigating the relation between the HLA -B*4403 allele and lamotrigine. ( Kim, SR; Koh, BS; Lee, JH; Leem, DW; Moon, IJ; Park, HJ; Park, JW; Park, KH, 2015) |
| " There are few cases reports of "Stevens-Johnson syndrome/Toxic Epidermal Necrolysis" associated with acetaminophen in the literature." | 3.83 | A Case of Toxic Epidermal Necrolysis Secondary to Acetaminophen in a Child. ( Alcalá, PJ; Cuello, JD; Pena, MÁ; Pérez, S; Reig, R; Zapater, P; Zazo, MC, 2016) |
| " Although a lymphocyte stimulation test was positive only for acetaminophen, he took other agents including carbamazepine for his depression." | 3.76 | Toxic epidermal necrolysis with prominent facial pustules: a case with reactivation of human herpesvirus 7. ( Honma, M; Iinuma, S; Iizuka, H; Ishida-Yamamoto, A; Komatsu, S; Shibuya, T; Takahashi, I; Tobisawa, S, 2010) |
| "This study investigated the association between 2 mood stabilizers (carbamazepine and valproate) and other medications (including other anticonvulsants) and the risks of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) among patients with bipolar disorder." | 3.74 | The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study. ( Chang, CJ; Chao, PF; Gau, CS; Gau, SS; Lin, YJ, 2008) |
| "Toxic epidermal necrolysis with epidermal shedding over almost the entire body occurred in a patient with classical rheumatoid arthritis treated with sulindac, penicillamine and a combination analgesic containing paracetamol and chlormezanone." | 3.67 | Toxic epidermal necrolysis with extensive mucosal erosions of the gastrointestinal and respiratory tracts. ( Ahlmén, M; Fagerberg, B; Roupe, G; Suurküla, M, 1986) |
| "Acetaminophen (paracetamol) is a widely used analgesic and antipyretic." | 2.72 | A review of published cases of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with the use of acetaminophen. ( Milosavljević, JZ; Milosavljević, MN; Pejčić, AV, 2021) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse skin reactions characterized by high fever, epidermal detachment, and mucositis." | 1.62 | A pediatric case of Stevens-Johnson syndrome with acute liver failure, resulting in liver transplantation. ( Aihara, M; Honda, Y; Kumamoto, T; Saito, S; Takamura, N; Totsuka, M; Watanabe, T; Watanabe, Y; Yamanaka, S; Yoneda, M, 2021) |
| "Acetaminophen is an over-the-counter drug used worldwide to treat pain and reduce fever." | 1.48 | Is acetaminophen associated with a risk of Stevens-Johnson syndrome and toxic epidermal necrolysis? Analysis of the French Pharmacovigilance Database. ( Gras-Champel, V; Guy, C; Jean-Pastor, MJ; Lebrun-Vignes, B; Zenut, M, 2018) |
| "She had poorly controlled ulcerative colitis and was treated with high doses of prednisolone, infliximab, acetaminophen and lansoprazole." | 1.43 | Toxic epidermal necrolysis caused by acetaminophen featuring almost 100% skin detachment: Acetaminophen is associated with a risk of severe cutaneous adverse reactions. ( Aruga, T; Fukuda, K; Kamiyama, T; Kobayashi, K; Miyake, Y; Sasaki, S; Sueki, H; Watanabe, H, 2016) |
| " In this research, we have explored the feasibility of retrospectively mapping population-level adverse events from the FDA Adverse Event Reporting System (FAERS) to chemical and biological databases to identify drug safety signals and the underlying molecular mechanisms." | 1.43 | Improving drug safety with a systems pharmacology approach. ( Bojunga, N; Lesko, LJ; Schotland, P; Trame, MN; Zien, A, 2016) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but fatal adverse mucocutaneous reactions to certain drugs." | 1.42 | Clinical features of and genetic predisposition to drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients-investigating the relation between the HLA -B*4403 allele and lamotrigine. ( Kim, SR; Koh, BS; Lee, JH; Leem, DW; Moon, IJ; Park, HJ; Park, JW; Park, KH, 2015) |
| "Steven Johnson Syndrome and Toxic Epidermal Necrolysis are rare but severe form of hypersensitivity inflammatory reactions to multiple offending agents including drugs." | 1.38 | Acetaminophen induced Steven Johnson syndrome-toxic epidermal necrolysis overlap. ( Hussain, SA; Khawaja, A; Shahab, A, 2012) |
| "To report a case of toxic epidermal necrolysis (TEN) associated with acetaminophen ingestion." | 1.31 | Toxic epidermal necrolysis associated with acetaminophen ingestion. ( Ben-Amitai, D; Garty, BZ; Halevi, A, 2000) |
| "We report a case of toxic epidermal necrolysis-type drug eruption." | 1.31 | A case of toxic epidermal necrolysis-type drug eruption induced by oral lysozyme chloride. ( Asahi, M; Kobayashi, M; Yamamoto, O; Yasuda, H, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.09) | 18.7374 |
| 1990's | 2 (6.06) | 18.2507 |
| 2000's | 6 (18.18) | 29.6817 |
| 2010's | 17 (51.52) | 24.3611 |
| 2020's | 5 (15.15) | 2.80 |
| Authors | Studies |
|---|---|
| Dégboé, B | 1 |
| Koudoukpo, C | 1 |
| Almeida, CD | 1 |
| Kouassi, A | 1 |
| Nguessie, C | 1 |
| Akpadjan, F | 1 |
| Adégbidi, H | 1 |
| Atadokpèdé, F | 1 |
| Liu, JB | 1 |
| Hao, D | 1 |
| Saito, Y | 2 |
| Nakamura, R | 2 |
| Jongkhajornpong, P | 1 |
| Ueta, M | 2 |
| Lekhanont, K | 1 |
| Puangsricharern, V | 1 |
| Prabhasawat, P | 1 |
| Chantaren, P | 1 |
| Pisuchpen, P | 1 |
| Kinoshita, S | 2 |
| Liccioli, G | 1 |
| Filippeschi, C | 1 |
| Giovannini, M | 1 |
| Capone, M | 1 |
| Oranges, T | 1 |
| Barni, S | 1 |
| Sarti, L | 1 |
| Parronchi, P | 1 |
| Mori, F | 1 |
| Totsuka, M | 1 |
| Watanabe, T | 1 |
| Takamura, N | 1 |
| Watanabe, Y | 1 |
| Kumamoto, T | 1 |
| Honda, Y | 1 |
| Yoneda, M | 1 |
| Saito, S | 1 |
| Yamanaka, S | 1 |
| Aihara, M | 2 |
| Milosavljević, MN | 1 |
| Pejčić, AV | 1 |
| Milosavljević, JZ | 1 |
| Lebrun-Vignes, B | 1 |
| Guy, C | 1 |
| Jean-Pastor, MJ | 1 |
| Gras-Champel, V | 1 |
| Zenut, M | 1 |
| Kuehn, BM | 1 |
| Biswal, S | 1 |
| Sahoo, SS | 1 |
| Kaniwa, N | 1 |
| Sotozono, C | 1 |
| Tokunaga, K | 1 |
| Sawai, H | 1 |
| Miyadera, H | 1 |
| Sugiyama, E | 1 |
| Maekawa, K | 1 |
| Nagato, M | 1 |
| Matsunaga, K | 1 |
| Takahashi, Y | 1 |
| Furuya, H | 1 |
| Muramatsu, M | 1 |
| Ikezawa, Z | 1 |
| Ladizinski, B | 1 |
| Sankey, C | 1 |
| Slim, R | 1 |
| Fathallah, N | 1 |
| Aounallah, A | 1 |
| Ksiaa, M | 1 |
| Sriha, B | 1 |
| Nouira, R | 1 |
| Ben Salem, C | 1 |
| Park, HJ | 1 |
| Kim, SR | 1 |
| Leem, DW | 1 |
| Moon, IJ | 1 |
| Koh, BS | 1 |
| Park, KH | 1 |
| Park, JW | 1 |
| Lee, JH | 1 |
| Harimoto, N | 1 |
| Wang, H | 1 |
| Ikegami, T | 1 |
| Takeishi, K | 1 |
| Itoh, S | 1 |
| Yamashita, YI | 1 |
| Yoshizumi, T | 1 |
| Aishima, S | 1 |
| Shirabe, K | 1 |
| Oda, Y | 1 |
| Maehara, Y | 1 |
| Watanabe, H | 1 |
| Kamiyama, T | 1 |
| Sasaki, S | 1 |
| Kobayashi, K | 1 |
| Fukuda, K | 1 |
| Miyake, Y | 1 |
| Aruga, T | 1 |
| Sueki, H | 1 |
| Pena, MÁ | 1 |
| Pérez, S | 1 |
| Zazo, MC | 1 |
| Alcalá, PJ | 1 |
| Cuello, JD | 1 |
| Zapater, P | 1 |
| Reig, R | 1 |
| Schotland, P | 1 |
| Bojunga, N | 1 |
| Zien, A | 1 |
| Trame, MN | 1 |
| Lesko, LJ | 1 |
| Gau, SS | 1 |
| Chao, PF | 1 |
| Lin, YJ | 1 |
| Chang, CJ | 1 |
| Gau, CS | 1 |
| Sahagún Flores, JE | 1 |
| Soto Ortiz, JA | 1 |
| Tovar Méndez, CE | 1 |
| Cárdenas Ochoa, EC | 1 |
| Hernández Flores, G | 1 |
| Honma, M | 1 |
| Tobisawa, S | 1 |
| Iinuma, S | 1 |
| Shibuya, T | 1 |
| Komatsu, S | 1 |
| Takahashi, I | 1 |
| Ishida-Yamamoto, A | 1 |
| Iizuka, H | 1 |
| Reese, D | 1 |
| Henning, JS | 1 |
| Rockers, K | 1 |
| Ladd, D | 1 |
| Gilson, R | 1 |
| Khawaja, A | 1 |
| Shahab, A | 1 |
| Hussain, SA | 1 |
| Selbst, SM | 1 |
| Osterhoudt, K | 1 |
| Halevi, A | 1 |
| Ben-Amitai, D | 1 |
| Garty, BZ | 1 |
| Kobayashi, M | 1 |
| Yamamoto, O | 1 |
| Yasuda, H | 1 |
| Asahi, M | 1 |
| Robak, E | 1 |
| Robak, T | 1 |
| Góra-Tybor, J | 1 |
| Chojnowski, K | 1 |
| Strzelecka, B | 1 |
| Waszczykowska, E | 1 |
| Sysa-Jedrzejowska, A | 1 |
| Cohen, AD | 1 |
| Cagnano, E | 1 |
| Halevy, S | 1 |
| Arturson, G | 1 |
| Hedlund, A | 1 |
| Andersson, C | 1 |
| Jordeby-Jönsson, A | 1 |
| Martinsson, EL | 1 |
| Cugurra, F | 1 |
| Roupe, G | 1 |
| Ahlmén, M | 1 |
| Fagerberg, B | 1 |
| Suurküla, M | 1 |
| Hunter, JA | 1 |
| Davison, AM | 1 |
3 reviews available for acetaminophen and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
[Mechanisms of Severe Cutaneous Adverse Reactions and a New Treatment Strategy].
Topics: Acetaminophen; Adrenal Cortex Hormones; Allopurinol; Antigens, Differentiation, T-Lymphocyte; Carbam | 2019 |
A review of published cases of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with the use of acetaminophen.
Topics: Acetaminophen; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Risk Factors; Stevens-Johnson | 2021 |
Cyclosporine for SJS/TEN: a case series and review of the literature.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Infective Agents; Anticonvulsants; Cyclosporine | 2011 |
30 other studies available for acetaminophen and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Severe Cutaneous Adverse Drug Reactions in Children: Epidemiological, Clinical and Etiological Aspects in Dermatology-Venereology Unit at National and Teaching Hospital of Cotonou.
Topics: Acetaminophen; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Benin; Child; Dermato | 2022 |
[Acetaminophen induced Stevens-Johnson syndrome in a child].
Topics: Acetaminophen; Child; Humans; Stevens-Johnson Syndrome | 2019 |
Association of HLA polymorphisms and acetaminophen-related Steven-Johnson syndrome with severe ocular complications in Thai population.
Topics: Acetaminophen; Case-Control Studies; Genetic Predisposition to Disease; HLA-A Antigens; HLA-B Antige | 2022 |
Mycoplasma pneumoniae-associated mucocutaneous disease in children: A case series with allergy workup in a tertiary care paediatric hospital.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Child; Child, Preschool; | 2021 |
A pediatric case of Stevens-Johnson syndrome with acute liver failure, resulting in liver transplantation.
Topics: Acetaminophen; Adolescent; Child; Female; Humans; Liver Failure, Acute; Liver Transplantation; Skin; | 2021 |
Is acetaminophen associated with a risk of Stevens-Johnson syndrome and toxic epidermal necrolysis? Analysis of the French Pharmacovigilance Database.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Analgesics, Non-Narcotic; Chi | 2018 |
FDA: Acetaminophen may trigger serious skin problems.
Topics: Acetaminophen; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcotic; Humans; Stevens-Jo | 2013 |
Paracetamol induced Stevens-Johnson syndrome--toxic epidermal necrolysis overlap syndrome.
Topics: Acetaminophen; Antipyretics; Child; Female; Fever; Humans; Stevens-Johnson Syndrome | 2014 |
Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studie | 2014 |
A topical matter: toxic epidermal necrolysis.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents; Anticonvulsants; Antiemetics; Antineopl | 2014 |
Paracetamol-induced Stevens Johnson syndrome and cholestatic hepatitis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Eruptio | 2015 |
Clinical features of and genetic predisposition to drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients-investigating the relation between the HLA -B*4403 allele and lamotrigine.
Topics: Acetaminophen; Acetazolamide; Adult; Aged; Aged, 80 and over; Alleles; Allopurinol; Anti-Bacterial A | 2015 |
Education and imaging. Hepatology: Rare Stevens-Johnson syndrome and vanishing bile duct syndrome induced by acetaminophen, requiring liver transplantation.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Bile Ducts, Intrahepatic; Cholestasis; Dilat | 2015 |
Toxic epidermal necrolysis caused by acetaminophen featuring almost 100% skin detachment: Acetaminophen is associated with a risk of severe cutaneous adverse reactions.
Topics: Acetaminophen; Adult; Colitis, Ulcerative; Female; Humans; Prednisolone; Stevens-Johnson Syndrome | 2016 |
A Case of Toxic Epidermal Necrolysis Secondary to Acetaminophen in a Child.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child, Preschool; Humans; Male; Stevens-Johnson Syndrome | 2016 |
Improving drug safety with a systems pharmacology approach.
Topics: Acetaminophen; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcotic; Anticonvulsants; C | 2016 |
The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study.
Topics: Acetaminophen; Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Case-Contr | 2008 |
[Stevens-Johnson syndrome plus intrahepatic cholestasis caused by clindamycin or chlorpheniramine].
Topics: Acetaminophen; Betamethasone; Bronchitis; Chlorpheniramine; Cholestasis, Intrahepatic; Clindamycin; | 2009 |
Toxic epidermal necrolysis with prominent facial pustules: a case with reactivation of human herpesvirus 7.
Topics: Acetaminophen; Acute Generalized Exanthematous Pustulosis; Adult; Anti-Inflammatory Agents; Antidepr | 2010 |
Acetaminophen induced Steven Johnson syndrome-toxic epidermal necrolysis overlap.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Diagnosis, Differential; Female; Humans; Stevens-Joh | 2012 |
Pediatric emergency medicine: legal briefs.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aortic Aneurysm; Aortic Dissection; Appendicitis; | 2012 |
Toxic epidermal necrolysis associated with acetaminophen ingestion.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Female; Fever; Humans; Stevens-Johnson Syndrome | 2000 |
A case of toxic epidermal necrolysis-type drug eruption induced by oral lysozyme chloride.
Topics: Acetaminophen; Administration, Oral; Adult; Anti-Inflammatory Agents; Betamethasone; Biopsy, Needle; | 2000 |
Toxic epidermal necrolysis in a patient with severe aplastic anemia treated with cyclosporin A and G-CSF.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anemia, Aplastic; Cyclosporine; Granulocyte Colony-S | 2001 |
Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis.
Topics: Acetaminophen; Acute Disease; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Cefuroxime; Cephalo | 2001 |
[Lobac caused a life-threatening burn-like skin injury].
Topics: Acetaminophen; Adult; Burns, Chemical; Humans; Male; Stevens-Johnson Syndrome | 1991 |
[The Lobac overview: little risk of adverse effects. Effects on skin and liver are the most common and the most severe].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chlormezanone; Drug Combinations; Humans; Ris | 1991 |
[XXVIII. Antipyretic and antineuralgic agents for grown-ups and little-ones].
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Humans; Infant, Ne | 1989 |
Toxic epidermal necrolysis with extensive mucosal erosions of the gastrointestinal and respiratory tracts.
Topics: Acetaminophen; Arthritis, Rheumatoid; Biopsy; Chlormezanone; Drug Combinations; Female; Humans; Inte | 1986 |
Toxic epidermal necrolysis associated with pentazocine therapy and severe reversible renal failure.
Topics: Acetaminophen; Acute Kidney Injury; Blood Cells; Blood Pressure; Chlorpheniramine; Cloxacillin; Dext | 1973 |