Page last updated: 2024-10-22

acetaminophen and Sleep Apnea, Obstructive

acetaminophen has been researched along with Sleep Apnea, Obstructive in 13 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Sleep Apnea, Obstructive: A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)

Research Excerpts

Excerpt	Relevance	Reference
" Inflammation and fibrosis were evaluated by transaminases, myeloperoxidase activity, hydroxyproline, and histological evaluation."	4.12	Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease. ( Abrante, B; Abreu-González, P; de la Barreda, R; Díaz-Flores, F; González-Paredes, FJ; Hernández-Bustabad, A; Hernández-Guerra, M; Morales-Arraez, D; Quintero, E, 2022)

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (23.08)	29.6817
2010's	8 (61.54)	24.3611
2020's	2 (15.38)	2.80

Authors

Authors	Studies
Hernández-Bustabad, A	1
Morales-Arraez, D	1
González-Paredes, FJ	1
Abrante, B	1
Díaz-Flores, F	1
Abreu-González, P	1
de la Barreda, R	1
Quintero, E	1
Hernández-Guerra, M	1
Roberts, C	1
Al Sayegh, R	1
Ellison, PR	1
Sedeek, K	1
Carr, MM	1
Borgström, A	1
Nerfeldt, P	1
Friberg, D	1
DeDea, L	1
Cillo, JE	1
Dattilo, DJ	1
Kelly, LE	1
Sommer, DD	1
Ramakrishna, J	1
Hoffbauer, S	1
Arbab-Tafti, S	1
Reid, D	1
Maclean, J	1
Koren, G	1
Ugurlu, AO	1
Esquinas, AM	1
Nilius, G	1
Savransky, V	1
Reinke, C	1
Jun, J	1
Bevans-Fonti, S	1
Nanayakkara, A	1
Li, J	1
Myers, AC	1
Torbenson, MS	1
Polotsky, VY	1
Lavie, L	1
Gurnaney, H	1
Ganesh, A	1
Nath, B	1
Szabo, G	1
Ericsson, E	1
Wadsby, M	1
Hultcrantz, E	1

Clinical Trials (13)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Evaluation of Perioperative Usage of Ketorolac on Postoperative Pain Reduction in Pediatric Patients With Adenotonsillectom[NCT05074056]	Phase 4	200 participants (Anticipated)	Interventional	2022-02-08	Recruiting
Post-operative Course of Dexamethasone to Reduce Tonsillectomy Morbidity[NCT04879823]	Phase 3	300 participants (Anticipated)	Interventional	2021-08-05	Recruiting
Randomised Surgical Intervention Study Between Adenotonsillectomy and Adenotonsillotomy in Children With Obstructive Sleep Apnea Syndrome[NCT01676181]		79 participants (Actual)	Interventional	2011-11-30	Completed
Opioid-Free Versus Transitional Anesthetic With Opioids From Tonsillectomy[NCT04528173]	Phase 4	550 participants (Anticipated)	Interventional	2020-07-22	Recruiting
A Prospective Randomized Double-blind Placebo Controlled Trial; Does Pre and Postoperative Dextromethorphan Reduce Post-tonsillectomy Pain in Children?[NCT02727491]	Phase 4	85 participants (Actual)	Interventional	2012-03-31	Completed
Investigating the Safety of Morphine and Ibuprofen in Children Post-adenotonsillectomy for Obstructive Sleep Apnea[NCT01680939]	Phase 3	120 participants (Anticipated)	Interventional	2012-05-31	Recruiting
Randomized Clinical Trial of Non-Opioid Pain Medications After Adenotonsillectomy[NCT03618823]	Phase 1/Phase 2	268 participants (Actual)	Interventional	2018-10-25	Terminated (stopped due to Early termination due to COVID-19 cases and cancelled surgeries.)
Postoperative Ibuprofen Use and Risk of Bleeding in Pediatric Tonsillectomy[NCT03385057]	Phase 1	0 participants (Actual)	Interventional	2018-09-30	Withdrawn (stopped due to Study design flaws; research design needed to be reconfigured)
Oxycodone or Ibuprofen for Suspected Isolated Forearm Fractures in Pediatric Patients: A Randomized Noninferiority Trial[NCT04523623]		200 participants (Anticipated)	Interventional	2020-09-30	Not yet recruiting
Clonidine for Tourniquet-related Pain in Children: A Pilot Study[NCT04564430]	Phase 4	20 participants (Anticipated)	Interventional	2021-03-01	Recruiting
Use of a Non-Opioid Pain Regimen for Post-Operative Analgesia Following Intracapsular Adenotonsillectomy[NCT04791761]	Phase 1/Phase 2	300 participants (Anticipated)	Interventional	2021-04-13	Recruiting
Effectiveness of a Combined Acetaminophen and Ibuprofen Regimen for Management of Post-Tonsillectomy Pain in Pediatric Patients[NCT04551196]	Phase 3	47 participants (Actual)	Interventional	2020-09-28	Completed
Use of IV Acetaminophen Intraoperatively in Obese Patients at Risk for Obstructive Sleep Apnea Undergoing Laparoscopic Cholecystectomy[NCT02056678]	Phase 4	0 participants (Actual)	Interventional	2014-02-28	Withdrawn (stopped due to Investigator left institution)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Non-opioid Group Switching to Opioid Group

Number of non-opioid group members switching to receiving opioid medication - assessed via the take-home pain diary. (NCT03618823)
Timeframe: 14 days post-operatively

Intervention	Participants (Count of Participants)
Non-opioid Pain Control	7

Number of Participants With ED (Emergency Department) or Urgent Care Visits

Number of participants with emergency department or urgent care visits in 14 post-operative days - assessed via the electronic medical record and the take-home pain diary. (NCT03618823)
Timeframe: 14 days post-operatively

Intervention	Participants (Count of Participants)
Opioid Pain Control	8
Non-opioid Pain Control	11

Number of Participants With Readmissions

Number of participants with hospitalizations after discharge in 14 days - assessed using the electronic medical record and the take-home pain diary. (NCT03618823)
Timeframe: 14 days post-operatively

Intervention	Participants (Count of Participants)
Opioid Pain Control	3
Non-opioid Pain Control	8

Overall Pain Relief Satisfaction

"Score assigned by the patient at the end of 14 post-operative days in the take-home pain diary using a Likert scale. Patients will respond to the following statement I am happy with the pain relief I received in the last 14 days with responses ranging from strongly agree to strongly disagree. The responses will be assigned a numerical value, from 0 (strongly disagree) to 4 (strongly agree), and the average value for all subjects in the group will be reported as the overall pain relief satisfaction. Higher scores mean a better outcome." (NCT03618823)
Timeframe: 14 days post-operatively

Intervention	score on a scale (Mean)
Opioid Pain Control	3.35
Non-opioid Pain Control	3.09

Post-operative Nursing Phone Calls

Number of post-operative phone calls to nursing staff, obtained using the electronic medical record. (NCT03618823)
Timeframe: 14 days post-operatively

Intervention	post-operative phone calls (Mean)
Opioid Pain Control	0.35
Non-opioid Pain Control	0.47

Average Dose of Each Analgesic Used

In the take-home pain diary, patients will record the amount of medication taken for each dose. The mean value of these doses will be calculated and averaged within each group to determine the average dose of each analgesic used. (NCT03618823)
Timeframe: 14 days post-operatively

Intervention	Milliliters (Mean)
	Acetaminophen	Ibuprofen	Oxycodone
Non-opioid Pain Control	7.52	7.53	0.04
Opioid Pain Control	6.54	7.53	0.13

Average Pain Burden

Average pain over 14 post-operative days before and after medications. This is quantified using the validated Wong-Baker FACES pain metric. Patients receive a take-home pain diary and for 14 days report their maximum pain both before and after taking pain medication. The mean of these pain ratings will be the primary outcome measure. The Wong-Baker FACES scale is from 0 (min) to 10 (max). A higher score indicates worse outcome/pain. (NCT03618823)
Timeframe: 14 days post-operatively

Intervention	Score on a scale (Mean)
	Before	After
Non-opioid Pain Control Group	5.66	2.24
Opioid Pain Control Group	5.78	2.33

Duration of Each Analgesic Used

Using the results of the take-home pain diary, we will calculate the average number of days of use of each analgesic for each group. The last day after which there is no subsequent use of analgesic will define the end-point of the duration of use. (NCT03618823)
Timeframe: 14 days post-operatively

Intervention	days (Mean)
	Acetaminophen	Ibuprofen	Oxycodone
Non-opioid Pain Control	8.64	8.75	0.45
Opioid Pain Control	8.61	8.49	2.62

Mean of Total Quantity of Pain Medications Taken

Using the take-home pain diary, the total amount in mL of each analgesic used over 14 days by each patient in a group will be averaged and reported. (NCT03618823)
Timeframe: 14 days post-operatively

Intervention	Milliliters (Mean)
	Acetaminophen	Ibuprofen	Oxycodone
Non-opioid Pain Control	326.98	334.65	2.96
Opioid Pain Control	292.48	324.14	6.47

Reviews

1 review available for acetaminophen and Sleep Apnea, Obstructive

Article	Year
Hypoxia and hypoxia inducible factors: diverse roles in liver diseases. Hepatology (Baltimore, Md.), 2012, Volume: 55, Issue:2 Topics: Acetaminophen; Animals; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Immunity, Innate; Lipid Metabol	2012

Trials

4 trials available for acetaminophen and Sleep Apnea, Obstructive

Article	Year
Postoperative pain and bleeding after adenotonsillectomy versus adenotonsillotomy in pediatric obstructive sleep apnea: an RCT. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019, Volume: 276, Issue:11 Topics: Acetaminophen; Adenoidectomy; Analgesics, Non-Narcotic; Child; Child, Preschool; Double-Blind Method	2019
Postoperative pain and bleeding after adenotonsillectomy versus adenotonsillotomy in pediatric obstructive sleep apnea: an RCT. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019, Volume: 276, Issue:11 Topics: Acetaminophen; Adenoidectomy; Analgesics, Non-Narcotic; Child; Child, Preschool; Double-Blind Method	2019
Postoperative pain and bleeding after adenotonsillectomy versus adenotonsillotomy in pediatric obstructive sleep apnea: an RCT. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019, Volume: 276, Issue:11 Topics: Acetaminophen; Adenoidectomy; Analgesics, Non-Narcotic; Child; Child, Preschool; Double-Blind Method	2019
Postoperative pain and bleeding after adenotonsillectomy versus adenotonsillotomy in pediatric obstructive sleep apnea: an RCT. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019, Volume: 276, Issue:11 Topics: Acetaminophen; Adenoidectomy; Analgesics, Non-Narcotic; Child; Child, Preschool; Double-Blind Method	2019
Pre-emptive analgesia with pregabalin and celecoxib decreases postsurgical pain following maxillomandibular advancement surgery: a randomized controlled clinical trial. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2014, Volume: 72, Issue:10 Topics: Acetaminophen; Administration, Intravenous; Adolescent; Adult; Analgesia, Patient-Controlled; Analge	2014
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adenoidectomy; Administration, Oral; Child; Child, Preschool; Dose-Response Relations	2015
Pre-surgical child behavior ratings and pain management after two different techniques of tonsil surgery. International journal of pediatric otorhinolaryngology, 2006, Volume: 70, Issue:10 Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Anti-Inflammato	2006

Other Studies

8 other studies available for acetaminophen and Sleep Apnea, Obstructive

Article	Year
Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease. American journal of physiology. Gastrointestinal and liver physiology, 2022, Oct-01, Volume: 323, Issue:4 Topics: Acetaminophen; Acetylcholine; Animals; Hydroxyproline; Hypoxia; Inflammation; Intercellular Adhesion	2022
How Pediatric Anesthesiologists Manage Children with OSA Undergoing Tonsillectomy. The Annals of otology, rhinology, and laryngology, 2020, Volume: 129, Issue:1 Topics: Acetaminophen; Adenoidectomy; Airway Extubation; Analgesics; Anesthesiology; Anesthetics; Anti-Infla	2020
Codeine and acetaminophen recommendations for children. JAAPA : official journal of the American Academy of Physician Assistants, 2013, Volume: 26, Issue:9 Topics: Acetaminophen; Adenoidectomy; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induce	2013
Effect of APAP and heated humidification with a heated breathing tube on adherence, quality of life, and nasopharyngeal complaints. Sleep & breathing = Schlaf & Atmung, 2016, Volume: 20, Issue:1 Topics: Acetaminophen; Continuous Positive Airway Pressure; Hot Temperature; Humans; Humidity; Quality of Li	2016
Response to "Effect of APAP and heated humidification with a heated breathing tube on adherence, quality of life, and nasopharyngeal complaints". Sleep & breathing = Schlaf & Atmung, 2016, Volume: 20, Issue:1 Topics: Acetaminophen; Continuous Positive Airway Pressure; Hot Temperature; Humans; Humidity; Quality of Li	2016
Chronic intermittent hypoxia and acetaminophen induce synergistic liver injury in mice. Experimental physiology, 2009, Volume: 94, Issue:2 Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; As	2009
Obstructive sleep apnoea and acetaminophen safety - is the liver at risk? Experimental physiology, 2009, Volume: 94, Issue:2 Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and	2009
A randomized clinical trial of the efficacy of scheduled dosing of acetaminophen and hydrocodone for the management of postoperative pain in children after tonsillectomy. The Clinical journal of pain, 2011, Volume: 27, Issue:1 Topics: Acetaminophen; Adenoidectomy; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Humans; Hydrocodo	2011