acetaminophen has been researched along with Sensitivity and Specificity in 211 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Studies published in the literature that investigated criteria for hepatic transplantation secondary to acetaminophen-induced liver failure as identified by a preestablished MEDLINE strategy (1966 through October 2001)." | 8.82 | Fulminant hepatic failure secondary to acetaminophen poisoning: a systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation. ( Amre, DK; Bailey, B; Gaudreault, P, 2003) |
| "Rhabdomyolysis and delayed acetaminophen hepatotoxicity may be associated with elevated serum transaminase values." | 7.88 | Transaminase and Creatine Kinase Ratios for Differentiating Delayed Acetaminophen Overdose from Rhabdomyolysis. ( Albertson, TE; Algren, DA; Chenoweth, JA; Ford, JB; Owen, KP; Radke, JB; Sutter, ME, 2018) |
| "Screening for acetaminophen toxicity is recommended in almost all cases of self poisoning." | 7.70 | Predictive properties of a qualitative urine acetaminophen screen in patients with self-poisoning. ( De Roos, F; Hollander, JE; Perrone, J; Shaw, L, 1999) |
| "A cohort of 484 febrile children were examined to (1) assess the utility of temperature response to acetaminophen as a diagnostic test for occult bacteremia (OB) and (2) compare it with the white blood cell (WBC) count." | 7.69 | Diagnostic tests for occult bacteremia: temperature response to acetaminophen versus WBC count. ( Kozinetz, CA; Mazur, LJ, 1994) |
| "Studies published in the literature that investigated criteria for hepatic transplantation secondary to acetaminophen-induced liver failure as identified by a preestablished MEDLINE strategy (1966 through October 2001)." | 4.82 | Fulminant hepatic failure secondary to acetaminophen poisoning: a systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation. ( Amre, DK; Bailey, B; Gaudreault, P, 2003) |
| "Rhabdomyolysis and delayed acetaminophen hepatotoxicity may be associated with elevated serum transaminase values." | 3.88 | Transaminase and Creatine Kinase Ratios for Differentiating Delayed Acetaminophen Overdose from Rhabdomyolysis. ( Albertson, TE; Algren, DA; Chenoweth, JA; Ford, JB; Owen, KP; Radke, JB; Sutter, ME, 2018) |
| "Recently, it was reported that the intraperitoneal administration of 30 mg/kg/day troglitazone to heterozygous superoxide dismutase 2 gene knockout (Sod2+/-) mice for twenty-eight days caused liver injury, manifested by increased serum ALT activity and hepatic necrosis." | 3.75 | Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen. ( Ando, Y; Arakawa, S; Fujimoto, K; Ito, K; Kumagai, K; Manabe, S; Oda, S; Yamoto, T, 2009) |
| "Screening for acetaminophen toxicity is recommended in almost all cases of self poisoning." | 3.70 | Predictive properties of a qualitative urine acetaminophen screen in patients with self-poisoning. ( De Roos, F; Hollander, JE; Perrone, J; Shaw, L, 1999) |
| " To study this, we reviewed serum enzyme patterns early in the course of acute liver injury in patients with acute viral hepatitis A and B (n = 51), ischemic hepatitis (n = 20), and acetaminophen injury (n = 26)." | 3.69 | Serum lactic dehydrogenase in the differential diagnosis of acute hepatocellular injury. ( Cassidy, WM; Reynolds, TB, 1994) |
| "A cohort of 484 febrile children were examined to (1) assess the utility of temperature response to acetaminophen as a diagnostic test for occult bacteremia (OB) and (2) compare it with the white blood cell (WBC) count." | 3.69 | Diagnostic tests for occult bacteremia: temperature response to acetaminophen versus WBC count. ( Kozinetz, CA; Mazur, LJ, 1994) |
| "Drug-induced liver injury (DILI) represents a serious medical challenge and a potentially fatal adverse event." | 2.53 | Recent advances in biomarkers and therapeutic interventions for hepatic drug safety - false dawn or new horizon? ( Antoine, DJ; Clarke, JI; Dear, JW, 2016) |
| "Accordingly, they have promise as cancer prophylactics, including in combination with agents operating through other mechanisms." | 2.41 | Anticarcinogenicity of monocyclic phenolic compounds. ( Iatropoulos, MJ; Jeffrey, AM; Williams, GM, 2002) |
| "2231 patients with postsurgical pain, arthritis, and musculoskeletal pain reported in 26 randomised controlled trials." | 2.40 | Systematic overview of co-proxamol to assess analgesic effects of addition of dextropropoxyphene to paracetamol. ( Li Wan Po, A; Zhang, WY, 1997) |
| "Acetaminophen (APAP) is a common medication that induces hepatocellular damage in a time- or dose-dependent manner." | 1.46 | FGF21 functions as a sensitive biomarker of APAP-treated patients and mice. ( Chen, J; Guo, C; Huang, Z; Li, R; Wu, X, 2017) |
| " Using this approach we determined, in terms of the model parameters, the critical dose between safe and overdose cases, timescales for exhaustion and regeneration of important cofactors for acetaminophen metabolism and total toxin accumulation as a fraction of initial dose." | 1.42 | Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity. ( Reddyhoff, D; Regan, S; Ward, J; Webb, S; Williams, D, 2015) |
| " The developed and validated method was successfully applied to a pharmacokinetic study of AAP (500mg) with DHC (20mg) capsule in Chinese healthy volunteers (N=20)." | 1.42 | Simultaneous determination of acetaminophen and dihydrocodeine in human plasma by UPLC-MS/MS: Its pharmacokinetic application. ( Gao, P; Liu, Z; Lou, D; Qiu, X; Su, D; Zhang, NS, 2015) |
| "Acetaminophen Psi Nomogram is a sensitive and specific tool for prediction of hepatotoxicity secondary to acute acetaminophen overdose." | 1.40 | Acetaminophen Psi Nomogram: a sensitive and specific clinical tool to predict hepatotoxicity secondary to acute acetaminophen overdose. ( Chomchai, C; Chomchai, S; Lawattanatrakul, N, 2014) |
| "Acetaminophen overdose is a common reason for hospital admission and the most frequent cause of hepatotoxicity in the Western world." | 1.39 | Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. ( Antoine, DJ; Bateman, DN; Coyle, J; Dear, JW; Goldring, CE; Gray, AJ; Lewis, PS; Masson, M; Moggs, JG; Park, BK; Platt, V; Thanacoody, RH; Webb, DJ, 2013) |
| "Methanol and water was used as the mobile phase with a gradient elution at a flow rate of 1mL/min." | 1.38 | Development and validation of a LC-MS/MS method for the quantification of the regioisomers of dihydroxybutylether in human plasma. ( Fu, Y; Guo, L; Jin, Y; Li, L; Xu, H; Yuan, B, 2012) |
| "A reproducible, rapid and sensitive method has been developed for the assay of chlorzoxazone (CHL), paracetamol (PCM) and aceclofenac (ACE) in their combined solid dosage forms using packed-column supercritical fluid chromatography (SFC)." | 1.38 | Development and validation of packed column supercritical fluid chromatographic technique for quantification of chlorzoxazone, paracetamol and aceclofenac in their individual and combined dosage forms. ( Desai, PP; Mehta, PJ; Patel, NR; Sherikar, OD, 2012) |
| "Acetaminophen (APAP) is a widely used analgesic and antipyretic drug." | 1.38 | Quantitative analysis of acetaminophen and its six metabolites in rat plasma using liquid chromatography/tandem mass spectrometry. ( An, JH; Jung, BH; Lee, HJ, 2012) |
| " The European Medicines Agency (EMEA) imposes analytical testing limits in the order of μg/g, depending on drug dosage and exposure period, that means the need of a sensitive and selective method of analysis." | 1.38 | A new liquid chromatography-mass spectrometry approach for generic screening and quantitation of potential genotoxic alkylation compounds without derivatization. ( Cappiello, A; Famiglini, G; Palma, P; Termopoli, V; Trufelli, H, 2012) |
| "A sensitive and selective liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) was developed and validated for the determination of salbutamol in human plasma and urine, and successfully applied to the pharmacokinetic study of salbutamol in Chinese healthy volunteers after inhalation of salbutamol sulfate aerosol." | 1.38 | Determination of salbutamol in human plasma and urine using liquid chromatography coupled to tandem mass spectrometry and its pharmacokinetic study. ( Chen, K; Guo, R; Liu, S; Liu, X; Teng, Y; Wang, B; Wei, C; Yuan, G; Zhang, D; Zhang, R, 2012) |
| " The prognostic value of patient-reported dosage cut-offs of 8, 10 and 12 g was determined." | 1.38 | Reliability of the reported ingested dose of acetaminophen for predicting the risk of toxicity in acetaminophen overdose patients. ( Awang, R; Sulaiman, SA; Zyoud, SH, 2012) |
| "Acetaminophen antibodies were purified using affinity chromatography and labelled with horseradish peroxidase (HRP)." | 1.37 | Highly specific, sensitive and rapid enzyme immunoassays for the measurement of acetaminophen in serum. ( Abuknesha, RA; Jeganathan, F; Paleodimos, M, 2011) |
| "Acetaminophen was used as the internal standard." | 1.36 | Determination of p-aminohippuric acid in rat plasma by liquid chromatography-tandem mass spectrometry. ( Fan, HY; Lin, CC; Pao, LH, 2010) |
| "Acetaminophen was stable in DBS stored at room temperature for at least 10 days." | 1.35 | Application of dried blood spots combined with HPLC-MS/MS for the quantification of acetaminophen in toxicokinetic studies. ( Barfield, M; Fowles, S; Lad, R; Parry, S; Spooner, N, 2008) |
| "Acetaminophen (APAP) is a leading cause of fatal overdose." | 1.35 | Evaluation of a urine screen for acetaminophen. ( Bosse, GN; Ingram, DN; Jortani, S; Womack, EP, 2008) |
| "The present study describes a new analytical approach for the detection and characterization of chemically reactive metabolites using glutathione ethyl ester (GSH-EE) as the trapping agent in combination with hybrid triple quadrupole linear ion trap mass spectrometry." | 1.35 | Screening and characterization of reactive metabolites using glutathione ethyl ester in combination with Q-trap mass spectrometry. ( Fitch, WL; Wen, B, 2009) |
| "Patients enrolled in the Acute Liver Failure Study Group registry with an admission amylase value available were included." | 1.35 | The role of etiology in the hyperamylasemia of acute liver failure. ( Blei, AT; Coté, GA; Daud, A; Gottstein, JH, 2009) |
| "Acetaminophen was the most common etiology, but LT proceeded more frequently in the non-acetaminophen cohort (acetaminophen: 45/326 patients received LT, 13." | 1.35 | The utilization of liver transplantation in the management of acute liver failure: comparison between acetaminophen and non-acetaminophen etiologies. ( Bates, CM; Garden, OJ; Hayes, PC; Henderson, NC; Lee, A; Masterton, G; Pollok, A; Simpson, KJ; Wigmore, SJ, 2009) |
| " The results of the proposed method were in excellent agreement with those obtained from PLS and HPLC methods and can be satisfactorily used for routine analysis of multicomponent dosage forms." | 1.33 | Content uniformity and dissolution tests of triplicate mixtures by a double divisor-ratio spectra derivative method. ( Koundourellis, JE; Malliou, ET; Markopoulou, CK, 2005) |
| " C57BL/6 mice were given an intraperitoneal toxic dose of APAP (500 mg/kg), which caused severe acute liver injury characterized by significant elevation of serum ALT, centrilobular hepatic necrosis, and increased hepatic inflammatory cell accumulation." | 1.33 | Neutrophil depletion protects against murine acetaminophen hepatotoxicity. ( Gunawan, B; Han, D; Kaplowitz, N; Liu, ZX, 2006) |
| "Serum samples from children with acute liver failure were measured for acetaminophen cysteine protein adducts using high-performance liquid chromatography with electrochemical detection." | 1.33 | Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause. ( Alonso, EM; Davern, TJ; Hinson, JA; Hynan, LS; James, LP; Lee, WM; Squires, RH, 2006) |
| "Meprobamate was also found as the metabolite of carisoprodol in both urine and plasma." | 1.32 | Simultaneous determination of carisoprodol and acetaminophen in an attempted suicide by liquid chromatography-mass spectrometry with positive electrospray ionization. ( Aoki, M; Maeno, Y; Matsumoto, T; Matsuoka, T; Nagao, M; Sano, T, 2003) |
| " As active ingredients may also change their solid-state form during formulation processing or storage and as this can adversely affect the final dosage performance, monitoring of pharmaceutical ingredients is essential for a 'right-first-time' philosophy within the industry." | 1.32 | Applications of terahertz spectroscopy to pharmaceutical sciences. ( Taday, PF, 2004) |
| " The drug's effect as well as adverse effects should be actively sought, and dosage alterations made in order to enhance the drug's effect." | 1.32 | Introduction to monitoring. What is what you prescribed actually doing? ( George, A; Shakib, S, 2003) |
| " It is considered one of the most important quality control tests performed on pharmaceutical dosage forms, and validation of dissolution methods is an important part of good manufacturing practices (GMP)." | 1.31 | Validation of tablet dissolution method by high-performance liquid chromatography. ( Dluzneski, PR; Guo, JH; Harcum, WW; Skinner, GW; Trumbull, DE, 2000) |
| " The proposed liquid chromatographic method was successfully applied to the analysis of commercially available paracetamol dosage forms with recoveries of 98-103%." | 1.31 | Simultaneous LC determination of paracetamol and related compounds in pharmaceutical formulations using a carbon-based column. ( Darghouth, F; Monser, L, 2002) |
| "A rapid, precise, and specific high-performance liquid chromatographic method is described for the simultaneous determination of paracetamol, phenylephrine HCI, and chlorpheniramine maleate in combined pharmaceutical dosage forms." | 1.31 | Simultaneous high-performance liquid chromatographic determination of paracetamol, phenylephrine HCl, and chlorpheniramine maleate in pharmaceutical dosage forms. ( Ozden, T; Senyuva, H, 2002) |
| " Acetaminophen protein adducts were detected in liver and serum as early as 15 min after hepatotoxic dosing of acetaminophen to mice." | 1.31 | Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection. ( Coop, L; Hendrickson, HP; Hinson, JA; James, LP; Mayeux, PR; McCullough, SS; Muldrew, KL, 2002) |
| "Thirty-five patients had proven drug allergy; 33 were not allergic to drugs and served as a control group together with 40 other subjects with no history of drug allergy." | 1.30 | Predictive capacity of histamine release for the diagnosis of drug allergy. ( Bousquet, J; Daurès, JP; Demoly, P; Godard, P; Lebel, B; Messaad, D; Rongier, M; Sahla, H, 1999) |
| "A rapid simple and robust reversed-phase HPLC method was developed for rapid screening in bioavailability studies or comparative bioequivalence studies." | 1.29 | Rapid high-performance liquid chromatographic determination of vancomycin in human plasma. ( Luksa, J; Marusic, A, 1995) |
| " After correction of recovery values using in vivo retrodialysis prior to dosing the animal, we obtained similar data as compared to conventional sampling techniques." | 1.29 | Application of microdialysis to the pharmacokinetics of analgesics: problems with reduction of dialysis efficiency in vivo. ( Brune, K; Geisslinger, G; Sauernheimer, C; Williams, KM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.47) | 18.7374 |
| 1990's | 38 (18.01) | 18.2507 |
| 2000's | 88 (41.71) | 29.6817 |
| 2010's | 80 (37.91) | 24.3611 |
| 2020's | 4 (1.90) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 3 |
| Sun, J | 1 |
| Sui, X | 1 |
| Liu, J | 2 |
| Yan, Z | 1 |
| Liu, X | 4 |
| Sun, Y | 2 |
| He, Z | 1 |
| Chomchai, S | 3 |
| Mekavuthikul, P | 1 |
| Phuditshinnapatra, J | 1 |
| Chomchai, C | 3 |
| Sebaiy, MM | 1 |
| El-Adl, SM | 1 |
| Mattar, AA | 1 |
| Haidar, MK | 1 |
| Morton, N | 1 |
| Roederer, T | 1 |
| Mayronne, S | 1 |
| Bawo, L | 1 |
| Kerkula, J | 1 |
| Porten, K | 1 |
| Baud, FJ | 1 |
| Karpińska, G | 1 |
| Dobrowolski, JC | 1 |
| Yinda, CK | 1 |
| Rector, A | 1 |
| Zeller, M | 1 |
| Conceição-Neto, N | 1 |
| Heylen, E | 1 |
| Maes, P | 1 |
| Ghogomu, SM | 1 |
| Van Ranst, M | 1 |
| Matthijnssens, J | 1 |
| Arthanari, SK | 1 |
| Vanitha, J | 1 |
| Ganesh, M | 1 |
| Venkateshwaran, K | 1 |
| de Lama Caro-Patón, G | 1 |
| García-Salido, A | 1 |
| Iglesias-Bouzas, MI | 1 |
| Guillén, M | 1 |
| Cañedo-Villaroya, E | 1 |
| Martínez-Romera, I | 1 |
| Serrano-González, A | 1 |
| Casado-Flores, J | 1 |
| Gale, P | 2 |
| Chen, X | 6 |
| Lucero-Prisno, DE | 1 |
| Abdullah, AS | 1 |
| Huang, J | 2 |
| Laurence, C | 1 |
| Liang, X | 1 |
| Ma, Z | 1 |
| Mao, Z | 1 |
| Ren, R | 2 |
| Wu, S | 1 |
| Wang, N | 1 |
| Wang, P | 2 |
| Wang, T | 2 |
| Yan, H | 1 |
| Zou, Y | 1 |
| Olsen, KM | 1 |
| Gabler, NK | 1 |
| Rademacher, CJ | 1 |
| Schwartz, KJ | 1 |
| Schweer, WP | 1 |
| Gourley, GG | 1 |
| Patience, JF | 1 |
| Rauch, JC | 1 |
| Stokes, RS | 1 |
| Shike, DW | 1 |
| Luebbe, KM | 1 |
| Stalker, LA | 1 |
| Klopfenstein, TJ | 1 |
| Funston, RN | 1 |
| Unger, PA | 1 |
| Lighaam, LC | 1 |
| Vermeulen, E | 1 |
| Kruithof, S | 1 |
| Makuch, M | 1 |
| Culver, EL | 1 |
| van Bruggen, R | 1 |
| Remmerswaal, EBM | 1 |
| Ten Berge, IJM | 1 |
| Emmens, RW | 1 |
| Niessen, HWM | 1 |
| Barnes, E | 1 |
| Wolbink, GJ | 1 |
| van Ham, SM | 1 |
| Rispens, T | 1 |
| Liang, JX | 1 |
| Lin, J | 1 |
| Wang, X | 2 |
| Zhang, T | 1 |
| Li, J | 2 |
| Wu, Y | 2 |
| Venier, M | 1 |
| Salamova, A | 1 |
| Gonçales, VR | 1 |
| Lian, J | 1 |
| Gautam, S | 1 |
| Tilley, RD | 1 |
| Gooding, JJ | 1 |
| Kandel, YR | 1 |
| Bradley, CA | 1 |
| Chilvers, MI | 1 |
| Mathew, FM | 1 |
| Tenuta, AU | 1 |
| Smith, DL | 1 |
| Wise, KA | 1 |
| Mueller, DS | 1 |
| Lu, N | 1 |
| Lu, M | 1 |
| Liu, P | 1 |
| Xu, H | 2 |
| Qiu, X | 2 |
| Hu, S | 1 |
| Bai, S | 2 |
| Wu, J | 1 |
| Xue, S | 1 |
| Dai, X | 1 |
| Dharmage, SC | 1 |
| Abramson, MJ | 1 |
| Erbas, B | 1 |
| Bennett, CM | 1 |
| Svanes, C | 1 |
| Hui, J | 1 |
| Axelrad, C | 1 |
| Lowe, AJ | 1 |
| Lodge, CJ | 1 |
| Hoshi, M | 1 |
| Osawa, Y | 1 |
| Nakamoto, K | 1 |
| Morita, N | 1 |
| Yamamoto, Y | 1 |
| Ando, T | 1 |
| Tashita, C | 1 |
| Nabeshima, T | 1 |
| Saito, K | 4 |
| Gianesello, L | 1 |
| Del Prete, D | 1 |
| Ceol, M | 1 |
| Priante, G | 1 |
| Calò, LA | 1 |
| Anglani, F | 1 |
| Vekaria, HJ | 1 |
| Hubbard, WB | 1 |
| Scholpa, NE | 1 |
| Spry, ML | 1 |
| Gooch, JL | 1 |
| Prince, SJ | 1 |
| Schnellmann, RG | 1 |
| Sullivan, PG | 1 |
| Zhang, Q | 1 |
| Hu, R | 1 |
| Gu, Z | 1 |
| Zhang, M | 1 |
| Zhang, Z | 3 |
| Peng, Y | 1 |
| Feng, L | 1 |
| Li, X | 3 |
| Zhao, C | 1 |
| Sarfaraz, K | 1 |
| Gao, L | 1 |
| Wang, H | 1 |
| Wan, C | 1 |
| Leng, J | 1 |
| Yang, P | 2 |
| Gao, X | 1 |
| Gao, J | 1 |
| Emam, HE | 1 |
| Saad, NM | 1 |
| Abdallah, AEM | 1 |
| Ahmed, HB | 1 |
| Palombo, M | 1 |
| Ianus, A | 1 |
| Guerreri, M | 1 |
| Nunes, D | 1 |
| Alexander, DC | 1 |
| Shemesh, N | 1 |
| Zhang, H | 3 |
| Xiong, Q | 1 |
| Liu, YS | 1 |
| Hu, LX | 1 |
| Shi, ZQ | 1 |
| Ying, GG | 1 |
| Chen, R | 1 |
| Hong, X | 1 |
| Yan, S | 1 |
| Zha, J | 1 |
| Gu, H | 1 |
| Zhong, Q | 1 |
| Zeng, Y | 1 |
| Zhang, S | 1 |
| Bu, Y | 1 |
| Farghali, M | 1 |
| Mayumi, M | 1 |
| Syo, K | 1 |
| Satoshi, A | 1 |
| Seiichi, Y | 1 |
| Takashima, S | 1 |
| Ono, H | 1 |
| Ap, Y | 1 |
| Yamashiro, T | 1 |
| Ahmed, MM | 2 |
| Kotb, S | 1 |
| Iwasaki, M | 1 |
| Ihara, I | 1 |
| Umetsu, K | 1 |
| Hu, B | 1 |
| Wang, Y | 4 |
| Quan, J | 1 |
| Huang, K | 1 |
| Gu, X | 1 |
| Zhu, J | 1 |
| Yan, Y | 1 |
| Wu, P | 1 |
| Yang, L | 2 |
| Zhao, J | 2 |
| Koók, L | 1 |
| Nemestóthy, N | 1 |
| Bélafi-Bakó, K | 1 |
| Bakonyi, P | 1 |
| Luo, X | 1 |
| Zhang, F | 1 |
| Li, Q | 1 |
| Xia, Q | 1 |
| Li, Z | 2 |
| Ye, W | 1 |
| Li, S | 1 |
| Ge, C | 1 |
| Zakkula, A | 1 |
| Pulipati, S | 1 |
| Dittakavi, S | 1 |
| Bestha, RM | 1 |
| Zainuddin, M | 1 |
| Trivedi, RK | 1 |
| Mullangi, R | 1 |
| Lo, GH | 1 |
| Lin, CW | 1 |
| Tai, CM | 1 |
| Perng, DS | 1 |
| Chen, IL | 1 |
| Yeh, JH | 1 |
| Lin, HC | 1 |
| Rocha, GS | 1 |
| Silva, MKL | 1 |
| Cesarino, I | 1 |
| Hazzaa, SM | 1 |
| Abdelaziz, SAM | 1 |
| Abd Eldaim, MA | 1 |
| Abdel-Daim, MM | 1 |
| Elgarawany, GE | 1 |
| Larsson, P | 1 |
| Ljuslinder, I | 1 |
| Öhlund, D | 1 |
| Myte, R | 1 |
| Löfgren-Burström, A | 1 |
| Zingmark, C | 1 |
| Ling, A | 1 |
| Edin, S | 1 |
| Palmqvist, R | 1 |
| Murthi, P | 1 |
| Rajaraman, G | 1 |
| Erwich, JJHM | 1 |
| Dimitriadis, E | 1 |
| Yoon, HG | 1 |
| Oh, D | 1 |
| Ahn, YC | 1 |
| Noh, JM | 1 |
| Pyo, H | 1 |
| Cho, WK | 1 |
| Song, YM | 1 |
| Park, M | 1 |
| Hwang, NY | 1 |
| Sun, JM | 1 |
| Kim, HK | 1 |
| Zo, JI | 1 |
| Shim, YM | 1 |
| Persano, A | 1 |
| Quaranta, F | 1 |
| Taurino, A | 1 |
| Siciliano, PA | 1 |
| Iannacci, J | 1 |
| Malekbala, MR | 1 |
| Soltani, S | 1 |
| Abdul Rashid, S | 1 |
| Abdullah, LC | 1 |
| Rashid, U | 1 |
| Nehdi, IA | 1 |
| Choong, TSY | 1 |
| Teo, SH | 1 |
| Xu, P | 1 |
| Yan, F | 1 |
| Zhao, Y | 1 |
| Sun, S | 1 |
| Ying, L | 1 |
| Quinzi, V | 1 |
| Caruso, S | 1 |
| Mummolo, S | 1 |
| Nota, A | 1 |
| Angelone, AM | 1 |
| Mattei, A | 1 |
| Gatto, R | 1 |
| Marzo, G | 1 |
| Xin, W | 1 |
| Severino, J | 1 |
| Venkert, A | 1 |
| Yu, H | 1 |
| Knorr, D | 1 |
| Yang, JM | 1 |
| Carlson, L | 1 |
| Hicks, R | 1 |
| De Rosa, I | 1 |
| Beckmann, NA | 1 |
| Bitsch, RG | 1 |
| Schonhoff, M | 1 |
| Siebenrock, KA | 1 |
| Schwarze, M | 1 |
| Jaeger, S | 1 |
| Ibrahim, H | 1 |
| Hamdy, AM | 1 |
| Merey, HA | 1 |
| Saad, AS | 1 |
| Wong, A | 1 |
| Sivilotti, MLA | 1 |
| Graudins, A | 1 |
| Li, R | 1 |
| Guo, C | 1 |
| Wu, X | 1 |
| Huang, Z | 1 |
| Chen, J | 1 |
| Rissin, DM | 1 |
| López-Longarela, B | 1 |
| Pernagallo, S | 1 |
| Ilyine, H | 1 |
| Vliegenthart, ADB | 1 |
| Dear, JW | 3 |
| Díaz-Mochón, JJ | 1 |
| Duffy, DC | 1 |
| van Gelder, MMHJ | 1 |
| Vorstenbosch, S | 1 |
| Te Winkel, B | 1 |
| van Puijenbroek, EP | 1 |
| Roeleveld, N | 1 |
| Zabron, A | 1 |
| Quaglia, A | 1 |
| Fatourou, E | 1 |
| Peddu, P | 1 |
| Lewis, D | 1 |
| Heneghan, M | 1 |
| Willars, C | 1 |
| Auzinger, G | 1 |
| Heaton, N | 1 |
| Wendon, J | 4 |
| Kane, P | 1 |
| Karani, J | 1 |
| Bernal, W | 2 |
| Nguyen, V | 1 |
| Muñoz Romo, R | 1 |
| M Borobia Pérez, A | 1 |
| A Muñoz, M | 1 |
| Carballo Cardona, C | 1 |
| Cobo Mora, J | 1 |
| Carcas Sansuán, AJ | 1 |
| Radke, JB | 1 |
| Algren, DA | 1 |
| Chenoweth, JA | 1 |
| Owen, KP | 1 |
| Ford, JB | 1 |
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| Frye, RF | 1 |
| Simon, RE | 1 |
| Walton, LK | 1 |
| Liang, Y | 1 |
| Denton, MB | 1 |
| Thatcher, NJ | 1 |
| Murray, S | 1 |
| Watanabe, H | 1 |
| Kawata, S | 1 |
| Ishikawa, K | 1 |
| Su, YC | 1 |
| Doran, S | 1 |
| Wittert, G | 1 |
| Chapman, IM | 1 |
| Jones, KL | 1 |
| Smout, AJ | 1 |
| Horowitz, M | 1 |
| Monser, L | 1 |
| Darghouth, F | 1 |
| Senyuva, H | 1 |
| Ozden, T | 1 |
| Muldrew, KL | 1 |
| Coop, L | 1 |
| McCullough, SS | 1 |
| Hendrickson, HP | 1 |
| Mayeux, PR | 1 |
| Wells, E | 1 |
| Beard, RH | 1 |
| Farrar, HC | 1 |
| Oliveira, EJ | 1 |
| Watson, DG | 1 |
| Morton, NS | 1 |
| Chen, G | 1 |
| Ye, J | 1 |
| Bao, H | 1 |
| Hallbach, J | 1 |
| Guder, WG | 1 |
| Benson, RW | 1 |
| Kadlubar, FF | 1 |
| Liu, G | 1 |
| Gelboin, HV | 1 |
| Myers, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety and Pharmacokinetics of Lisinopril in Pediatric Kidney Transplant Recipients[NCT01491919] | Phase 1 | 26 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| 13C-Methacetin Breath Test for the Prediction of Outcome in in Acute Liver Injury or Acute Liver Failure[NCT02786836] | Phase 2/Phase 3 | 76 participants (Actual) | Interventional | 2016-06-10 | Completed | ||
| Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001] | Phase 4 | 60 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| A Full-Factorial, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Dose Efficacy and Safety Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen, and Naproxen Sodium in Postoperative Dental Pain[NCT05761574] | Phase 3 | 440 participants (Anticipated) | Interventional | 2023-05-22 | Recruiting | ||
| A Multi-Center Group to Study Acute Liver Failure in Children[NCT00986648] | 158 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| A Multi-center Study of the Safety and Efficacy of N-acetylcysteine in the Treatment of Acute Liver Failure in Pediatric Patients Not Caused by Acetaminophen.[NCT00248625] | Phase 3 | 184 participants (Actual) | Interventional | 2000-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Potassium values will be obtained at Baseline and Day 14 prior to the final dose of study drug. Mean calculated from the two measurements. (NCT01491919)
Timeframe: At baseline visit and Day 14 prior to final study dose.
| Intervention | mEq/L (Mean) |
|---|---|
| Low Dose: Lisinopril | 0.1 |
| Medium Dose: Lisinopril | -0.3 |
| High Dose: Lisinopril | 0.3 |
Change in urine protein/creatinine obtained as follows: Mean change (worst post-dose from baseline) presented for urine protein/creatinine ratio. Geometric mean of the ratio (worst post-dose / baseline with Geometric Coefficient of Variation percent (CV%) and greatest decrease presented for eGFR by dose group. Two patients in the high dose group had an evaluable urine protein/creatinine change. (NCT01491919)
Timeframe: Baseline to worst post-dose before Day 14 (+/- 3 days)
| Intervention | mg/mg (Geometric Mean) |
|---|---|
| Low Dose: Lisinopril | -0.45 |
| Medium Dose: Lisinopril | -0.08 |
| High Dose: Lisinopril | -0.74 |
"The eGFR at entry will need to be ≥ 30 ml/min/1.73m^2 to minimize concerns about an acute angiotensin-converting enzyme inhibitor (ACEI) mediated reduction in kidney function.~Largest eGFR percent decrease from baseline reported in results section." (NCT01491919)
Timeframe: Baseline to Day 14 (+/- 3 days)
| Intervention | percentage (Number) |
|---|---|
| Low Dose: Lisinopril | 15 |
| Medium Dose: Lisinopril | 12 |
| High Dose: Lisinopril | 21 |
At the Day 14 (±3 days) visit, blood (1 mL) will be collected at 0 hour (pre-dose) and at 1, 2, 4, 5, 8, 12 and 24 hours post-lisinopril dose for determination of AUC. Geometric mean was calculated from all measurements. (NCT01491919)
Timeframe: Day 14 (+/- 3 days) of lisinopril therapy at hours 0 (pre-dose) and 1,2,4,5,8,12 and 24 hrs after dose
| Intervention | ng*h/mL (Geometric Mean) |
|---|---|
| Low Dose: Lisinopril | 298 |
| Medium Dose: Lisinopril | 640 |
| High Dose: Lisinopril | 702 |
At the Day 14 (±3 days) visit, blood (1 mL) will be collected at 0 hour (pre-dose) and at 1, 2, 4, 5, 8, 12 and 24 hours post-lisinopril dose for determination of Cmax. Geometric mean was calculated from all measurements. (NCT01491919)
Timeframe: Day14 (+/- 3 d) of dose at 0 hour and 1, 2, 4, 5, 8, 12, and 24 hrs after dose
| Intervention | ng/ml (Geometric Mean) |
|---|---|
| Low Dose: Lisinopril | 20.9 |
| Medium Dose: Lisinopril | 47.7 |
| High Dose: Lisinopril | 58.0 |
At the Day 14 (±3 days) visit, blood (1 mL) will be collected at 0 hour (pre-dose) and at 1, 2, 4, 5, 8, 12 and 24 hours post-lisinopril dose for determination of CL/F. Geometric mean was calculated from all measurements. (NCT01491919)
Timeframe: Day 14 (+/- 3 d) of dose at 0 hour and at 1, 2, 4, 5, 8, 12, and 24 hrs after dose
| Intervention | L/h/70 kg (Geometric Mean) |
|---|---|
| Low Dose: Lisinopril | 17.9 |
| Medium Dose: Lisinopril | 18.6 |
| High Dose: Lisinopril | 32.8 |
At the Day 14 (±3 days) visit, blood (1 mL) will be collected at 0 hour (pre-dose) and at 1, 2, 4, 5, 8, 12 and 24 hours post-lisinopril dose for determination of plasma lisinopril concentration. Medium was calculated from all measurements. (NCT01491919)
Timeframe: Day 14 (+/- 3 d) of dose at 0 hour and 1, 2, 4, 5, 8, 12, and 24 hrs after dose
| Intervention | hours (Median) |
|---|---|
| Low Dose: Lisinopril | 5.0 |
| Medium Dose: Lisinopril | 5.0 |
| High Dose: Lisinopril | 4.5 |
At the Day 14 (±3 days) visit, blood (1 mL) will be collected at 0 hour (pre-dose) and at 1, 2, 4, 5, 8, 12 and 24 hours post-lisinopril dose for determination of CLrenal. Geometric mean was calculated from all measurements. (NCT01491919)
Timeframe: Day 14 (+/- 3 d) of dose at 0 hour and 1, 2, 4, 5, 8, 12, and 24 hrs after dose.
| Intervention | L/h/70 kg (Geometric Mean) |
|---|---|
| Low Dose: Lisinopril | 3.4 |
| Medium Dose: Lisinopril | 3.4 |
| High Dose: Lisinopril | 6.8 |
The eGFR at entry will need to be ≥ 30 ml/min/1.73m^2 to minimize concerns about an acute angiotensin-converting enzyme inhibitors (ACE-I)-mediated reduction in kidney function. eGFR ratio was computed from the worst post-dose value divided by the Baseline value. (NCT01491919)
Timeframe: Baseline to Day 14 (+/- 3 days)
| Intervention | ratio (Geometric Mean) |
|---|---|
| Low Dose: Lisinopril | 1 |
| Medium Dose: Lisinopril | 1.02 |
| High Dose: Lisinopril | 0.89 |
Lisinopril SOC participants were not given the ambulatory blood pressure machine to obtain readings at home, as was the Lisinopril-naive participants. Instead BP measurements were obtained during screening visit and compared to the Day 14 to 40 visit measurements (note: the participants were not required to attend a Day 14 (+/-3 day visit) but did need to attend sometime between Day 14 to Day 40. The mean from the blood pressure measurements was calculated. (NCT01491919)
Timeframe: Screening to Day 14 to 40
| Intervention | mmHg (Mean) | |
|---|---|---|
| eGFR 30-59 ml/min per 1.73m2 (n=2, 2, 0) | eGFR >=60 ml/min per 1.73m2 (n=5, 2, 0) | |
| Low Dose: Lisinopril | -6.0 | 3.4 |
| Medium Dose: Lisinopril | -6.5 | -3.0 |
"Ambulatory blood pressure readings were measured during the baseline/pre-study dose period using a SpaceLabs (Redmond, WA) device at home to avoid the confounding effects of venipuncture and abnormal sleep pattern.~Another blood pressure reading was performed at 1 day before the final dose of lisinopril (day before the last scheduled visit).~The mean of these measurements was calculated." (NCT01491919)
Timeframe: Baseline to Day 14 (+/-3 days)
| Intervention | mmHg (Mean) | |
|---|---|---|
| eGFR 30-59 ml/min per 1.73m^2 (n=3, 1, 0) | eGFR >=60 ml/min per 1.73m^2 (n=3, 5, 3) | |
| High Dose: Lisinopril | NA | -4.0 |
| Low Dose: Lisinopril | -4.0 | -9.0 |
| Medium Dose: Lisinopril | 7.0 | -6.0 |
Lisinopril SOC participants were not given the ambulatory blood pressure machine to obtain readings at home, as was the Lisinopril-naive participants. Instead BP measurements were obtained during screening visit and compared to the Day 14 to 40 visit measurements. Note: these participants were not required to attend a Day 14 (+/-3 day visit) but did need to attend sometime between Day 14 to Day 40 (inclusive). The mean of these blood pressure measurements was calculated. (NCT01491919)
Timeframe: Screening to Day 14 to 40
| Intervention | mmHg (Mean) | |
|---|---|---|
| eGFR 30-59 ml/min per 1.73m2 (n=2, 2, 0) | eGFR >=60 ml/min per 1.73m2 (n=5, 2, 0) | |
| Low Dose: Lisinopril | -6.0 | 6.4 |
| Medium Dose: Lisinopril | -1.0 | -1.0 |
"Ambulatory blood pressure readings were measured during the baseline/pre-study dose period using a SpaceLabs (Redmond, WA) device at home to avoid the confounding effects of venipuncture and abnormal sleep pattern.~Another blood pressure reading was performed at 1 day before the final dose of lisinopril (day before the last scheduled visit).~The mean from these measurements was calculated." (NCT01491919)
Timeframe: Baseline to Day 14 (+/- 3 days)
| Intervention | mmHg (Mean) | |
|---|---|---|
| eGFR 30-59 ml/min per 1.73m2 (n=3, 1, 0) | eGFR >+60 ml/min per 1.732 (n=3, 5, 3) | |
| High Dose: Lisinopril | NA | -11.3 |
| Low Dose: Lisinopril | -5.0 | -6.7 |
| Medium Dose: Lisinopril | -6.0 | -8.8 |
Number of Adverse Events (AEs) related and not related to study drug; number of Serious Adverse Events (SAEs) related and not related to study drug (NCT01491919)
Timeframe: First dose of study drug to 30 days after final study visit for AEs and until resolution for SAEs
| Intervention | events (Number) | ||||
|---|---|---|---|---|---|
| AEs | AE related to study drug | AEs not related to study drug | SAE | SAE not related to study drug | |
| Lisinopril Standard of Care (SOC) | 12 | 0 | 12 | 0 | 0 |
| Lisinopril-naive | 12 | 5 | 7 | 1 | 1 |
The relationship between the cPDR (cumulative PDR of metabolized 13C-Methacetin 20 minutes after ingestion) in single time points of MBT measurements and TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT/transplant free survival at Day 21 | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 1.4 | 0.2 |
Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 (normal carbon dioxide) ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS (transplant free survival) and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: Days 1 and 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Mean Peak PDR for TFS subjects at Day 21 | Mean Peak PDR for non-TFS subjects at Day 21 | |
| 13C-Methacetin Breath Test (MBT) | 10.2 | 1.9 |
This outcome is similar to the peak PDR defined in the primary outcome but as a secondary we are looking at Day 1 or Day 2 peak PDR values. Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT & Day 21 TFS | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 9.1 | 2.3 |
(NCT00248625)
Timeframe: Within 1 year of randomization
| Intervention | percentage of participants (Number) |
|---|---|
| N-acetylcysteine (NAC) | 45 |
| Placebo | 35 |
(NCT00248625)
Timeframe: Within 7 days of randomization
| Intervention | Participants (Number) |
|---|---|
| N-acetylcysteine (NAC) | 20 |
| Placebo | 21 |
(NCT00248625)
Timeframe: Randomization to hospital discharge
| Intervention | days (Median) |
|---|---|
| N-acetylcysteine (NAC) | 103 |
| Placebo | 21 |
Survival without liver transplantation (NCT00248625)
Timeframe: One year following randomization
| Intervention | participants (Number) |
|---|---|
| N-acetylcysteine (NAC) | 33 |
| Placebo | 49 |
Spontaneous survival without transplant plus survival following transplantation (NCT00248625)
Timeframe: One year following randomization
| Intervention | Participants (Number) |
|---|---|
| N-acetylcysteine (NAC) | 68 |
| Placebo | 76 |
The length of ICU stay was categorized as number of days in ICU within 7 days of randomization, unless participant either died or received an LTx within this time period. Special categories were created for these cases. (NCT00248625)
Timeframe: Within 7 days of randomization
| Intervention | participants (Number) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 days | 1 day | 2 days | 3 days | 4 days | 5 days | 6 days | 7 days | underwent LTx w/i 7 days of randomization | died w/o LTx w/i 7 days of randomization | |
| N-acetylcysteine (NAC) | 29 | 3 | 3 | 2 | 1 | 4 | 5 | 9 | 28 | 8 |
| Placebo | 34 | 4 | 4 | 0 | 3 | 3 | 3 | 14 | 22 | 5 |
West Haven Criteria for hepatic encephalopathy (Grade 0 - IV ) is used for participants > 3 year of age. Coma grade IV indicates a participant who is comatose , with no reflexes, is decerebrate and has abnormal EEG changes with very slow delta activity. For participants less than 3 years the Whittington Scale was used. The Whittington scale does not use EEG changes and has only 3 levels, early (grades I and II), Mid (III) with somnolence, stupor, combativeness and Late (IV) for participants who are comatose with absent reflexes and decerebrate or decorticate posturing. (NCT00248625)
Timeframe: Within 7 days of randomization
| Intervention | participants (Number) | ||||
|---|---|---|---|---|---|
| 0 | I | II | III | IV | |
| N-acetylcysteine (NAC) | 28 | 16 | 20 | 15 | 11 |
| Placebo | 27 | 21 | 19 | 17 | 6 |
(NCT00248625)
Timeframe: Within 7 days of randomization
| Intervention | participants (Number) | ||||
|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | |
| N-acetylcysteine (NAC) | 44 | 21 | 15 | 11 | 1 |
| Placebo | 46 | 23 | 12 | 8 | 3 |
11 reviews available for acetaminophen and Sensitivity and Specificity
| Article | Year |
|---|---|
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
[5-0xoproline (pyroglutamic acid) acidosis and acetaminophen- a differential diagnosis in high anion gap metabolic acidosis].
Topics: Acetaminophen; Acidosis; Analgesics, Non-Narcotic; Biomarkers; Diagnosis, Differential; Humans; Medi | 2015 |
Recent advances in biomarkers and therapeutic interventions for hepatic drug safety - false dawn or new horizon?
Topics: Acetaminophen; Biomarkers; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adv | 2016 |
Systematic review: prognostic tests of paracetamol-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Humans; Liver F | 2010 |
Fulminant hepatic failure secondary to acetaminophen poisoning: a systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation.
Topics: Acetaminophen; Health Status Indicators; Humans; Liver Failure; Liver Transplantation; Patient Selec | 2003 |
Anticarcinogenicity of monocyclic phenolic compounds.
Topics: Acetaminophen; Animals; Anticarcinogenic Agents; Butylated Hydroxyanisole; Butylated Hydroxytoluene; | 2002 |
Systematic overview of co-proxamol to assess analgesic effects of addition of dextropropoxyphene to paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Dextropropoxyphene; Drug Combinations; | 1997 |
Guide for judicious use of the paracetamol absorption technique in a study of gastric emptying rate of liquids.
Topics: Acetaminophen; Administration, Oral; Area Under Curve; Cross-Sectional Studies; Gastric Emptying; Gu | 1998 |
As compared to Paracetamol, does the Paracetamol and Methionine combinations have better efficacy and safety and can it be used safely in the management of pyrexia associated with liver diseases?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Therapy, Combination; Female; Fever; Humans; Liver Dis | 1999 |
Novel testing of human gastric motor and sensory functions: rationale, methods, and potential applications in clinical practice.
Topics: Acetaminophen; Breath Tests; Diagnostic Imaging; Gastrointestinal Motility; Humans; Reproducibility | 2000 |
Critical considerations in the immunochemical detection and quantitation of antigenic biomarkers.
Topics: Acetaminophen; Aminobiphenyl Compounds; Antigens; Biomarkers; Carcinogens; DNA Damage; Humans; Immun | 1991 |
10 trials available for acetaminophen and Sensitivity and Specificity
| Article | Year |
|---|---|
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Therapeutic paracetamol treatment in older persons induces dietary and metabolic modifications related to sulfur amino acids.
Topics: Acetaminophen; Aged; Aging; Algorithms; Amino Acids, Sulfur; Analgesics, Non-Narcotic; Arthritis; Bi | 2012 |
Assessment of a point-of-care test for paracetamol and salicylate in blood.
Topics: Acetaminophen; Adult; Blood Chemical Analysis; Drug Overdose; Female; Humans; Male; Point-of-Care Sy | 2005 |
Simultaneous determination of paracetamol and dextropropoxyphene in human plasma by liquid chromatography/tandem mass spectrometry: application to clinical bioequivalence studies.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Blood Chemical An | 2005 |
Reduction of acetaminophen interference in glucose sensors by a composite Nafion membrane: demonstration in rats and man.
Topics: Acetaminophen; Adult; Animals; Biosensing Techniques; Blood Glucose; Blood Glucose Self-Monitoring; | 1994 |
Serum sickness-like reactions to cefaclor: role of hepatic metabolism and individual susceptibility.
Topics: Acetaminophen; Adolescent; Adult; Biotransformation; Cefaclor; Cell Death; Cephalexin; Child; Child, | 1994 |
Additive analgesic effect of codeine and paracetamol can be detected in strong, but not moderate, pain after Caesarean section. Baseline pain-intensity is a determinant of assay-sensitivity in a postoperative analgesic trial.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Codeine; Double-Blind Method; Drug | 1996 |
Impaired neutrophil functions in patients with leukocytoclastic vasculitis.
Topics: Acetaminophen; Amoxicillin; Analysis of Variance; Cells, Cultured; Chemotaxis; Cloxacillin; Humans; | 1997 |
Variation in surgical trauma and baseline pain intensity: effects on assay sensitivity of an analgesic trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; | 1998 |
Effects of exogenous corticotropin-releasing factor on antropyloroduodenal motility and appetite in humans.
Topics: Acetaminophen; Adult; Analysis of Variance; Appetite; Corticotropin-Releasing Hormone; Double-Blind | 2002 |
191 other studies available for acetaminophen and Sensitivity and Specificity
| Article | Year |
|---|---|
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metab | 2009 |
Sensitivity of dose-estimations for acute acetaminophen overdose in predicting hepatotoxicity risk using the Rumack-Matthew Nomogram.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Antidotes; Charcoal; Chemical and Drug Induc | 2022 |
Different techniques for overlapped UV spectra resolution of some co-administered drugs with paracetamol in their combined pharmaceutical dosage forms.
Topics: Acetaminophen; Caffeine; Diclofenac; Linear Models; Models, Chemical; Orphenadrine; Reproducibility | 2020 |
Evaluating lactate prognostic value in children suspected of acetaminophen-induced liver failure in Liberia.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Hospital Mor | 2020 |
Simultaneous Determination of Paracetamol, Propyphenazone and Caffeine in Presence of Paracetamol Impurities Using Dual-Mode Gradient HPLC and TLC Densitometry Methods.
Topics: Acetaminophen; Aminophenols; Antipyrine; Caffeine; Chromatography, High Pressure Liquid; Chromatogra | 2021 |
Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcot | 2017 |
FGF21 functions as a sensitive biomarker of APAP-treated patients and mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2017 |
Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury.
Topics: Acetaminophen; Adult; Base Sequence; Biomarkers; Case-Control Studies; Chemical and Drug Induced Liv | 2017 |
Using Web-Based Questionnaires to Assess Medication Use During Pregnancy: A Validation Study in 2 Prospectively Enrolled Cohorts.
Topics: Acetaminophen; Adult; Analgesics; Drug Prescriptions; Female; Histamine Antagonists; Humans; Nonpres | 2018 |
Clinical and prognostic associations of liver volume determined by computed tomography in acute liver failure.
Topics: Acetaminophen; Adult; Budd-Chiari Syndrome; Decision Support Techniques; Disease Progression; Female | 2018 |
Calculated decisions: King's College Criteria for Acetaminophen Toxicity
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Biomarkers; Decision Making; Hum | 2018 |
Efficient diagnosis and treatment of acute paracetamol poisoning: cost-effectiveness analysis of approaches based on a hospital toxicovigilance program.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Cost-Benefit | 2018 |
Transaminase and Creatine Kinase Ratios for Differentiating Delayed Acetaminophen Overdose from Rhabdomyolysis.
Topics: Acetaminophen; Adult; Creatine Kinase; Diagnosis, Differential; Drug Overdose; Female; Humans; Male; | 2018 |
Performance evaluation of five commercial assays for detection of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Bilirubin; Hemolysis; Humans; Immunoenzyme Techniques; Linear Models; | 2019 |
Predicting daily outcomes in acetaminophen-induced acute liver failure patients with machine learning techniques.
Topics: Acetaminophen; Adult; Area Under Curve; Bayes Theorem; Databases, Factual; Female; Humans; Linear Mo | 2019 |
Copper Nanowires Modified with Graphene Oxide Nanosheets for Simultaneous Voltammetric Determination of Ascorbic Acid, Dopamine and Acetaminophen.
Topics: Acetaminophen; Ascorbic Acid; Biosensing Techniques; Copper; Dopamine; Electrochemical Techniques; G | 2019 |
Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol.
Topics: Absorption, Physiological; Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Evaluation, Precli | 2019 |
Rapid determination of N-acetyl-4-aminophenol (paracetamol) in urine by tandem mass spectrometry coupled with on-line clean-up by two dimensional turbulent flow/reversed phase liquid chromatography.
Topics: Acetaminophen; Adult; Body Burden; Chromatography, High Pressure Liquid; Chromatography, Reverse-Pha | 2013 |
Direct separation of faradaic and double layer charging current in potential step voltammetry.
Topics: Acetaminophen; Copper Sulfate; Electricity; Electrochemical Techniques; Electrodes; Ferricyanides; H | 2013 |
Acetaminophen Psi Nomogram: a sensitive and specific clinical tool to predict hepatotoxicity secondary to acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2014 |
Predicting acute acetaminophen hepatotoxicity with acetaminophen-aminotransferase multiplication product and the Psi parameter.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Antidotes; Aspartate Aminotransferases; | 2014 |
Quantification of a biomarker of acetaminophen protein adducts in human serum by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: clinical and animal model applications.
Topics: Acetaminophen; Animals; Biomarkers; Chromatography, High Pressure Liquid; Humans; Male; Mice; Mice, | 2015 |
Development of a solvent-free analytical method for paracetamol quantitative determination in Blood Brain Barrier in vitro model.
Topics: Acetaminophen; Blood-Brain Barrier; Cell Line; Chromatography, High Pressure Liquid; Chromatography, | 2015 |
Bio-generation of stable isotope-labeled internal standards for absolute and relative quantitation of phase II drug metabolites in plasma samples using LC-MS/MS.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimida | 2015 |
Assessment of protein modifications in liver of rats under chronic treatment with paracetamol (acetaminophen) using two complementary mass spectrometry-based metabolomic approaches.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Gene Expression | 2015 |
Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation.
Topics: Acetaminophen; Animals; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Hum | 2015 |
Simultaneous determination of acetaminophen and dihydrocodeine in human plasma by UPLC-MS/MS: Its pharmacokinetic application.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Codeine; Drug Stability; Humans; Linear Models; | 2015 |
Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Bile Acids and Salts; Biomarkers; Chemical and Drug | 2015 |
Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Ov | 2015 |
A novel composite electrode based on tungsten oxide nanoparticles and carbon nanotubes for the electrochemical determination of paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Conductometry; Electrodes; Equipment Design; Equipment Fail | 2015 |
A novel electrochemical sensor based on magneto Au nanoparticles/carbon paste electrode for voltammetric determination of acetaminophen in real samples.
Topics: Acetaminophen; Biosensing Techniques; Carbon; Conductometry; Electrodes; Equipment Design; Equipment | 2015 |
A quadruplet electrochemical platform for ultrasensitive and simultaneous detection of ascorbic acid, dopamine, uric acid and acetaminophen based on a ferrocene derivative functional Au NPs/carbon dots nanocomposite and graphene.
Topics: Acetaminophen; Ascorbic Acid; Dopamine; Ferrous Compounds; Humans; Limit of Detection; Metallocenes; | 2016 |
A Systematic Strategy for Screening and Application of Specific Biomarkers in Hepatotoxicity Using Metabolomics Combined With ROC Curves and SVMs.
Topics: Acetaminophen; Animals; Atorvastatin; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Li | 2016 |
Ultra-sensitive film sensor based on Al2O3-Au nanoparticles supported on PDDA-functionalized graphene for the determination of acetaminophen.
Topics: Acetaminophen; Aluminum Oxide; Biosensing Techniques; Conductometry; Electrodes; Equipment Design; E | 2016 |
Offline solid-phase extraction for preconcentration of pharmaceuticals and personal care products in environmental water and their simultaneous determination using the reversed phase high-performance liquid chromatography method.
Topics: Acetaminophen; Benzophenones; Caffeine; Carbanilides; Chromatography, High Pressure Liquid; Chromato | 2016 |
Paracetamol no worse than ibuprofen in children with mild asthma.
Topics: Acetaminophen; Asthma; Child; Child, Preschool; Disease Progression; Female; Humans; Ibuprofen; Male | 2016 |
An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure.
Topics: Acetaminophen; Adult; Aged; Chromatography, High Pressure Liquid; Electrochemical Techniques; Female | 2017 |
Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine?
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Female; Human | 2017 |
A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Ea | 2017 |
In-Vivo Validation of Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism.
Topics: Acetaminophen; Animals; Biosensing Techniques; Blood Chemical Analysis; Blood Glucose; Conductometry | 2016 |
Application of dried blood spots combined with HPLC-MS/MS for the quantification of acetaminophen in toxicokinetic studies.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Dogs; Female; Male; Sensitivity and Sp | 2008 |
Evaluation of a urine screen for acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chromatography, High Pressure Liquid; Drug Overdose; Fluoro | 2008 |
Online concentration by head-column field-amplified with large-volume sample stacking using flow injection-capillary electrophoresis for the analysis of four active components in cold medicines.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Allergic Agents; Antitussive Agents; Chlorpheniramine; | 2008 |
Simultaneous determination of aceclofenac, paracetamol, and chlorzoxazone by RP-HPLC in pharmaceutical dosage form.
Topics: Acetaminophen; Chlorzoxazone; Chromatography, High Pressure Liquid; Diclofenac; Reproducibility of R | 2008 |
Screening and characterization of reactive metabolites using glutathione ethyl ester in combination with Q-trap mass spectrometry.
Topics: Acetaminophen; Amodiaquine; Carbamazepine; Glutathione; Humans; Imipramine; Mass Spectrometry; Metab | 2009 |
Electroanalytical determination of acetaminophen using nano-TiO(2)/polymer coated electrode in the presence of dopamine.
Topics: Acetaminophen; Carbon; Catalysis; Dopamine; Electrochemistry; Electrodes; Hydrogen-Ion Concentration | 2008 |
Dried blood spots as a sample collection technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanalytical method.
Topics: Acetaminophen; Blood Chemical Analysis; Blood Circulation; Blood Specimen Collection; Clinical Trial | 2009 |
The role of etiology in the hyperamylasemia of acute liver failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Female; Humans; Hyperamylasemia; Liver Failure, Acut | 2009 |
Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartat | 2009 |
Liver injury from diclofenac or acetaminophen?
Topics: Acetaminophen; Diclofenac; Humans; Liver; Liver Failure; Risk Assessment; Sensitivity and Specificit | 2009 |
The utilization of liver transplantation in the management of acute liver failure: comparison between acetaminophen and non-acetaminophen etiologies.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcoholism; Analgesics, Non-Narcotic; Cohort Studies; Contra | 2009 |
Second-order advantage applied to simultaneous spectrofluorimetric determination of paracetamol and mefenamic acid in urine samples.
Topics: Acetaminophen; Humans; Hydrogen-Ion Concentration; Least-Squares Analysis; Mefenamic Acid; Multivari | 2009 |
A determination of submicromolar concentrations of glycine in periaqueductal gray matter microdialyzates using capillary zone electrophoresis with contactless conductivity detection.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carrageenan; Electric Conductivity; Electrophoresi | 2009 |
Performance of a new interference-resistant glucose meter.
Topics: Acetaminophen; Ascorbic Acid; Biosensing Techniques; Blood Chemical Analysis; Blood Glucose; Blood G | 2010 |
Direct quantitative bioanalysis of drugs in dried blood spot samples using a thin-layer chromatography mass spectrometer interface.
Topics: Acetaminophen; Aminoquinolines; Benzethonium; Blood Chemical Analysis; Chromatography, High Pressure | 2009 |
Simultaneous determination of paracetamol, pseudoephedrine, dextrophan and chlorpheniramine in human plasma by liquid chromatography-tandem mass spectrometry.
Topics: Acetaminophen; Chromatography, Liquid; Dextrorphan; Drug Stability; Humans; Linear Models; Pseudoeph | 2010 |
Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury.
Topics: Acetaminophen; Alanine Transaminase; Albumins; Analgesics, Non-Narcotic; Anesthetics, Local; Animals | 2010 |
The value of the dental impaction pain model in drug development.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Human | 2010 |
The value of the dental impaction pain model in drug development.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Human | 2010 |
The value of the dental impaction pain model in drug development.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Human | 2010 |
The value of the dental impaction pain model in drug development.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Human | 2010 |
Determination of picamilon concentration in human plasma by liquid chromatography-tandem mass spectrometry.
Topics: Acetaminophen; Chemical Fractionation; Chromatography, Liquid; Drug Stability; gamma-Aminobutyric Ac | 2010 |
Improved detection of reactive metabolites with a bromine-containing glutathione analog using mass defect and isotope pattern matching.
Topics: Acetaminophen; Animals; Bromine Compounds; Chromatography, Liquid; Clozapine; Glutathione; Microsome | 2010 |
Determination of p-aminohippuric acid in rat plasma by liquid chromatography-tandem mass spectrometry.
Topics: Acetaminophen; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Drug Stability; Line | 2010 |
Multivariate optimization and validation of a capillary electrophoresis method for the simultaneous determination of dextromethorphan hydrobromur, phenylephrine hydrochloride, paracetamol and chlorpheniramine maleate in a pharmaceutical preparation using
Topics: Acetaminophen; Chlorpheniramine; Chromatography, High Pressure Liquid; Dextromethorphan; Electrophor | 2010 |
A sensitive HPLC-ESI-MS-MS method for the determination of cotinine in urine.
Topics: Acetaminophen; Adult; Chromatography, High Pressure Liquid; Cotinine; Drug Stability; Female; Humans | 2010 |
A reliable method of liquid chromatography for the quantification of acetaminophen and identification of its toxic metabolite N-acetyl-p-benzoquinoneimine for application in pediatric studies.
Topics: Acetaminophen; Adolescent; Benzoquinones; Child; Child, Preschool; Chromatography, High Pressure Liq | 2011 |
Rapid and sensitive drug metabolism studies by SU-8 microchip capillary electrophoresis-electrospray ionization mass spectrometry.
Topics: Acetaminophen; Acetates; Chemical Fractionation; Electrophoresis, Microchip; Epoxy Compounds; Ethano | 2011 |
Application of experimental design in optimization of the separation condition for determination of four active components in cold medicines by flow injection-capillary electrophoresis.
Topics: Acetaminophen; Analysis of Variance; Chlorpheniramine; Dextromethorphan; Electrophoresis, Capillary; | 2011 |
Simultaneous spectrophotometric determination of paracetamol and para-aminophenol in pharmaceutical dosage forms using two novel multivariate standard addition methods based on net analyte signal and rank annihilation factor analysis.
Topics: Acetaminophen; Aminophenols; Analgesics, Non-Narcotic; Factor Analysis, Statistical; Limit of Detect | 2012 |
Rat primary hepatocytes show enhanced performance and sensitivity to acetaminophen during three-dimensional culture on a polystyrene scaffold designed for routine use.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Culture Techniques; Cell Survival; Collagen; | 2011 |
Aldo-keto reductase-7A protects liver cells and tissues from acetaminophen-induced oxidative stress and hepatotoxicity.
Topics: Acetaminophen; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Cells, Cu | 2011 |
Patch testing in fixed drug eruptions--a 20-year review.
Topics: Acetaminophen; Adult; Aged; Allopurinol; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroi | 2011 |
Reliability of the reported ingested dose of acetaminophen for predicting the risk of toxicity in acetaminophen overdose patients.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cohort Studies; Dose-Response Relationship, Drug; Drug Over | 2012 |
Highly specific, sensitive and rapid enzyme immunoassays for the measurement of acetaminophen in serum.
Topics: Acetaminophen; Chromatography, Affinity; Enzyme-Linked Immunosorbent Assay; Horseradish Peroxidase; | 2011 |
Development, validation, and application of a fast and simple GC-MS method for determination of some therapeutic drugs relevant in emergency toxicology.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Gas Chromatography-Mass Spe | 2011 |
Electrodeposited acetaminophen as a bifunctional electrocatalyst for simultaneous determination of ascorbic acid, glutathione, adrenaline and tryptophan.
Topics: Acetaminophen; Ascorbic Acid; Catalysis; Electrochemical Techniques; Electrodes; Epinephrine; Glutat | 2011 |
Method of applying internal standard to dried matrix spot samples for use in quantitative bioanalysis.
Topics: Acetaminophen; Aminoquinolines; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Huma | 2011 |
Correlation of MRI findings to histology of acetaminophen toxicity in the mouse.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Expectorants; Liver Fai | 2012 |
Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) for determination of risedronate concentrations in human plasma.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Diazomethane; Drug Stability; Etidronic Acid; H | 2012 |
Determination of salbutamol in human plasma and urine using liquid chromatography coupled to tandem mass spectrometry and its pharmacokinetic study.
Topics: Acetaminophen; Adult; Albuterol; Area Under Curve; Chromatography, Reverse-Phase; Drug Stability; Hu | 2012 |
A new liquid chromatography-mass spectrometry approach for generic screening and quantitation of potential genotoxic alkylation compounds without derivatization.
Topics: Acetaminophen; Alkylation; Benzene Derivatives; Chromatography, Liquid; Drug Contamination; Mutagens | 2012 |
Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and death.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical | 2012 |
Does paracetamol prevent apnoea in infants? The current dilemma of evaluation of therapies in the absence of randomized controlled trials.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Apnea; Female; Humans; Infant; Male; Needs Assessment; Rand | 2012 |
Simultaneous quantitative determination of paracetamol and its glucuronide conjugate in human plasma and urine by liquid chromatography coupled to electrospray tandem mass spectrometry: application to a clinical pharmacokinetic study.
Topics: Acetaminophen; Adult; Chromatography, Liquid; Humans; Linear Models; Reproducibility of Results; Sen | 2012 |
Quantification of active ingredients in suppositories by FT-Raman spectroscopy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Least- | 2013 |
Quantitative analysis of acetaminophen and its six metabolites in rat plasma using liquid chromatography/tandem mass spectrometry.
Topics: Acetaminophen; Animals; Chromatography, Liquid; Drug Stability; Linear Models; Male; Metabolic Netwo | 2012 |
Development and validation of packed column supercritical fluid chromatographic technique for quantification of chlorzoxazone, paracetamol and aceclofenac in their individual and combined dosage forms.
Topics: Acetaminophen; Carbon Dioxide; Chlorzoxazone; Chromatography, Supercritical Fluid; Diclofenac; Drug | 2012 |
Stability-indicating TLC-densitometric method for simultaneous determination of paracetamol and chlorzoxazone and their toxic impurities.
Topics: Acetaminophen; Aminophenols; Capsules; Chlorophenols; Chlorzoxazone; Chromatography, Thin Layer; Den | 2013 |
Quantification of acetaminophen and two of its metabolites in human plasma by ultra-high performance liquid chromatography-low and high resolution tandem mass spectrometry.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Humans; Linear Models; Reproducibility of Resul | 2012 |
Investigation on the downregulation of dopamine by acetaminophen administration based on their simultaneous determination in urine.
Topics: Acetaminophen; Antipyretics; Biosensing Techniques; Dopamine; Electrochemical Techniques; Electrodes | 2013 |
Acetaminophen glucuronide and plasma glucose report identical estimates of gluconeogenesis and glycogenolysis for healthy and prediabetic subjects using the deuterated water method.
Topics: Acetaminophen; Adult; Blood Glucose; Deuterium; Female; Gluconeogenesis; Glycogenolysis; Humans; Mag | 2013 |
Effect of metoclopramide on the excretion rate of paracetamol using HPLC-DAD.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Drug Interactions; Drug Stability; Humans; Line | 2013 |
Electrosynthesis of an imidazole derivative and its application as a bifunctional electrocatalyst for simultaneous determination of ascorbic acid, adrenaline, acetaminophen, and tryptophan at a multi-wall carbon nanotubes modified electrode surface.
Topics: Acetaminophen; Ascorbic Acid; Biosensing Techniques; Catalysis; Complex Mixtures; Conductometry; Ele | 2013 |
Development and validation of a LC-MS/MS method for the quantification of the regioisomers of dihydroxybutylether in human plasma.
Topics: Acetaminophen; Blood Specimen Collection; Chemical Precipitation; Chromatography, Liquid; Drug Stabi | 2012 |
Fluorescent transgenic zebrafish Tg(nkx2.2a:mEGFP) provides a highly sensitive monitoring tool for neurotoxins.
Topics: Acetaminophen; Animals; Animals, Genetically Modified; Atenolol; Atrazine; Axons; Central Nervous Sy | 2013 |
Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital.
Topics: Acetaminophen; Adult; Alanine Transaminase; Biomarkers; Chemical and Drug Induced Liver Injury; Dise | 2013 |
Determination of theophylline by HPLC and GC-IDMS, the effect of chemically similar xanthine derivatives on the specificity of the method and the possibility of paracetamol as interfering substance.
Topics: Acetaminophen; Calibration; Chemical Precipitation; Chromatography, High Pressure Liquid; Gas Chroma | 2002 |
[Estimation of precision in system suitability tests].
Topics: Acetaminophen; Calibration; Chromatography, High Pressure Liquid; Confidence Intervals; Sensitivity | 2002 |
Rapid spectrophotometric method for serum glutathione S-transferases activity.
Topics: Acetaminophen; Adolescent; Adult; Aged; Child; Child, Preschool; Dinitrochlorobenzene; Enzyme Inhibi | 2002 |
High-voltage capacitively coupled contactless conductivity detection for microchip capillary electrophoresis.
Topics: Acetaminophen; Citric Acid; Electric Conductivity; Electrodes; Electrophoresis, Capillary; Ibuprofen | 2002 |
The formation of oxidative stress condition in the experimental chemically induced hepatotoxicity.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2002 |
Simultaneous determination of carisoprodol and acetaminophen in an attempted suicide by liquid chromatography-mass spectrometry with positive electrospray ionization.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Carisoprodol; Chromatography, Liquid; Drug Combinati | 2003 |
The use of dimethylsulfoxide as a vehicle in cell culture experiments using ovarian carcinoma cell lines.
Topics: Acetaminophen; Aspirin; Cell Count; Cell Culture Techniques; Cell Division; Cell Line, Tumor; Cultur | 2003 |
[Research into simultaneous spectrophotometric determination of components in cough syrup by principal component regression method].
Topics: Acetaminophen; Aminophenols; Analgesics, Non-Narcotic; Caffeine; Chlorpheniramine; Drug Combinations | 2002 |
[Assay for paracetamol by derivative spectrophotometry in compound amantadine tablets].
Topics: Acetaminophen; Amantadine; Antiviral Agents; Caffeine; Drug Combinations; Pharmaceutical Preparation | 2002 |
[Nondestructive quantitative analysis of Paracetamoli powder pharmaceutical by artificial neural network and near-infrared spectroscopy].
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Models, Theoretical; Neural Networks, Computer; | 2001 |
Introduction to monitoring. What is what you prescribed actually doing?
Topics: Acetaminophen; Aged; Aspirin; Australia; Celecoxib; Drug Interactions; Drug Therapy, Combination; Fa | 2003 |
Liquid chromatographic determination of ceterizine hydrochloride and paracetamol in human plasma and pharmaceutical formulations.
Topics: Acetaminophen; Adult; Histamine H1 Antagonists; Humans; Pharmaceutical Preparations; Piperazines; Re | 2003 |
Image curvature correction and cosmic removal for high-throughput dispersive Raman spectroscopy.
Topics: Acetaminophen; Algorithms; Artifacts; Cosmic Radiation; Equipment Design; Equipment Failure Analysis | 2003 |
CSF Glucose Concentrations in Infants with Febrile Convulsions and the Possible Effect of Acetaminophen.
Topics: Acetaminophen; Biomarkers; Case-Control Studies; Dose-Response Relationship, Drug; Drug Administrati | 2003 |
Poly(dimethylsiloxane) microchip capillary electrophoresis with electrochemical detection for rapid measurement of acetaminophen and its hydrolysate.
Topics: Acetaminophen; Aminophenols; Dimethylpolysiloxanes; Electrochemistry; Electrophoresis, Capillary; El | 2004 |
Applications of terahertz spectroscopy to pharmaceutical sciences.
Topics: Acetaminophen; Algorithms; Aspirin; Chemistry, Pharmaceutical; Drug Contamination; Infrared Rays; Mi | 2004 |
Sequential injection chromatographic determination of paracetamol, caffeine, and acetylsalicylic acid in pharmaceutical tablets.
Topics: Acetaminophen; Aspirin; Caffeine; Chromatography; Indicators and Reagents; Sensitivity and Specifici | 2004 |
LC/MS for the degradation profiling of cough-cold products under forced conditions.
Topics: Acetaminophen; Chlorpheniramine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug | 2004 |
The flow-cytometric determination of basophil activation induced by aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is useful for in vitro diagnosis of the NSAID hypersensitivity syndrome.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Basophil Degra | 2004 |
Proabsorptive action of gum arabic in isotonic solutions orally administered to rats. II. Effects on solutes under normal and secretory conditions.
Topics: Acetaminophen; Administration, Oral; Animals; Area Under Curve; Biological Availability; Disease Mod | 2004 |
Potentiometric immunosensor using artificial antibody based on molecularly imprinted polymers.
Topics: Acetaminophen; Antibodies; Biosensing Techniques; Calibration; Polymers; Potentiometry; Procainamide | 2004 |
Simplified gas chromatographic assay for paracetamol.
Topics: Acetaminophen; Calibration; Chromatography, Gas; Humans; Sensitivity and Specificity; Spectrophotome | 1975 |
Sensitive liquid chromatography-tandem mass spectrometry method for the simultaneous determination of paracetamol and guaifenesin in human plasma.
Topics: Acetaminophen; Administration, Oral; Guaifenesin; Humans; Reproducibility of Results; Sensitivity an | 2005 |
Content uniformity and dissolution tests of triplicate mixtures by a double divisor-ratio spectra derivative method.
Topics: Acetaminophen; Aspirin; Caffeine; Chlorpheniramine; Chromatography, High Pressure Liquid; Reproducib | 2005 |
Rapid determination of acetaminophen in physiological fluids by liquid chromatography using SDS mobile phase and ED detection.
Topics: Acetaminophen; Calibration; Chromatography, Liquid; Electrochemistry; Hydrogen-Ion Concentration; Re | 2005 |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Topics: 1-Naphthylisothiocyanate; Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2005 |
Hydrogen bonding interactions between adsorbed polymer molecules and crystal surface of acetaminophen.
Topics: Acetaminophen; Adsorption; Crystallization; Hydrogen Bonding; Microscopy, Atomic Force; Models, Mole | 2005 |
Application of stable isotope labeled glutathione and rapid scanning mass spectrometers in detecting and characterizing reactive metabolites.
Topics: Acetaminophen; Animals; Drug Evaluation, Preclinical; Flufenamic Acid; Glutathione; Humans; In Vitro | 2005 |
Australia: the N of 1 trial, an underappreciated research method.
Topics: Acetaminophen; Aged; Attention Deficit Disorder with Hyperactivity; Australia; Child; Child, Prescho | 2006 |
Effect of platelet-activating factor (PAF) receptor antagonist (BN52021) on acetaminophen-induced acute liver injury and regeneration in rats.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Acetaminophen; Analysis of Variance; Animals; Apopto | 2006 |
Rapid separation and determination of process-related substances of paracetamol using reversed-phase HPLC with photo diode array as a detector.
Topics: Acetaminophen; Acetonitriles; Buffers; Calibration; Chemistry Techniques, Analytical; Chemistry, Pha | 2006 |
A Friday afternoon case of apparent anti-glomerular basement nephritis.
Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Animals; Anti-Glomerular Basement Membrane Disease; | 2006 |
Disruption of NaS1 sulfate transport function in mice leads to enhanced acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analysis of Variance; Animals; Chemical and Drug Induced Liver | 2006 |
Neutrophil depletion protects against murine acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biopsy, Needle; Blotting, Western; Chemical and Drug I | 2006 |
How relevant are neutrophils for acetaminophen hepatotoxicity?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2006 |
Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blood Proteins; Chil | 2006 |
Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blood Proteins; Chil | 2006 |
Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blood Proteins; Chil | 2006 |
Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blood Proteins; Chil | 2006 |
Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blood Proteins; Chil | 2006 |
Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blood Proteins; Chil | 2006 |
Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blood Proteins; Chil | 2006 |
Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blood Proteins; Chil | 2006 |
Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blood Proteins; Chil | 2006 |
Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulations.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Buffers; Carbon; Chemistry, Pharmaceutical; Electrochemistr | 2007 |
Quantification of nitrated tryptophan in proteins and tissues by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cattle; Chromatography, High Pressure Liquid; Isom | 2007 |
Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy.
Topics: Acetaminophen; Humans; Ibuprofen; Magnetic Resonance Spectroscopy; Metabolic Networks and Pathways; | 2007 |
Population studies of drug metabolites in urine.
Topics: Acetaminophen; Humans; Ibuprofen; Magnetic Resonance Spectroscopy; Racial Groups; Sensitivity and Sp | 2007 |
Optimisation and validation of a rapid and efficient microemulsion liquid chromatographic (MELC) method for the determination of paracetamol (acetaminophen) content in a suppository formulation.
Topics: Acetaminophen; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Emulsions; Hydrophob | 2007 |
The development of heated tip force-distance measurements as a novel approach to site-specific characterization of pharmaceutical materials.
Topics: Acetaminophen; Adhesives; Calibration; Hot Temperature; Ibuprofen; Indomethacin; Microscopy, Atomic | 2008 |
The significance of autoantibodies and immunoglobulins in acute liver failure: a cohort study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antibodies, Viral; Autoantibodies; Autoantigens; Coh | 2007 |
Desorption atmospheric pressure photoionization.
Topics: Acetaminophen; Adsorption; Atmospheric Pressure; Gases; Ions; Nebulizers and Vaporizers; Photochemis | 2007 |
Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering.
Topics: Acetaminophen; Animals; Bile; Carbamazepine; Chromatography, Liquid; Clozapine; Cresols; Diclofenac; | 2007 |
Time to review the selection criteria for transplantation in paracetamol-induced fulminant hepatic failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biomarkers; Humans; Lactic Acid; Liver Failure, Acute; Live | 2007 |
Development of an HPLC-MS/MS method for the selective determination of paracetamol metabolites in mouse urine.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Male; Mice; Sensitivity and Specificit | 2008 |
Nonenzymatic electrochemical glucose sensor based on nanoporous PtPb networks.
Topics: Acetaminophen; Ascorbic Acid; Biosensing Techniques; Electrochemistry; Electrodes; Glucose; Hydrogen | 2008 |
Validation of a fluorimetric assay for 4-aminophenol in paracetamol formulations.
Topics: Acetaminophen; Aminophenols; Color; Fluorometry; Pharmaceutical Preparations; Powders; Reproducibili | 2008 |
Development of a low-flow multiplexed interface for capillary electrophoresis/electrospray ion trap mass spectrometry using sequential spray.
Topics: Acetaminophen; Electronics, Medical; Electrophoresis, Capillary; Equipment Design; Sensitivity and S | 2008 |
Determination of paracetamol and its main impurity 4-aminophenol in analgesic preparations by micellar electrokinetic chromatography.
Topics: Acetaminophen; Aminophenols; Analgesics, Non-Narcotic; Buffers; Chromatography, Micellar Electrokine | 2008 |
Electrochemical behavior and differential pulse voltammetric determination of paracetamol at a carbon ionic liquid electrode.
Topics: Acetaminophen; Calibration; Carbon; Electrochemistry; Electrodes; Humans; Hydrogen-Ion Concentration | 2008 |
Process characterization of powder blending by near-infrared spectroscopy: blend end-points and beyond.
Topics: Acetaminophen; Algorithms; Calibration; Cellulose; Chemistry, Pharmaceutical; Lactose; Least-Squares | 2008 |
Sensitive adsorptive stripping voltammetric determination of paracetamol at multiwalled carbon nanotube modified basal plane pyrolytic graphite electrode.
Topics: Acetaminophen; Adsorption; Buffers; Electrochemistry; Electrodes; Graphite; Hydrogen-Ion Concentrati | 2008 |
Cold light fluorimetry: a microtitration technology for cell culture to evaluate anethole dithiolethione and other biothiols.
Topics: Acetaminophen; Anethole Trithione; Antioxidants; Bisbenzimidazole; Cells, Cultured; Drug Evaluation, | 1995 |
Rapid high-performance liquid chromatographic determination of vancomycin in human plasma.
Topics: Acetaminophen; Aspirin; Caffeine; Chromatography, High Pressure Liquid; Humans; Quality Control; Sen | 1995 |
A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocol.
Topics: Acetaminophen; Animals; Cell Extracts; Cells, Cultured; Dithionitrobenzoic Acid; Extracellular Space | 1994 |
Application of microdialysis to the pharmacokinetics of analgesics: problems with reduction of dialysis efficiency in vivo.
Topics: Acetaminophen; Animals; Male; Metabolic Clearance Rate; Microdialysis; Rats; Rats, Sprague-Dawley; S | 1994 |
Serum lactic dehydrogenase in the differential diagnosis of acute hepatocellular injury.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug I | 1994 |
Diagnostic tests for occult bacteremia: temperature response to acetaminophen versus WBC count.
Topics: Acetaminophen; Bacteremia; Body Temperature; Child; Child, Preschool; Cohort Studies; Emergency Serv | 1994 |
Improvement of the selectivity of an FIA amperometric biosensor system for glucose.
Topics: Acetaminophen; Ascorbic Acid; Blood Glucose; Chromatography, Ion Exchange; Enzymes, Immobilized; Flo | 1993 |
Coagulation factor V levels as a prognostic indicator in fulminant hepatic failure.
Topics: Acetaminophen; Adolescent; Adult; Case-Control Studies; Drug Overdose; Factor V; Hepatic Encephalopa | 1996 |
Inhibition of DNA synthesis by paracetamol in different tissues of the rat in vivo.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Brain; Digestive System; DNA; Dose-Response Relati | 1997 |
Development and validation of a high-performance liquid chromatography method for the determination of cold relief ingredients in chewing gum.
Topics: Acetaminophen; Chewing Gum; Chlorpheniramine; Chromatography, High Pressure Liquid; Ephedrine; Place | 1997 |
The determination of inorganic sulphate in serum and synovial fluid by high performance ion chromatography.
Topics: Acetaminophen; Arthritis; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Female | 1997 |
Comparison of two assays for measuring plasma concentrations of paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Monitoring; Drug Overdose; Humans; Sensitivity and Spe | 1997 |
Earlier identification of patients at risk from acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; APACHE; Female; Hospital Mortality; Huma | 1998 |
Comparison of assays for measuring plasma paracetamol. Possibility of calibration error needs evaluation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Calibration; Chromatography, High Pressure Liquid; Drug Mon | 1998 |
Comparison of assays for measuring plasma paracetamol. Training and education in use of assay are important.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Medical Staff, Hospital; Observer Variation; Sensit | 1998 |
Performance of human mass balance studies with stable isotope-labeled drug and continuous flow-isotope ratio mass spectrometry: a progress report.
Topics: Acetaminophen; Carbon Isotopes; Feces; Humans; Male; Mass Spectrometry; Nitrogen Isotopes; Pharmaceu | 1998 |
Aqueous two-phase partitioning sample preparation prior to liquid chromatography of hydrophilic drugs in blood.
Topics: Acetaminophen; Animals; Blood Proteins; Buffers; Cattle; Chemical Precipitation; Chromatography, Hig | 1998 |
Highly sensitive hepatitis B surface antigen detection by measuring stable nitroxide radical formation with ESR spectroscopy.
Topics: Acetaminophen; Adult; Blood Donors; Cyclic N-Oxides; DNA, Viral; Electron Spin Resonance Spectroscop | 1998 |
Flow diagram or prose: does the format of practice guidelines matter?
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Communication; Decision Support Techniques; Emergenc | 1998 |
A validated method for the determination of paracetamol and its glucuronide and sulphate metabolites in the urine of HIV+/AIDS patients using wavelength-switching UV detection.
Topics: Acetaminophen; Acetonitriles; Acquired Immunodeficiency Syndrome; Chromatography, High Pressure Liqu | 1998 |
Comparison of present pain intensity assessments on horizontally and vertically oriented visual analogue scales.
Topics: Acetaminophen; Adolescent; Adult; Codeine; Female; Humans; Male; Molar, Third; Oral Surgical Procedu | 1998 |
Direct determination of paracetamol and its metabolites in urine and serum by capillary electrophoresis with ultraviolet and mass spectrometric detection.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Electrophoresis, Capillary; Humans; Mass Spectrometry; Repr | 1999 |
Comparing the performance of automated diluters with the accuracy standards for class A volumetric glassware.
Topics: Acetaminophen; Autoanalysis; Chemistry, Clinical; Chromatography, High Pressure Liquid; Glass; Labor | 1998 |
Predictive capacity of histamine release for the diagnosis of drug allergy.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Child; Drug | 1999 |
Predictive properties of a qualitative urine acetaminophen screen in patients with self-poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Drug Overdose; False Positive Reactions; Female; Humans; Mal | 1999 |
Spectrofluorometric determination of diclofenac in tablets and ointments.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Diclofenac; Excipients; Hydro | 1999 |
Simultaneous determination of paracetamol, caffeine and acetylsalicylic acid by means of a FI ultraviolet pls multioptosensing device.
Topics: Acetaminophen; Aspirin; Caffeine; Electronic Data Processing; Flow Injection Analysis; Hydrogen-Ion | 1999 |
Simultaneous determination of paracetamol and chlorpheniramine in human plasma by liquid chromatography-tandem mass spectrometry.
Topics: Acetaminophen; Chlorpheniramine; Chromatography, Liquid; Humans; Mass Spectrometry; Reference Standa | 2000 |
Validation of tablet dissolution method by high-performance liquid chromatography.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Chromatography, High Pressure Liq | 2000 |
Fast urinary screening for paracetamol using on-line microwave assisted hydrolysis and spectrophotometric detection.
Topics: Acetaminophen; Humans; Hydrolysis; Microwaves; Sensitivity and Specificity; Spectrophotometry | 2000 |
Simultaneous determination of paracetamol and methocarbamol in tablets by ratio spectra derivative spectrophotometry and LC.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Methocarbamol; Reproducibility of Results; Sens | 2001 |
High-performance liquid chromatographic assay for acetaminophen glucuronide in human liver microsomes.
Topics: Acetaminophen; Calibration; Chromatography, High Pressure Liquid; Humans; Microsomes, Liver; Reprodu | 2001 |
Fluorescence quenching high-performance thin-layer chromatographic analysis utilizing a scientifically operated charge-coupled device detector.
Topics: Acetaminophen; Aspirin; Autoanalysis; Caffeine; Chromatography, High Pressure Liquid; Chromatography | 2001 |
Analysis of the glutathione conjugate of paracetamol in human liver microsomal fraction by liquid chromatography mass spectrometry.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chromatography, High Pressure Liquid; Glutathione; Humans; | 2001 |
Clinical significance of a highly sensitive enzyme immunoassay of hepatitis B surface antigen using a novel electron spin resonance technique.
Topics: Acetaminophen; Adult; Aged; Cyclic N-Oxides; DNA, Viral; Electron Spin Resonance Spectroscopy; Femal | 2002 |
Simultaneous LC determination of paracetamol and related compounds in pharmaceutical formulations using a carbon-based column.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentr | 2002 |
Simultaneous high-performance liquid chromatographic determination of paracetamol, phenylephrine HCl, and chlorpheniramine maleate in pharmaceutical dosage forms.
Topics: Acetaminophen; Calibration; Chlorpheniramine; Chromatography, High Pressure Liquid; Dosage Forms; Ph | 2002 |
Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminot | 2002 |
Predictors of outcome after acetaminophen poisoning in children and adolescents.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Arkansas; | 2002 |
A simple microanalytical technique for the determination of paracetamol and its main metabolites in blood spots.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chromatography, High Pressure Liquid; Humans; Magnetic Reso | 2002 |
Determination of the rate constants and activation energy of acetaminophen hydrolysis by capillary electrophoresis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Buffers; Electrodes; Electrophoresis, Capillary; Hydrogen-I | 2002 |
Mechanized toxicological serum tests in screening hospitalized patients.
Topics: Acetaminophen; Alcoholic Intoxication; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Autoan | 1991 |
Role of cytochrome P450 IA2 in acetanilide 4-hydroxylation as determined with cDNA expression and monoclonal antibodies.
Topics: Acetaminophen; Animals; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Chromatography, High | 1991 |