acetaminophen has been researched along with Seizures, Febrile in 30 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Seizures, Febrile: Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was undertaken to evaluate the efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen in comparison with as-needed acetaminophen alone for prevention of seizure recurrence during the same fever episode in suspected pediatric simple febrile seizures (SFS)." | 8.12 | Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures. ( Fujita, S; Hataya, H; Kishibe, S; Miyama, S; Morikawa, EK; Morikawa, Y; Narita, K; Sammori, H; Suzuki, S; Takehira, K; Tanaka, M; Tsukamoto, J; Wang, Q; Yano, M, 2022) |
| "This study was undertaken to evaluate the efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen in comparison with as-needed acetaminophen alone for prevention of seizure recurrence during the same fever episode in suspected pediatric simple febrile seizures (SFS)." | 4.12 | Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures. ( Fujita, S; Hataya, H; Kishibe, S; Miyama, S; Morikawa, EK; Morikawa, Y; Narita, K; Sammori, H; Suzuki, S; Takehira, K; Tanaka, M; Tsukamoto, J; Wang, Q; Yano, M, 2022) |
| "Treatment of pediatric fever is based on two main molecules, paracetamol and ibuprofen." | 3.80 | [How to treat pediatric fever in 2013 with little evidence-based?]. ( Gehri, M; Pauchard, JY, 2014) |
| "The results of this survey concerning antipyretic treatment of children by their Jewish and Bedouin Moslem caregivers suggest that lighter body weight and the use of acetaminophen rectal suppositories were associated with the administration of higher-than-recommended doses of acetaminophen." | 3.73 | Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study. ( Bilenko, N; Gorodischer, R; Okbe, R; Press, J; Tessler, H, 2006) |
| "Acetaminophen is a safe antipyretic against FSs and has the potential to prevent FS recurrence during the same fever episode." | 2.87 | Acetaminophen and Febrile Seizure Recurrences During the Same Fever Episode. ( Inoue, K; Kashiwagi, M; Murata, S; Nomura, S; Oba, C; Ogino, M; Okasora, K; Shirasu, A; Syabana, K; Tamai, H; Tanabe, T; Yamazaki, S, 2018) |
| "Acetaminophen had no effect on the recurrence rate." | 2.68 | Effect of acetaminophen and of low intermittent doses of diazepam on prevention of recurrences of febrile seizures. ( Kurttila, R; Rantala, H; Uhari, M; Vainionpää, L, 1995) |
| " Unsolicited adverse events (UAEs) were reported through phone calls or visits, and serious adverse events (SAEs) were recorded per International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use guidelines." | 1.91 | Monitoring of Adverse Events in Recipients of the 2-Dose Ebola Vaccine Regimen of Ad26.ZEBOV Followed by MVA-BN-Filo in the UMURINZI Ebola Vaccination Campaign. ( Allen, S; Hammoud, N; Ingabire, R; Karita, E; Katwere, M; Magod, B; Mazarati, JB; Mazzei, A; Noben, J; Nsanzimana, S; Nyombayire, J; Parker, R; Priddy, F; Robinson, C; Sayinzoga, F; Tichacek, A; Wall, KM, 2023) |
| "Conflicting attitudes toward febrile convulsions were highlighted by beliefs that antipyretic therapy prevents these and that antipyretics do not prevent initial febrile convulsions." | 1.33 | Fever management: paediatric nurses' knowledge, attitudes and influencing factors. ( Courtney, MD; Edwards, HE; Monaghan, SJ; Walsh, AM; Wilson, JE, 2005) |
| "Several descriptions of acetaminophen-associated liver injury caused by therapeutic or a dosage slightly above the recommended dosage have been described." | 1.32 | Silent acetaminophen-induced hepatotoxicity in febrile children: does this entity exist? ( Jaffe, M; Maor, I; Novikov, J; Shaoul, R, 2004) |
| "Sixty-nine children with first febrile seizures and no history of previous unprovoked seizures were matched for age (+/- 6 months), site of routine pediatric care, and date of visit (+/- 2 weeks) with 1 or 2 febrile controls who had no history of previous febrile or unprovoked seizures." | 1.29 | Risk factors for a first febrile seizure: a matched case-control study. ( Berg, AT; Crain, EF; Hauser, WA; Salomon, ME; Shapiro, ED; Shinnar, S, 1995) |
| "The management of children with febrile seizures admitted to hospital within the Mersey region was evaluated by case note review." | 1.29 | The management of febrile seizures in the Mersey Region. ( Appleton, R; Choonara, I; Gibbs, J; Monteil, F; Sweeney, A, 1996) |
| " Acetaminophen and diazepam seemed to be well absorbed from the rectal suppositories, the maximal plasma concentration of diazepam after a rectal dose of 0." | 1.26 | Antipyretic effect and plasma concentrations of rectal acetaminophen and diazepam in children. ( Kangas, L; Keinänen-Kiukaanniemi, S; Luoma, P; Saukkonen, AL; Similä, S, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.00) | 18.7374 |
| 1990's | 10 (33.33) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tanaka, M | 1 |
| Wang, Q | 1 |
| Morikawa, Y | 1 |
| Tsukamoto, J | 1 |
| Sammori, H | 1 |
| Takehira, K | 1 |
| Yano, M | 1 |
| Miyama, S | 1 |
| Fujita, S | 1 |
| Narita, K | 1 |
| Kishibe, S | 1 |
| Morikawa, EK | 1 |
| Suzuki, S | 1 |
| Hataya, H | 1 |
| Nyombayire, J | 1 |
| Ingabire, R | 1 |
| Magod, B | 1 |
| Mazzei, A | 1 |
| Mazarati, JB | 1 |
| Noben, J | 1 |
| Katwere, M | 1 |
| Parker, R | 1 |
| Nsanzimana, S | 1 |
| Wall, KM | 1 |
| Sayinzoga, F | 1 |
| Tichacek, A | 1 |
| Robinson, C | 1 |
| Hammoud, N | 1 |
| Priddy, F | 1 |
| Allen, S | 1 |
| Karita, E | 1 |
| Hashimoto, R | 1 |
| Suto, M | 1 |
| Tsuji, M | 1 |
| Sasaki, H | 1 |
| Takehara, K | 1 |
| Ishiguro, A | 1 |
| Kubota, M | 1 |
| Walter, EB | 1 |
| Hornik, CP | 1 |
| Grohskopf, L | 1 |
| McGee, CE | 1 |
| Todd, CA | 1 |
| Museru, OI | 1 |
| Harrington, L | 1 |
| Broder, KR | 1 |
| Murata, S | 1 |
| Okasora, K | 1 |
| Tanabe, T | 1 |
| Ogino, M | 1 |
| Yamazaki, S | 1 |
| Oba, C | 1 |
| Syabana, K | 1 |
| Nomura, S | 1 |
| Shirasu, A | 1 |
| Inoue, K | 1 |
| Kashiwagi, M | 1 |
| Tamai, H | 1 |
| Chiappini, E | 1 |
| D'Elios, S | 1 |
| Mazzantini, R | 1 |
| Becherucci, P | 1 |
| Pierattelli, M | 1 |
| Galli, L | 1 |
| de Martino, M | 1 |
| Pauchard, JY | 1 |
| Gehri, M | 1 |
| Warwick, C | 1 |
| Strengell, T | 1 |
| Uhari, M | 3 |
| Tarkka, R | 2 |
| Uusimaa, J | 1 |
| Alen, R | 1 |
| Lautala, P | 1 |
| Rantala, H | 3 |
| Miller, RJ | 1 |
| Bailey, J | 1 |
| Sullivan, K | 1 |
| Riedl, B | 1 |
| Mohammadi, M | 1 |
| Mohebbi, MR | 1 |
| Naderi, F | 1 |
| Shaoul, R | 1 |
| Novikov, J | 1 |
| Maor, I | 1 |
| Jaffe, M | 1 |
| Walsh, AM | 1 |
| Edwards, HE | 1 |
| Courtney, MD | 1 |
| Wilson, JE | 1 |
| Monaghan, SJ | 1 |
| Bilenko, N | 1 |
| Tessler, H | 1 |
| Okbe, R | 1 |
| Press, J | 1 |
| Gorodischer, R | 1 |
| Hoption Cann, SA | 1 |
| Done, AK | 1 |
| Berg, AT | 1 |
| Shinnar, S | 1 |
| Shapiro, ED | 1 |
| Salomon, ME | 1 |
| Crain, EF | 1 |
| Hauser, WA | 1 |
| Van Esch, A | 1 |
| Van Steensel-Moll, HA | 1 |
| Steyerberg, EW | 1 |
| Offringa, M | 1 |
| Habbema, JD | 1 |
| Derksen-Lubsen, G | 1 |
| Camfield, PR | 1 |
| Camfield, CS | 1 |
| Gordon, K | 1 |
| Dooley, JM | 1 |
| Vainionpää, L | 1 |
| Kurttila, R | 1 |
| Schnaiderman, D | 1 |
| Lahat, E | 1 |
| Sheefer, T | 1 |
| Aladjem, M | 1 |
| Sweeney, A | 1 |
| Gibbs, J | 1 |
| Monteil, F | 1 |
| Appleton, R | 1 |
| Choonara, I | 1 |
| Pokka, T | 1 |
| Carley, S | 1 |
| O'Connor, S | 1 |
| Keinänen-Kiukaanniemi, S | 1 |
| Similä, S | 1 |
| Luoma, P | 1 |
| Kangas, L | 1 |
| Saukkonen, AL | 1 |
| Boréus, LO | 1 |
| Sunami, K | 1 |
| Hayashi, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipyretics for Preventing Recurrences of Febrile Seizures[NCT00568217] | Phase 4 | 231 participants (Actual) | Interventional | 1997-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for acetaminophen and Seizures, Febrile
| Article | Year |
|---|---|
Use of antipyretics for preventing febrile seizure recurrence in children: a systematic review and meta-analysis.
Topics: Acetaminophen; Aged; Antipyretics; Child; Humans; Pharmaceutical Preparations; Prospective Studies; | 2021 |
Clinical inquiries. Does lowering a fever >101 degrees F in children improve clinical outcomes?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chickenpox; Cryotherapy; Fasciitis, Necrotizing; Fever; Hum | 2010 |
Treatment of fever in 1982: a review.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature Regulation; Chemical and Dr | 1983 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Paracetamol or ibuprofen in febrile children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child, Preschool; Emergency Medicine; Evidence-Based Medici | 1999 |
Antipyretics in the paediatric A&E setting: a review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Emergency Nursing; Evidence-Based Medicine; Fever; H | 2002 |
6 trials available for acetaminophen and Seizures, Febrile
| Article | Year |
|---|---|
Acetaminophen and Febrile Seizure Recurrences During the Same Fever Episode.
Topics: Acetaminophen; Administration, Rectal; Antipyretics; Child, Preschool; Female; Humans; Infant; Logis | 2018 |
Antipyretic agents for preventing recurrences of febrile seizures: randomized controlled trial.
Topics: Acetaminophen; Administration, Oral; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; | 2009 |
Antipyretic efficacy of ibuprofen and acetaminophen in children with febrile seizures.
Topics: Acetaminophen; Body Temperature; Child, Preschool; Cross-Over Studies; Dose-Response Relationship, D | 1995 |
Effect of acetaminophen and of low intermittent doses of diazepam on prevention of recurrences of febrile seizures.
Topics: Acetaminophen; Child, Preschool; Diazepam; Double-Blind Method; Drug Administration Schedule; Drug T | 1995 |
Antipyretic effectiveness of acetaminophen in febrile seizures: ongoing prophylaxis versus sporadic usage.
Topics: Acetaminophen; Body Temperature; Child, Preschool; Drug Administration Schedule; Female; Fever; Huma | 1993 |
Risk of recurrence and outcome after the first febrile seizure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Drug Therapy, | 1998 |
19 other studies available for acetaminophen and Seizures, Febrile
| Article | Year |
|---|---|
Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures.
Topics: Acetaminophen; Child; Diazepam; Fever; Humans; Infant; Prospective Studies; Recurrence; Seizures, Fe | 2022 |
Monitoring of Adverse Events in Recipients of the 2-Dose Ebola Vaccine Regimen of Ad26.ZEBOV Followed by MVA-BN-Filo in the UMURINZI Ebola Vaccination Campaign.
Topics: Acetaminophen; Adolescent; Adult; Antibodies, Viral; Child; Child, Preschool; Ebola Vaccines; Ebolav | 2023 |
The effect of antipyretics on immune response and fever following receipt of inactivated influenza vaccine in young children.
Topics: Acetaminophen; Antibodies, Viral; Antipyretics; Child, Preschool; Female; Fever; Hemagglutination In | 2017 |
Adherence among Italian paediatricians to the Italian guidelines for the management of fever in children: a cross sectional survey.
Topics: Acetaminophen; Administration, Rectal; Antipyretics; Child; Cross-Sectional Studies; Fever; Guidelin | 2013 |
[How to treat pediatric fever in 2013 with little evidence-based?].
Topics: Acetaminophen; Child; Evidence-Based Practice; Fever; Humans; Ibuprofen; Seizures, Febrile | 2014 |
Paracetamol and fever management.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Evidence-Based Medicine; Fever; Humans; Patient Education a | 2008 |
[A common emergency in childhood. Febrile convulsions -- what to do?].
Topics: Acetaminophen; Administration, Rectal; Age Factors; Analgesics, Non-Narcotic; Anticonvulsants; Clona | 2003 |
CSF Glucose Concentrations in Infants with Febrile Convulsions and the Possible Effect of Acetaminophen.
Topics: Acetaminophen; Biomarkers; Case-Control Studies; Dose-Response Relationship, Drug; Drug Administrati | 2003 |
Silent acetaminophen-induced hepatotoxicity in febrile children: does this entity exist?
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical | 2004 |
Fever management: paediatric nurses' knowledge, attitudes and influencing factors.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Attitude of Health Personnel; Child; Cross-Sectional | 2005 |
Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid | 2006 |
Acetaminophen and the sodium balance during febrile seizures.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Seizures, Febrile; Sodium | 2008 |
Risk factors for a first febrile seizure: a matched case-control study.
Topics: Acetaminophen; Acute Disease; Case-Control Studies; Comorbidity; Female; Fever; Gastroenteritis; Hum | 1995 |
Prevention of recurrent febrile seizures.
Topics: Acetaminophen; Child; Diazepam; Humans; Recurrence; Seizures, Febrile | 1995 |
The management of febrile seizures in the Mersey Region.
Topics: Acetaminophen; Anti-Bacterial Agents; Anticonvulsants; Emergency Service, Hospital; England; Hospita | 1996 |
Antipyretic effect and plasma concentrations of rectal acetaminophen and diazepam in children.
Topics: Acetaminophen; Body Temperature; Child; Child, Preschool; Diazepam; Drug Therapy, Combination; Fever | 1979 |
[Treatment: fever depressive measures].
Topics: Acetaminophen; Analgesics; Aspirin; Child; Cryotherapy; Humans; Seizures; Seizures, Febrile | 1977 |
[Is the use of antipyretics justified in lowering fever and preventing febrile convulsions in children?].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Humans; Seizures, Febrile | 1992 |
Prophylactic effects of acetaminophen suppository on febrile convulsions: an epidemiologic and twin study.
Topics: Acetaminophen; Child, Preschool; Cross-Sectional Studies; Diseases in Twins; Female; Humans; Inciden | 1990 |