acetaminophen and Scoliosis studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Scoliosis: An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)

Research Excerpts

Excerpt	Relevance	Reference
"The goal of this prospective cohort study was to model cost-effectiveness of adding acetaminophen or acetaminophen + ketorolac to opioids for postoperative outcomes in children having scoliosis surgery."	7.88	Cost-effectiveness of intravenous acetaminophen and ketorolac in adolescents undergoing idiopathic scoliosis surgery. ( Chidambaran, V; Ding, L; Eckman, MH; Geisler, K; Jain, V; Sadhasivam, S; Stubbeman, B; Sturm, P; Subramanyam, R, 2018)
"A randomized, placebo-controlled, double-blind study to evaluate the effect of intravenously (IV) administered acetaminophen on postoperative pain in children and adolescents undergoing surgery for idiopathic scoliosis or spondylolisthesis."	5.16	Acetaminophen improves analgesia but does not reduce opioid requirement after major spine surgery in children and adolescents. ( Hartikainen, T; Helenius, I; Hiller, A; Kaukonen, M; Korpela, R; Meretoja, OA; Neuvonen, PJ; Nurmi, E; Taivainen, T, 2012)
"The goal of this prospective cohort study was to model cost-effectiveness of adding acetaminophen or acetaminophen + ketorolac to opioids for postoperative outcomes in children having scoliosis surgery."	3.88	Cost-effectiveness of intravenous acetaminophen and ketorolac in adolescents undergoing idiopathic scoliosis surgery. ( Chidambaran, V; Ding, L; Eckman, MH; Geisler, K; Jain, V; Sadhasivam, S; Stubbeman, B; Sturm, P; Subramanyam, R, 2018)
"The incidence of severe postoperative pain is not significantly related to CK level."	1.40	Validity of creatine kinase as an indicator of muscle injury in spine surgery and its relation with postoperative pain. ( Bagó Granell, J; Lombao Iglesias, D; Vilor Rivero, T, 2014)

Research

Studies (7)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

PACU Length of Stay

Patient Reported Total Narcotic Use Post-discharge

Patient Satisfaction.

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (14.29)	18.2507
2000's	1 (14.29)	29.6817
2010's	5 (71.43)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Olbrecht, VA	1
Ding, L	2
Spruance, K	1
Hossain, M	1
Sadhasivam, S	2
Chidambaran, V	2
Subramanyam, R	1
Geisler, K	1
Stubbeman, B	1
Sturm, P	1
Jain, V	1
Eckman, MH	1
Lombao Iglesias, D	1
Bagó Granell, J	1
Vilor Rivero, T	1
Hiller, A	1
Helenius, I	1
Nurmi, E	1
Neuvonen, PJ	1
Kaukonen, M	1
Hartikainen, T	1
Korpela, R	1
Taivainen, T	1
Meretoja, OA	1
Blanco, JS	1
Perlman, SL	1
Cha, HS	1
Delpizzo, K	1
Deogaonkar, K	1
Ghandour, A	1
Jones, A	1
Ahuja, S	1
Lyons, K	1
Kádas, I	1
Könczöl, F	1
Illés, T	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Comparative Efficacy of Intravenous Acetaminophen vs. Oral Acetaminophen in Ambulatory Surgery[NCT03558555]	Phase 4	103 participants (Actual)	Interventional	2017-12-08	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	minutes (Mean)
Oral Acetaminophen	82.93
Acetaminophen IV Soln	64.05

Intervention	MME (Mean)
Oral Acetaminophen	14.06
Acetaminophen IV Soln	17.56

Patient satisfaction total scale from 1 to 10, with higher score indicating more satisfaction (NCT03558555)
Timeframe: 7 days post surgery

Total MME Intraoperatively

Intervention	score on a scale (Mean)
Oral Acetaminophen	5.05
Acetaminophen IV Soln	6.20

Total Morphine Milligram Equivalent (MME) use intraoperatively (NCT03558555)
Timeframe: Day 1

Total Narcotic Use in PACU.

Intervention	MME (Mean)
Oral Acetaminophen	63.75
Acetaminophen IV Soln	57.24

Total narcotic use in PACU expressed in total morphine milligram equivalents (MME) (NCT03558555)
Timeframe: Day 1

PACU Visual Analogue Pain Scores

Intervention	MME (Mean)
Oral Acetaminophen	11.33
Acetaminophen IV Soln	9.83

Post-Anesthesia Care Unity (PACU) pain scores at baseline, 1 hour, and on discharge from PACU. Pain score by visual analogue score, total scale from 0 to 10 with 10 being the worse pain. (NCT03558555)
Timeframe: baseline, 1 hour, and Day 1 discharge

Intervention	score on a scale (Mean)
	Baseline	1 hour	Discharge from PACU, up to 2.5 hours	6 hour post op	24 hour post op
Acetaminophen IV Soln	1.52	2.41	1.59	4.27	4.16
Oral Acetaminophen	2.13	2.88	1.45	3.82	3.64

Article	Year
Intravenous Acetaminophen Reduces Length of Stay Via Mediation of Postoperative Opioid Consumption After Posterior Spinal Fusion in a Pediatric Cohort. The Clinical journal of pain, 2018, Volume: 34, Issue:7 Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Adolescent; Analgesics; Analgesics	2018
Cost-effectiveness of intravenous acetaminophen and ketorolac in adolescents undergoing idiopathic scoliosis surgery. Paediatric anaesthesia, 2018, Volume: 28, Issue:3 Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N	2018
Validity of creatine kinase as an indicator of muscle injury in spine surgery and its relation with postoperative pain. Acta orthopaedica Belgica, 2014, Volume: 80, Issue:4 Topics: Acetaminophen; Adult; Age Factors; Aged; Aged, 80 and over; Analgesics; Creatine Kinase; Dipyrone; F	2014
Multimodal pain management after spinal surgery for adolescent idiopathic scoliosis. Orthopedics, 2013, Volume: 36, Issue:2 Suppl Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Female; Humans; Infusions, Intravenous; Pain Ma	2013
[Fatal acute liver damage caused by a therapeutic dose of paracetamol]. Orvosi hetilap, 1998, Jan-25, Volume: 139, Issue:4 Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Child, Preschool; Dose-Response R	1998

acetaminophen and Scoliosis